Tag: 200-300

《Enhancing the Open-Circuit Voltage of Perovskite Solar Cells by Embedding Molecular Dipoles within Their Hole-Blocking Layer》 was written by Butscher, Julian F.; Intorp, Sebastian; Kress, Joshua; An, Qingzhi; Hofstetter, Yvonne J.; Hippchen, Nikolai; Paulus, Fabian; Bunz, Uwe H. F.; Tessler, Nir; Vaynzof, Yana. Reference of 2,5-Dibromothiophene And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

Engineering the energetics of perovskite photovoltaic devices through deliberate introduction of dipoles to control the built-in potential of the devices offers an opportunity to enhance their performance without the need to modify the active layer itself. In this work, we demonstrate how the incorporation of mol. dipoles into the bathocuproine (BCP) hole-blocking layer of inverted perovskite solar cells improves the device open-circuit voltage (VOC) and, consequently, their performance. We explore a series of four thiaazulenic derivatives that exhibit increasing dipole moments and demonstrate that these mols. can be introduced into the solution-processed BCP layer to effectively increase the built-in potential within the device without altering any of the other device layers. As a result, the VOC of the devices is enhanced by up to 130 mV, with larger dipoles resulting in higher VOC. To investigate the limitations of this approach, we employ numerical device simulations that demonstrate that the highest dipole derivatives used in this work eliminate all limitations on the VOC stemming from the built-in potential of the device. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Reference of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.Reference of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Manganese-Catalyzed anti-Selective Asymmetric Hydrogenation of α-Substituted β-Ketoamides》 was written by Zhang, Linli; Wang, Zheng; Han, Zhaobin; Ding, Kuiling. Application of 14516-54-2 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

A Mn-catalyzed diastereo- and enantioselective hydrogenation of α-substituted β-ketoamides has been realized for the first time under dynamic kinetic resolution conditions. anti-α-Substituted β-hydroxy amides, which are useful building blocks for the synthesis of bioactive mols. and chiral drugs, were prepared in high yields with excellent selectivity (up to >99% dr and >99% ee) and unprecedentedly high activity (TON up to 10000). The origin of the excellent stereoselectivity was clarified by DFT calculations In the experiment, the researchers used many compounds, for example, Bromopentacarbonylmanganese(I)(cas: 14516-54-2Application of 14516-54-2)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Application of 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer》 was written by Wei, Mingming; Xie, Maodun; Zhang, Zhen; Wei, Yujiao; Zhang, Juan; Pan, Hongli; Li, Benlong; Wang, Jingjing; Song, Yang; Chong, Chuangke; Zhao, Rui; Wang, Jiefu; Yu, Li; Yang, Guang; Yang, Cheng. Computed Properties of C8H15BrO2 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

In this study, a class of novel HDACs inhibitors I (R = H, 4-CH3OC6H4; R1 = H, C6H5, 4-CH3OC6H4, 4-OHC6H4; R2 = H, OH; X = (CH2)n, n = 1, 3, 4, 5, 6, 7), II•HCl (R3 = N(CH3)2, 4-methylpiperazin-1-yl, morpholin-4-yl, piperidin-1-yl, pyrrolidin-1-yl; Y = (CH2)n, n = 5, 6, 7; Z = (CH2)n, n = 2, 3) was designed and synthesized based on the structure of flavones and isoflavones, followed by biol. evaluation. To be specific, a lead compound II•HCl [R3 = N(CH3)2; Y = (CH2)5; Z = (CH2)2 (III)] was discovered with strong anti-proliferative effects on a variety of solid tumor cells, especially for breast cancer cells with resistance to SAHA. Studies demonstrated that III could significantly inhibit the activity of HDAC 1,2,3 (class I) and 6 (class IIB), leading to a dose-dependent accumulation of acetylated histones and α-Tubulin, cell cycle arrest (G1/S phase) and apoptosis in breast cancer cells. Furthermore, the lead compound III could also antagonize the activation of STAT3 induced by HDACs inhibition in some breast cancer cells, which further reduced the level of pro-survive proteins in tumor cells and enhanced anti-tumor activity regulated by STAT3 signaling in vivo. Overall, findings demonstrated that the novel compound III might be a HDACs inhibitor candidate, which could be used as promising chemotherapeutic agent for breast cancer. The experimental part of the paper was very detailed, including the reaction process of 8-Bromooctanoic acid(cas: 17696-11-6Computed Properties of C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Computed Properties of C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes》 was published in ACS Medicinal Chemistry Letters in 2020. These research results belong to Rangasamy, Loganathan; Ortin, Irene; Zapico, Jose Maria; Coderch, Claire; Ramos, Ana; de Pascual-Teresa, Beatriz. Related Products of 17696-11-6 The article mentions the following:

Four potent CK2 inhibitors derived from CX-4945 are described. They also provided nanomolar activity against HDAC1, therefore having promising utility as dual-target agents for cancer. The linker length between the hydroxamic acid and the CX-4945 scaffold plays an important role in dictating balanced activity against the targeted enzymes. The seven-carbon linker (compound 15c) was optimal for inhibition of both CK2 and HDAC1. Remarkably, 15c showed 3.0 and 3.5 times higher inhibitory activity than the reference compounds CX-4945 (against CK2) and SAHA (against HDAC1), resp. Compound 15c exhibited micromolar activity in cell-based cytotoxic assays against multiple cell lines. In addition to this study using 8-Bromooctanoic acid, there are many other studies that have used 8-Bromooctanoic acid(cas: 17696-11-6Related Products of 17696-11-6) was used in this study.

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Related Products of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines》 were Pupo, Gabriele; Vicini, Anna Chiara; Ascough, David M. H.; Ibba, Francesco; Christensen, Kirsten E.; Thompson, Amber L.; Brown, John M.; Paton, Robert S.; Gouverneur, Veronique. And the article was published in Journal of the American Chemical Society in 2019. COA of Formula: C6H5Br2N The author mentioned the following in the article:

Potassium fluoride (KF) is an ideal reagent for fluorination because it is safe, easy to handle and low-cost. However, poor solubility in organic solvents coupled with limited strategies to control its reactivity has discouraged its use for asym. C-F bond formation. Here, we demonstrate that hydrogen bonding phase-transfer catalysis with KF provides access to valuable β-fluoroamines in high yields and enantioselectivities. This methodol. employs a chiral N-Et bis-urea catalyst that brings solid KF into solution as a tricoordinated urea-fluoride complex. This operationally simple reaction affords enantioenriched fluoro-diphenidine (up to 50 g scale) using 0.5 mol % of recoverable bis-urea catalyst.3,5-Dibromoaniline(cas: 626-40-4COA of Formula: C6H5Br2N) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.COA of Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Acid-selective mass spectrometric analysis of petroleum fractions》 were Omari, Isaac; Zhu, Haoxuan; McGarvey, G. Bryce; McIndoe, J. Scott. And the article was published in International Journal of Mass Spectrometry in 2019. Electric Literature of C8H8Br2 The author mentioned the following in the article:

Naphthenic acids are cycloaliphatic carboxylic acids that are naturally-occurring constituents of petroleum. Anal. mass spectrometric methods aimed at carboxylic acids tend to involve deprotonation to generate carboxylate anions, but also produce detectable ions of every acidic component of the mixture A charged tag carbodiimide is able to facilitate detection of model naphthenic acids as well as low levels of naphthenic acids in petroleum fractions via tandem electrospray ionization mass spectrometry. This approach exhibits greater selectivity than deprotonation, and a picture of the acidic components of a petroleum fraction emerges after a quick derivatization step and without the use of chromatog. separation The method may prove useful in the context of characterizing the naphthenic acid components of complicated matrixes. In the experiment, the researchers used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Electric Literature of C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Electric Literature of C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 14660-52-7In 2022 ,《Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues》 was published in Journal of Medicinal Chemistry. The article was written by Ahmed-Belkacem, Rostom; Hausdorff, Marcel; Delpal, Adrien; Sutto-Ortiz, Priscila; Colmant, Agathe M. G.; Touret, Franck; Ogando, Natacha S.; Snijder, Eric J.; Canard, Bruno; Coutard, Bruno; Vasseur, Jean-Jacques; Decroly, Etienne; Debart, Francoise. The article contains the following contents:

Enzymes involved in RNA capping of SARS-CoV-2 are essential for the stability of viral RNA, translation of mRNAs, and virus evasion from innate immunity, making them attractive targets for antiviral agents. In this work, we focused on the design and synthesis of nucleoside-derived inhibitors against the SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) that catalyzes the transfer of the Me group from the S-adenosyl-L-methionine (SAM) cofactor to the N7-guanosine cap. Seven compounds out of 39 SAM analogs showed remarkable double-digit nanomolar inhibitory activity against the N7-MTase nsp14. Mol. docking supported the structure-activity relationships of these inhibitors and a bisubstrate-based mechanism of action. The three most potent inhibitors significantly stabilized nsp14 (ΔTm ≈ 11°C), and the best inhibitor demonstrated high selectivity for nsp14 over human RNA N7-MTase. After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C8H15BrO2In 2018 ,《Synthesis and biological characterization of novel rose bengal derivatives with improved amphiphilicity for sono-photodynamic therapy》 was published in European Journal of Medicinal Chemistry. The article was written by Chen, Hai-Jun; Zhou, Xiao-Bin; Wang, Ai-Lan; Zheng, Bi-Yuan; Yeh, Chih-Kuang; Huang, Jian-Dong. The article contains the following contents:

Sono-Photodynamic therapy (SPDT) utilizing ultrasound and light has been demonstrated that this novel approach can lower dosage resulting in reduction of the potential side effects caused by sensitizers. Recently, a new formulation of rose bengal (RB) as an intralesional injection has completed clin. trials phase II for PDT treatment of melanoma cancer. However, the inherent unfavorable pharmacol. properties of RB hindered its extensive clin. development. With the aim to identify new RB derivatives (RBDs) with enhanced photodynamic and sonodynamic anticancer efficiency, a series of amphiphilic RBDs have been designed, synthesized and biol. characterized. Among them, RBD4 significantly improved cellular uptake and enhanced intracellular ROS generation efficiency upon light and ultrasound irradiation, resulting in dramatically improved anticancer potency. Notably, RBD4 has a relative potency similar to sinoporphyrin sodium (DVDMS), indicating its further potential application for SPDT. The experimental part of the paper was very detailed, including the reaction process of 8-Bromooctanoic acid(cas: 17696-11-6Electric Literature of C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Electric Literature of C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 14516-54-2In 2022 ,《Basic Promotors Impact Thermodynamics and Catalyst Speciation in Homogeneous Carbonyl Hydrogenation》 appeared in Journal of the American Chemical Society. The author of the article were Yang, Wenjun; Kalavalapalli, Tejas Y.; Krieger, Annika M.; Khvorost, Taras A.; Chernyshov, Ivan Yu.; Weber, Manuela; Uslamin, Evgeny A.; Pidko, Evgeny A.; Filonenko, Georgy A.. The article conveys some information:

Homogeneously catalyzed reactions often make use of additives and promotors that affect reactivity patterns and improve catalytic performance. While the role of reaction promotors is often discussed in view of their chem. reactivity, we demonstrate that they can be involved in catalysis indirectly. In particular, we demonstrate that promotors can adjust the thermodn. of key transformations in homogeneous hydrogenation catalysis and enable reactions that would be unfavorable otherwise. We identified this phenomenon in a set of well-established and new Mn pincer catalysts that suffer from persistent product inhibition in ester hydrogenation. Although alkoxide base additives do not directly participate in inhibitory transformations, they can affect the equilibrium constants of these processes. Exptl., we confirm that by varying the base promotor concentration one can control catalyst speciation and inflict substantial changes to the standard free energies of the key steps in the catalytic cycle. Despite the fact that the latter are universally assumed to be constant, we demonstrate that reaction thermodn. and catalyst state are subject to external control. These results suggest that reaction promotors can be viewed as an integral component of the reaction medium, on its own capable of improving the catalytic performance and reshaping the seemingly rigid thermodn. landscape of the catalytic transformation. In addition to this study using Bromopentacarbonylmanganese(I), there are many other studies that have used Bromopentacarbonylmanganese(I)(cas: 14516-54-2Related Products of 14516-54-2) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Related Products of 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 17696-11-6In 2020 ,《Discovery of potent small molecule PROTACs targeting mutant EGFR》 appeared in European Journal of Medicinal Chemistry. The author of the article were Zhao, Hong-Yi; Yang, Xue-Yan; Lei, Hao; Xi, Xiao-Xiao; Lu, She-Min; Zhang, Jun-Jie; Xin, Minhang; Zhang, San-Qi. The article conveys some information:

Epidermal growth factor receptor (EGFR) is an important therapeutic target for the treatment of non-small cell lung cancer. A number of efficacious EGFR tyrosine kinase inhibitors have been developed. However, acquired drug resistance largely encumbered their clin. practicability. Therefore, there is an urgent need to develop new therapeutic regime. Herein, we designed and synthesized a set of EGFR-targeting small mol. PROTACs which showed promising efficacy. In particular, VHL-recruiting compound P3 showed potent anti-proliferative activity against HCC827 and H1975 cell lines with IC50 values of 0.83 and 203.01 nM, resp. Furthermore, both EGFRdel19 and EGFRL858R/T790M could be significantly induced to be degraded under treatment of P3 with DC50 values of 0.51 and 126.2 nM, resp. Compound P3 was able to dramatically suppress EGFR pathway signal transduction. Moreover, compound P3 could significantly induce cell apoptosis, arrest cell cycle and suppress cell colony formation. In addition, we identified that ubiquitination was indispensable in the degradation process, and found that the degradation was related to autophagy. Our work would provide an alternative approach for development of potentially effective EGFR degraders and give a new clue for investigation of PROTAC-induced protein degradation After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.HPLC of Formula: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary