Tag: 200-300

《Salt-Stabilized Silylzinc Pivalates for Nickel-Catalyzed Carbosilylation of Alkenes》 was written by Wang, Jixin; Duan, Zhili; Liu, Xingchen; Dong, Shoucheng; Chen, Kaixin; Li, Jie. COA of Formula: C7H5Br2F And the article was included in Angewandte Chemie, International Edition on April 19 ,2022. The article conveys some information:

The authors herein report the preparation of solid and salt-stabilized silylzinc pivalates from the corresponding silyllithium reagents via transmetalation with Zn(OPiv)2. These resulting organosilylzinc pivalates show enhanced air and moisture stability and unique reactivity in the silylative difunctionalization of alkenes. Thus, a practical chelation-assisted Ni-catalyzed regioselective alkyl and benzylsilylation of alkenes was developed, which provides an easy method to access alkyl silanes with broad substrate scope and wide functional group compatibility. Kinetic experiments highlight that the OPiv-coordination is crucial to improve the reactivity of silylzinc pivalates. Also, late-stage functionalizations of druglike mols. and versatile modifications of the products illustrate the synthetical utility of this protocol. The experimental part of the paper was very detailed, including the reaction process of 4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5COA of Formula: C7H5Br2F)

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. COA of Formula: C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Rhodium-Catalyzed Atroposelective Click Cycloaddition of Azides and Alkynes》 was written by Zeng, Linwei; Li, Jiaming; Cui, Sunliang. Computed Properties of C9H9BrO2This research focused ontriazole preparation enantioselective; azide alkyne atroposelective click cycloaddition rhodium catalyst; Atroposelectivity; Click Chemistry; Cycloaddition; Rhodium Catalysis; Triazoles. The article conveys some information:

Herein, a rhodium-catalyzed enantioselective click cycloaddition of azides R1N3 (R1 = benzyl, 2-naphthyl, pyridin-3-yl, etc.) and alkynes R3CCR2 (R2 = Ph, 2-naphthyl, cyclopropyl, etc.; R3 = 2-hydroxynaphthalen-1-yl, 6-bromo-2-hydroxynaphthalen-1-yl, 6-hydroxyquinolin-5-yl, etc.) for rapid and modular access to atropisomeric triazoles I in excellent yields and enantioselectivities was reported. The process is mild, efficient and scalable, and features broad substrate scope. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6Computed Properties of C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Computed Properties of C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1,4-Bis(bromomethyl)benzeneIn 2020 ,《Precisely Controlled Multidimensional Covalent Frameworks: Polymerization of Supramolecular Colloids》 was published in Angewandte Chemie, International Edition. The article was written by Li, Yongguang; Wu, Shanshan; Zhang, Lingling; Xu, Xin; Fang, Yajun; Yi, Juzhen; Kim, Jehan; Shen, Bowen; Lee, Myongsoo; Huang, Liping; Zhang, Liwei; Bao, Junhui; Ji, Hongbing; Huang, Zhegang. The article contains the following contents:

Rapid and selective removal of micropollutants from water is important for the reuse of water resources. Despite hollow frameworks with specific functionalized porous walls for the selective adsorption based on a series of interactions, tailoring a stable shape of nanometer- and micrometer-sized architectures for the removal of specific pollutants remains a challenge. Here, exactly controlled sheets, tubes, and spherical frameworks were presented from the crosslinking of supramol. colloids in polar solvents. The frameworks strongly depended on the architecture of original supramol. colloids. As the entropy of colloids increased, the initial laminar framework rolled up into hollow tubules, and then further curled into hollow spheres. These shape-persistent frameworks showed unprecedented selectivity as well as specific recognition for the shape of pollutants, thus contributing to efficient pollutant separation In the experiment, the researchers used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Reference of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Reference of 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: 2,5-DibromothiopheneIn 2020 ,《Novel Sulfur-Containing Cross-Linking Agent for Si-Based Preceramic Polymers》 was published in Macromolecular Chemistry and Physics. The article was written by Taheri, Poroshat; Bokka, Apparao; Asgari, Parham; Jeon, Junha; Lang, John C.; Campostrini, Renzo; Soraru, Gian Domenico; Kroll, Peter. The article contains the following contents:

Crosslinking polymethylhydrosiloxane (PMHS) with divinylthiophene (DVT) via hydrosilylation in highly dilute conditions and subsequent supercritical drying in CO2 yield a polymeric aerogel containing aromatic sulfur integrally and uniformly distributed throughout the monolith. Fourier-transform IR (FT-IR) spectroscopy indicates almost complete consumption of vinyl groups and Si-H bonds in the product. Both FT-IR and Raman spectroscopic analyses support loss of conjugation of vinyl groups with the retained double bonds of the thiophene ring. SEM indicates a condensed colloidal structure with characteristic particulate diameters of about 165 nm. SEM coupled with energy dispersive X-ray spectroscopy elemental mapping shows that sulfur is distributed homogeneously in the polymeric aerogel. Porosimetry of the mesoporous aerogel indicates the effective average pore diameters are about 12 nm. Thermogravimetric anal. (TGA) establishes greater thermal stability of the PMHS-DVT product than either of the pure unreacted components. TGA coupled with mass spectrometric (TG-MS) identification of the volatiles released during pyrolysis shows that sulfur is driven from the crosslinked polymer as thiophene and its derivatives Recorded mass spectra support the hypothesis that crosslinking DVT bridges between PMHS chains in the polymeric aerogel, and that this results in a more thermally stable monolith. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromothiophene(cas: 3141-27-3Name: 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Name: 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of 4-Bromobenzoic acidIn 2021 ,《Influence of Isomerism on Radioluminescence of Purely Organic Phosphorescence Scintillators》 appeared in Angewandte Chemie, International Edition. The author of the article were Dong, Chaomin; Wang, Xiao; Gong, Wenqi; Ma, Wenbo; Zhang, Meng; Li, Jingjie; Zhang, Yuan; Zhou, Zixing; Yang, Zhijian; Qu, Shuli; Wang, Qian; Zhao, Zhu; Yang, Guohui; Lv, Anqi; Ma, Huili; Chen, Qiushui; Shi, Huifang; Yang, Yang; An, Zhongfu. The article conveys some information:

There are few reports about purely organic phosphorescence scintillators, and the relation between mol. structures and radioluminescence in organic scintillators is still unclear. An isomerism strategy to study the effect of mol. structures on radioluminescence is presented. Bromobenzoic acid (BA) isomers can achieve phosphorescence efficiency of ≤22.8% by UV irradiation Under x-ray irradiation, both m-BA and p-BA show excellent radioluminescence, while o-BA has almost no radioluminescence. Through exptl. and theor. study, radioluminescence was not only affected by nonradiation in emissive process, but also highly depended on the material conductivity caused by the different mol. packing. This study allows clear understanding of the relation between the mol. structures and radioluminescence and provides a guidance to rationally design new organic scintillators.4-Bromobenzoic acid(cas: 586-76-5Quality Control of 4-Bromobenzoic acid) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Quality Control of 4-Bromobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yan, Xiang-Yu; Leng, Jia-Fu; Chen, Ting-Ting; Zhao, Yong-Jun; Kong, Ling-Yi; Yin, Yong published an article in European Journal of Medicinal Chemistry. The title of the article was 《Design, synthesis, and biological evaluation of novel diphenylamine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site》.HPLC of Formula: 2635-13-4 The author mentioned the following in the article:

A novel series of diphenylamine derivatives were designed and synthesized I and their biol. activities were evaluated. The anti-proliferative activities of the derivatives were tested against five human cancer cell lines (MCF-7, MDA-MB-231, A549, HeLa and HT29). Among them, I exhibited the promising anti-proliferative activity against HT29 cell lines with the IC50 value of 23 nM. Further biol. studies depicted that I inhibited cancer cell migration, colony formation and angiogenesis. Besides, dynamics studies and mol. docking studies revealed that I inhibited tubulin polymerization which may be a result of the compound binding to the colchicine site of tubulin. Furthermore,I arrested HT29 cell cycle at G2/M phase, and induced HT29 cell apoptosis by upregulating cyclin B1, Bcl-2, Bax, Cleaved-caspase9, Cleaved-caspase3, PARP, Cleaved-PARP proteins, and downregulating p-cdc25c (S216), p-cdc2 (T15) proteins. Mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) were also determined to confirm the cell apoptosis process. Finally, I greatly inhibited the tumor growth in HT29 xenograft mice by 75.5% at 10 mg/kg. Meanwhile, I owned the good pharmacokinetic properties. All the results promised that I is of potential to act as an antitumor candidate and worthy of further investigation. In the part of experimental materials, we found many familiar compounds, such as 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4HPLC of Formula: 2635-13-4)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.HPLC of Formula: 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Oliva, Paola; Scortichini, Mirko; Dobelmann, Clemens; Jain, Shanu; Gopinatth, Varun; Toti, Kiran S.; Phung, Ngan B.; Junker, Anna; Jacobson, Kenneth A. published an article in 2021. The article was titled 《Structure-activity relationships of pyrimidine nucleotides containing a 5′-α,β-methylene diphosphonate at the P2Y6 receptor》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Related Products of 1129-28-8 The information in the text is summarized as follows:

The Gq-coupled P2Y6 receptor (P2Y6R) is a component of the purinergic signaling system and functions in inflammatory, cardiovascular and metabolic processes. UDP, the native P2Y6R agonist and P2Y14R partial agonist, is subject to hydrolysis by ectonucleotidases. Therefore, we have synthesized UDP/CDP analogs, e.g. I, containing a stabilizing α,β-methylene bridge as P2Y6R agonists and identified compatible affinity-enhancing pyrimidine modifications. A distal binding region on the receptor was explored with 4-benzyloxyimino CDP analogs and their potency determined in a calcium mobilization assay. A 4-trifluoromethyl-benzyloxyimino substituent provided the highest human P2Y6R potency (MRS4554, 0.57μM), and a 5-fluoro substitution of the cytosine ring similarly enhanced potency, with >175- and 39-fold selectivity over human P2Y14R, resp. However, 3-alkyl, β-D-arabinofuranose, and 6-aza substitution prevented P2Y6R activation. Thus, we have identified new α,β-methylene bridged N4-extended CDP analogs as P2Y6R agonists that are highly selective over the P2Y14R. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Related Products of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Cheng; Yue, Hu; Sun, Ping; Hua, Lei; Liang, Shuli; Ou, Yitao; Wu, Dan; Wu, Xinyi; Chen, Hao; Hao, Ying; Hu, Wenhui; Yang, Zhongjin published an article in 2021. The article was titled 《Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities》, and you may find the article in European Journal of Medicinal Chemistry.Quality Control of Ethyl 5-bromovalerate The information in the text is summarized as follows:

NLRP3 inflammasome activation plays a critical role in inflammation and its related disorders. Herein we report a hit-to-lead effort resulting in the discovery of a novel and potent class of NLRP3 inflammasome inhibitors. Among these, the most potent lead 40 exhibited improved inhibitory potency and almost no toxicity. Further mechanistic study indicated that compound 40 inhibited the NLRP3 inflammasome activation via suppressing ROS production More importantly, treatment with 40 showed remarkable therapeutic effects on LPS-induced sepsis and DSS-induced colitis. This study encourages further development of more potent inhibitors based on this chem. scaffold and provides a chem. tool to identify its cellular binding target. In the experiment, the researchers used many compounds, for example, Ethyl 5-bromovalerate(cas: 14660-52-7Quality Control of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Quality Control of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors》 were Zhou, Guangyan; Chu, Shidong; Nemati, Ariana; Huang, Chunsheng; Snyder, Beth A.; Ptak, Roger G.; Gochin, Miriam. And the article was published in European Journal of Medicinal Chemistry in 2019. Recommanded Product: Methyl 3-(bromomethyl)benzoate The author mentioned the following in the article:

In previous work, we described 6-6′-bisindole compounds targeting a hydrophobic pocket on the N-heptad repeat region of viral glycoprotein-41 as effective inhibitors of HIV-1 fusion. Two promising compounds with sub-micromolar IC50’s contained a benzoic acid group and a benzoic acid ester attached at the two indole nitrogens. Here we have conducted a thorough structure-activity relationship (SAR) study evaluating the contribution of each of the ring systems and various substituents to compound potency. Hydrophobicity, polarity and charge were varied to produce 35 new compounds that were evaluated in binding, cell-cell fusion and viral infectivity assays. We found that (a) activity based solely on increasing hydrophobic content plateaued at ∼ 200 nM; (b) the bisindole scaffold surpassed other heterocyclic ring systems in efficacy; (c) a polar interaction possibly involving Gln575 in the pocket could supplant less specific hydrophobic interactions; and (d) the benzoic acid ester moiety did not appear to form specific contacts with the pocket. The importance of this hydrophobic group to compound potency suggests a mechanism whereby it might interact with a tertiary component during fusion, such as membrane. A promising small mol. 10b with sub-μM activity was discovered with mol. weight <500 da and reduced logP compared to earlier compounds The work provides insight into requirements for small mol. inhibition of HIV-1 fusion. In the experiment, the researchers used many compounds, for example, Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Recommanded Product: Methyl 3-(bromomethyl)benzoate The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Angewandte Chemie, International Edition included an article by Sun, Haotian; Haque, Farihah M.; Zhang, Yi; Commisso, Alex; Mohamed, Mohamed Alaa; Tsianou, Marina; Cui, Honggang; Grayson, Scott M.; Cheng, Chong. Application In Synthesis of Ethyl 5-bromovalerate. The article was titled 《Linear-Dendritic Alternating Copolymers》. The information in the text is summarized as follows:

Herein, the design, synthesis, and characterization of an unprecedented copolymer consisting of alternating linear and dendritic segments is described. First, a 4th-generation Hawker-type dendron with two azide groups was synthesized, followed by a step-growth azide-alkyne “”click”” reaction between the 4th-generation diazido dendron and poly(ethylene glycol) diacetylene to create the target polymers. Unequal reactivity of the functional groups was observed in the step-growth polymerization The resulting copolymers, with alternating hydrophilic linear and hydrophobic dendritic segments, can spontaneously associate into a unique type of microphase-segregated nanorods in water. After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7Application In Synthesis of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Application In Synthesis of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary