Tag: 200-300

COA of Formula: C8H15BrO2In 2019 ,《Solvolysis of acrylate-urethane coatings cured by electron-beam and UV radiation》 appeared in Progress in Organic Coatings. The author of the article were Sanchez-Cadena, Lorena E.; Tersac, Gilles; Coqueret, Xavier; Gamino-Arroyo, Zeferino. The article conveys some information:

Solvolysis was investigated for two different types of thermosetting polyacrylate-urethane resin coatings. One type of resin was cross-linked by ultra violet (UV) radiation and the other by electron beam (EB). The cured coatings were deposited on aluminum sheets. Solvolysis was carried out with diethylene glycol (DEG) catalyzed by KOH. The resins were characterized by FT-IR ATR spectroscopy prior to solvolysis. The kinetics of the solvolysis process were investigated, and the depolymerization products were studied by FT-IR ATR spectroscopy and size exclusion chromatog. The results show that total solvolysis is possible for both cured resins, albeit it is faster for resins cured by UV radiation. In the experimental materials used by the author, we found 8-Bromooctanoic acid(cas: 17696-11-6COA of Formula: C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.COA of Formula: C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Toscani, Anita; Hind, Charlotte; Clifford, Melanie; Kim, Seong-Heun; Gucic, Antonia; Woolley, Charlotte; Saeed, Naima; Rahman, Khondaker Miraz; Sutton, J. Mark; Castagnolo, Daniele published an article in 2021. The article was titled 《Development of photoactivable phenanthroline-based manganese(I) CO-Releasing molecules (PhotoCORMs) active against ESKAPE bacteria and bacterial biofilms》, and you may find the article in European Journal of Medicinal Chemistry.Quality Control of Bromopentacarbonylmanganese(I) The information in the text is summarized as follows:

The synthesis and biol. evaluation of a series of phenanthroline-based visible-light-activated manganese(I) carbon-monoxide-releasing mols. (PhotoCORMs) against ESKAPE bacteria and bacterial biofilms is reported. Four carbonyl compounds of general formula fac-[Mn(NN)(CO)3(L)] have been synthesized and characterized. Despite being thermally stable in the absence of light, these PhotoCORMs readily release CO upon blue (435-450 nm) LED light irradiation as confirmed by spectrophotometric CO releasing experiments (Mb Assay). The antibacterial activity of the four PhotoCORMs has been investigated against a panel of ESKAPE bacteria. The compoundsI[ bromo 1,10-phenanthroline-5-amine, bromo 1,10-phenanthroline-5,6-dione, azido 1,10-phenanthroline-5,6-dione] were found to be effective antibacterials at low concentrations against multidrug-resistant Klebsiella pneumoniae and Acinetobacter baumannii when photoactivated with blue-light. In addition, the PhotoCORMs I[ bromo 1,10-phenanthroline-5-amine, bromo 1,10-phenanthroline-5,6-dione] were found to inhibit the formation of Klebsiella pneumoniae and Acinetobacter baumannii bacterial biofilms at low concentrations (MIC = 4-8 μg/mL), turning out to be promising candidates to combat antimicrobial resistance. The antibacterial and biofilm inhibitory effect of the PhotoCORMs is plausibly due to the release of CO as well as the formation of phenanthroline photo-byproducts as revealed by spectroscopy and microbiol. experiments In the part of experimental materials, we found many familiar compounds, such as Bromopentacarbonylmanganese(I)(cas: 14516-54-2Quality Control of Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Quality Control of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kircher, Theresa; Pantsar, Tatu; Oder, Andreas; Peter von Kries, Jens; Juchum, Michael; Pfaffenrot, Bent; Kloevekorn, Philip; Albrecht, Wolfgang; Selig, Roland; Laufer, Stefan published an article in 2021. The article was titled 《Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4》, and you may find the article in European Journal of Medicinal Chemistry.SDS of cas: 586-76-5 The information in the text is summarized as follows:

The azaindole-based scaffold of FDA-approved BRAF inhibitor vemurafenib 1, which displays off-target activity on mitogen-activated protein kinase kinase 4 (MKK4), as a starting point in fluorescent compound design was utilized. Chem. variation of the scaffold and optimization led to a selection of fluorescent 5-TAMRA derivatives I (R = Pr, benzyl; R1 = -NHC(O)-, -C(O)NH-; X = CH; Y = N, CH; n = 1, 4), II (R = n-propyl; R1 = -NHC(O)-, -C(O)NH-; X = CH, N; Y = CH, N; n = 1-6) which possess high binding affinities on MKK4. Compound II (R = n-propyl; R1 = -NHC(O)-; X = CH; Y = N; n = 4) represents a suitable tool compound for fluorescence polarization assays to identify new small-mol. inhibitors of MKK4.4-Bromobenzoic acid(cas: 586-76-5SDS of cas: 586-76-5) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.SDS of cas: 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ding, Li; Wang, Zi-Yuan; Yao, Ze-Fan; Liu, Nai-Fu; Wang, Xin-Yi; Zhou, Yang-Yang; Luo, Longfei; Shen, Zhihao; Wang, Jie-Yu; Pei, Jian published their research in Macromolecules (Washington, DC, United States) in 2021. The article was titled 《Controllable Transformation between the Kinetically and Thermodynamically Stable Aggregates in a Solution of Conjugated Polymers》.Formula: C4H2Br2S The article contains the following contents:

The aggregation behaviors of conjugated polymers significantly influence their performance in solution-processed optoelec. devices. Traditionally, the formation of aggregates from the self-assembly of conjugated polymers is considered as a thermodn. equilibrium process. The abundant degree of conformation freedom of conjugated polymers might lead to complex aggregation behaviors in solution However, the energy landscape of conjugated polymers during aggregation has rarely been studied before, which would provide the energetic and structural information about different aggregates. Our work tried to unravel the energy landscape of conjugated polymers during aggregation and investigate the energetic and structural information of the thermodynamically and kinetically stable aggregates in solution Herein, kinetically and thermodynamically stable aggregates of naphthalene diimide (NDI)-based polymers are obtained through rational mol. design and thermodn. control. Investigation of the theor. calculation, photophys. properties, and morphologies of the conjugated polymers demonstrates the formation of and differences between kinetically and thermodynamically stable aggregates. The energetic and structural anal. of kinetically and thermodynamically stable aggregates here provide insight into the relations among the structure, morphol., and properties of conjugated polymers at the mol. level. This work demonstrates the energy landscape of conjugated polymers during aggregation and further extends our understanding of the aggregation mechanisms. The results came from multiple reactions, including the reaction of 2,5-Dibromothiophene(cas: 3141-27-3Formula: C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Formula: C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Percec, Virgil; Wang, Shitao; Huang, Ning; Partridge, Benjamin E.; Wang, Xuefeng; Sahoo, Dipankar; Hoffman, David J.; Malineni, Jagadeesh; Peterca, Mihai; Jezorek, Ryan L.; Zhang, Na; Daud, Hina; Sung, Paul D.; McClure, Emily R.; Song, Se Lin published their research in Journal of the American Chemical Society in 2021. The article was titled 《An Accelerated Modular-Orthogonal Ni-Catalyzed Methodology to Symmetric and Nonsymmetric Constitutional Isomeric AB2 to AB9 Dendrons Exhibiting Unprecedented Self-Organizing Principles》.Application of 2675-79-8 The article contains the following contents:

Three libraries consisting of 30 sym. and nonsym. constitutional isomeric phenolic acids with unprecedented sequenced patterns, including two AB2, three AB3, eight AB4, five AB5, six AB6, three AB7, two AB8, and one AB9 synthesized by accelerated modular-orthogonal Ni-catalyzed borylation and cross-coupling were reported. A single etherification step with 4-(n-dodecyloxy)benzyl chloride transformed all these phenolic acids, of interest also for other applications, into self-assembling dendrons. Despite this synthetic simplicity, they led to a diversity of unprecedented self-organizing principles: lamellar structures of interest for biol. membrane mimics, helical columnar assemblies from rigid-solid angle dendrons forming Tobacco Mosaic Virus-like assemblies, columnar organizations from adaptable-solid angle dendrons forming disordered micellar-like nonhelical columns, columns from supramol. spheres, five body-centered cubic phases displaying supramol. orientational memory, rarely encountered in previous libraries forming predominantly Frank-Kasper phases, and two Frank-Kasper phases. Lessons from these self-organizing principles, discovered within a single generation of self-assembling dendrons, might help elaborate design principles for complex helical and nonhelical organizations of synthetic and biol. matter. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Baiula, Monica; Cirillo, Martina; Martelli, Giulia; Giraldi, Valentina; Gasparini, Elisa; Anelli, Alessandro Claudio; Spampinato, Santi Mario; Giacomini, Daria published their research in ACS Pharmacology & Translational Science in 2021. The article was titled 《Selective Integrin Ligands Promote Cell Internalization of the Antineoplastic Agent Fluorouracil》.Recommanded Product: 5437-45-6 The article contains the following contents:

Drug conjugates consisting of an antineoplastic drug and a targeting receptor ligand could be effective to overcome the heavy side effects of unselective anticancer agents. To address this need, we report here the results of a project aimed to study agonist and antagonist integrin ligands as targeting head of mol. cargoes for the selective delivery of 5-fluorouracil (5-FU) to cancer or noncancer cells. Initially, two fluorescent β-lactam-based integrin ligands were synthesized and tested for an effective and selective internalization mediated by α4β1 or α5β1 integrins in Jurkat and K562 cells, resp. No cellular uptake was observed for both fluorescent compounds in HEK293 noncancerous control cells. Afterward, three conjugates composed of the β-lactam-based integrin ligand, suitable linkers, and 5-FU were realized. The best compound E (I), acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Recommanded Product: 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Erdogan, Merve; Kilic, Burcu; Sagkan, Rahsan Ilikci; Aksakal, Fatma; Ercetin, Tugba; Gulcan, Hayrettin O.; Dogruer, Deniz S. published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer’s disease》.Recommanded Product: 14660-52-7 The article contains the following contents:

In this study, four series of compounds I [R = N(Me)(Bn), N(CH2)2CH(Ph)(CH2)2, N(CH2)2N(Bn)(CH2)2, etc.; X = O, S], II [n = 2,3] and III with benzoxazolone and benzothiazolone cores were designed, synthesized and evaluated as multifunctional agents against Alzheimer’s disease (AD). Addnl., in order to shed light on the effect of the carbonyl groups of benzoxazolone/benzothiazolone, benzoxazole/benzothiazole-containing analogs were also synthesized and evaluated. Inhibition potency of all final compounds towards cholinesterase enzymes and their antioxidant activity were tested. Subsequently, the anti-inflammatory activity, cytotoxicity, apoptosis, and Aβ aggregation inhibition tests were also performed for selected compounds The results indicated that compounds II [R = N(CH2)2CH(Ph)(CH2)2, X = S, n = 3] and III [R = N(CH2)2CH(Ph)(CH2)2, X = S] were considered as promising multi-functional agents for further investigation against AD. The reversibility, kinetic and mol. docking studies were also performed for the compounds with the highest AChE III [R = N(CH2)2CH(Ph)(CH2)2, X = S] and BChE II [R = N(CH2)2CH(Ph)(CH2)2, X = S, n = 3] inhibitory activities.Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: 14660-52-7) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Design, synthesis and biological evaluation of novel hybrids of N-aryl pyrrothine-base α-pyrone as bacterial RNA polymerase inhibitors》 was published in Bioorganic & Medicinal Chemistry Letters in 2020. These research results belong to Tan, Xiangduan; Huang, Mohan; Nian, Siyun; Peng, Yanfen; Qin, Jianli; Kong, Bo; Duan, Xiaoqun. Category: bromides-buliding-blocks The article mentions the following:

Antibiotic resistance in bacteria has been an emerging public health problem, thus discovery of novel and effective antibiotics is urgent. A series of novel hybrids of N-aryl pyrrothine-base α-pyrone hybrids was designed, synthesized and evaluated as bacterial RNA polymerase (RNAP) inhibitors. Among them, compound I exhibited potent antibacterial activity against antibiotic-resistant S. aureus with the min. inhibitory concentration (MIC) in the range of 1-4μg/mL. Moreover, compound I exhibited strong inhibitory activity against E. coli RNAP with an IC50 value of 16.06μM, and cytotoxicity in HepG2 cells with IC50 value of 7.04μM. The mol. docking study further suggested that compound I binds to the switch region of bacterial RNAP. In summary, compound I is a novel bacterial RNAP inhibitor, and a promising lead compound for further optimization. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Palladium-Catalyzed Construction of Quaternary Stereocenters by Enantioselective Arylation of γ-Lactams with Aryl Chlorides and Bromides》 were Jette, Carina I.; Geibel, Irina; Bachman, Shoshana; Hayashi, Masaki; Sakurai, Shunya; Shimizu, Hideki; Morgan, Jeremy B.; Stoltz, Brian M.. And the article was published in Angewandte Chemie, International Edition in 2019. Synthetic Route of C7H4BrF3 The author mentioned the following in the article:

The first Pd-catalyzed enantioselective arylation of α-substituted γ-lactams were reported. Two sets of conditions were developed for this transformation, allowing for the use of either aryl chlorides or bromides as electrophiles. Utilizing a highly electron-rich dialkylphosphine ligand, α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee) was constructed.1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Synthetic Route of C7H4BrF3) was used in this study.

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Synthetic Route of C7H4BrF3 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of the American Chemical Society included an article by Phelan, James P.; Lang, Simon B.; Sim, Jaehoon; Berritt, Simon; Peat, Andrew J.; Billings, Katelyn; Fan, Lijun; Molander, Gary A.. Synthetic Route of C7H5BrO2. The article was titled 《Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis》. The information in the text is summarized as follows:

DNA-encoded library (DEL) technol. is a powerful tool commonly used by the pharmaceutical industry for the identification of compounds with affinity to biomol. targets. Success in this endeavor lies in sampling diverse chem. libraries. However, current DELs tend to be deficient in C(sp3) carbon counts. The authors report unique solutions to the challenge of increasing both the chem. diversity of these libraries and their C(sp3) carbon counts by merging Ni/photoredox dual catalytic C(sp2)-C(sp3) cross-coupling as well as photoredox-catalyzed radical/polar crossover alkylation protocols with DELs. The successful integration of multiple classes of radical sources enables the rapid incorporation of a diverse set of alkyl fragments. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary