Tag: 200-300

Electric Literature of C8H15BrO2In 2018 ,《Synthesis and biodistribution studies of 99mTc labeled fatty acid derivatives prepared via “”Click approach”” for potential use in cardiac imaging》 was published in Journal of Labelled Compounds and Radiopharmaceuticals. The article was written by Das, Soumen; Mathur, Anupam; Sakhare, Navin; Mallia, Madhava B.; Sarma, Haladhar Dev; Sachdev, Satbir Singh; Dash, Ashutosh. The article contains the following contents:

123I-Iodophenylpentadecanoic acid (IPPA) is a metabolic agent used in nuclear medicine for diagnosis of myocardial defects. Efforts are underway worldwide to develop a 99mTc substitute of the above radiopharmaceutical for the aforementioned application. Herein, we report synthesis and biodistribution studies of 99mTc labeled fatty acids (8, 11, and 15 carbons) obtained via “”click chem.”” for its potential use in myocardial imaging. ω-Bromo fatty acids (8C/11C/15C) were synthetically modified at bromo terminal to introduce a heterocyclic triazole with glycine sidearm in a five step procedure. Modified fatty acids were subsequently radiolabeled with preformed [99mTc(CO)3]+ synthon to yield the desired fatty acid complexes which were evaluated in Swiss mice. All the radiolabeled complexes were obtained with radiochem. purities >80%, as characterized by HPLC. Biodistribution studies of all three complexes in Swiss mice showed myocardial uptake of ∼6-9% ID/g at 2 min post-injection, close to*I-IPPA (∼9% ID/g). Complexes exhibited significant retention in the myocardium up to 30 min (∼1% ID/g) but were lower to the standard agent (∼7% ID/g). Similar uptake of activity in myocardium for the newly synthesized complexes in comparison to 125I-IPPA along with favorable in vivo pharmacokinetics merits potential for the present “”click”” design of complexes for myocardial imaging. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Electric Literature of C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Electric Literature of C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of 8-Bromooctanoic acidIn 2020 ,《Bis-quaternary ammonium gemini surfactants for gene therapy: Effects of the spacer hydrophobicity on the DNA complexation and biological activity》 was published in Colloids and Surfaces, B: Biointerfaces. The article was written by Acosta-Martinez, Delvis R.; Rodriguez-Velazquez, Eustolia; Araiza-Verduzco, Fernanda; Taboada, Pablo; Prieto, Gerardo; Rivero, Ignacio A.; Pina-Luis, Georgina; Alatorre-Meda, Manuel. The article contains the following contents:

Gemini surfactants (GS) have been highlighted as attractive gene carriers for a few years now; however, key aspects of the role of the GS chem. structure on the DNA-GS complexation and subsequent biol. activity remain to be determined Aiming to elucidate the effects of the GS spacer hydrophobicity, this work was focused on the biophys. characterization of the self-assembly, DNA complexation, cytocompatibility, and DNA transfection of a series of bis-quaternary ammonium GS with fixed side alkyl chains of 14 carbons and varying head-to-head alkyl chain spacers of 4, 6, and 14 carbons (referred to as GS4, GS6, and GS14, resp.). The characterization was carried out by a battery of exptl. techniques including UV-vis and fluorescence spectroscopies, ζ potential, dynamic light scattering (DLS), isothermal titration calorimetry (ITC), and flow cytometry, among others. Overall, the spectroscopic results showed that the self-assembly of the GS was favored with the spacer hydrophobicity since lower values of critical micelle concentration (CMC) were observed for samples with longer spacer chains. On the other hand, the ITC results revealed that the DNA-GS complexation was driven by an initial electrostatic attraction between DNA and GS monomers/micelles followed by complementary hydrophobic interactions which strengthen the DNA-GS binding, the latter being more pronounced for GS with longer spacers. Finally, the biol. tests demonstrated that while GS with moderate hydrophobicity (GS4 and GS6) yielded outstanding levels of cytocompatibility and DNA transfection over a range of concentrations, the most hydrophobic sample (GS14) proved to be cytotoxic upon administration to cultured HeLa cells (p < 0.05). In our opinion, the fundamental information here presented might be pivotal not only for understanding the DNA-GS complexation mechanism, but also for developing efficient GS-based carriers for gene therapy. In the experiment, the researchers used many compounds, for example, 8-Bromooctanoic acid(cas: 17696-11-6Quality Control of 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Quality Control of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mondal, Anirban; Visser, Paco; Doze, Anna M.; Buter, Jeffrey; Feringa, Ben L. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Pd-catalyzed sp-sp3 cross-coupling of benzyl bromides using lithium acetylides》.COA of Formula: C9H9BrO2 The article contains the following contents:

An efficient method for the cross-coupling of benzyl bromides (sp3) with lithium acetylides (sp) was developed to obtain benzylic alkynes I [R = H, 3-MeO, 4-Me, etc.; R1 = Si(CH3)3, Si(i-Pr)3, Ph, 9-phenanthryl]. The reaction proceeded within 10 min at room temperature and could be performed in the presence of organolithium-sensitive functional groups such as esters, nitriles, amides and boronic esters. The potential application of the methodol. was demonstrated in the preparation of key intermediates used in pharmaceuticals, chem. biol. and natural products. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8COA of Formula: C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. COA of Formula: C9H9BrO2 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Xiao-Qiang; Liu, Zi-Kui; Hou, Ye-Xing; Zhang, Guodong; Gao, Yang published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Ru-catalyzed C(sp2)-H vinylation/annulation of benzoic acids and alkynes: rapid access to medium-sized lactones》.Formula: C8H7BrO2 The article contains the following contents:

An unprecedented ruthenium catalyzed [4+4] annulation of readily available benzoic acids and alkynes was reported. The carboxylate group acted as both a directing group and an internal nucleophilic reagent to facilitated a C(sp2)-H vinylation/annulation cascade. This reaction avoided the classically oxidative [4+2] annulation, allowed the efficient synthesis of a wide array of eight-membered lactones under oxidant-free conditions. Moreover, this catalytic system would be successfully extended to [4+3] and [4+5] annulations for the assembly of seven- and nine-membered lactones. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Formula: C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C8H7BrO2 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Indo American Journal of Pharmaceutical Research included an article by Joshi, Shrinivas D.; Kulkarni, V. H.; Kumar, S. R. Prem; Basha, Jeelan. COA of Formula: C7H5BrO2. The article was titled 《Synthesis, antitubercular and antibacterial activities of novel N’-(substituted)-(2-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzamide derivatives》. The information in the text is summarized as follows:

A series of substituted N-(2-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzamides I (R = H, 4-Cl, 4-Br, 4-F, 4-NO2, 3-Cl) was synthesized by reacting different substituted aromatic acids RC6H4C(O)OH with 2-(2,5-dimethyl-1H-pyrrol-1-yl)aniline by using HBTU as a coupling agent, DIEA as a catalyst and DMF as a solvent. Further they were tested for their anti-tubercular and antibacterial activities and compounds showed moderate to good activity. In the experiment, the researchers used many compounds, for example, 4-Bromobenzoic acid(cas: 586-76-5COA of Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.COA of Formula: C7H5BrO2 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Chemical Communications (Cambridge, United Kingdom) included an article by Deng, Zhixin; Han, Sheng; Ke, Miaolin; Ning, Yingtang; Chen, Fen-Er. Safety of Ethyl 3-(2-bromophenyl)propanoate. The article was titled 《Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters》. The information in the text is summarized as follows:

Palladium-catalyzed linear-selective hydroesterification of vinyl arenes with alcs. enabled by diphosphine ligands derived from bis[2-(diphenylphosphino)ethyl]amides has been developed. A variety of 3-arylpropanoate esters were obtained in high yields and regioselectivity. The robustness of this methodol. was further demonstrated by the efficient gram-scale synthesis of the Et 3-phenylpropanoate as a precursor to hydrocinnamic acid. After reading the article, we found that the author used Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1Safety of Ethyl 3-(2-bromophenyl)propanoate)

Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Safety of Ethyl 3-(2-bromophenyl)propanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Lenis-Rojas, Oscar A.; Carvalho, Beatriz; Cabral, Rui; Silva, Margarida; Friaes, Sofia; Roma-Rodrigues, Catarina; Meireles, Marta S. H.; Gomes, Clara S. B.; Fernandez, Jhonathan A. A.; Vila, Sabela F.; Rubiolo, Juan A.; Sanchez, Laura; Baptista, Pedro V.; Fernandes, Alexandra R.; Royo, Beatriz published an article in JBIC, Journal of Biological Inorganic Chemistry. The title of the article was 《Manganese(I) tricarbonyl complexes as potential anticancer agents》.COA of Formula: C5BrMnO5 The author mentioned the following in the article:

The antiproliferative activity of [Mn(CO)3(NN)Br] (NN = phendione 1, bipy 3) and of the two newly synthesized Mn complexes [Mn(CO)3(acridine)(phendione)]OTf (2) and [Mn(CO)3(di-triazole)Br] (4) has been evaluated by MTS against three tumor cell lines A2780 (ovarian carcinoma), HCT116 (colorectal carcinoma), HCT116doxR (colorectal carcinoma resistant to doxorubicin), and in human dermal fibroblasts. The antiproliferative assay showed a dose-dependent effect higher in complex 1 and 2 with a selectivity toward ovarian carcinoma cell line 21 times higher than in human fibroblasts. Exposure of A2780 cells to IC50 concentrations of complex 1 and 2 led to an increase of reactive oxygen species that led to the activation of cell death mechanisms, namely via intrinsic apoptosis for 2 and autophagy and extrinsic apoptosis for 1. Both complexes do not target DNA or interfere with cell cycle progression but are able to potentiate cell migration and neovascularization (for 2) an indicative that their application might be directed for initial tumor stages to avoid tumor invasion and metastization and opening a new avenue for complex 2 application in regenerative medicine. Interestingly, both complexes do not show toxicity in both in vivo models (CAM and zebrafish). In addition to this study using Bromopentacarbonylmanganese(I), there are many other studies that have used Bromopentacarbonylmanganese(I)(cas: 14516-54-2COA of Formula: C5BrMnO5) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.COA of Formula: C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Photochemistry and Photobiology, A: Chemistry included an article by Heydari, Zahra; Rashidi-Ranjbar, Parviz. Electric Literature of C8H8Br2. The article was titled 《Synthesis and photophysical properties of a new carbazole-based acidochromic molecular switch》. The information in the text is summarized as follows:

A reversible color-changing and fluorescence mol. switch was designed and synthesized based on carbazole fluorophores and amino group receptors. The crab shape mol. 1 is not soluble in most organic solvents and showslow solubility in acetic acid and DMSO (1 mg/mL in DMSO). The solution of 1 in DMSO performed as single on/off switch triggered by acidic protons. The colorless solution in basic and neutral conditions turned to yellow upon addition of a small amount of acid together with quench in fluorescence emission. The solid state of 1 has a dual-mode fluorescence switching property. The creamy white powder of 1has an emission λmax at 398 nm but when exposed to acidic vapors or suspended into acidic mediathe color of the powder changed to yellow and its emission λmax appeared at 516 nm. Monte-Carlo simulation has been performed to search the conformational space of the neutral and acidic forms. The frontier MOs of the most stable conformers has been calculated using DFT/B3LYP method using 6-31 g (d) basis set in attempt to explain the difference in electronic transition of 1 and its porotonated form.1,4-Bis(bromomethyl)benzene(cas: 623-24-5Electric Literature of C8H8Br2) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Electric Literature of C8H8Br2 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Greulich, Tobias W.; Suzuki, Naoya; Daniliuc, Constantin G.; Fukazawa, Aiko; Yamaguchi, Eriko; Studer, Armido; Yamaguchi, Shigehiro published 《A biphenyl containing two electron-donating and two electron-accepting moieties: a rigid and small donor-acceptor-donor ladder system》.Chemical Communications (Cambridge, United Kingdom) published the findings.Application In Synthesis of 3,5-Dibromoaniline The information in the text is summarized as follows:

Ladder π-conjugated materials and also push-pull systems belong to important classes of compounds for the development of organic electronic devices. In this communication, a novel π-conjugated material that unifies the properties of both of these classes is presented. The material comprises a rigid biphenyl framework, which bears two bridging electron-accepting phosphine oxide moieties as well as two electron-donating amino groups. The structure and photophys. properties of this compound are discussed and compared with those of a related system lacking the second P-moiety. After reading the article, we found that the author used 3,5-Dibromoaniline(cas: 626-40-4Application In Synthesis of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application In Synthesis of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Varakala, Saiprasad Dasugari; Reshma, Rudraraju Srilakshmi; Schnell, Robert; Dharmarajan, Sriram published an article in European Journal of Medicinal Chemistry. The title of the article was 《Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens》.Reference of 3-Bromo-2-methylbenzoic acid The author mentioned the following in the article:

Our previous studies on FabG have identified two compounds 5-bromo-2-(thiophene-2-carboxamido) benzoic acid (A) and Et 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate(B) as best hits with allosteric mode of inhibition. FabG is an integral part of bacterial fatty acid biosynthetic system FAS II shown to be an essential gene in most ESKAPE Pathogens. The current work is focussed on lead expansion of these two hit mols. which ended up with forty-three analogs (twenty-nine analogs from lead compound A and fourteen compounds from lead compound B). The enzyme inhibition studies revealed that compound I (effective against EcFabG, AbFabG, StFabG, MtFabG1) and II (inhibiting EcFabG and StFabG) had potency of broad-spectrum inhibition on FabG panel. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 3-Bromo-2-methylbenzoic acid Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary