Tag: 200-300

《Defluorinative Functionalization of Pd(II) Fluoroalkyl Complexes》 was published in Journal of the American Chemical Society in 2020. These research results belong to Wade Wolfe, Michael M.; Shanahan, James P.; Kampf, Jeff W.; Szymczak, Nathaniel K.. Synthetic Route of C9H11BrO3 The article mentions the following:

When subjected to arylboranes, anionic trifluoromethyl and difluorobenzyl palladium(II) complexes undergo fluoride abstraction followed by 1,1-migratory insertion. The resulting intermediate fluoroalkyl species can be induced to undergo a subsequent transmetalation and reductive elimination from either an in situ formed fluoroboronate (FB(Ar3)-) or an exogenous boronic acid/ester (ArB(OR)2) and nucleophilic activator, representing a net defluorinative arylation reaction. The latter method enabled a structurally diverse substrate scope to be prepared from either an isolated palladium-CF3 complex, or from Pd(PPh3)4 and other com. available reagents. In the experiment, the researchers used many compounds, for example, 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Synthetic Route of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Synthetic Route of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of the American Chemical Society included an article by Christiansen, Dylan T.; Tomlinson, Aimee L.; Reynolds, John R.. Category: bromides-buliding-blocks. The article was titled 《New Design Paradigm for Color Control in Anodically Coloring Electrochromic Molecules》. The information in the text is summarized as follows:

A new paradigm is established for the design of conjugated anodically coloring electrochromic mols. It is shown that through cross-conjugation the electronic energy levels of the radical cation state may be controllably tuned independent of the neutral state. It is shown how cross-conjugation can be used to tune the radical cation state independent of the neutral state. Manipulating the oscillator strengths of radical cation transitions allows for tuning of the color by shifting the λmax of the low-energy absorption by over 400 nm. The neutral states of these mols. are UV absorbing, providing solutions that are colorless with L*a*b* values of 100, 0, 0. They are oxidized to vibrantly colored radical cations with absorptions that span the visible spectrum, creating green, yellow, and red chromophores. These mols. are then mixed to create transmissive, colorless blends that switch to opaque black solutions The results came from multiple reactions, including the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Category: bromides-buliding-blocks)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Category: bromides-buliding-blocks1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Liu, Lixin; Dong, Jianyu; Yan, Yani; Yin, Shuang-Feng; Han, Li-Biao; Zhou, Yongbo. Recommanded Product: 8-Bromooctanoic acid. The article was titled 《Photoredox-catalyzed decarboxylative alkylation/cyclization of alkynylphosphine oxides: a metal- and oxidant-free method for accessing benzo[b]phosphole oxides》. The information in the text is summarized as follows:

By photoredox-catalysis, alkylation/aryl C-H cyclization of readily available alkynylphosphine oxides towards benzo[b]phospholes has been realized under metal- and oxidant-free conditions at room temperature This reaction readily incorporates various functionalized alkyl groups into the benzo[b]phosphole skeletons, representing a mild and versatile tool for the preparation of valuable phosphole compounds The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Recommanded Product: 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Recommanded Product: 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mitchell, T. Andrew; Bode, Jeffrey W. published their research in Journal of the American Chemical Society on December 23 ,2009. The article was titled 《Synthesis of Dialkyl Ethers from Organotrifluoroborates and Acetals》.Formula: C6H4BBrF3K The article contains the following contents:

The formation of ethers by C-O bond formation under harsh basic or acidic conditions is an entrenched synthetic disconnection in organic chem. We report a strategic alternative that involves the BF3·OEt2-promoted coupling of stable, easily prepared acetals with widely available potassium aryl-, alkenyl-, and alkynyltrifluoroborates. This fast, operationally simple process offers straightforward access to dialkyl ethers, many of which would be difficult to prepare using classical methods. The use of MOM-protected alcs. and acetal-protected aldehydes enables ether formation without recourse to protecting-group manipulations or strong bases. In addition to this study using potassium (3-bromophenyl)trifluoroborate, there are many other studies that have used potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8Formula: C6H4BBrF3K) was used in this study.

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C6H4BBrF3K

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dankwardt, Sharon M.; Ferla, Steven; Krstenansky, John L.; Bhakta, Sunil; Ostrelich, Helene; Jarnagin, Kurt published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Nonpeptide bradykinin antagonist analogs based on a model of a Sterling-Winthrop nonpeptide bradykinin antagonist overlapped with cyclic hexapeptide bradykinin antagonist peptide》.Reference of Methyl 5-(bromomethyl)-2-nitrobenzoate The author mentioned the following in the article:

A proposed overlap between cyclic hexapeptide bradykinin antagonist and nonpeptide bradykinin antagonists D- and L-3-(2-naphthyl)alanines I [R1 = Bu3P+, Bu3N+, H2N, HO, H2NC(:NH)NH, EtNHC(:NEt)NH, H-L-Arg-NH, H-D-Arg-NH, aca-D-Arg-NH; aca = 1-adamantylcarbonyl; R2 = H, CO2H; R3 = H, CH2CH2CO2H; X = cyclohexylimino, O] is discussed. Synthetic procedures for both enantiomers of I are given. Structural variations on both the peptides and nonpeptides support the proposed overlap based on an increase or decrease in the biol. activities of the antagonists. The experimental process involved the reaction of Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4Reference of Methyl 5-(bromomethyl)-2-nitrobenzoate)

Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Reference of Methyl 5-(bromomethyl)-2-nitrobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 76283-09-5On March 15, 2019, Ndikuryayo, Ferdinand; Kang, Wei-Ming; Wu, Feng-Xu; Yang, Wen-Chao; Yang, Guang-Fu published an article in European Journal of Medicinal Chemistry. The article was 《Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors》. The article mentions the following:

Involved in the tyrosine degradation pathway, 4-hydroxyphenylpyruvate dioxygenase (HPPD) is an important target for treating type I tyrosinemia. To discover novel HPPD inhibitors, we proposed a hydrophobicity-oriented drug design (HODD) strategy based on the interactions between HPPD and the com. drug NTBC. Most of the new compounds showed improved activity, compound d23 being the most active candidate (IC50 = 0.047 μM) with about 2-fold more potent than NTBC (IC50 = 0.085 μM). Therefore, compound d23 is a potential drug candidate to treat type I tyrosinemia. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Product Details of 76283-09-5)

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Product Details of 76283-09-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A highly stable amino-coordinated MOF for unprecedented block off N2 adsorption and extraordinary CO2/N2 separation》 was written by Zhang, Ling; Jiang, Ke; Jiang, Mengdie; Yue, Dan; Wan, Yating; Xing, Huabin; Yang, Yu; Cui, Yuanjing; Chen, Banglin; Qian, Guodong. Synthetic Route of C6H5Br2NThis research focused onzinc aminophenylenediacrylate coordination polymer preparation gas adsorption; crystal structure zinc aminophenylenediacrylate coordination polymer. The article conveys some information:

A highly stable amino-coordinated metal-organic framework ZJU-198 from (2E,2E0)-3,30-(5-amino-1,3-phenylene) diacrylic acid, was synthesized and structurally characterized, exhibiting high CO2 uptake of 105.8 cm3 cm-3 while blocking off N2 adsorption at 1.0 bar and 298 K, attributed to the unique pore window sizes. In addition to this study using 3,5-Dibromoaniline, there are many other studies that have used 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 586-76-5In 2019 ,《C-H and N-H bond annulation of aryl amides with unactivated olefins by merging cobalt(III) and photoredox catalysis》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Kalsi, Deepti; Barsu, Nagaraju; Chakrabarti, Sagnik; Dahiya, Pardeep; Rueping, Magnus; Sundararaju, Basker. The article conveys some information:

A mild, environment-friendly protocol was developed to carry out the [4+2] annulation of aryl amides with unactivated olefins. A range of sterically and electronically diverse aryl amides and unactivated olefins were successfully employed under the developed conditions to get a variety of dihydroisoquinolinones in good to excellent yields. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Related Products of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Related Products of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of 1-Bromo-3,4,5-trimethoxybenzeneIn 2020 ,《In-depth examination of the pterolactams behaviour in Lewis/Bronsted acid catalysis environment: Total isolation of the reaction products》 appeared in ARKIVOC (Gainesville, FL, United States). The author of the article were Dumitriu, Gina-Mirabela; Bicu, Elena; Rigo, Benoit; Moncol, Jan; Daich, Adam; Ghinet, Alina. The article conveys some information:

To gain some insights on the amidoalkylation process, authors were interested in studying the product distribution when pterolactam was exposed to acids. The reactivity of pterolactam and its N-aryl derivatives towards TMSOTf or TfOH has been carefully examined in presence and absence of TMS-protected anilines. Under these conditions, the N-acyliminium precursors showed high reactivity at both α- and β-positions of the nitrogen atom. In this context, these salts can induce cascade processes including Povarov type reaction among other transformations. In that way, novel quinolines and tetrahydro-quinolines, among other compounds, were isolated for the first time.1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Quality Control of 1-Bromo-3,4,5-trimethoxybenzene) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Quality Control of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Ling, Huan; Wu, Jianchang; Su, Fengyu; Tian, Yanqing; Yan, Jun Liu published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The title of the article was 《High performance electrochromic supercapacitors powered by perovskite-solar-cell for real-time light energy flow control》.Computed Properties of C4H2Br2S The author mentioned the following in the article:

Electrochromic devices (ECDs) can alter their optical transmittances under external elec. power but are unable to spontaneously modulate the light flow in real-time along with the intensity change of surrounding light. To address this problem, a module of smart perovskite solar cell (PSC)-powered all-in-one gel ECDs was reported. The PSC-powered ECDs could modulate their transmittance swiftly in visible-IR regions, hence regulating the photo energy flow in real time according to the surrounding light intensity. The ECD based on 4, 4′-(thiophene- 2, 5-diyl)bis(1-ethylpyridin-1-ium) diiodide (TEV) showed large optical contrast (79.7% at 570 nm, 64.9% at 908 nm), excellent coloration efficiency (231.2 cm2/C), and outstanding stability (only 1.1% ΔT change after 60,000 cycles). The PSC-powered ECDs showed fast response time (≤5 s) and high stability (negligible degradation after 5000 s consecutive switching between bright and dark conditions in air). Meanwhile, the stored power accompanied with the electrochromic process could drive a red LED with high cyclic stability (95.6% of areal capacitance maintained after 10,000 charging-discharging cycles), indicating that ECDs can serve as ideal electrochromic supercapacitors (ECSs). In addition, the fabricated ECD with large area (5.0 cm x 5.4 cm) showed excellent thermal regulation (7°C of temperature difference between colored and bleached states). We expect this work would pave a new way to save energy and improve energy efficiency in modern buildings and automobiles. In the experiment, the researchers used 2,5-Dibromothiophene(cas: 3141-27-3Computed Properties of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.Computed Properties of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary