Tag: 200-300

In 2019,Macromolecules (Washington, DC, United States) included an article by Su, Xin; Jessop, Philip G.; Cunningham, Michael F.. Related Products of 2675-79-8. The article was titled 《Versatility of Organocatalyzed Atom Transfer Radical Polymerization and CO2-Switching for Preparing Both Hydrophobic and Hydrophilic Polymers with the Recycling of a Photocatalyst》. The information in the text is summarized as follows:

A new approach was designed to prepare both hydrophobic and hydrophilic polymers by organocatalyzed atom transfer radical polymerization (O-ATRP). The method is based on using a recoverable photocatalyst whose properties can be switched using only CO2 addition and removal as triggers. The effectiveness of the CO2-switching approach in O-ATRP is demonstrated using a new CO2-switchable photoinitiated catalyst, which can be extracted from the polymer and reused. The residual catalyst in the polymer is reduced to less than 15 ppb. The feasibility of recovering and reusing the photoinitiated catalyst for subsequent polymerizations is also established. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Related Products of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Related Products of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Applied Catalysis, B: Environmental included an article by Samudrala, Priya S.; Nakhate, Akhil V.; Gupta, Shyam Sunder R.; Rasal, Kalidas B.; Deshmukh, Gunjan P.; Gadipelly, Chandrakanth R.; Theegala, Srinivas; Dumbre, Deepa K.; Periasamy, Selvakannan; Komandur, V. R. Chary; Bhargava, Suresh K.; Mannepalli, Lakshmi Kantam. HPLC of Formula: 586-76-5. The article was titled 《Oxidative coupling of carboxylic acids or benzaldehydes with DMF using hydrotalicite-derived oxide catalysts》. The information in the text is summarized as follows:

Hydrotalcite-derived (HT-derived) oxide catalysts were synthesized from hydrotalcite-like (HT-like) materials prepared by co-precipitation method (Cu-Al, Cu-Fe, Mg-Al, Mg-Fe, Ni-Fe and Ni-Al) followed by calcination and their catalytic activity was studied for oxidative amidation of carboxylic acids and substituted benzaldehydes with DMF. Catalyst screening was done using benzoic acid and DMF as a model reaction. Subsequently, the authors have optimized the reaction with different reaction parameters, catalyst loading, temperatures and oxidants. Cu-Fe HT-derived oxide catalyst showed excellent activity towards oxidative amidation using TBHP as an oxidant at 80° in 10 h. The fresh and spent catalysts were thoroughly characterized by different anal. techniques; XRD, SEM, HRTEM, TPD, N2 adsorption-desorption isotherm and XPS. Also, the catalyst was easily separated by simple filtration and reused up to four cycles without significant loss in catalytic activity. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5HPLC of Formula: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.HPLC of Formula: 586-76-5 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,European Journal of Organic Chemistry included an article by Kianmehr, Ebrahim; Nasab, Sepideh Bahrami. Category: bromides-buliding-blocks. The article was titled 《Ruthenium-Catalyzed Regioselective Direct Ortho-Acyloxylation of Azoarenes with Carboxylic Acids via C-H Bond Activation》. The information in the text is summarized as follows:

A highly regio and chemo-selective procedure for the synthesis of ortho-acyloxy-azoarene derivatives I [R = H, 4-Me, 4-Cl, etc.; R1 = H, 3-Et, 4-OH, etc.; R2 = i-Pr, Ph, Bn, etc.] was described via Ru-catalyzed C-H acyloxylation of azoarenes with inexpensive alkyl and aryl carboxylic acids as an acyloxylation agent. The reaction demonstrated a broad substrate scope and good functional group tolerance.4-Bromobenzoic acid(cas: 586-76-5Category: bromides-buliding-blocks) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Category: bromides-buliding-blocks It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Procopiou, Panayiotis A.; Anderson, Niall A.; Barrett, John; Barrett, Tim N.; Crawford, Matthew H. J.; Fallon, Brendan J.; Hancock, Ashley P.; Le, Joelle; Lemma, Seble; Marshall, Richard P.; Morrell, Josie; Pritchard, John M.; Rowedder, James E.; Saklatvala, Paula; Slack, Robert J.; Sollis, Steven L.; Suckling, Colin J.; Thorp, Lee R.; Vitulli, Giovanni; Macdonald, Simon J. F. published 《Discovery of (S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis》.Journal of Medicinal Chemistry published the findings.Related Products of 626-40-4 The information in the text is summarized as follows:

A series of 3-aryl-(pyrrolidin-1-yl)butanoic acids were synthesized using a diastereoselective route, which involved rhodium catalyzed asym. 1,4-addition of arylboronic acids in the presence of (R)-BINAP to a crotonate ester to provide the (S) absolute configuration for the major product. A variety of aryl substituents including morpholine, pyrazole, triazole, imidazole and cyclic ether were screened in cell adhesion assays for affinity against αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8 integrins. Several analogs with high affinity and selectivity for the αvβ6 integrin were identified. The analog I·HCl was found to have high affinity for αvβ6 integrin in a radioligand binding assay (pKi = 11), a long dissociation half-life (7 h) , high solubility in saline at pH 7 (>71 mg/mL) and pharmacokinetic properties commensurate with inhaled dosing by nebulization. It was selected for further investigation as a potential therapeutic agent for the treatment of idiopathic pulmonary fibrosis. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Related Products of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Related Products of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2013,Xia, Guangxin; You, Xiaodi; Liu, Lin; Liu, Haiyan; Wang, Jianfa; Shi, Yufang; Li, Ping; Xiong, Bing; Liu, Xuejun; Shen, Jingkang published 《Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors》.European Journal of Medicinal Chemistry published the findings.Related Products of 76006-33-2 The information in the text is summarized as follows:

The potential roles of 11β-HSD1 inhibitors in metabolic syndrome, T2D and obesity were well established and currently several classes of 11β-HSD1 inhibitors have been developed as promising agents against metabolic diseases. To find potent compounds with good pharmacokinetics, the authors used the bioisosterism approach, and designed the compounds I (R = Ph, cyclohexyl) bearing a 1,2,4-oxadiazole ring to replace the amide group in compound II. Guided by docking study, they then transformed compound I (R = phenyl) into a potent lead compound III by changing the sulfonamide group to an amide. To elaborate this series of piperidyl-oxadiazole derivatives as human 11β-HSD1 inhibitors, they explored the structure-activity relationship of several parts of the lead compound Based on their potency toward human 11β-HSD1 two compounds IV (R1 = 2-Me-3-Br-C6H3, cyclohexyl) were advanced to pharmacokinetic study. It was found that compounds IV are potent and selective human 11β-HSD1 inhibitors with better pharmacokinetic properties than those of the original piperidine-3-carboxamide compound II, and suitable for further in vivo preclin. study in primate model. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2009,Gao, Shuanhu; Wang, Qiaoling; Chen, Chuo published 《Synthesis and Structure Revision of Nakiterpiosin》.Journal of the American Chemical Society published the findings.Related Products of 76006-33-2 The information in the text is summarized as follows:

This manuscript describes a convergent synthesis and the revision of the relative stereochem. of nakiterpiosin (I), a marine C-nor-D-homosteroid. Our synthesis features a late-stage carbonylative Stille cross-coupling reaction and a photo-Nazarov cyclization reaction that deliver the complete nakiterpiosin skeleton efficiently. In the part of experimental materials, we found many familiar compounds, such as 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Kaolin-assisted Aromatic Chlorination and Bromination》 were Hirano, Masao; Monobe, Hiroyuki; Yakabe, Shigetaka; Morimoto, Takashi. And the article was published in Journal of Chemical Research, Synopses in 1998. HPLC of Formula: 30752-31-9 The author mentioned the following in the article:

Moist kaolin catalyzes the regioselective and high-yielding chlorination and bromination of C6H5OR (R = C1-C8 alkyl, But, allyl, cyclohexyl, benzyl) to 4-XC6H4OR (X = Cl and Br, resp.) with NaClO2 and Mn(acac)3 in CH2Cl2 in the absence and presence of NaBr, resp., under mild and neutral conditions. After reading the article, we found that the author used 1-Bromo-4-(cyclohexyloxy)benzene(cas: 30752-31-9HPLC of Formula: 30752-31-9)

1-Bromo-4-(cyclohexyloxy)benzene(cas: 30752-31-9) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 30752-31-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Son, Jung-Ho; Phuan, Puay-Wah; Zhu, Jie S.; Lipman, Elena; Cheung, Amy; Tsui, Ka Yi; Tantillo, Dean J.; Verkman, Alan S.; Haggie, Peter M.; Kurth, Mark J. published an article in European Journal of Medicinal Chemistry. The title of the article was 《1-Benzylspiro[piperidine-4,1′-pyrido[3,4-b]indole] ‘co-potentiators’ for minimal function CFTR mutants》.Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene The author mentioned the following in the article:

A spiro [piperidine-4,1-pyrido [3,4-b]indoles] I (R1 = 6-OMe, 6-Br, 6-Cl, 7-OMe; R2 = benzyl, furan-2-ylmethyl, pyridin-2-ylmethyl, etc.) class of co-potentiators that function in synergy with existing CFTR potentiators such as VX-770 or GLGP1837 to restore channel activity of a defined subset of minimal function cystic fibrosis transmembrane conductance regulator (CFTR) mutants has been described. Here, structure-activity studies were conducted to improve their potency over the previously identified compound, I (R1 = 6-OMe; R2 = benzyl) 20 (originally termed CP-A01). Targeted synthesis of 37 spiro [piperidine-4,1-pyrido [3,4-b]indoles] I was generally accomplished using versatile two or three step reaction protocols with each step having high efficiency. Structure-activity relationship studies established that analog I [R1 = 6-OMe; R2 = (2,4,5-trifluorophenyl)methyl], with 6′-methoxyindole and 2,4,5-trifluorobenzyl substituents, had the greatest potency for activation of N1303K-CFTR, with EC50 ∼600 nM representing an ∼17-fold improvement over the original compound identified in a small mol. screen.4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene) was used in this study.

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C6H2BrF2NO2On September 15, 2020 ,《Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists》 was published in European Journal of Medicinal Chemistry. The article was written by Sun, Nannan; Huang, Yafei; Yu, Mingcheng; Zhao, Yunpeng; Chen, Ji-An; Zhu, Chenyu; Song, Meiqi; Guo, Huimin; Xie, Qiong; Wang, Yonghui. The article contains the following contents:

GSK805 (1) is a potent RORγt inverse agonist, but a drawback of 1 is its low solubility, leading to a limited absorption in high doses. We have explored detailed structure-activity relationship on the amide linker, biaryl and arylsulfonyl moieties of 1 trying to improve solubility while maintaining RORγt activity. As a result, a novel series of carboxyl-containing biaryl urea derivatives was discovered as potent RORγt inverse agonists with improved drug-like properties. Compound 3i(I) showed potent RORγt inhibitory activity and subtype selectivity with an IC50 of 63.8 nM in RORγ FRET assay and 85 nM in cell-based RORγ-GAL4 promotor reporter assay. Reasonable inhibitory activity of 3i was also achieved in mouse Th17 cell differentiation assay (76% inhibition at 0.3 μM). Moreover, 3i had greatly improved aqueous solubility at pH 7.4 compared to 1, exhibited decent mouse PK profile and demonstrated some in vivo efficacy in an imiquimod-induced psoriasis mice model. In addition to this study using 2-Bromo-1,3-difluoro-5-nitrobenzene, there are many other studies that have used 2-Bromo-1,3-difluoro-5-nitrobenzene(cas: 886762-62-5Formula: C6H2BrF2NO2) was used in this study.

2-Bromo-1,3-difluoro-5-nitrobenzene(cas: 886762-62-5) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Formula: C6H2BrF2NO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Photocatalytically Active Conjugated Porous Polymers via Click Chemistry for Heterogeneous Dehydrogenation of Hydrazo Aromatics》 was written by Song, Chaoyang; Liu, Biao; Nie, Junqi; Ma, Chao; Lu, Cuifen; Wang, Feiyi; Yang, Guichun; Chen, Zuxing. Category: bromides-buliding-blocks And the article was included in ACS Sustainable Chemistry & Engineering in 2020. The article conveys some information:

Aromatic azo compounds are an important class of raw materials and are widely used in chem. industries. However, current synthetic methods have many disadvantages, which limit their practical utility. Here, we report a facile approach to prepare 1,2,3-triazole-contained conjugated porous polymers (CPPs; Ta-Ths) through click reaction of azide and terminal alkynes and employ the click-based CPPs for the first time as photocatalysts. By changing the structure of alkyne monomer, Ta-Ths with distinct optoelectronic properties are obtained to effectively catalyze the visible light-driven oxidative dehydrogenation of hydrazo aromatics Moreover, the Ta-Ths show much higher catalytic activity as compared with previous homogeneous photocatalysts. The CPP that possesses better charge transfer efficiency and lower charge recombination rate was found to have more catalytic activity than the others. In addition, this protocol was demonstrated on a gram scale without any erosion of yield. Furthermore, the polymer photocatalyst has shown reliable recyclability with no significant loss in its catalytic activity. The click-based conjugated porous polymers (Ta-Ths) are found to be highly active heterogeneous photocatalysts for the synthesis of aromatic azo compounds2,5-Dibromothiophene(cas: 3141-27-3Category: bromides-buliding-blocks) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary