Tag: 200-300

Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents was written by Rai, Ganesha;Thomas, Craig J.;Leister, William;Maloney, David J.. And the article was included in Tetrahedron Letters in 2009.Electric Literature of C9H6BrFO2 This article mentions the following:

The synthesis of a series of 4,5-disubstituted furoxans, 1,2,5-oxadiazole-2-oxides I (e.g., R¹ = 4-F, 3-CF₃, etc) was described. These compounds were prepared in an effort to probe the SAR around the Ph substituent and oxadiazole core for studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1Electric Literature of C9H6BrFO2).

3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Electric Literature of C9H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, Synthesis, and Pharmacological Evaluation of Fused 灏?Homophenylalanine Derivatives as Potent DPP-4 Inhibitors was written by Jiang, Tao;Zhou, Yuren;Chen, Zhuxi;Sun, Peng;Zhu, Jianming;Zhang, Qiang;Wang, Zhen;Shao, Qiang;Jiang, Xiangrui;Li, Bo;Chen, Kaixian;Jiang, Hualiang;Wang, Heyao;Zhu, Weiliang;Shen, Jingshan. And the article was included in ACS Medicinal Chemistry Letters in 2015.Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene This article mentions the following:

Dipeptidyl peptidase-4 (DPP-4) inhibitors are accepted as a favorable class of agents for the treatment of type 2 diabetes. Herein, a series of fused 灏?homophenylalanine derivatives as novel DPP-4 inhibitors was designed, synthesized, and evaluated for their inhibitory activities against DPP-4. Most of them displayed excellent DPP-4 inhibitory activities and good selectivity. Among them, 9aa, 18a, and 18m also showed good efficacy in an oral glucose tolerance test (OGTT) in ICR mice. Moreover, when dosed 8 h prior to glucose challenge, 18m showed significantly greater potency than sitagliptin. It thus provides potential candidates for the further development into potent drugs targeting DPP-4. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Construction of Chiral 2-Substituted Octahydroindoles from Cyclic Ketones and Nitroolefins Bearing only One 浼?Substituent was written by Han, Yong;Zheng, Bo;Peng, Yungui. And the article was included in Advanced Synthesis & Catalysis in 2015.Computed Properties of C9H11BrO This article mentions the following:

A dual catalytic system was developed following the screening of a series of chiral primary amine catalysts and chiral phosphoric acid catalysts for the Michael addition of cyclic ketones to nitroolefins bearing only one 浼?substituent. The resulting 绾?nitro ketones, which contain a substituent on the carbon connected to the nitro group, were formed in excellent yields (>80%) with high levels of stereoselectivity (up to 94:6 dr and 98% ee) when the reaction was performed in benzene at 0鎺?with 10 mol% of the optimal amine/phosphoric acid combination (1:1) as a catalyst. Subsequent reduction of the nitro group followed by intramol. reductive amination afforded optically active cis-octahydroindole analogs bearing a non-functional substituent at their 2-position. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Computed Properties of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Computed Properties of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Palladium-Catalyzed Regioselective Synthesis of 1-Hydroxycarbazoles Under Aerobic Conditions was written by Youn, So Won;Kim, Young Ho;Jo, Yoon Hyung. And the article was included in Advanced Synthesis & Catalysis in 2019.Recommanded Product: 192810-12-1 This article mentions the following:

A palladium-catalyzed aerobic C-H amidation of N-Ts-2-amino-3′-hydroxylbiaryls was developed to afford a diverse range of 1-hydroxycarbazoles with high regioselectivity and efficiency. This protocol benefits from operational simplicity, robustness, and sustainability using ambient air as the sole terminal oxidant. Further elaboration of the products obtained from this process provides facile access to various carbazole alkaloids including carbazolequinones and biscarbazoles. A mechanism involving dual directing group-assisted regioselective C-H activation at the more sterically hindered C2′-position of 2-amino-3′-hydroxylbiaryls is proposed. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Recommanded Product: 192810-12-1).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 192810-12-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The kinetics of the reactions of picryl chloride with some substituted anilines. Part 6. 4-Substituted and 3,4-disubstituted anilines was written by Emokpae, Thomas A.;Eguavoen, Osa;Khalil-Ur-Rahman;Hirst, Jack. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1980.Safety of 3,4-Dibromoaniline This article mentions the following:

Arrhenius parameters were determined for the reactions of picryl chloride in MeCN with substituted anilines: 4-RC₆H₄NH₂ (R = F, Cl, Br, iodo, Me, OMe), 3,4-R₂C₆H₃NH₂ (R = Cl, Br, Me, OMe), 4,3-R(O₂N)C₆H₃NH₂ (R = F, Cl, Me), 3,4-R(MeO)C₆H₃NH₂ (R = F, Cl, Br, iodo), 3,4-F(O₂N)C₆H₃NH₂ and 3,4,5-(MeO)₃C₆H₂NH₂. In the 3,4-disubstituted series the effect of 2 Me groups on the free energy of activation is strictly additive, but for the rest the measured rate constants are greater than those calculated on the assumption of additivity. The results are rationalized in terms of the positions of the transition states on the reaction coordinate. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Safety of 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Safety of 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Undecahydro-closo-dodecaborates as good leaving groups in organic synthesis: generation of substituted styrenes via elimination of arylethyl dodecaborates was written by Genady, Afaf R.;Nakamura, Hiroyuki. And the article was included in Organic & Biomolecular Chemistry in 2010.COA of Formula: C9H11BrO This article mentions the following:

New functionalized arylethyl undecahydro-closo-dodecaborates (S,S-disubstituted [B₁₂H₁₁SH]^2-, N,N-disubstituted [B₁₂H₁₁NH₃]^– and O-substituted [B₁₂H₁₁OH]^2-) are prepared by a simple one-step reaction. Moderate to good yields are obtained in the presence of various functional aryl groups. The synthesis of functionalized styrene derivatives can be readily achieved by treating arylethyl undecahydro-closo-dodecaborates with various bases. The scope and limitations of this procedure are demonstrated by investigating an array of alkylated dodecaborates. Based on an E2 elimination reaction, we identify the mechanistic pathway for dealkylation of arylethyl dodecaborates. Mechanistic studies indicate the following essential requirements to promote the elimination reaction: (i) the presence of 浼?CH acidity of the phenethyl group; (ii) steric hindrance; (iii) a substituted heteroatom on the closo-[B₁₂H₁₁]^2- cage and (iv) the presence of an electron-withdrawing group on the aromatic ring. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0COA of Formula: C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.COA of Formula: C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Biocatalytic Platform for Synthesis of Chiral 浼?Trifluoromethylated Organoborons was written by Huang, Xiongyi;Garcia-Borras, Marc;Miao, Kun;Kan, S. B. Jennifer;Zutshi, Arjun;Houk, K. N.;Arnold, Frances H.. And the article was included in ACS Central Science in 2019.Safety of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

There are few biocatalytic transformations that produce fluorine-containing mols. prevalent in modern pharmaceuticals. To expand the scope of biocatalysis for organofluorine synthesis, we have developed an enzymic platform for highly enantioselective carbene B-H bond insertion to yield versatile 浼?trifluoromethylated (浼?CF₃) organoborons, an important class of organofluorine mols. that contain stereogenic centers bearing both CF₃ and boron groups. In contrast to current “carbene transferase” enzymes that use a limited set of simple diazo compounds as carbene precursors, this system based on Rhodothermus marinus cytochrome c (Rma cyt c) can accept a broad range of trifluorodiazo alkanes and deliver versatile chiral 浼?CF₃ organoborons with total turnovers up to 2870 and enantiomeric ratios up to 98.5:1.5. Computational modeling reveals that this broad diazo scope is enabled by an active-site environment that directs the alkyl substituent on the heme CF₃-carbene intermediate toward the solvent-exposed face, thereby allowing the protein to accommodate diazo compounds with diverse structural features. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Safety of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins was written by Galli, Marzia;Fletcher, Catherine J.;del Pozo, Marc;Goldup, Stephen M.. And the article was included in Organic & Biomolecular Chemistry in 2016.Recommanded Product: 57293-19-3 This article mentions the following:

To improve access to a key synthetic intermediate a direct hydrobromination-Negishi route was targeted. Unsurprisingly, the anti-Markovnikov addition of HBr to estragole in the presence of AIBN proved successful. However, even in the absence of an added initiator, anti-Markovnikov addition was observed Re-examination of early reports revealed that selective Markovnikov addition, often simply termed “normal” addition, was not always observed with HBr unless air was excluded, leading to the rediscovery of a reproducible and scalable initiator-free protocol. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Recommanded Product: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Facile, direct reaction of benzaldehydes to 3-arylprop-2-enoic acids and 3-arylprop-2-ynoic acids in aqueous medium was written by Thiemann, Thies;Elshorbagy, Mohamed W.;Salem, Mostafa H. F. A.;Ahmadani, Siraj A. N.;Al-Jasem, Yosef;Al Azani, Mariam;Al-Sulaibi, Mazen A. M.;Al-Hindawi, Bassam. And the article was included in International Journal of Organic Chemistry in 2016.Recommanded Product: 3,5-Dibromo-4-methoxybenzaldehyde This article mentions the following:

Wittig reactions of benzaldehydes, alkanals, and cycloalkanals as well as of acetophenones are carried out with alkoxycarbonyl methylidenetriphenylphosphoranes in 10 w% aqueous NaOH, where the cinnamates and alkenoates produced are hydrolyzed in situ and the corresponding acids are obtained after mostly simple extractive work-up, often without employing organic solvents. Under the same conditions, benzaldehydes are reacted with alkoxycarbonyl bromomethylidenephosphorane to produce 3-arylprop-2-ynoic acids (arylpropiolic acids). In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Recommanded Product: 3,5-Dibromo-4-methoxybenzaldehyde).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 3,5-Dibromo-4-methoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of S-alkylisothiuronium halides by reaction of thiourea with 锠?(4-hydroxyaryl)alkyl halides was written by Kandalintseva, N. V.;Prosenko, A. E.;Dyubchenko, O. I.;Stoyanov, E. S.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 2001.Category: bromides-buliding-blocks This article mentions the following:

A number of new S-arylalkylisothiuronium salts, e.g., I, were synthesized by reaction of 锠?[4-hydroxy(methoxy)aryl]alkyl halides with thiourea. The resulting isothiuronium salts in aqueous solution react with sodium (potassium) halides to form halogen exchange products. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Category: bromides-buliding-blocks).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary