Tag: 200-300

In 2015,Kusumi, Kensuke; Shinozaki, Koji; Kanaji, Toshiya; Kurata, Haruto; Naganawa, Atsushi; Otsuki, Kazuhiro; Matsushita, Takeshi; Sekiguchi, Tetsuya; Kakuuchi, Akito; Seko, Takuya published 《Discovery of novel S1P2 antagonists. Part 1: Discovery of 1,3-bis(aryloxy)benzene derivatives》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: 76006-33-2 The information in the text is summarized as follows:

The structure-activity relationships of a novel series of sphingosine-1-phosphate receptor antagonists have been examined in detail. The initial hit compound 1 was modified through synthesis to improve its S1P2 activity. The synthesis of a series of analogs revealed that 1,3-bis(aryloxy)benzene derivatives, as represented by 22, are potent and selective S1P2 antagonists.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 76006-33-2) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2012,Tamura, Yuusuke; Omori, Naoki; Kouyama, Naoki; Nishiura, Yuji; Hayashi, Kyouhei; Watanabe, Kana; Tanaka, Yukari; Chiba, Takeshi; Yukioka, Hideo; Sato, Hiroki; Okuno, Takayuki published 《Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles》.Bioorganic & Medicinal Chemistry Letters published the findings.Name: 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

Optimization of the HTS hit I, mainly focused on modification at the C-2 position of the benzimidazole core, is described. Elimination of the flexible and metabolically labile -S-CH2- part and utilization of less lipophilic pyridone substructure led to identification of novel NPY Y5 receptor antagonists II (R = n-Pr, t-Bu, CF3, F3CCH2), which have low to sub-nanomolar Y5 receptor binding affinity with improved CYP450 inhibition profiles, good solubilities and high metabolic stabilities. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Name: 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Name: 3-Bromo-2-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schuetz, Ramona; Mueller, Martin; Geisslinger, Franz; Vollmar, Angelika; Bartel, Karin; Bracher, Franz published their research in European Journal of Medicinal Chemistry on December 1 ,2020. The article was titled 《Synthesis, biological evaluation and toxicity of novel tetrandrine analogues》.SDS of cas: 85366-66-1 The article contains the following contents:

In this work, the design and synthesis of novel fully synthetic analogs of the bisbenzylisoquinoline tetrandrines e.g., I, a mol. with numerous pharmacol. properties and the potential to treat life-threatening diseases, such as viral infections and cancer were presented. Its toxicity to liver and lungs and the underlying mechanisms, however, are controversially discussed. Along this line, novel tetrandrine analogs e.g., I were synthesized and biol. evaluated for their hepatotoxicity, as well as their antiproliferative and chemoresistance reversing activity on cancer cells. Previous studies suggesting CYP-mediated toxification of tetrandrine prompted to amend/replace the suspected metabolically instable 12-methoxy group. Of note, employing several in vitro models showed that the proposed CYP3A4-driven metabolism of tetrandrine and analogs is not the major cause of hepatotoxicity. Biol. characterization revealed that some of the novel tetrandrine analogs e.g., I sensitized drug-resistant leukemia cells by inhibition of the P-glycoprotein. Interestingly, direct anticancer effects improved in comparison to tetrandrine, as several compounds displayed markedly enhanced ability to reduce proliferation of drug-resistant leukemia cells and to induce cell death of liver cancer cells. Those enhanced anticancer properties were linked to influences on activation of the kinase Akt and mitochondrial events. In sum, the role of CYP3A4-mediated toxicity of the bisbenzylisoquinoline alkaloid tetrandrine and the basis for exploitation of novel synthetic analogs for their antitumoral potential were clarified. The experimental process involved the reaction of 3-Bromo-4-(trifluoromethoxy)benzaldehyde(cas: 85366-66-1SDS of cas: 85366-66-1)

3-Bromo-4-(trifluoromethoxy)benzaldehyde(cas: 85366-66-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. SDS of cas: 85366-66-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger published their research in Bioorganic & Medicinal Chemistry Letters on August 1 ,2009. The article was titled 《Design, synthesis and identification of novel colchicine-derived immunosuppressant》.Computed Properties of C9H8BrNO4 The article contains the following contents:

Colchicine-derived nitrate esters I [R = MeO, SMe, Me2N; R1 = O2NO(CH2)3, 3-(O2NOCH2)C6H4, 4-(O2NOCH2)C6H4; R2 = H, Me] and II (R3, R4, R5 = H, MeO, F, Cl, Br, I, NC, O2N, Ph) are prepared as potential immunosuppressant agents and tested for their inhibition of the allogenic mixed-lymphocyte reaction. The cytotoxicities, inhibition of NO production, and inducible nitric oxide synthase and tumor necrosis factor-α levels for I [R = MeS; R1 = O2NO(CH2)3, 3-(O2NOCH2)C6H4] are determined; the inhibition of lymphoproliferation by I [R = MeS; R1 = O2NO(CH2)3, 3-(O2NOCH2)C6H4, 4-(O2NOCH2)C6H4; R2 = H] and by II (R3 = R4 = H; R5 = F), II (R3 = Cl; R4 = R5 = H), II (R3 = R4 = H; R5 = Cl), and II (R3 = O2N; R4 = R5 = H) are also determined The cytotoxicity of II (R3 = Cl; R4 = R5 = H) and its effectiveness in increasing skin allograft survival are determined and compared to that of cyclosporin A. After reading the article, we found that the author used Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4Computed Properties of C9H8BrNO4)

Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Computed Properties of C9H8BrNO4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 1-Bromo-2-((methylsulfonyl)methyl)benzeneOn May 9, 2013 ,《Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Christiansen, Elisabeth; Hansen, Steffen V. F.; Urban, Christian; Hudson, Brian D.; Wargent, Edward T.; Grundmann, Manuel; Jenkins, Laura; Zaibi, Mohamed; Stocker, Claire J.; Ullrich, Susanne; Kostenis, Evi; Kassack, Matthias U.; Milligan, Graeme; Cawthorne, Michael A.; Ulven, Trond. The article conveys some information:

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist (I) with favorable physicochem. and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing. In the experiment, the researchers used 1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2Recommanded Product: 1-Bromo-2-((methylsulfonyl)methyl)benzene)

1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 1-Bromo-2-((methylsulfonyl)methyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Study of Reaction Rate between Zinc(II)-Histidine [Zn(II)-his]+ Complex and Ninhydrin: Effect of Three Dicationic Gemini (Alkanediyl-α,ω-Type) Surfactants》 was written by Kumar, Dileep; Rub, Malik Abdul. Recommanded Product: 1,6-DibromohexaneThis research focused onzinc histidine complex ninhydrin reaction kinetics dicationic gemini surfactant. The article conveys some information:

Reaction rate between Zn(II)-histidine and ninhydrin in three dicationic gemini (alkanediyl-α,ω-type) surfactants has been investigated at 343 K by spectroscopic methods. The first- and fractional-order dependencies of the reaction rate on concentration of [Zn(II)-his]+ complex and ninhydrin, resp., have been detected. Critical micellar concentrations of pure surfactants and their mixtures were determined with the help of conductometry. Effects of all three gemini (alkanediyl-α,ω-type) surfactants on the rate at different concentrations were studied. The experimental process involved the reaction of 1,6-Dibromohexane(cas: 629-03-8Recommanded Product: 1,6-Dibromohexane)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Recommanded Product: 1,6-Dibromohexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Photocontrolled Synthesis of n-Type Conjugated Polymers》 was written by Woods, Eliot F.; Berl, Alexandra J.; Kalow, Julia A.. Product Details of 3141-27-3 And the article was included in Angewandte Chemie, International Edition on 3 30 ,2020. The article conveys some information:

Current approaches to synthesize π-conjugated polymers (CPs) are dominated by thermally driven, transition-metal-mediated reactions. Herein we show that electron-deficient Grignard monomers readily polymerize under visible-light irradiation at room temperature in the absence of a catalyst. The product distribution can be tuned by the wavelength of irradiation based on the absorption of the polymer. Conversion studies are consistent with an uncontrolled chain-growth process; correspondingly, chain extension produces all-conjugated n-type block copolymers. Preliminary results demonstrate that the polymerization can be expanded to donor-acceptor alternating copolymers. We anticipate that this method can serve as a platform to access new architectures of n-type CPs without the need for transition-metal catalysis. In the experiment, the researchers used 2,5-Dibromothiophene(cas: 3141-27-3Product Details of 3141-27-3)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Product Details of 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 626-40-4In 2021 ,《Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Kent, Caitlin N.; Fulton, Mark G.; Stillwell, Kaylee J.; Dickerson, Jonathan W.; Loch, Matthew T.; Rodriguez, Alice L.; Blobaum, Anna L.; Boutaud, Olivier; Rook, Jerri L.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.. The article contains the following contents:

A high throughput screen (HTS) identified a novel, but weak (EC50 = 6.2μM, 97% Glu Max) mGlu4 PAM chemotype based on a 1,4-thiazepane core, VU0544412. Reaction development and chem. optimization delivered a potent mGlu4 PAM VU6022296 (EC50 = 32.8 nM, 108% Glu Max) with good CNS penetration (Kp = 0.45, Kp,uu = 0.70) and enantiopreference. Finally, VU6022296 displayed robust, dose-dependent efficacy in reversing Haloperidol-Induced Catalepsy (HIC), a rodent preclin. Parkinson’s disease model.3,5-Dibromoaniline(cas: 626-40-4HPLC of Formula: 626-40-4) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.HPLC of Formula: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Kreisel, Tatjana; Mendel, Marvin; Queen, Adele E.; Deckers, Kristina; Hupperich, Daniel; Riegger, Julian; Fricke, Christoph; Schoenebeck, Franziska published an article in Angewandte Chemie, International Edition. The title of the article was 《Modular Generation of (Iodinated) Polyarenes Using Triethylgermane as Orthogonal Masking Group》.Quality Control of 2,5-Dibromothiophene The author mentioned the following in the article:

Herein, a complementary modular coupling approach to the widely employed Suzuki coupling strategy of boron containing precursors, which relied on organogermane containing building blocks as key orthogonal functionality and an electrophilic (rather than nucleophilic) unmasking event paired with air-stable PdI dimer based bond construction was disclosed. This allowed to significantly shorten the reaction times for the iterative coupling steps and/or to close gaps in the accessible compound space, enabling straightforward access also to iodinated compounds In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Quality Control of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Quality Control of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dilauro, Giuseppe; Azzollini, Claudia S.; Vitale, Paola; Salomone, Antonio; Perna, Filippo M.; Capriati, Vito published an article in 2021. The article was titled 《Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands》, and you may find the article in Angewandte Chemie, International Edition.Computed Properties of C7H5BrO2 The information in the text is summarized as follows:

Pd-catalyzed Negishi cross-coupling reactions between organozinc compounds and (hetero)aryl bromides have been reported when using bulk water as the reaction medium in the presence of NaCl or the biodegradable choline chloride/urea eutectic mixture Both C(sp3)-C(sp2) and C(sp2)-C(sp2) couplings have been found to proceed smoothly, with high chemoselectivity, under mild conditions (room temperature or 60°C) in air, and in competition with protonolysis. Addnl. benefits include very short reaction times (20 s), good to excellent yields (up to 98%), wide substrate scope, and the tolerance of a variety of functional groups. The proposed novel protocol is scalable, and the practicability of the method is further highlighted by an easy recycling of both the catalyst and the eutectic mixture or water. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Computed Properties of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Computed Properties of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary