Tag: 200-300

In 2009,Chemistry – A European Journal included an article by Gendrineau, Thomas; Demoulin, Nicolas; Navarre, Laure; Genet, Jean-Pierre; Darses, Sylvain. COA of Formula: C6H4BBrF3K. The article was titled 《Rhodium-Catalyzed Formation of Stereocontrolled Trisubstituted Alkenes from Baylis-Hillman Adducts》. The information in the text is summarized as follows:

Efficient and general conditions for the formation of stereodefined trisubstituted alkenes by using the rhodium-catalyzed reaction of unactivated Baylis-Hillman adducts with either organoboronic acids or potassium trifluoro(organo)borates are reported (see scheme). We report here efficient and general conditions for the formation of stereodefined trisubstituted alkenes using the rhodium-catalyzed reaction of unactivated Baylis-Hillman adducts with either organoboronic acids and potassium trifluoro(organo)borates. The use of the [{Rh(cod)OH}2] precursor gave very fast coupling reactions under low catalyst loading, very mild reaction conditions (from room temperature up to 50 °C) and without the need of addnl. phosphane ligands. Based on the new reaction conditions, the reaction, originally limited to Baylis-Hillman adducts derived from esters, could be extended to a large variety of Baylis-Hillman adducts, bearing either keto, cyano or amido functionalities. Moreover, the reaction of Baylis-Hillman adducts bearing esters functionality was improved and could be conducted at lower temperature using lower catalyst loading. In addition to this study using potassium (3-bromophenyl)trifluoroborate, there are many other studies that have used potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8COA of Formula: C6H4BBrF3K) was used in this study.

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.COA of Formula: C6H4BBrF3K

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2009,Chemistry – A European Journal included an article by Andaloussi, Mounir; Lindh, Jonas; Saevmarker, Jonas; Sjoeberg, Per J. R.; Larhed, Mats. COA of Formula: C6H4BBrF3K. The article was titled 《Microwave-Promoted Palladium(II)-Catalyzed C-P Bond Formation by Using Arylboronic Acids or Aryltrifluoroborates》. The information in the text is summarized as follows:

The first PdII-catalyzed P arylation has been performed by using palladium acetate, the rigid bidentate ligand dmphen (dmphen = 2,9-dimethyl-1,10-phenanthroline), and without the addition of base or acid. Couplings of arylboronic acids or aryl trifluoroborates with H-phosphonate dialkyl esters were conducted in 30 min with controlled microwave (MW) heating under non-inert conditions. Aryl phosphites were also synthesized at room temperature with atm. air as the sole reoxidant. The arylated phosphonates were isolated in 44-90% yields. The excellent chemoselectivity of the method was illustrated in the synthesis of a Mycobacterium tuberculosis glutamine synthetase (MTB-GS) inhibitor. Online ESI-MS was used to detect cationic palladium species in ongoing reactions directly, and a catalytic cycle has been proposed based on these results. In the experiment, the researchers used many compounds, for example, potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8COA of Formula: C6H4BBrF3K)

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. COA of Formula: C6H4BBrF3K Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C7H5Br2FOn May 13, 2021 ,《Design and Structure-Activity Relationships of Isothiocyanates as Potent and Selective N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibitors》 appeared in Journal of Medicinal Chemistry. The author of the article were Malamas, Michael S.; Pavlopoulos, Spiro; Alapafuja, Shakiru O.; Farah, Shrouq I.; Zvonok, Alexander; Mohammad, Khadijah A.; West, Jay; Perry, Nicholas Thomas; Pelekoudas, Dimitrios N.; Rajarshi, Girija; Shields, Christina; Chandrashekhar, Honrao; Wood, Jodi; Makriyannis, Alexandros. The article conveys some information:

N-Acylethanolamines are signaling lipid mols. implicated in pathophysiol. conditions associated with inflammation and pain. N-Acylethanolamine acid amidase (NAAA) favorably hydrolyzes lipid palmitoylethanolamide, which plays a key role in the regulation of inflammatory and pain processes. The synthesis and structure-activity relationship studies encompassing the isothiocyanate pharmacophore have produced potent low nanomolar inhibitors for hNAAA, while exhibiting high selectivity (>100-fold) against other serine hydrolases and cysteine peptidases. We have followed a target-based structure-activity relationship approach, supported by computational methods and known cocrystals of hNAAA. We have identified systemically active inhibitors with good plasma stability (t1/2 > 2 h) and microsomal stability (t1/2 ∼ 15-30 min) as pharmacol. tools to investigate the role of NAAA in inflammation, pain, and drug addiction. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Synthetic Route of C7H5Br2F)

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Synthetic Route of C7H5Br2F Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pandiri, Madhuri; Nukala, Satheesh Kumar; Dasari, Gouthami; Badithapuram, Vinitha; Bandari, Srinivas published an article in 2021. The article was titled 《Design and Synthesis of Some New N-Phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-1-sulfonamide Derivatives and Their Anti-Cancer Activity》, and you may find the article in Russian Journal of General Chemistry.Recommanded Product: 626-40-4 The information in the text is summarized as follows:

Synthesis of some new derivatives of N-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-1-sulfonamide and their in vitro anticancer activity on four human cancer lines like MCF-7 (human breast cancer cell line), HeLa (human cervical cancer cell line), A549 (human lung cancer cell line), and IMR32 (human neuroblastoma cell line) have been studied. Among the products, N-(3,5-dichloronitrophenyl)-[1,2,4]triazolo[4,3-a]quinoxaline-1-sulfonamide, is characterized by the activity higher than the standard Etoposide against the tested cancer cell lines. In the experiment, the researchers used many compounds, for example, 3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zuo, Ziqing; Kim, Raphael S.; Watson, Donald A. published an article in 2021. The article was titled 《Synthesis of Axially Chiral 2,2′-Bisphosphobiarenes via a Nickel-Catalyzed Asymmetric Ullmann Coupling: General Access to Privileged Chiral Ligands without Optical Resolution》, and you may find the article in Journal of the American Chemical Society.SDS of cas: 2635-13-4 The information in the text is summarized as follows:

The authors report an asym. homocoupling of ortho-(iodo)arylphosphine oxides and ortho-(iodo)arylphosphonates resulting in highly enantioenriched axially chiral bisphosphine oxides and bisphosphonates. These products are readily converted to enantioenriched biaryl bisphosphines without need for chiral auxiliaries or optical resolution This provides a practical route for the development of previously unstudied atroposelective biaryl bisphosphine ligands. The conditions also proved effective for asym. dimerization of other, nonphosphorus-containing aryl halides. In addition to this study using 5-Bromobenzo[d][1,3]dioxole, there are many other studies that have used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4SDS of cas: 2635-13-4) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.SDS of cas: 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Yumeng; Li, Yueshan; Miao, Zhuang; Yang, Ruicheng; Zhang, Yun; Wu, Ming; Lin, Guifeng; Li, Linli published an article in 2021. The article was titled 《Discovery of 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one derivatives as a new class of ROCK inhibitors for the treatment of glaucoma》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Product Details of 1129-28-8 The information in the text is summarized as follows:

The Rho-associated protein kinases (ROCKs) are associated with the pathol. of glaucoma and discovery of ROCK inhibitors has attracted much attention in recent years. Herein, we report a series of 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one derivatives as a new class of ROCK inhibitors. Structure-activity relationship studies led to the discovery of compound 12b, which showed potent activities against ROCK I and ROCK II with IC50 values of 93 nM and 3 nM, resp. 12b also displayed considerable selectivity for ROCKs. The mean IOP-lowering effect of 12b in an ocular normotensive model was 34.3%, and no obvious hyperemia was observed Overall, this study provides a good starting point for ROCK-targeting drug discovery against glaucoma. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Product Details of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Product Details of 1129-28-8Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kim, Minjae; Park, Bohyun; Shin, Minkyeong; Kim, Suyeon; Kim, Junghoon; Baik, Mu-Hyun; Cho, Seung Hwan published their research in Journal of the American Chemical Society in 2021. The article was titled 《Copper-Catalyzed Enantiotopic-Group-Selective Allylation of gem-Diborylalkanes》.SDS of cas: 2635-13-4 The article contains the following contents:

The authors report a Cu-catalyzed enantiotopic-group-selective allylation of gem-diborylalkanes with allyl bromides. The combination of Cu(I) bromide and H8-BINOL derived phosphoramidite ligand proved to be the most effective catalytic system to provide various enantioenriched homoallylic boronate esters, containing a B-substituted stereogenic center that is solely derived from gem-diborylalkanes, in good yields with high enantiomeric ratios under mild conditions. Exptl. and theor. studies were conducted to elucidate the reaction mechanism, revealing how the enatiotopic-group-selective transmetalation of gem-diborylalkanes with chiral Cu complex occurs to generate chiral α-borylalkyl-Cu species for the 1st time. Addnl. synthetic applications to the synthesis of various chiral building blocks are also included. In the experiment, the researchers used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4SDS of cas: 2635-13-4)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.SDS of cas: 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Abed, Dhulfiqar Ali; Lee, Sumi; Wen, Xia; Ali, Ahmed R.; Mangipudy, Vaibhav; Aleksunes, Lauren M.; Hu, Longqin published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N’-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation》.Application In Synthesis of Benzyl 2-bromoacetate The article contains the following contents:

The protein-protein interaction (PPI) between kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2) is recognized as a promising target for the prevention and treatment of oxidative stress-related inflammatory diseases. Herein, a series of novel 1,4-bis(arylsulfonamido)naphthalene-N,N’-diacetic acid analogs such as I were designed to further explore the structure-activity relationships of the series. Their activities were measured first with a fluorescence polarization (FP) assay and more potent compounds were further evaluated using a more sensitive time-resolved fluorescence energy transfer (TR-FRET) assay, demonstrating IC50 values between 7.2 and 31.3 nM. In cytotoxicity studies, the naphthalene derivatives did not show noticeable toxicity to human HepG2-C8 and mouse brain BV-2 microglia cells. Among them, I bearing oxygen-containing fused rings was shown to significantly stimulate the cellular Nrf2 signaling pathway, including activation of antioxidant response element (ARE)-controlled expression of Nrf2 target genes and proteins. More importantly, I suppressed up-regulation of several pro-inflammatory cytokines in lipopolysaccharide (LPS)-challenged BV-2 microglial cells, representing a potential therapeutic application for controlling neuroinflammatory disorders.Benzyl 2-bromoacetate(cas: 5437-45-6Application In Synthesis of Benzyl 2-bromoacetate) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Application In Synthesis of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yin, Jianpeng; Zhan, Desheng; Ma, Hui; Liu, Huanan; Yu, Lifang; Zhang, Yangming; Nan, Fajun published their research in Organic Process Research & Development in 2021. The article was titled 《Optimization and Development of a Scalable Palladium-Catalyzed C-H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator》.Recommanded Product: Methyl 3-(bromomethyl)benzoate The article contains the following contents:

AMP-activated protein kinase (AMPK) activator YLF466D is a promising preclin. drug candidate to treat metabolic diseases and myocardial ischemia-reperfusion injury (MIRI). Herein, we report our efforts on optimization and development of a practical and scalable process for the preparation of YLF466D in kilogram scale. The process features a palladium-catalyzed C-H activation under mild reaction conditions, geometry selectivity, effective impurities purging, and low levels of residual solvents in the final active pharmaceutical ingredient (API). We applied this process successfully to prepare more than 17 kg (3.0-3.6 kg per batch) of YLF466D to support its preclin. study. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Recommanded Product: Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Selective targeting of the αC and DFG-out pocket in p38 MAPK》 was written by Roehm, Sandra; Schroeder, Martin; Dwyer, Jessica E.; Widdowson, Caroline S.; Chaikuad, Apirat; Berger, Benedict-Tilman; Joerger, Andreas C.; Kraemer, Andreas; Harbig, Jule; Dauch, Daniel; Kudolo, Mark; Laufer, Stefan; Bagley, Mark C.; Knapp, Stefan. Safety of 3,5-Dibromoaniline And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

The p38 MAPK cascade is a key signaling pathway linked to a multitude of physiol. functions and of central importance in inflammatory and autoimmune diseases. Although studied extensively, little is known about how conformation-specific inhibitors alter signaling outcomes. Here, we have explored the highly dynamic back pocket of p38 MAPK with allosteric urea fragments. However, screening against known off-targets showed that these fragments maintained the selectivity issues of their parent compound BIRB-796, while combination with the hinge-binding motif of VPC-00628 greatly enhanced inhibitor selectivity. Further efforts focused therefore on the exploration of the αC-out pocket of p38 MAPK, yielding compound 137 as a highly selective type-II inhibitor. Even though 137 is structurally related to a recent p38 type-II chem. probe, SR-318, the data presented here provide valuable insights into back-pocket interactions that are not addressed in SR-318 and it provides an alternative chem. tool with good cellular activity targeting also the p38 back pocket. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Safety of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Safety of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary