Tag: 200-300

Ranjini, P.; Shilpa, Chaitramallu M.; Kesagodu, Devaraju; Basavaraju, Y. B. published their research in World Journal of Pharmacy and Pharmaceutical Sciences in 2021. The article was titled 《Synthesis of substituted 6,7-dimethoxy-4-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalen-1(2H)-one and their apoptosis study》.SDS of cas: 2675-79-8 The article contains the following contents:

The field of biomedical analogs of podophyllotoxin is more in its infancy, but the explosion of interest in these mols. as inherently active therapeutic agents is increasing. There is growing interest in the design and synthesis of novel biocompatible analogs. The series of novel substituted podophyllotoxin derivatives I (R1 = H, OCH3; R2 = H, OCH3, Cl, etc.) were synthesized under mild conditions with satisfactory yield. Auto dock server anal. of the these analogs structure showed that the compounds were shown to interact with the proteins involved in Bcl-xL mediated pathway with inhibition constant of 0.000149 and 0.000584 for I (R1 = H; R2 = NH2) and I (R1 = H; R2 = CH3) resp. The recorded results of lipid peroxidation with treated samples were increased with increasing concentration In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8SDS of cas: 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.SDS of cas: 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Elastic and durable multi-cation-crosslinked anion exchange membrane based on poly(styrene-b-(ethylene-co-butylene)-b-styrene)》 was published in Journal of Polymer Science (Hoboken, NJ, United States) in 2020. These research results belong to Li, Ziming; Li, Conghui; Long, Chuan; Sang, Jing; Tian, Lin; Wang, Fanghui; Wang, Zhihua; Zhu, Hong. Recommanded Product: 1,6-Dibromohexane The article mentions the following:

Anion exchange membranes (AEMs), as the core component of the new generation anion exchange membrane fuel cells (AEMFCs), directly determine the performance and the lifetime of this energy conversion device. Here, AEMs with pendant multiple quaternary ammonium anchored onto the poly(styrene-b-(ethylene-co-butylene)-b-styrene) (SEBS) backbone are synthesized. The comb-shaped copolymer SEBS-C16 is synthesized with N,N-dimethyl-1-hexadecylamine and chloromethylated SEBS to improve solubility, then the multi-cation crosslinker is prepared and grafted on the above backbone to fabricate a series of flexible multi-cation crosslinked SEBS-based AEMs (SEBS-C16-xC4, where x% is the ratio of the crosslinker to polystyrene block) with practical properties. The obtained SEBS-C16-20C4 membrane exhibits a microphase separated morphol. with an interdomain spacing of 18.87 nm. Benefited from the ion channels, SEBS-C16-20C4 shows high conductivity of 77.78 mS/cm at 80°C. Addnl., the prepared SEBS-C16-20C4 membrane with ion exchange capacity of 2.35 mmol/g also exhibits enhanced alk. stability (5.87% hydroxide conductivity decrease in 2 M NaOH solution at 80°C after 1,700 h) and improved mech. properties, compared with the non-crosslinked SEBS-C16 sample. Furthermore, AEMFC single cell performance is evaluated with the SEBS-C16-20C4 membrane, and a maximum power d. of 182 mW/cm2 is achieved at 80°C under H2/O2 conditions.1,6-Dibromohexane(cas: 629-03-8Recommanded Product: 1,6-Dibromohexane) was used in this study.

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Recommanded Product: 1,6-Dibromohexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo》 were Paranawithana, Namini N.; Martins, Andre F.; Clavijo Jordan, Veronica; Zhao, Piyu; Chirayil, Sara; Meloni, Gabriele; Sherry, A. Dean. And the article was published in Journal of the American Chemical Society in 2019. Related Products of 1129-28-8 The author mentioned the following in the article:

The design, synthesis, and properties of a new gadolinium-based copper-responsive magnetic resonance imaging (MRI) contrast agent is presented. The sensor (GdL1) has high selectivity for copper ions and exhibits a 43% increase in r1 relaxivity (20 MHz) upon binding to 1 equiv of Cu2+ in aqueous buffer. Interestingly, in the presence of physiol. levels of human serum albumin (HSA), the r1 relaxivity is amplified further up to 270%. Addnl. spectroscopic and X-ray absorption spectroscopy (XAS) studies show that Cu2+ is coordinated by two carboxylic acid groups and the single amine group on an appended side chain of GdL1 and forms a ternary complex with HSA (GdL1-Cu2+-HSA). T1-weighted in vivo imaging demonstrates that GdL1 can detect basal, endogenous labile copper(II) ions in living mice. This offers a unique opportunity to explore the role of copper ions in the development and progression of neurol. diseases such as Wilson’s disease. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Related Products of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis》 were Kim, Won Young; Won, Miae; Salimi, Abbas; Sharma, Amit; Lim, Jong Hyeon; Kwon, Seung-Hae; Jeon, Joo-Yeong; Lee, Jin Yong; Kim, Jong Seung. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Safety of 1,6-Dibromohexane The author mentioned the following in the article:

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential. In the experimental materials used by the author, we found 1,6-Dibromohexane(cas: 629-03-8Safety of 1,6-Dibromohexane)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Safety of 1,6-Dibromohexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Wang, Kai-Min; Du, Lin; Ma, Yu-Lu; Zhao, Qi-Hua published 《A dual-functional cadmium(II) coordination polymer as a luminescent sensor for selective sensing of iron(III) ions and detecting the temperature》.Transition Metal Chemistry (Dordrecht, Netherlands) published the findings.Safety of Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:

A Cd(II) coordination polymer (1), {[Cd2(Ccbp)2(dca)Cl(H2O)3]·4H2O} Ccbp- = 4-carboxy-1-(3-carboxybenzyl)pyridin-1-ium and dca- = dicyanamide, has been synthesized via a hydrothermal reaction and fully characterized by single-crystal x-ray structural anal., FTIR spectroscopy, powder X-ray diffraction, and TGA. Complex 1 has a 2D network structure with uncoordinated functional groups. Its solid-state luminescence properties were measured at room temperature Complex 1 exhibited a high sensitivity for Fe3+ in DMF solutions of mixed metal ions. In addition, the temperature-dependent luminescence properties of 1 have been investigated and show that the complex acts as a luminescent thermometer at 10-90 K. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Safety of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Safety of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Pd(II)-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates under mild conditions》 was published in Chemical Communications (Cambridge, United Kingdom) in 2011. These research results belong to Li, Mingzong; Wang, Cong; Fang, Ping; Ge, Haibo. Quality Control of potassium (3-bromophenyl)trifluoroborate The article mentions the following:

A novel Pd-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates has been realized under mild reaction conditions. This method provides an efficient access to N-mono- or N,N-disubstituted benzamides and benzoates.potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8Quality Control of potassium (3-bromophenyl)trifluoroborate) was used in this study.

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Quality Control of potassium (3-bromophenyl)trifluoroborateSome of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《General and selective syn-carboxylation-trifluoromethylation of terminal alkynes: application to the late-stage modification of dehydrocholic acid》 was written by Zhang, Song-Lin; Xiao, Chang; Wan, Hai-Xing; Zhang, Xiaoming. Formula: C7H5BrO2This research focused ontrifluoromethyl enol carboxylic ester preparation regioselective diastereoselective; terminal aryl alkyne carboxylic acid syn carboxylation trifluoromethylation. The article conveys some information:

A general and selective method is developed that allows difunctionalization of terminal alkynes by a Cu(III)-CF3 complex and a carboxylic acid regioselectively and with unusual syn-stereochem. This method is broadly applicable to various carboxylic acids and terminal alkynes, producing a range of biol. active trifluoromethyl enol carboxylic esters I (Ar = 4-ClC6H4, 4-EtC6H4, Ph, etc.; R = tBu, Bu, 4-BrC6H4, etc.). The synthetic potential of this method is further demonstrated by the late-stage functionalization of a complex pharmaceutical compound dehydrocholic acid. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Formula: C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C6H5Br2NIn 2020 ,《Made-to-order porous electrodes for supercapacitors: MOFs embedded with redox-active centers as a case study》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Mallick, Arijit; Liang, Hanfeng; Shekhah, Osama; Jia, Jiangtao; Mouchaham, Georges; Shkurenko, Aleksander; Belmabkhout, Youssef; Alshareef, Husam N.; Eddaoudi, Mohamed. The article conveys some information:

In this work, a pre-designed Zr-based-MOF encompassing an organic linker with a redox active core is synthesized and its structure-property relationship as a supercapacitor electrode is investigated. An enhanced performance is revealed by the combination of this MOF’s high porosity and redox core incorporation, which alters its double-layer and pseudocapacitance, resp. An increase in the capacitance performance by a factor of two is achieved via post-synthetic structure rigidification using organic pillars. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dibromoaniline(cas: 626-40-4Computed Properties of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Computed Properties of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mansour, Ahmed M.; Radacki, Krzysztof; Khaled, Rabaa M.; Soliman, Marwa H.; Abdel-Ghani, Nour T. published an article in 2021. The article was titled 《Phototriggered cytotoxic properties of tricarbonyl manganese(I) complexes bearing α-diimine ligands towards HepG2》, and you may find the article in JBIC, Journal of Biological Inorganic Chemistry.Quality Control of Bromopentacarbonylmanganese(I) The information in the text is summarized as follows:

Reaction between bromo tricarbonyl manganese(I) and N,N’-bis(phenyl)-1,4-diaza-1,3-butadiene ligands, bearing different electron-donating and electron-withdrawing groups R = OCH3, Cl, and NO2 in the ortho- and para-positions on the Ph substituent, afforded [MnBr(CO)3(N-N)]. The influence of the character and position of the substituent on the dark stability and carbon monoxide releasing kinetics was systematically investigated and correlated with the data of the time-dependent d. functional theory calculations The combined UV/visible and IR data clearly revealed that the aerated solutions of [MnBr(CO)3(N-N)] in either coordinating or noncoordinating solvents are dark stable and the fluctuations observed during the incubation period especially in the case of the nitro derivatives may be attributed to the exchange of the axial bromo ligand with the coordinating solvent mols. The free ligands and nitro complexes were noncytotoxic to HepG2 cells under both the dark and illumination conditions. In the dark, Mn(I) compounds, incorporating o-OCH3 and o-Cl, exhibited excellent cytotoxicity with IC50 values of 18.1 and 11.8μM, while their para-substituted analogs were inactive in the dark and active upon the irradiation at 365 nm with IC50 values of 5.7 and 6.7μM, resp.Bromopentacarbonylmanganese(I)(cas: 14516-54-2Quality Control of Bromopentacarbonylmanganese(I)) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Quality Control of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Single Wavelength Laser Excitation Ratiometric NIR-II Fluorescent Probe for Molecule Imaging in Vivo》 was written by Ge, Xiaoguang; Lou, Yuheng; Su, Lichao; Chen, Bin; Guo, Zhiyong; Gao, Shi; Zhang, Wenmin; Chen, Tao; Song, Jibin; Yang, Huanghao. Computed Properties of C4H2Br2S And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020. The article conveys some information:

Fluorescence (FL) imaging in the second near-IR window (NIR-II, 1000-1700 nm) has emerged as a promising bioimaging modality that enables noninvasive visualization of deep tissue with an unprecedented resolution However, there is a paucity of studies on high-quality responsive NIR-II FL mols. Herein we report a novel activated NIR-II FL mol., 4,7-bis(5-(4-(diphenylamine)phenyl)-2-thiophene) [1,2,5]selenadiazolo[3,4-f]benzo[c][1,2,5]thiadiazole (SeTT), which exhibits fast and specific responsive capability to hypochlorous acid (HClO). To obtain the NIR-II ratiometric nanoprobe, SeTT was encapsulated on the surface of Er3+-doped down-conversion nanoparticles (DCNP), achieving the DCNP@SeTT nanoprobe. With a single 980 nm laser excitation, the ratiometric FL signal of SeTT at 1150 nm and DCNP at 1550 nm (I1150 nm/I1550 nm) was linearly correlated with the concentration of HClO with a detection limit of 0.4μM. The ratiometric nanoprobe was successfully investigated for variations in HClO concentration in the tumor progression, visualization of anatomical structures of the peritoneal cavity in the mice model with inflammation, and quant. detection of the HClO concentration in a rabbit model of osteoarthritis, achieving a fast response and high selectivity for the detection of HClO. The NIR-II-responsive nanoprobe can serve as a promising and effective tool for highly sensitive monitoring and imaging of HClO in living systems. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromothiophene(cas: 3141-27-3Computed Properties of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.Computed Properties of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary