Tag: 200-300

In 2022,Zhang, Qingyu; Chan, Yung-Yin; Zhang, Muyin; Yeung, Ying-Yeung; Ke, Zhihai published an article in Angewandte Chemie, International Edition. The title of the article was 《Hypervalent Chalcogenonium…π Bonding Catalysis》.Application of 2635-13-4 The author mentioned the following in the article:

A proof-of-concept study of hypervalent chalcogenonium…π bonding catalysis was performed. A new catalytic strategy using 1,2-oxaselenolium salts as chalcogen bond donors and alkenes as chalcogen bond acceptors is described. The feasibility of this concept is demonstrated by the use of trisubstituted selenonium salts in the metal-free catalytic hydrofunctionalization and polymerization of alkenes via unconventional seleniranium ion-like intermediates. The results indicate that counter anions have a significant effect on the catalysis based on hypervalent chalcogenonium…π bonding interactions. In addition to this study using 5-Bromobenzo[d][1,3]dioxole, there are many other studies that have used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Application of 2635-13-4) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Application of 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yang, Ju-Song; Lu, Ka; Li, Chen-Xiao; Zhao, Zu-Hang; Zhang, Xiao-Ming; Zhang, Fu-Min; Tu, Yong-Qiang published an article in Angewandte Chemie, International Edition. The title of the article was 《Chiral 1,2,3-Triazolium Salt Catalyzed Asymmetric Mono- and Dialkylation of 2,5-Diketopiperazines with the Construction of Tetrasubstituted Carbon Centers》.SDS of cas: 5437-45-6 The author mentioned the following in the article:

Novel asym. mono- and dialkylation reactions of α-substituted 2,5-diketopiperazines catalyzed by new chiral spirocyclic-amide-derived triazolium organocatalysts was developed, resulting in a range of enantioenriched 2,5-diketopiperazine derivatives containing one or two tetrasubstituted carbon stereocenters. The reactions featured high yields (up to 98%) and excellent cis-diastereo- and enantioselectivities (up to >20:1 dr, >99% ee) and they provided a new asym. synthetic approach to important functionalized 2,5-diketopiperazine skeletons. Furthermore, a possible reaction mechanism was proposed based on both control experiments and extensive DFT calculations In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6SDS of cas: 5437-45-6) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.SDS of cas: 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Merad, Jeremy; Grant, Phillip S.; Stopka, Tobias; Sabbatani, Juliette; Meyrelles, Ricardo; Preinfalk, Alexander; Matyasovsky, Jan; Maryasin, Boris; Gonzalez, Leticia; Maulide, Nuno published an article in 2022. The article was titled 《Direct stereodivergent olefination of carbonyl compounds with sulfur ylides》, and you may find the article in Journal of the American Chemical Society.Application of 5437-45-6 The information in the text is summarized as follows:

The reactivity of phosphorus and sulfur ylides towards carbonyl compounds constitutes a well-known dichotomy: the former gives olefins, while the latter gives epoxides. Herein, a stereodivergent carbonyl olefination which challenges this dichotomy, showcasing thiuronium ylides as valuable olefination reagents is presented. With this method, aldehydes are converted to Z-alkenes with high stereoselectivity and broad substrate scope, while N-tosylimines provide a similarly proficient entry to E-alkenes. In-depth computational and exptl. studies clarified the mechanistic details of this unusual reactivity. In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Application of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Upp, David M.; Huang, Rui; Li, Ying; Bultman, Max J.; Roux, Benoit; Lewis, Jared C. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Engineering Dirhodium Artificial Metalloenzymes for Diazo Coupling Cascade Reactions》.Formula: C9H9BrO2 The article contains the following contents:

Artificial metalloenzymes (ArMs) are commonly used to control the stereoselectivity of catalytic reactions, but controlling chemoselectivity remains challenging. In this study, we engineer a dirhodium ArM to catalyze diazo cross-coupling to form an alkene that, in a one-pot cascade reaction, is reduced to an alkane with high enantioselectivity (typically >99% ee) by an alkene reductase. The numerous protein and small mol. components required for the cascade reaction had minimal effect on ArM catalysis. Directed evolution of the ArM led to improved yields and E/Z selectivities for a variety of substrates, which translated to cascade reaction yields. MD simulations of ArM variants were used to understand the structural role of the cofactor on ArM conformational dynamics. These results highlight the ability of ArMs to control both catalyst stereoselectivity and chemoselectivity to enable reactions in complex media that would otherwise lead to undesired side reactions. In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6Formula: C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Formula: C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Bioorganic & Medicinal Chemistry Letters included an article by Wang, Jian-Ta; Peng, Jin-Gang; Zhang, Ji-Quan; Wang, Zhong-Xiao; Zhang, Yi; Zhou, Xun-Rong; Miao, Jing; Tang, Lei. Related Products of 14660-52-7. The article was titled 《Novel berberine-based derivatives with potent hypoglycemic activity》. The information in the text is summarized as follows:

Four series of berberine derivatives were designed and synthesized. All the synthetic compounds were screened for in vitro glucose consumption activity in HepG2 cell lines. The results showed that most of the tested compounds exhibited potent hypoglycemic activity, and the most potent compound I exhibited its potency by 3.23-fold of berberine, 1.39-fold of metformin and 1.20-fold of rosiglitazone, resp. Western blot assay indicated these novel berberine-based derivatives executed their glucose-decreasing activity via the activation of AMPK pathway. In the experiment, the researchers used many compounds, for example, Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Angewandte Chemie, International Edition included an article by Zheng, Danqing; Studer, Armido. Quality Control of Benzyl 2-bromoacetate. The article was titled 《Asymmetric Synthesis of Heterocyclic γ-Amino-Acid and Diamine Derivatives by Three-Component Radical Cascade Reactions》. The information in the text is summarized as follows:

An enantioselective three-component radical reaction of quinolines or pyridines with enamides and α-bromo carbonyl compounds by dual photoredox and chiral Bronsted acid catalysis is presented. A range of valuable chiral γ-amino-acid derivatives are accessible in high chemo-, regio-, and enantioselectivity from simple, readily available starting materials under mild reaction conditions. Using the same strategy, the asym. synthesis of 1,2-diamine derivatives is also reported. Thus, e.g., 4-methylquinoline + N-vinylacetamide + Me bromoacetate → I (88%, 96:4 er). In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6Quality Control of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Quality Control of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,van Haren, Matthijs J.; Taig, Rebecca; Kuppens, Jilles; Sastre Torano, Javier; Moret, Ed E.; Parsons, Richard B.; Sartini, Davide; Emanuelli, Monica; Martin, Nathaniel I. published 《Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state》.Organic & Biomolecular Chemistry published the findings.Related Products of 1129-28-8 The information in the text is summarized as follows:

Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the methylation of nicotinamide to form N’-methylnicotinamide. Both NNMT and its methylated product have recently been linked to a variety of diseases, suggesting a role for the enzyme as a therapeutic target beyond its previously ascribed metabolic function in detoxification. We here describe the systematic development of NNMT inhibitors derived from the structures of the substrates involved in the methylation reaction. By covalently linking fragments of the NNMT substrates a diverse library of bisubstrate-like compounds was prepared The ability of these compounds to inhibit NNMT was evaluated providing valuable insights into the structural tolerances of the enzyme active site. These studies led to the identification of new NNMT inhibitors that mimic the transition state of the methylation reaction and inhibit the enzyme with activity on par with established methyltransferase inhibitors. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. Related Products of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Luan, Shenglin; Ge, Qi; Chen, Yedong; Dai, Mingyang; Yang, Jinyu; Li, Kun; Liu, Dan; Zhao, Linxiang published 《Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: 1129-28-8 The information in the text is summarized as follows:

Myeloid cell leukemia-1 (Mcl-1) is an important antiapoptotic protein functioning through protein-protein interactions. The authors discovered LSL-A6 (2-((2-carbamoyl-1-(3-(4-methoxyphenoxy)propyl)-1H-indol-6-yl)oxy)acetic acid)with a novel N-substituted indole scaffold to interfere Mcl-1 binding as a novel Mcl-1 inhibitor. Mol. modeling indicated that this compound binds with Mcl-1 by interaction with P2 and R263 hot-spots. Structure modification focused on several moieties including indole core, hydrophobic tail and acidic chain were conducted and structure-activity relationship was analyzed. The most potent compound 24d which exhibited Ki value of 110 nM for interfering Mcl-1 binding was obtained after hit-to-lead modification. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. Recommanded Product: 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2015,Zhang, Xi-Sha; Zhang, Yun-Fei; Li, Zhao-Wei; Luo, Fei-Xian; Shi, Zhang-Jie published 《Synthesis of Dibenzo[c,e]oxepin-5(7H)-ones from Benzyl Thioethers and Carboxylic Acids: Rhodium-Catalyzed Double C-H Activation Controlled by Different Directing Groups》.Angewandte Chemie, International Edition published the findings.COA of Formula: C8H7BrO2 The information in the text is summarized as follows:

A rhodium(III)-catalyzed cross-coupling of benzyl thioethers and aryl carboxylic acids through the two directing groups is reported. Useful structures with diverse substituents were efficiently synthesized in one step with the cleavage of four bonds, such as carbon-hydrogen bond (C-H bond), carbon-sulfur bond (C-S bond), oxygen-hydrogen bond (O-H bond) and the formation of two bonds (carbon-carbon bond C-C bond) and carbon-oxygen bond (C-O bond) formation. The formed structure is the privileged core in natural products and bioactive mols. This work highlights the power of using two different directing groups to enhance the selectivity of a double C-H activation, the first of such examples in cross-oxidative coupling. Under optimized conditions the synthesis of the target compounds was achieved using di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]dirhodium or tris(acetonitrile)[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]rhodium(2+) bis[hexafluoroantimonate] as catalysts. Starting materials included benzyl thioethers, such as [(Methylthio)methyl]benzene derivatives and benzoic acid derivatives The title compounds thus formed included Dibenz[c,e]oxepin-5(7H)-one derivatives, 3,9-dimethyldibenz[c,e]oxepin-5(7H)-one. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2COA of Formula: C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. COA of Formula: C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes》 were Zhou, Yujing; Engl, Oliver D.; Bandar, Jeffrey S.; Chant, Emma D.; Buchwald, Stephen L.. And the article was published in Angewandte Chemie, International Edition in 2018. COA of Formula: C8H4BrF3O2 The author mentioned the following in the article:

A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes was developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups. The experimental process involved the reaction of 3-Bromo-4-(trifluoromethoxy)benzaldehyde(cas: 85366-66-1COA of Formula: C8H4BrF3O2)

3-Bromo-4-(trifluoromethoxy)benzaldehyde(cas: 85366-66-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. COA of Formula: C8H4BrF3O2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary