Tag: 200-300

In 2022,Staerz, Sophia D.; Jones, Corey L.; Tepe, Jetze J. published an article in Journal of Medicinal Chemistry. The title of the article was 《Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies》.Quality Control of Methyl 3-(bromomethyl)benzoate The author mentioned the following in the article:

While neurodegenerative diseases affect millions of patients worldwide, there are insufficient available therapeutics to halt or slow down the progression of these diseases. A key pathol. feature of several neurodegenerative diseases is the oligomerization and aggregation of specific intrinsically disordered proteins (IDPs) creating neuronal deposits, such as Lewy bodies in Parkinson’s disease. Clearance of these pathogenic, aggregation-prone IDPs is mediated by the 20S isoform of the human proteasome. Thus, enhancing the 20S proteasome-mediated proteolysis could be a very useful therapeutic pathway to prevent neurotoxicity. Here, authors report the successful development of sub-microM 20S proteasome activators based on a phenothiazine scaffold. This class of compounds prevented the accumulation of pathol. relevant IDPs, such as the pathogenic A53T mutated α-synuclein, in vitro and in mammalian cell lines. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Quality Control of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Quality Control of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Chen, Xiaodong; Chen, Qian; He, Dan; Yang, Sanxiu; Yang, Yunfei; Qian, Jing; Long, Lingliang; Wang, Kun published an article in Sensors and Actuators, B: Chemical. The title of the article was 《Mitochondria targeted and immobilized ratiometric NIR fluorescent probe for investigating SO2 phytotoxicity in plant mitochondria》.Application In Synthesis of 1,4-Bis(bromomethyl)benzene The author mentioned the following in the article:

Exposure to excessive SO2 will induce severe phytotoxicity to plants. Dissecting mechanisms of SO2 phytotoxicity is vital for preventing adverse effect of SO2. But unfortunately, the mechanisms of SO2 phytotoxicity remain elusive. We speculated that interaction of SO2 derivatives with mitochondria might be an important mechanism for SO2 phytotoxicity. To authenticate this speculation, it is urgently need to detect SO2 derivatives in plant mitochondria when it is suffering from SO2 phytotoxicity. Herein, we presented a novel ratiometric NIR fluorescent probe for highly sensitive and selective detection of SO2 derivatives in plant mitochondria. Notably, the probe not only could target into the mitochondria, but also can immobilize in the mitochondria to continue detecting SO2 derivatives even when the mitochondrial membrane potential was collapsed by high concentration of SO2 derivatives Importantly, the probe has been successfully employed for monitoring high concentration of SO2 derivatives in the plant mitochondria when the plant is suffering from SO2 phytotoxicity. The results demonstrated that the SO2 derivatives level in plant mitochondria is strictly associated with SO2 phytotoxicity. Thus, the interaction of SO2 derivatives with plant mitochondria could be considered as an important mechanism for SO2 phytotoxicity. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application In Synthesis of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Application In Synthesis of 1,4-Bis(bromomethyl)benzene The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Yuxiang; Wu, Jun; Wang, Feng published an article in Applied Catalysis, B: Environmental. The title of the article was 《Dibenzothiophene-S,S-dioxide-containing conjugated polymer with hydrogen evolution rate up to 147 mmol g-1 h-1》.HPLC of Formula: 3141-27-3 The author mentioned the following in the article:

Mol. engineering in donor-acceptor conjugated polymers is currently one of the most successful and popular strategy to prepare high performance photocatalysts for hydrogen evolution. In this contribution, we have designed and synthesized two novel conjugated polymers with tailored donor-acceptor structures based on dibenzothiophene-S,S-dioxide and thiophene derivatives, which exhibited tunable band gaps and adjustable charge separation efficiencies. As a result, PDBTSO-T showed an outstanding hydrogen evolution rate (HER) of 1.47 mmol h-1 by DMF exfoliation under UV-vis region with Pt cocatalyst in ascorbic acid aqueous solution at 10 mg level, which is among the top performance for photocatalysis conversion reported so far. Very excitingly, when the photocatalysis tests were subjected to natural sunlight irradiation, an impressive HER of ∼27 mL (107 mmol g-1 h-1) was achieved after 0.5 h of illumination (12:30 pm – 13:00 pm) on a consistently sunny day under identical reaction conditions. The experimental process involved the reaction of 2,5-Dibromothiophene(cas: 3141-27-3HPLC of Formula: 3141-27-3)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.HPLC of Formula: 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Thermo-sensitive Microgels Supported Gold Nanoparticles as Temperature-mediated Catalyst》 were Zhou, Xian-Jing; Lu, Hai-Peng; Kong, Ling-Li; Zhang, Dong; Zhang, Wei; Nie, Jing-Jing; Yuan, Jia-Yin; Du, Bin-Yang; Wang, Xin-Ping. And the article was published in Chinese Journal of Polymer Science in 2019. Related Products of 629-03-8 The author mentioned the following in the article:

Microgels with a thermo-sensitive poly(N-isopropylacrylamide) (polyNIPAm) backbone and bis-imidazolium (VIM) ionic cross-links, denoted as poly(NIPAm-co-VIM), were successfully prepared The as-synthesized ionic microgels were converted to nanoreactors, denoted as Au@PNI MGs, upon generation and immobilization of gold nanoparticles (Au NPs) of 5-8 nm in size into poly(NIPAm-co-VIM). The content of Au NPs in microgels could be regulated by controlling the 1,6-dibromohexane/vinylimidazole molar ratio in the quaternization reaction. The microgel-based nanoreactors were morphol. spherical and uniform in size, and presented reversible thermo-sensitive behavior with volume phase transition temperatures (VPTTs) at 39-40 °C. The Au@PNI MGs were used for the reduction of 4-nitrophenol, of which the catalytic activity could be modulated by temperature In the experiment, the researchers used 1,6-Dibromohexane(cas: 629-03-8Related Products of 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Related Products of 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Novel hapten design, antibody recognition mechanism study, and a highly sensitive immunoassay for diethylstilbestrol in shrimp》 were Mi, Jiafei; Dong, Xiaoyun; Zhang, Xiya; Li, Chenglong; Wang, Jianyi; Mujtaba, Mari Ghulam; Zhang, Suxia; Wen, Kai; Yu, Xuezhi; Wang, Zhanhui. And the article was published in Analytical and Bioanalytical Chemistry in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:

Over the past few years, there has been a lack of progress in the quality of diethylstilbestrol (DES) antibodies used in immunoassay. In this study, a new immunizing hapten was designed for remarkably sensitive and specific antibody generation against diethylstilbestrol. By introducing a benzene ring instead of the traditional linear chain alkane as the hapten spacer, a more specific immune reaction was induced in the process of immunization. The developed polyclonal antibodies were characterized using the indirect competitive ELISA (icELISA). Under optimized conditions, the half maximal inhibitory concentration (IC50) of the best polyclonal antibody was 0.14 ng/mL and it displayed low cross-reactions (CRs) with the structural analogs such as hexestrol (HEX) and dienestrol (DI). The mol. modeling and quantum chem. computation revealed that the lowest CR of the DES antibody to DI was mainly due to the huge three-dimensional conformational difference between DES and DI. Finally, a highly sensitive icELISA method based on the polyclonal antibody was developed for the determination of DES in shrimp tissue. The limit of detection (LOD) was as low as 0.2μg/kg in shrimp and the recoveries in the spiked samples ranged from 83.4 to 90.8% with the coefficient of variation less than 13.8%. These results indicated that the use of an aromatic ring as the immunizing hapten spacer arm could be a potential strategy for the enhancement of anti-DES antibody sensitivity, and the established icELISA was applicable to the trace detection of DES in shrimp. In addition to this study using Methyl 3-(bromomethyl)benzoate, there are many other studies that have used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Category: bromides-buliding-blocks) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Effect of aromatic spacer groups and counterions on aqueous micellar and thermal properties of the synthesized quaternary ammonium gemini surfactants》 were Shakil Hussain, S. M.; Kamal, Muhammad Shahzad; Murtaza, Mobeen. And the article was published in Journal of Molecular Liquids in 2019. HPLC of Formula: 623-24-5 The author mentioned the following in the article:

One of the major challenges for the oil industry in the 21st century is to get the desired surfactants that are soluble in high saline water (220, 000 ppm) and stable at high temperature (100°C). Most com. surfactants suffering due to hydrolysis at high temperature and the monovalent and divalent reservoir ions leads to surfactant precipitation In order to address these issues, a new series of cationic gemini surfactants with a different number of aromatic rings in the spacer group as well as different counter ions were synthesized and characterized with the aid of MALDI-TOF MS, FTIR, 1H NMR, and 13C NMR spectroscopy. The effect of number of Ph aromatic rings in the spacer and counterions on thermal and surface properties was determined Thermogravimetric results showed the decomposition temperature of all the gemini surfactant near to 300°C which is larger than the existing oilfield temperature (≥100°C). The insertion of ethoxy units between the lipophilic tail and lipophobic headgroup resulted in good solubility of cationic gemini surfactants in high saline and normal water without cloudiness or precipitation The critical micelle concentration and the corresponding surface tension were lower for gemini surfactants containing bromide counterions compared to the surfactants containing chloride counterions. The gemini surfactants containing two aromatic Ph rings in the spacer have lower critical micelle concentration compared to the gemini surfactants with one Ph ring. The properties of the synthesized cationic gemini surfactants mark them a material of choice for high salinity/temperature reservoirs. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5HPLC of Formula: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. HPLC of Formula: 623-24-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Russian Journal of General Chemistry included an article by Yakantham, T.; Sreenivasulu, R.; Raju, R. R.. Formula: C7H5BrO2. The article was titled 《Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives》. The information in the text is summarized as follows:

A series of new 2-(3-(4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl)isoxazol-5-yl)-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives I (R = H, MeO, NO2; R1 = H, MeO, Br, Cl, Me, NO2; R2 = H, MeO, NO2) is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds I are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference All compounds I demonstrate good to moderate activity on all cell lines.4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Formula: C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Greulich, Tobias W.; Yamaguchi, Eriko; Doerenkamp, Carsten; Luebbesmeyer, Maximilian; Daniliuc, Constantin G.; Fukazawa, Aiko; Eckert, Hellmut; Yamaguchi, Shigehiro; Studer, Armido published 《Synthesis and Physical Properties of Strained Doubly Phosphorus-Bridged Biaryls and Viologens》.Chemistry – A European Journal published the findings.Electric Literature of C6H5Br2N The information in the text is summarized as follows:

New P/N-containing π-electron systems comprising fully planar biaryl arrays are synthesized by multiple radical phosphanylation. The biaryl moiety in these highly strained planar π-systems is rigidified by double P-bridging. The electronic properties of the core biaryl entity are varied by introducing N-donor substituents or by installing N-atoms within the π-system, thereby moving to the viologen core structure. The electrochem. and photophys. properties of these compounds are discussed and compared with those of related systems.3,5-Dibromoaniline(cas: 626-40-4Electric Literature of C6H5Br2N) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Electric Literature of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzeneOn September 9, 2021 ,《1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors》 was published in Journal of Medicinal Chemistry. The article was written by Dolbois, Aymeric; Bedi, Rajiv K.; Bochenkova, Elena; Muller, Anna; Moroz-Omori, Elena V.; Huang, Danzhi; Caflisch, Amedeo. The article contains the following contents:

N6-methyladenosine (m6A) is the most frequent of the 160 RNA modifications reported so far. Accumulating evidence suggests that the METTL3/METTL14 protein complex, part of the m6A regulation machinery, is a key player in a variety of diseases including several types of cancer, type 2 diabetes, and viral infections. Here we report on a protein crystallog.-based medicinal chem. optimization of a METTL3 hit compound that has resulted in a 1400-fold potency improvement (IC50 of 5 nM for the lead compound 22 (UZH2)(I) in a time-resolved Forster resonance energy transfer (TR-FRET) assay). The series has favorable ADME properties as physicochem. characteristics were taken into account during hit optimization. UZH2 shows target engagement in cells and is able to reduce the m6A/A level of polyadenylated RNA in MOLM-13 (acute myeloid leukemia) and PC-3 (prostate cancer) cell lines. In addition to this study using 4-Bromo-1-(bromomethyl)-2-fluorobenzene, there are many other studies that have used 4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene) was used in this study.

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quertinmont, Jean; Beaujean, Pierre; Stiennon, Julien; Aidibi, Youssef; Leriche, Philippe; Rodriguez, Vincent; Sanguinet, Lionel; Champagne, Benoit published their research in Journal of Physical Chemistry B in 2021. The article was titled 《Combining Benzazolo-Oxazolidine Twins toward Multi-state Nonlinear Optical Switches》.Computed Properties of C4H2Br2S The article contains the following contents:

Mol. switches are chem. compounds exhibiting the possibility of reversible transformations between their different forms accompanied by a modification in their properties. Among these, switching of multi-addressable Benzazolo-OXazolidines (BOXs) from a closed form to an open form results in drastic modifications in their linear and nonlinear optical properties. Here, we target mols. containing two identical BOX units (DiBOX) connected by different π-conjugated linkers, and we combine synthesis, UV/visible absorption, and hyper-Rayleigh scattering (HRS) measurements, together with d. functional theory (DFT) calculations Three derivatives have been considered, which differ by the linker: (i) a bithiophene moiety (Bt), (ii) two 3,4-ethylenedioxythiopene (EDOT) units, and (iii) a triad composed of an EDOT-thiophene-EDOT sequence (TtO). As a matter of fact, these systems can adopt three states (CF-CF, POF-POF, and CF-POF) depending on the closed form (CF) or the protonated open form (POF) of each BOX unit. Despite chem. equivalence, stepwise switching of such systems under the addition of a chem. acid or an oxidant has been exptl. evidenced for two of them (DiBOX-Bt and DiBOX-TtO). Then, DFT calculations show that the first BOX opening leads to the formation of a push-pull π-conjugated segment, exhibiting a huge increase in the first hyperpolarizability (β) and a bathochromic shift with respect to the fully closed form. On the contrary, the second BOX opening induces not only a slight bathochromic shift but also a reduction in their β values conferring the great and uncommon abilities to modulate their linear and nonlinear properties over three discrete levels. Among these results, those on DiBOX-Bt agree with the exptl. data obtained by HRS measurements and further shed light on their structure-property relationship. The results came from multiple reactions, including the reaction of 2,5-Dibromothiophene(cas: 3141-27-3Computed Properties of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Computed Properties of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary