Tag: 200-300

《Oxidative Deconstruction of Azetidinols to α-Amino Ketones》 was written by Raclea, Robert-Cristian; Natho, Philipp; Allen, Lewis A. T.; White, Andrew J. P.; Parsons, Philip J.. Application of 2675-79-8 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A silver-mediated synthesis of α-amino ketones via the oxidative deconstruction of azetidinols has been developed using a readily scalable protocol with isolated yields up to 80%. The azetidinols are easily synthesized in one step and can act as protecting groups for these pharmaceutically relevant synthons. Furthermore, mechanistic insights are presented and these data have revealed that the transformation is likely to proceed through the β-scission of an alkoxy radical, followed by oxidation and C-N cleavage of the resulting α-amido radical. The results came from multiple reactions, including the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Metal-Free Photocatalytic Hydrogenation Using Covalent Triazine Polymers》 was written by Hu, Yongpan; Huang, Wei; Wang, Hongshuai; He, Qing; Zhou, Yuan; Yang, Ping; Li, Youyong; Li, Yanguang. HPLC of Formula: 3141-27-3 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Photocatalytic hydrogenation of biomass-derived organic mols. transforms solar energy into high-energy-d. chem. bonds. Reported herein is the preparation of a thiophene-containing covalent triazine polymer as a photocatalyst, with unique donor-acceptor units, for the metal-free photocatalytic hydrogenation of unsaturated organic mols. Under visible-light illumination, the polymeric photocatalyst enables the transformation of maleic acid into succinic acid with a production rate of about 2 mmol g-1 h-1, and furfural into furfuryl alc. with a production rate of about 0.5 mmol g-1 h-1. Great catalyst stability and recyclability are also measured. Given the structural diversity of polymeric photocatalysts and their readily tunable optical and electronic properties, metal-free photocatalytic hydrogenation represents a highly promising approach for solar energy conversion. In addition to this study using 2,5-Dibromothiophene, there are many other studies that have used 2,5-Dibromothiophene(cas: 3141-27-3HPLC of Formula: 3141-27-3) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.HPLC of Formula: 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Mechanical-Bond-Induced Exciplex Fluorescence in an Anthracene-Based Homo[2]catenane》 was written by Garci, Amine; Beldjoudi, Yassine; Kodaimati, Mohamad S.; Hornick, Jessica E.; Nguyen, Minh T.; Cetin, M. Mustafa; Stern, Charlotte L.; Roy, Indranil; Weiss, Emily A.; Stoddart, J. Fraser. Electric Literature of C8H8Br2 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Collisional intermol. interactions between excited states form short-lived dimers and complexes that lead to the emergence of excimer/exciplex emission of lower energy, a phenomenon which must be differentiated from the photoluminescence (PL) arising from the monomeric mols. Although the utilization of noncovalent bonding interactions, leading to the generation of excimer/exciplex PL, was studied extensively, precise control of the aggregates and their persistence at low concentrations remains a rare phenomenon. In the search for a fresh approach, we sought to obtain exciplex PL from permanent structures by incorporating anthracene moieties into pyridinium-containing mech. interlocked mols. (MIMs). Beyond the optical properties of the anthracene moieties, their π-extended nature enforces [π···π] stacking that can overcome the Coulombic repulsion between the pyridinium units, affording an efficient synthesis of an octacationic homo[2]catenane. Notably, upon increasing the ionic strength by adding tetrabutylammonium hexafluorophosphate, the catenane yield increases significantly as a result of the decrease in Coulombic repulsions between the pyridinium units. Although the ground state photophys. properties of the free cyclophane and the catenane are similar and show a charge transfer band at ∼455 nm, their PL characters are distinct, denoting different excited states. The cyclophane emits at ∼562 nm (quantum yield (ΦF) = 3.6%, emission lifetime Γs = 3 ns in MeCN), which characteristic of a disubstituted anthracene-pyridinium linker. By contrast, the catenane displays an exciplex PL at low concentration (10-8 M) with an emission band centered on 650 nm (ΦF = 0.5%, Γs = 14 ns) in MeCN and at 675 nm in aqueous solution Live-cell imaging performed in MIAPaCa-2 prostate cancer cells confirmed that the catenane exciplex emission can be detected at micromolar concentrations1,4-Bis(bromomethyl)benzene(cas: 623-24-5Electric Literature of C8H8Br2) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Electric Literature of C8H8Br2 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 14660-52-7In 2020 ,《Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer》 appeared in European Journal of Medicinal Chemistry. The author of the article were Yao, Dahong; Li, Chenyang; Jiang, Jin; Huang, Jian; Wang, Jinhui; He, Zhendan; Zhang, Jin. The article conveys some information:

The dysfunction of histone deacetylase (HDACs) is closely related to tumorigenesis and development, which has been emerged as an attractive drug design target for cancer therapy. In the present study, a series of novel HDAC inhibitors using a substituted quinazoline as the capping group and attaching 3,5-dimethylbenyl as a potential metabolic site protector have been designed and synthesized. Compounds I and II demonstrated potent HDAC inhibitory activities and anti-proliferative effects against MDA-MB-231 cells. In addition, I and II both could significantly increase the acetylation level of intracellular proteins, especially in α-Tubulin and HSP90. Compounds I and II displayed a slight different anti-tumor mechanism, I mainly induced apoptosis while II induced obviously ER-Stress. Furthermore, I and II both induced autophagy and migration inhibition. In pharmacokinetics assay, I showed a significant improvement of pharmacokinetic profile for oral administration. Addnl., I presented more potent anti-proliferation and anti-migration activity than SAHA in zebrafish MDA-MB-231 cell line-derived xenograft model. Together, these results demonstrate that I is a novel oral HDAC inhibitor with a potential capacity of treating breast cancer. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C4H2Br2SIn 2020 ,《Push-pull thiophene chromophores for electro-optic applications: from 1D linear to β-branched structures》 appeared in Physical Chemistry Chemical Physics. The author of the article were Rothe, Christian; Neusser, David; Hoppe, Niklas; Dirnberger, Klaus; Vogel, Wolfgang; Gamez-Valenzuela, Sergio; Lopez Navarrete, Juan T.; Villacampa, Belen; Berroth, Manfred; Ruiz Delgado, M. Carmen; Ludwigs, Sabine. The article conveys some information:

The authors report the synthesis and characterization of push-pull chromophores bearing one-dimensional (1D) linear and β-branched thiophenes as π-conjugated spacers between a 2,2,4,7-tetramethyl-1,2,3,4-tetrahydroquinoline electron donor unit and dicyano- and tricyanovinylene electron acceptor groups. The effect of the introduction of β-thiophenes on the linear and nonlinear optical (NLO) properties as well as electrochem. and thermal data is studied in detail by performing a comparative study between the branched and 1D linear systems. A parallel DFT computational study is used to evaluate structure-property relations. The NLO behavior of the mols. both in solution and in solid state as electrooptic (EO) films using a guest-host approach shows very promising performance for electrooptic applications with high mol. 1st hyperpolarizabilities (μβ) of 4840 × 10-48 esu and electrooptic coefficients r33 reaching 650 pm V-1. One highlight is that the EO films of the β-branched chromophores are superior in terms of thermal stability in device operation as measured by a transmissive modified reflective Teng-Man method. This work provides guidelines for the design of improved electrooptic materials including β-branched chromophores which could be useful for practical EO applications, where both enhanced β and r33 values together with chem. and thermal stability are necessary. After reading the article, we found that the author used 2,5-Dibromothiophene(cas: 3141-27-3Computed Properties of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Computed Properties of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2020 ,《Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity》 appeared in European Journal of Medicinal Chemistry. The author of the article were Zhang, Xuan; Thummuri, Dinesh; Liu, Xingui; Hu, Wanyi; Zhang, Peiyi; Khan, Sajid; Yuan, Yaxia; Zhou, Daohong; Zheng, Guangrong. The article conveys some information:

Anti-apoptotic protein BCL-XL plays a key role in tumorigenesis and cancer chemotherapy resistance, rendering it an attractive target for cancer treatment. However, BCL-XL inhibitors such as ABT-263 cannot be safely used in the clinic because platelets solely depend on BCL-XL to maintain their viability. To reduce the on-target platelet toxicity associated with the inhibition of BCL-XL, we designed and synthesized PROTAC BCL-XL degraders that recruit CRBN or VHL E3 ligase because both of these enzymes are poorly expressed in human platelets compared to various cancer cell lines. We confirmed that platelet-toxic BCL-XL/2 dual inhibitor ABT-263 can be converted into platelet-sparing CRBN/VHL-based BCL-XL specific degraders. A number of BCL-XL degraders are more potent in killing cancer cells than their parent compound ABT-263. Specifically, XZ739, a CRBN-dependent BCL-XL degrader, is 20-fold more potent than ABT-263 against MOLT-4 T-ALL cells and has >100-fold selectivity for MOLT-4 cells over human platelets. Our findings further demonstrated the utility of PROTAC technol. to achieve tissue selectivity through recruiting differentially expressed E3 ligases. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C6H5Br2NIn 2021 ,《Aggregation-induced fluorescent response of urea-bearing polyphenyleneethynylenes toward anion sensing》 appeared in Science and Technology of Advanced Materials. The author of the article were Li, Jian; Saleem, Muhammad; Duan, Qian; Kakuchi, Toyoji; Chen, Yougen. The article conveys some information:

A π-conjugated urea-bearing phenyleneethynylene polymer () was rationally designed by the Sonogashira coupling condensation reaction and had been demonstrated to have a unique fluorescent quenching effect for the optical detection of all determined anions, especially for CN-. The fluorescent emission of was significantly quenched upon adding CN-, together accompanied with a continuous red shift of the emission peak from 442 to 464 nm with the cyanide concentration increased from 0 to 1.0 mM. On the contrary, its precursor polymer, , itself also displayed fluorescent responsibility with all selected anions but had no obvious selectivity and tendency. For instance, the addition of highly basic CN-, N3-, AcO-, or F- to solution in DMF/H2O (volume/volume = 1:1) led to the photoluminescence amplification, while the addition of weakly basic anions like Cl-, I-, and Br- showed a fluorescence quenching effect. Both polymers were in a seriously self-aggregated state in solution no matter in the absence or presence of an anion. Interestingly, it was found that exhibited an aggregation-induced emission behavior, while had an aggregation-caused quenching effect, based on the relationship between photoluminescence and polymer aggregation state. The structural characterizations were carried out by NMR spectroscopy and size exclusion chromatog. measurements; the photoluminescence properties of and together with anion sensing properties were followed by fluorescence spectroscopy, and the relationship between photoluminescence and aggregation behavior of both polymers in solution was investigated by dynamic light scattering measurements. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 629-03-8In 2021 ,《Removal of Co2+, Cu2+ and Au3+ ions from contaminated wastewater by using new fluorescent and antibacterial polymer as sorbent》 appeared in Polymer Bulletin (Heidelberg, Germany). The author of the article were Qureshi, Farah; Memon, Saima Q.; Khuhawar, Muhammad Yar; Jahangir, Taj Muhammad. The article conveys some information:

New Schiff base polymer was synthesized through polycondensation reaction of dialdehyde (2,2′-hexamethylenebis(oxybenzaldehyde)) and diamine (dapsone). The resulting polymer was characterized through CHN anal., 1HNMR, FT-IR, UV-Vis spectroscopy, fluorescence spectroscopy, TG/DTA and SEM. The synthesized polymer was fluorescent and showed violet color emission. The antimicrobial activity of the polymer was tested, and the polymer showed moderate antibacterial activity against Shigella flexneri. New effective method was developed for the removal of Co2+, Cu2+ and Au3+ ions from contaminated wastewater, and the synthesized polymer was employed as sorbent. Multivariate optimization of parameters (pH, concentration, amount and time) was attained through factorial design (face-centered Draper-Lin composite design) with 18 batch experiments The method was applied successfully at predicted optimum conditions for the removal of heavy metal ions (Co2+, Cu2+ and Au3+) from contaminated wastewater samples. The synthesized sorbent polymer removed up to 78% Co2+, 99% Cu2+ and 98% Au3+ from wastewater samples. The concentration of metal ions before and after adsorption was measured through AAS. The presence of metal ions on the polymer surface was confirmed through SEM and EDX anal. of the polymer after adsorption. Equilibrium of the adsorption process was studied through Langmuir, Freundlich and D-R isotherms, and kinetics was studied through Lagergren pseudo-first-order, Lagergren pseudo-second-order and intra-particle diffusion models. The experimental part of the paper was very detailed, including the reaction process of 1,6-Dibromohexane(cas: 629-03-8Recommanded Product: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.Recommanded Product: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Thomas, Jisha Mary; Vidhyapriya, Pitchavel; Sivan, Akhil K.; Sakthivel, Natarajan; Sivasankar, Chinnappan published an article in Applied Organometallic Chemistry. The title of the article was 《Synthesis, spectroscopic, CO-releasing ability, and anticancer activity studies of [Mn(CO)3(L-L)Br] complexes: Experimental and density functional theory studies》.SDS of cas: 14516-54-2 The author mentioned the following in the article:

Two different series of manganese(I) tricarbonyl complexes containing phosphine-based (1-5) and 4′-substituted 2,2′:6′,2′′-terpyridine-based ligands (6-10) have been synthesized in order to study their CO-releasing ability and to investigate their anticancer activity. All the synthesized complexes (1-10) have been fully characterized using standard spectroscopic and anal. techniques. Further 5, 7, and 9 have also been characterized by single-crystal x-ray diffraction studies. Although both the sets of ligands are π-acceptors, they tend to change the Mn-CO bond strength upon complexation, thus affecting the CO release. Photoactivation of 1-5 and 6-10 has been achieved using 365 nm UV irradiation and low intensity visible light, resp. The MnCO bond strength has been examined using the d. functional theory (DFT) and time-dependent DFT (TD-DFT) calculations In order to find the therapeutic viability of the visible light activated complexes, their cytotoxicity has been investigated both in the dark and under irradiation The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay reveals the potential application of some of the synthesized complexes especially towards the lung cancer cells in the dark condition. In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2SDS of cas: 14516-54-2)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.SDS of cas: 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Deng, Xuemei; Luo, Tian; Li, Zhao; Wen, Huaixiu; Zhang, Honghua; Yang, Xiaoyan; Lei, Fang; Liu, Dan; Shi, Tao; Zhao, Quanyi; Wang, Zhen published an article in European Journal of Medicinal Chemistry. The title of the article was 《Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids》.Related Products of 2635-13-4 The author mentioned the following in the article:

This article describes the syntheses and biol. activity of five 3-arylisoquinoline natural products corydamine (1), N-formyl Corydamine (2), hypecumine (3), Decumbenine B (XW) and 2-(1,3-dioxolo [4,5-h]isoquinolin-7-yl)-4,5-dimethoxy-N-methyl-Benzeneethanamine (A), and twelve analogs. Among them, 1, 2, and A were synthesized for the first time. In vitro screening for anti-proliferative activity showed that derivative 1a could significantly inhibit the proliferation of HCC cells (IC50 = 9.82 μM on Huh7 cells and 6.83 μM on LM9 cells), and arrest cell cycle at G2/M phase. The mechanistic studies further suggested compound 1a was a dual inhibitor of Topo I and Topo II, and Topo II inhibitory activity was superior to etoposide. In addition, 1a could significantly inhibit the invasion and migration of cancer cells by inhibiting the expression of MMP-9, and induce apoptosis through inhibiting the activation of the PI3K/Akt/mTOR signaling pathway. Moreover, in vivo studies demonstrated 1a could obviously reduce the growth of xenograft tumor and possessed good pharmacokinetic parameters, which indicated the potential value of 1a in treating liver cancer.5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Related Products of 2635-13-4) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Related Products of 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary