Tag: 200-300

In 2019,Angewandte Chemie, International Edition included an article by Anamimoghadam, Ommid; Cooper, James A.; Nguyen, Minh T.; Guo, Qing-Hui; Mosca, Lorenzo; Roy, Indranil; Sun, Junling; Stern, Charlotte L.; Redfern, Louis; Farha, Omar K.; Stoddart, J. Fraser. Application In Synthesis of 1,4-Bis(bromomethyl)benzene. The article was titled 《Cyclotris(paraquat-p-phenylenes)》. The information in the text is summarized as follows:

Reported here is the synthesis, solid-state characterization, and redox properties of new triangular, threefold sym., viologen-containing macrocycles. Cyclotris(paraquat-p-phenylene) (CTPQT6+) and cyclotris(paraquat-p-1,4-dimethoxyphenylene) (MCTPQT6+) were prepared and their X-ray single-crystal (super)structures reveal intricate three-dimensional packing. MCTPQT6+ results in nanometer-sized channels, in contrast with its parent counterpart CTPQT6+ which crystallizes as a couple of polymorphs in the form of intercalated assemblies. In the solid state, MCTPQT3(.+) exhibits stacks between the 1,4-dimethoxyphenylene and bipyridinium radical cations, providing new opportunities for the manipulation and control of the recognition motif associated with viologen radical cations. These redox-active cyclophanes demonstrate that geometry-matching and weak intermol. interactions are of paramount importance in dictating the formation of their intricate solid-state superstructures. After reading the article, we found that the author used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application In Synthesis of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Application In Synthesis of 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2004,Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R. published 《Isoindolinone ureas: a novel class of KDR kinase inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.HPLC of Formula: 76006-33-2 The information in the text is summarized as follows:

A series of substituted isoindolinone ureas was prepared and evaluated for enzymic and cellular inhibition of KDR kinase activity. Several of these analogs, such as I, are potent inhibitors of KDR both enzymically (<50 nM) and cellularly (≤100 nM). A 3D KDR/CDK2/MAP kinase overlay model with several structurally related tyrosine kinase inhibitors was used to predict the binding interactions of the isoindolinone ureas with the KDR active site. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.HPLC of Formula: 76006-33-2 Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Cyclic peptides as selective substrates and suicide substrate precursors of trypsin-like proteinases》 were Boggetto, Nicole; Vilain, Anne Cecile; Montagne, Jean Jacuqes; Reboud-Ravaux, Michele; Mazaleyrat, Jean Paul; Xie, Juan; Wakselman, Michel. And the article was published in Bulletin de la Societe Chimique de France in 1994. SDS of cas: 88071-91-4 The author mentioned the following in the article:

Cyclopeptides of general formula c[P1-aB(CH2X)-Gly4], in which P1 is arginine or lysine and aB(CH2X) an ortho- or meta-aminobenzoic acid residue substituted in the para position to the nitrogen atom by a Me (X = H), a phenoxymethyl (X = OC6H5) or an acetoxymethyl (X = OCOCH3) group, have been evaluated as substrates and/or inhibitors of serine proteinases. These compounds are selective substrates of trypsin-like enzymes (urokinase, plasmin, thrombin). The presence of lysine or arginine at the P1 position induces a selective cleavage of the P1-P’1 anilide bond. The efficiency of the enzymic hydrolysis is generally higher for cyclopeptides containing a meta rather than an ortho-aminobenzoic acid residue. The arginine derivatives are more easily cleaved by urokinase (u-PA) than their lysine analogs. No hydrolysis is observed in the presence of t-PA. The compounds with X = OC6H5 or OCOCH3 are the most reactive substrates. In spite of the presence of the phenolate or acetate latent nucleofugal substituent, which could induce the formation of an electrophilic quinonium methide moiety, they fail to inactivate the studied proteases. However, substitution of X by better latent leaving groups makes these compounds immediate precursors of suicide substrates, in particular of urokinase, an enzyme involved in the process of metastasis. In the experiment, the researchers used Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4SDS of cas: 88071-91-4)

Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.SDS of cas: 88071-91-4 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Maddirala, Amarendar Reddy; Klein, Roger; Pinkner, Jerome S.; Kalas, Vasilios; Hultgren, Scott J.; Janetka, James W. published an article on January 24 ,2019. The article was titled 《Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design》, and you may find the article in Journal of Medicinal Chemistry.Related Products of 1214323-39-3 The information in the text is summarized as follows:

The F9/Yde/Fml pilus, tipped with the FmlH adhesin, has been shown to provide uropathogenic Escherichia coli (UPEC) a fitness advantage in urinary tract infections (UTIs). Here, the authors used X-ray structure guided design to optimize our previously described ortho-biphenyl Gal and GalNAc FmlH antagonists by replacing the carboxylate with a sulfonamide. Other groups which can accept H-bonds were also tolerated. The authors pursued further modifications to the biphenyl aglycon resulting in significantly improved activity. Two of the most potent compounds (IC50 = 0.051 μM) and (IC50 = 0.034 μM), exhibited excellent metabolic stability in mouse plasma and liver microsomes but showed only limited oral bioavailability (<1%) in rats. Another compound also showed a good pharmacokinetic (PK) profile in mice after IP dosing with compound exposure above the IC50 for 6 h. These new FmlH antagonists represent new antivirulence drugs for UTIs. In addition to this study using 2-Bromo-3-(trifluoromethyl)phenol, there are many other studies that have used 2-Bromo-3-(trifluoromethyl)phenol(cas: 1214323-39-3Related Products of 1214323-39-3) was used in this study.

2-Bromo-3-(trifluoromethyl)phenol(cas: 1214323-39-3) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Related Products of 1214323-39-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Thermotropic Columnar Liquid Crystals Based on Wedge-Shaped Phenylphosphonic Acids》 was written by Kumar, K. R. Sunil; Gupta, Monika; Sakamoto, Takeshi; Kato, Takashi. Quality Control of 1-Bromo-3,4,5-trimethoxybenzeneThis research focused onwedge shaped phenylphosphonic acid thermotropic columnar liquid crystal. The article conveys some information:

Wedge-shaped phenylphosphonic acids with variation in the peripheral alkoxy chains have been synthesized. These derivatives show a hexagonal columnar liquid-crystalline behavior upon thermal treatment. These materials have potential to be used as efficient anisotropic proton conductors. In addition to this study using 1-Bromo-3,4,5-trimethoxybenzene, there are many other studies that have used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Quality Control of 1-Bromo-3,4,5-trimethoxybenzene) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Quality Control of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1,4-Bis(bromomethyl)benzeneIn 2020 ,《Tetraphenylethene-based tetracationic dicyclophanes: synthesis, mechanochromic luminescence, and photochemical reactions》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Nian, Hao; Li, Aisen; Li, Yawen; Cheng, Lin; Wang, Ling; Xu, Weiqing; Cao, Liping. The article contains the following contents:

Two tetraphenylethene-based tetracationic dicyclophanes 1 and 2 were synthesized via a one-step SN2 reaction. Based on the central TPE unit and the slight difference of the outer linkers, 1 and 2 exhibited a classic aggregation-induced emission but contrasting mechanochromic luminescence under grinding, vaporing, or hydrostatic pressure in the solid state, and photochem. reactions with various emitting colors induced by photoirradiation in the solution state.1,4-Bis(bromomethyl)benzene(cas: 623-24-5Reference of 1,4-Bis(bromomethyl)benzene) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 1,4-Bis(bromomethyl)benzene Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2019 ,《Thinking Outside the “”Blue Box””: Induced Fit within a Unique Self-Assembled Polycationic Cyclophane》 was published in Journal of the American Chemical Society. The article was written by Blanco-Gomez, Arturo; Fernandez-Blanco, Angel; Blanco, Victor; Rodriguez, Jaime; Peinador, Carlos; Garcia, Marcos D.. The article contains the following contents:

We present herein the development of a new polycationic mol. receptor, inspired by the ubiquitous cyclobis(paraquat-p-phenylene)cyclophane (“”blue box””). Our analog, the “”white box””, has been easily self-assembled on a preparative scale in water, using a template-assisted process by acyl hydrazone bonding of complementary bis(pyridinium)xylylene tweezers, followed by kinetic trapping of the empty receptor. The obtained macrocycle was found to display a marked pH responsiveness in water, because of an abnormal acidity of the amide protons within its structure. Consequently, and because of the concurrence of rotational isomerism under acidic conditions (fixed at higher pH values), the compound was found to display a dual behavior as a conformationally locked/flexible mol. host, being able to recognize appropriate aromatic substrates, in a lock and key or induced fit fashion, by a conjunction of π-π, C-H···π, and, crucially, the hydrophobic effect. In addition to this study using 1,4-Bis(bromomethyl)benzene, there are many other studies that have used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Category: bromides-buliding-blocks) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of Benzyl 2-bromoacetateIn 2022 ,《Photocatalytic 1,2-oxo-alkylation reaction of styrenes with diazoacetates》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Li, Fang; Zhu, Siqi; Koenigs, Rene M.. The article contains the following contents:

The photocatalytic 1,2-difunctionalization reaction of styrenes with acceptor-only diazoalkanes are reported. In the presence of DABCO and tBuOOH, the carbene reactivity of diazoalkanes can be suppressed and a 1,2 oxo-alkylation reaction can be achieved (32 examples, up to 94% yield) without the formation of cyclopropane byproducts via the formation of radical intermediates from Et diazoacetate. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Safety of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 17696-11-6In 2021 ,《Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein》 appeared in Journal of the American Chemical Society. The author of the article were Besten, Willem den; Verma, Kshitij; Yamazoe, Sayumi; Blaquiere, Nicole; Phung, Wilson; Izrael-Tomasevic, Anita; Mulvihill, Melinda M.; Helgason, Elizabeth; Prakash, Sumit; Goncharov, Tatiana; Vucic, Domagoj; Dueber, Erin; Fairbrother, Wayne J.; Wertz, Ingrid; Yu, Kebing; Staben, Steven T.. The article conveys some information:

We hypothesized that the proximity-driven ubiquitylation of E3-interacting small mols. could affect the degradation of E3 ubiquitin ligases. A series of XIAP BIR2 domain-binding small mols. was modified to append a nucleophilic primary amine. This modification transforms XIAP binders into inducers of XIAP degradation The degradation of XIAP is E1- and proteasome-dependent, dependent on the ligase function of XIAP, and is rescued by subtle modifications of the small mol. that would obviate ubiquitylation. We demonstrate in vitro ubiquitylation of the small mol. that is dependent on its interaction with XIAP. Taken together, these results demonstrate the designed ubiquitylation of an engineered small mol. and a novel approach for the degradation of E3 ubiquitin ligases. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Application of 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Application of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C8H15BrO2In 2018 ,《Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat》 appeared in European Journal of Medicinal Chemistry. The author of the article were Chu-Farseeva, Yu-yi; Mustafa, Nurulhuda; Poulsen, Anders; Tan, Eng Chong; Yen, Jeffrey J. Y.; Chng, Wee Joo; Dymock, Brian W.. The article conveys some information:

Specifically blocking more than one oncogenic pathway simultaneously in a cancer cell with a combination of different drugs is the mainstay of the majority of cancer treatments. Being able to do this via two targeted pathways without inducing side effects through a general mechanism, such as chemotherapy, could bring benefit to patients. In this work we describe a new dual inhibitor of the JAK-STAT and HDAC pathways through designing and developing two types of mol. based on the JAK2 selective inhibitor XL019 and the pan-HDAC inhibitor, vorinostat. Both series of compounds had examples with low nanomolar JAK2 and HDAC1/6 inhibition. In some cases good HDAC1 selectivity was achieved while retaining HDAC6 activity. The observed potency is explained through mol. docking studies of all three enzymes. One example, 69c had 16-25 fold selectivity against the three other JAK-family proteins JAK1, JAK3 and TYK2. A number of compounds had sub-micromolar potencies against a panel of 4 solid tumor cell lines and 4 hematol. cell lines with the most potent compound, 45h, having a cellular IC50 of 70 nM against the multiple myeloma cell line KMS-12-BM. Evidence of both JAK and HDAC pathway inhibition is presented in Hela cells showing that both pathways are modulated. Evidence of apoptosis with two compounds in 4 sold tumor cell lines is also presented. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Synthetic Route of C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Synthetic Route of C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary