Tag: 200-300

Boldt, Andrew M.; Dickinson, Sidney I.; Ramirez, Jonathan R.; Benz-Weeden, Anna M.; Wilson, David S.; Stevenson, Susan M. published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Reactions of benzyltriphenylphosphonium salts under photoredox catalysis》.HPLC of Formula: 1129-28-8 The article contains the following contents:

The development of benzyltriphenylphosphonium salts RCH2P+(C6H5)3X- (R = 3-methylphenyl, 4-bromophenyl, 3,5-dimethylphenyl, etc.; X = Cl, Br) as alkyl radical precursors using photoredox catalysis is described. Depending on substituents, the benzylic radicals may couple to form C-C bonds or abstract a hydrogen atom to form C-H bonds. A natural product, brittonin A, was also synthesized using this method. In addition to this study using Methyl 3-(bromomethyl)benzoate, there are many other studies that have used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8HPLC of Formula: 1129-28-8) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. HPLC of Formula: 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Heck, Matthias; Botha, Carlo; Wilhelm, Manfred; Hirschberg, Valerian published their research in Macromolecular Rapid Communications in 2021. The article was titled 《One-Pot Synthesis of Alternating (Ultra-High Molecular Weight) Multiblock Copolymers via a Combination of Anionic Polymerization and Polycondensation》.Quality Control of 1,4-Bis(bromomethyl)benzene The article contains the following contents:

This article presents a fast, straightforward synthesis approach to polymerize alternating multiblock copolymers, ultra-high mol. weight (UHMW) (homo)polymers as well as precursors for complex macromol. topologies such as comb or barbwire architectures. The one-pot synthesis strategy proposed in this work is based on anionic polymerization via a bifunctional initiator and the subsequent linking of macro dianions with a bifunctional linker, addnl. overcoming the limitations associated with the monomer reactivity. Thus, the synthetic route guarantees the repeating size of polymer blocks and an equal distribution of functional groups in precursors for complex topologies. Dianions of polystyrene (PS), polyisoprene-b-polystyrene-b-polyisoprene, and poly-2-vinylpyridine-b-polystyrene-b-poly-2-vinylpyridine are linked with α,α’-dibromo-para-xylene to UHMW and multiblock copolymers. Multiblock copolymers with on average up to 50 well-defined alternating A and B blocks are accessible within 15 min. The experimental part of the paper was very detailed, including the reaction process of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Quality Control of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Quality Control of 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus》 was written by Grolla, Ambra A.; Miggiano, Riccardo; Marino, Daniele Di; Bianchi, Michele; Gori, Alessandro; Orsomando, Giuseppe; Gaudino, Federica; Galli, Ubaldina; Del Grosso, Erika; Mazzola, Francesca; Angeletti, Carlo; Guarneri, Martina; Torretta, Simone; Calabro, Marta; Boumya, Sara; Fan, Xiaorui; Colombo, Giorgia; Travelli, Cristina; Rocchio, Francesca; Aronica, Eleonora; Wohlschlegel, James A.; Deaglio, Silvia; Rizzi, Menico; Genazzani, Armando A.; Garavaglia, Silvia. Quality Control of 8-Bromooctanoic acid And the article was included in Journal of Biological Chemistry in 2020. The article conveys some information:

All cells require sustained intracellular energy flux, which is driven by redox chem. at the subcellular level. NAD+, its phosphorylated variant NAD(P)+, and its reduced forms NAD(P)/NAD(P)H are all redox cofactors with key roles in energy metabolism and are substrates for several NAD-consuming enzymes (e.g. poly(ADP-ribose) polymerases, sirtuins, and others). The nicotinamide salvage pathway, constituted by NMN adenylyltransferase (NMNAT) and nicotinamide phosphoribosyltransferase (NAMPT), mainly replenishes NAD+ in eukaryotes. However, unlike NMNAT1, NAMPT is not known to be a nuclear protein, prompting the question of how the nuclear NAD+ pool is maintained and how it is replenished upon NAD+ consumption. In the present work, using human and murine cells; immunoprecipitation, pulldown, and surface plasmon resonance assays; and immunofluorescence, small-angle X-ray scattering, and MS-based analyses, we report that GAPDH and NAMPT form a stable complex that is essential for nuclear translocation of NAMPT. This translocation furnishes NMN to replenish NAD+ to compensate for the activation of NAD-consuming enzymes by stressful stimuli induced by exposure to H2O2 or S-nitrosoglutathione and DNAdamage inducers. These results indicate that by forming a complex with GAPDH, NAMPT can translocate to the nucleus and thereby sustain the stress-induced NMN/NAD salvage pathway. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Quality Control of 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Quality Control of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide》 was written by Zhang, Fangqing; Wu, Zhenwei; Chen, Pan; Zhang, Jian; Wang, Tao; Zhou, Jinpei; Zhang, Huibin. Safety of Ethyl 5-bromovalerate And the article was included in Bioorganic & Medicinal Chemistry in 2020. The article conveys some information:

Synthesis of dihydroquinazolinone-lenalidomide/pomalidomide derivatives I [n=1,2,3,4,5,6], II [n=4,5,6] and III [X = CH2, CO; n=0,1,2,3] and biol. evaluation of PROTAC BRD4 degraders was discovered. Gratifyingly, several compounds showed excellent inhibitory activity against BRD4 and high anti-proliferative potency against human monocyte lymphoma cell line THP-1. Especially, compound III [X = CO; n=0] (BRD4 BD1, IC50 = 41.8 nM) achieved a submicromolar IC50 value of 0.81μM in inhibiting the growth of THP-1 cell line, and was 4 times more potent than compound IV. Moreover, the mechanism study established that III [X = CO; n=0] could effectively induced the degradation of BRD4 protein and suppression of c-Myc. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Safety of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Safety of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis, biological evaluation, and modeling studies of 1,3-disubstituted cyclobutane-containing analogs of combretastatin A4》 was published in Journal of Molecular Structure in 2020. These research results belong to Malashchuk, Andrii; Chernykh, Anton V.; Hurmach, Vasyl V.; Platonov, Maxim O.; Onopchenko, Oleksandra; Zozulya, Sergey; Daniliuc, Constantin G.; Dobrydnev, Alexey V.; Kondratov, Ivan S.; Moroz, Yuriy S.; Grygorenko, Oleksandr O.. Computed Properties of C9H11BrO3 The article mentions the following:

With the aim of circumventing the adverse cis/trans-isomerization of combretastatin A4 (CA4), a naturally occurring tumor-vascular disrupting agent, novel CA4 analogs, e.g., I, bearing 1,3-disubstituted cyclobutane moiety instead of the cis-stilbene unit of the parent compd was designed. The corresponding cis and trans cyclobutane-containing derivatives were prepared as pure diastereomers. The structure of the target compounds was confirmed by X-ray diffraction study. The title compounds were evaluated for their cytotoxic properties in human cancer cell lines HepG2 (hepatocarcinoma) and SK-N-DZ (neuroblastoma), and the overall activity was found in micromolar range. Mol. docking studies and mol. dynamics simulation within the colchicine binding site of tubulin were in good agreement with the obtained cytotoxicity data.1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Computed Properties of C9H11BrO3) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Computed Properties of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Fotsing, Joseph R.; Darmohusodo, Vincent; Patron, Andrew P.; Ching, Brett W.; Brady, Thomas; Arellano, Melissa; Chen, Qing; Davis, Timothy J.; Liu, Hanghui; Servant, Guy; Zhang, Lan; Williams, Mark; Saganich, Michael; Ditschun, Tanya; Tachdjian, Catherine; Karanewsky, Donald S.. Name: Methyl 3-(bromomethyl)benzoate The article mentions the following:

In humans, bitter taste is mediated by 25 TAS2Rs. Many compounds, including certain active pharmaceutical ingredients, excipients, and nutraceuticals, impart their bitter taste (or in part) through TAS2R8 activation. However, effective TAS2R8 blockers that can either suppress or reduce the bitterness of these compounds have not been described. We are hereby reporting a series of novel 3-(pyrazol-4-yl) imidazolidine-2,4-diones as potent and selective TAS2R8 antagonists. In human sensory tests, S6821(I) and S7958(II), two of the most potent analogs from the series, demonstrated efficacy in blocking TAS2R8-mediated bitterness and were selected for development. Following data evaluation by expert panels of a number of national and multinational regulatory bodies, including the US, the EU, and Japan, S6821 and S7958 were approved as safe under conditions of intended use as bitter taste blockers. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Name: Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Name: Methyl 3-(bromomethyl)benzoate The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《The first used butylene linked bis(N-heterocyclic carbene)-palladium-PEPPSI complexes in the direct arylation of furan and pyrrole》 was published in Journal of Organometallic Chemistry in 2020. These research results belong to Kaloglu, Murat; Dusunceli, Serpil Demir; Ozdemir, Ismail. SDS of cas: 402-43-7 The article mentions the following:

The synthesis and characterization of butylene linked bis-benzimidazole based N-heterocyclic carbene (NHC) precursors I [R = 2-[bis(propan-2-yl)amino]ethyl, propan-2-yl, (pentamethylphenyl)methyl] and their PEPPSI-type bimetallic Pd-complexes II were reported, and its activities in the direct C5-arylation of 2-acetylfuran and 1-methylpyrrole-2-carboxaldehyde with various aryl bromides 4-R1C6H4Br (R1= H, MeO, Me, CHO, C(O)Me, CF3) and 3-bromoquinoline were implemented. The catalytic activities of the synthesized palladium-complexes II were found to be very high. The experimental process involved the reaction of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7SDS of cas: 402-43-7)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. SDS of cas: 402-43-7 Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Ligand-Free Iron-Catalyzed Homo-Coupling of Aryllithium Reagents》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Wang, Zhi-Yong; Peng, Xiao-Shui; Wong, Henry N. C.. Safety of 1-Bromo-3,4,5-trimethoxybenzene The article mentions the following:

The synthesis of sym. biaryls via the iron-catalyzed homo-coupling of aryllithium reagents was developed under a mild condition, in the absence of ligand, with wide range of scope, and in good yields. Investigation on reaction concentration and practical utility of this environmentally friendly procedure also indicates a promising application outlook. The experimental process involved the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Safety of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Safety of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Regioselective Hydroformylation of Internal and Terminal Alkenes via Remote Supramolecular Control》 was published in Chemistry – A European Journal in 2020. These research results belong to Linnebank, Pim R.; Ferreira, Stephan Falcao; Kluwer, Alexander M.; Reek, Joost N. H.. Computed Properties of C8H15BrO2 The article mentions the following:

Herein, the redesign of a supramol. Rh-bisphosphite hydroformylation catalyst containing a neutral carboxylate receptor (DIM pocket) with a larger distance between the phosphite metal binding moieties and the DIM pocket was reported. For the first time regioselective hydroformylation of internal CH3(CH2)nCH:CH(CH2)7C(O)OH (n = 3, 5, 7), CH3CH:CH(CH2)nC(O)OH (n = 6, 7) and terminal CH2:CH(CH2)nC(O)OH (n = 2, 3, 4, etc.) alkenes containing a remote carboxylate directing group is demonstrated. For carboxylate substrates that possess an internal double bond at the Δ-9 position, regioselectivity was observed As such, the catalyst was used to hydroformylate natural monounsaturated fatty acids (MUFAs) in a regioselective fashion, forming of an excess of the 10-formyl product (10-formyl/9-formyl product ratio of 2.51), which is the first report of a regioselective hydroformylation reaction of such substrates. The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Computed Properties of C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Computed Properties of C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Investigation into the influence of an acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Fuse, Shinichiro; Moriya, Wataru; Sato, Shinichi; Nakamura, Hiroyuki. Safety of 2,5-Dibromothiophene The article mentions the following:

Photodynamic therapy (PDT) is a non-invasive, selective, and cost-effective cancer therapy. We previously reported that thiophene-based organic D-π-A sensitizers consist of an electron-donating (D) moiety, a π-conjugated bridge (π) moiety, and an electron-accepting (A) moiety, and are readily accessible and stable templates for photosensitizers that could be used in PDT. In addition, acrylic acid acceptor-containing photosensitizers exert a high level of phototoxicity. This study was an investigation into 1) the possibility of increasing phototoxicity by introducing another carboxyl group or by replacing a carboxyl group with a pyridinium group, and 2) the importance of an alkene in the acrylic acid acceptor for phototoxicity. A review of the design, synthesis, and evaluation of sensitizers revealed that neither dicarboxylic acid nor pyridinium photosensitizers enhance phototoxicity. An evaluation of a photosensitizer without an alkene in the acrylic acid moiety revealed that the alkene was not indispensable in the pursuit of phototoxicity. The obtained results provided new insight into the design of ideal D-π-A photosensitizers for PDT. After reading the article, we found that the author used 2,5-Dibromothiophene(cas: 3141-27-3Safety of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Safety of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary