Tag: 200-300

《Nonpeptide Urotensin-II Receptor Antagonists: A New Ligand Class Based on Piperazino-Phthalimide and Piperazino-Isoindolinone Subunits》 was written by Lawson, Edward C.; Luci, Diane K.; Ghosh, Shyamali; Kinney, William A.; Reynolds, Charles H.; Qi, Jenson; Smith, Charles E.; Wang, Yuanping; Minor, Lisa K.; Haertlein, Barbara J.; Parry, Tom J.; Damiano, Bruce P.; Maryanoff, Bruce E.. Safety of 3-Bromo-2-methylbenzoic acidThis research focused onurotensin receptor antagonist preparation structure activity piperazino phthalimide isoindolinone. The article conveys some information:

We have discovered two related chem. series of nonpeptide urotensin-II (U-II) receptor antagonists based on piperazino-phthalimide (5 and 6) and piperazino-isoindolinone (7) scaffolds. These structure types are distinctive from those of U-II receptor antagonist series reported in the literature. One of the antagonists exhibited single-digit nanomolar potency in rat and human cell-based functional assays, as well as strong binding to the human U-II receptor. In advanced pharmacol. testing, one of the antagonists blocked the effects of U-II in vitro in a rat aortic ring assay and in vivo in a rat ear-flush model. A discussion of U-II receptor antagonist pharmacophores is presented, and a specifically defined model is suggested from tricycle compound, which has a high degree of conformational constraint. In the part of experimental materials, we found many familiar compounds, such as 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Safety of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Safety of 3-Bromo-2-methylbenzoic acid Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 17696-11-6In 2019 ,《Fenton-Inspired C-H Functionalization: Peroxide-Directed C-H Thioetherification》 was published in Journal of Organic Chemistry. The article was written by Groendyke, Brian J.; Modak, Atanu; Cook, Silas P.. The article contains the following contents:

Substoichiometric iron mediates the thioetherification of unactivated aliphatic C-H bonds directed by resident silylperoxides. Upon exposure to a catalytic amount of iron(II) triflate, TIPS-protected peroxides bearing primary, secondary, and tertiary C-H sites undergo chemoselective thioetherification of remote C-H bonds with diaryl disulfides. The reaction demonstrates a broad substrate scope and functional group tolerance without the use of any noble metal additives. Mechanistic experiments suggest that the reaction proceeds through 1,5-H atom abstraction by a hydroxyl radical generated with iron. The results came from multiple reactions, including the reaction of 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.HPLC of Formula: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C8H8Br2In 2019 ,《A Dynamic Tetracationic Macrocycle Exhibiting Photoswitchable Molecular Encapsulation》 was published in Journal of the American Chemical Society. The article was written by Wu, Huang; Chen, Yong; Zhang, Long; Anamimoghadam, Ommid; Shen, Dengke; Liu, Zhichang; Cai, Kang; Pezzato, Cristian; Stern, Charlotte L.; Liu, Yu; Stoddart, J. Fraser. The article contains the following contents:

Designing macrocycles with appropriate mol. recognition features that allow for the integration of suitable external stimuli to control host-guest processes is a challenging endeavor which enables mol. containers to solubilize, stabilize, and sep. chem. entities in an externally controllable manner. Herein, we introduce photo- and thermal-responsive elements into a semi-rigid tetracationic cyclophane, OPVEx2Box4+, that is composed of oligo(p-phenylenevinylene) pyridinium units and the biphenylene-bridged 4,4-bipyridinium extended viologens and adopts a rectangle-like geometry. It transpires that when the photoactive oligo(p-phenylenevinylene) pyridinium unit is incorporated in a macrocyclic scaffold, its reversibility is dramatically improved, and the configurations of the cyclophane can go back and forth between (EE)- and (EZ)-isomers upon alternating blue light irradiation and heating. When the macrocycle is found in its (EE)-configuration, it is capable of binding various π-electron-rich guests-e.g., anthracene and perylene-as well as π-electron-deficient guests-e.g., 9,10-anthraquinone and 5,12-tetracenequinone-through charge-transfer and van der Waals interactions. When irradiated with blue light, the (EE)-isomer of the cyclophane can be transformed successfully to the (EZ)-isomer, resulting in the switching off of the binding affinity for guest mols., which are bound once again upon heating. The use of light and heat as external stimuli to control host-guest interactions involving a multi-responsive host and various guests provides us with a new opportunity to design and construct more-advanced mol. switches and machines. In the part of experimental materials, we found many familiar compounds, such as 1,4-Bis(bromomethyl)benzene(cas: 623-24-5COA of Formula: C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.COA of Formula: C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 1,4-Bis(bromomethyl)benzeneIn 2021 ,《Tailoring the Pore Size and Chemistry of Ionic Ultramicroporous Polymers for Trace Sulfur Dioxide Capture with High Capacity and Selectivity》 was published in Angewandte Chemie, International Edition. The article was written by Suo, Xian; Yu, Ying; Qian, Siheng; Zhou, Lin; Cui, Xili; Xing, Huabin. The article contains the following contents:

Here we demonstrate the deep removal of SO2 with high uptake capacity (1.55 mmol g-1) and record SO2/CO2 selectivity (>5000) at ultra-low pressure of 0.002 bar, using ionic ultramicroporous polymers (IUPs) with high d. of basic anions. The successful construction of uniform ultramicropores via polymerizing ionic monomers into IUPs enables the fully exploitation of the selective anionic sites. Notably, the aperture size and surface chem. of IUPs can be finely tuned by adjusting the branched structure of ionic monomers, which play critical roles in excluding CH4 and N2, as well as reducing the coadsorption of CO2. The swelling property of IUPs with adsorption of SO2 contributed to the high SO2 uptake capacity and high separation selectivity. Systematic investigations including static gas adsorption, dynamic breakthrough experiments, stability tests and modeling studies confirmed the efficient performance of IUPs for trace SO2 capture. The results came from multiple reactions, including the reaction of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Safety of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Safety of 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C5BrMnO5In 2020 ,《In Situ Solution-State Characterization of MOF-Immobilized Transition-Metal Complexes by Infrared Spectroscopy》 was published in ACS Applied Materials & Interfaces. The article was written by Mamlouk, Hind; Elumalai, Palani; Kumar, Manyam Praveen; Aidoudi, Farida H.; Bengali, Ashfaq A.; Madrahimov, Sherzod T.. The article contains the following contents:

Transition metal catalysts immobilized on the surface of MOFs, are being utilized for an ever increasing number of reactions ranging from couplings to olefin oligomerization. While these reactions are usually performed in solution, unlike their homo-geneous counterparts, the insolubility of the MOF systems makes it difficult to obtain detailed mechanistic information by in situ spectroscopic anal. in solution In this report, we present a synthetic method to solubilize these systems by grafting oligomers on the surface of the MOF particles, making it possible to characterize these species by transmission IR spectros-copy. The fundamental photochem. of these catalysts was also studied and compared to that of their homogeneous counterparts. This work establishes a proof of principle for in solution monitoring of heterogeneous catalysts. In the part of experimental materials, we found many familiar compounds, such as Bromopentacarbonylmanganese(I)(cas: 14516-54-2Formula: C5BrMnO5)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Formula: C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 623-24-5In 2022 ,《Quantifying the barrier for the movement of cyclobis(paraquat-p-phenylene) over the dication of monopyrrolotetrathiafulvalene》 was published in Organic & Biomolecular Chemistry. The article was written by Kristensen, Rikke; Neumann, Mathias S.; Andersen, Sissel S.; Stein, Paul C.; Flood, Amar H.; Jeppesen, Jan O.. The article contains the following contents:

A bistable [2]pseudorotaxane 1⊂CBPQT·4PF6 and a bistable [2]rotaxane 2·4PF6 have been synthesized to measure the height of an electrostatic barrier produced by double mol. oxidation (0 to +2). Both systems have monopyrrolotetrathiafulvalene (MPTTF) and oxyphenylene (OP) as stations for cyclobis(paraquat-p-phenylene) (CBPQT4+). They have a large stopper at one end while the second stopper in 24+ is composed of a thioethyl (SEt) group and a thiodiethyleneglycol (TDEG) substituent, whereas in 1⊂CBPQT4+, the SEt group has been replaced with a less bulky thiomethyl (SMe) group. This seemingly small difference in the substituents on the MPTTF unit leads to profound changes when comparing the phys. properties of the two systems allowing for the first measurement of the deslipping of the CBPQT4+ ring over an MPTTF2+ unit in the [2]pseudorotaxane. Cyclic voltammetry and 1H NMR spectroscopy were used to investigate the switching mechanism for 1⊂CBPQT·MPTTF4+ and 2·MPTTF4+, and it was found that CBPQT4+ moves first to the OP station producing 1⊂CBPQT·OP6+ and 2·OP6+, resp., upon oxidation of the MPTTF unit. The kinetics of the complexation/decomplexation process occurring in 1⊂CBPQT·MPTTF4+ and in 1⊂CBPQT·OP6+ were studied, allowing the free energy of the transition state when CBPQT4+ moves across a neutral MPTTF unit (17.0 kcal mol-1) or a di-oxidised MPTTF2+ unit (24.0 kcal mol-1) to be determined These results demonstrate that oxidation of the MPTTF unit to MPTTF2+ increases the energy barrier that the CBPQT4+ ring must overcome for decomplexation to occur by 7.0 kcal mol-1. In the experiment, the researchers used many compounds, for example, 1,4-Bis(bromomethyl)benzene(cas: 623-24-5SDS of cas: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. SDS of cas: 623-24-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《trans-Selective Aryldifluoroalkylation of Endocyclic Enecarbamates and Enamides by Nickel Catalysis》 was written by Xu, Chang; Cheng, Ran; Luo, Yun-Cheng; Wang, Ming-Kuan; Zhang, Xingang. Name: 5-Bromobenzo[d][1,3]dioxole And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Efficient methods for the dicarbofunctionalization of the cyclic alkenes 2-pyrroline and 2-azetine are limited. Particularly, the dicarbofunctionalization of endocyclic enecarbamates to achieve fluorinated compounds remains an unsolved issue. Reported here is a nickel-catalyzed trans-selective dicarbofunctionalization of N-Boc-2-pyrroline and N-Boc-2-azetine, a class of endocyclic enecarbamates previously unexplored for transition metal catalyzed dicarbofunctionalization. The reaction can be extended to six- and seven-membered endocyclic enamides. A variety of arylzinc reagents and bromodifluoroacetate, and its derivatives, undergo the reaction, providing straightforward and efficient access to an array of pyrrolidine- and azetidine-containing fluorinated amino acids and oligopeptides, which may have applications in the life sciences. The results came from multiple reactions, including the reaction of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Name: 5-Bromobenzo[d][1,3]dioxole)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Name: 5-Bromobenzo[d][1,3]dioxole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Mechanistic Insights into the Triplet Sensitized Photochromism of Diarylethenes》 was published in Chemistry – A European Journal in 2020. These research results belong to Fredrich, Sebastian; Morack, Tobias; Sliwa, Michel; Hecht, Stefan. Reference of 2,5-Dibromothiophene The article mentions the following:

Operating photoswitchable mols. repetitively and reliably is crucial for most of their applications, in particular in (opto)electronic devices, and related to reversibility and fatigue resistance, which both critically depend on the photoisomerization mechanism defined by the substitution pattern. Two diarylethene photoswitches bearing biacetyl triplet sensitizers either at the periphery or at the core were investigated using both stationary as well as transient UV/Vis absorption spectroscopy ranging from the femtosecond to the microsecond time scale. The diarylethene with two biacetyl moieties at the periphery is switching predominantly from the triplet excited state, giving rise to an enhanced fatigue resistance. In contrast, the diarylethene bearing one diketone at the photoreactive inner carbon atom cyclizes from the singlet excited state and shows significantly higher quantum yields for both cyclization and cycloreversion. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromothiophene(cas: 3141-27-3Reference of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Reference of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Renewable Solvents for Palladium-Catalyzed Carbonylation Reactions》 was published in Organic Process Research & Development in 2020. These research results belong to Ismael, Aya; Gevorgyan, Ashot; Skrydstrup, Troels; Bayer, Annette. Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene The article mentions the following:

Solvents constitute the largest component for many chem. processes and substitution of nonrenewable solvents is a longstanding goal for green chem. Here, we show that Pd-catalyzed carbonylative couplings, such as carbonylative cross-couplings, aminocarbonylations, and alkoxycarbonylations, can be successfully realized using renewable solvents. The present research covers not only well-established renewable solvents, such as 2-methyltetrahydrofuran (2MeTHF), limonene, and di-Me carbonate, but also recently introduced biomass-derived 1,1-diethoxyethane, isosorbide di-Me ether, eucalyptol, rose oxide, γ-terpinene, and α-pinene. The carbonylative coupling of boronic acids and aryl bromides works well in limonene. Aminocarbonylation gave excellent results in di-Me carbonate, α-pinene, and limonene, while alkoxycarbonylation was successful in 2MeTHF, α-pinene, γ-terpinene, and di-Me carbonate. The developed methods based on renewable solvents can be used for the synthesis of com. drug Trimetozine and an analog of Itopride. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Catalytic Reductions Without External Hydrogen Gas: Broad Scope Hydrogenations with Tetrahydroxydiboron and a Tertiary Amine》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Korvinson, Kirill A.; Akula, Hari K.; Malinchak, Casina T.; Sebastian, Dellamol; Wei, Wei; Khandaker, Tashrique A.; Andrzejewska, Magdalena R.; Zajc, Barbara; Lakshman, Mahesh K.. Synthetic Route of C7H5BrO2 The article mentions the following:

Aryl bromides, iodides, chlorides, and triflates, benzylic halides and ethers, benzyl carbamates, alkenes, alkynes, azides, and aldehydes underwent reductive cleavage, hydrogenation, and reduction reactions using B2(OH)4 as reductant in the presence of Pd/C and 4-methylmorpholine. Aryl dihalides containing two different halogen atoms underwent selective reduction, with reduction of I favored over reduction of Br and Cl, and Br reduction favored over the reduction of Cl. Cyano groups were unaffected, but nitro group and ketones underwent reduction to a low extent. B2(OD)4 and N,N-bis(methyl-d3)pyridin-4-amine (DMAP-d6) were used as reagents for the reductive deuteration of aryl halides. Hydrogen gas has been observed to form with this reagent combination.4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary