Tag: 200-300

Novel Selective PDE4 Inhibitors. 3. In Vivo Antiinflammatory Activity of a New Series of N-Substituted cis-Tetra- and cis-Hexahydrophthalazinones was written by Van der Mey, Margaretha;Boss, Hildegard;Hatzelmann, Armin;Van der Laan, Ivonne J.;Sterk, Geert J.;Timmerman, Hendrik. And the article was included in Journal of Medicinal Chemistry in 2002.Formula: C8H7BrO2 This article mentions the following:

The synthesis and biol. activities of a series of N-substituted cis-4a,5,6,7,8,8a-hexa- and cis-4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones I [XY = (CH₂)₂, HC:CH; R = Me, cyclopentyl, allyl, PhCOCH₂, etc.] are described. It was found that compounds bearing a cycloalkyl group at the 2-position exhibit the highest PDE4 inhibitory activities (pIC₅₀ = 8.6-9.4). The N-cycloheptyl- and N-adamantanyltetrahydrophthalazinones I (XY = HC:CH; R = cycloheptyl, 2-adamantyl) and II [R¹ = R² = Me, R¹R² = (CH₂)₄] show high in vivo antiinflammatory activities after oral application. Addnl., some phthalazinones were found to exhibit potent suppression of LPS-induced TNFα release and show moderate potency against fMLP-stimulated production of ROS. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Formula: C8H7BrO2).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Formula: C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular Charge-Transfer Interaction in a New Dyad Based on C₆₀ and Bis(4′-tert-butylbiphenyl-4-yl)aniline (BBA) Donor was written by Ohno, Toshinobu;Moriwaki, Kazuyuki;Miyata, Toshiyuki. And the article was included in Journal of Organic Chemistry in 2001.Synthetic Route of C16H17Br This article mentions the following:

A novel methanofullerene dyad based on C₆₀ and bis(4′-tert-butylbiphenyl-4-yl)aniline (BBA) has been prepared and characterized. Cyclic voltammetry (CV) and UV-vis spectra of the C₆₀-BBA methanofullerene dyad, 61-phenyl-1,2-methanofullerene[60], 1,2-methanofullerene[60], and BBA were measured and analyzed. CV measurements showed that a reversible oxidation wave of the C₆₀-BBA methanofullerene dyad was pos. shifted by 40 mV compared to that of BBA. More remarkably, comparing UV-vis spectra of the C₆₀-BBA methanofullerene dyad and 1,2-methanofullerene[60] shows a large increase in intensity for a broad band at 500 nm in the dyad despite the lack of an absorbance at >400 nm for BBA. These results indicate the presence of charge-transfer interactions in the C₆₀-BBA methanofullerene dyad between the fullerene moiety and diarylaniline moieties. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Synthetic Route of C16H17Br).

4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Synthetic Route of C16H17Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On the Scope of Trimethylaluminum-Promoted 1,2-Additions of ArZnX Reagents to Aldehydes was written by Glynn, Daniel;Shannon, Jonathan;Woodward, Simon. And the article was included in Chemistry – A European Journal in 2010.Recommanded Product: 35065-86-2 This article mentions the following:

A practical asym. 1,2-addition of functionalized arylzinc halides to aromatic and aliphatic aldehydes is described by the use of aminoalc. catalysis in the presence of AlMe₃. The process is simple to carry out, uses only com. available reagents/ligands and provides moderate to good (80-96 % ee) enantioselectivities for a wide range of substrates. Either com. ArZnX reagents or those prepared in situ from low cost aryl bromides can be used. In the latter case electrophilic functional groups are tolerated (CO₂Et, CN). The reaction relies on rapid exchange between ArZnX and AlMe₃ to generate mixed organometallic species that lead to the formation of a key intermediate that is distinctly different from the classic “anti” transition states of Noyori. NMR monitoring and related experiments have been used to probe the validity of the proposed selective transition state. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Recommanded Product: 35065-86-2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 35065-86-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of benzocarbacephem and benzocarbapemen derivatives by copper-promoted intramolecular aromatic substitution was written by Joyeau, Roger;Yadav, Lal D. S.;Wakselman, Michel. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.Product Details of 2178-24-7 This article mentions the following:

Copper-mediated cyclization of 4-[2-(o-bromophenyl)ethyl]azetidinones and 4-[o-bromophenyl)methyl]azetidinones gave benzocarbacephem and benzocarbapenem derivatives resp. Halogenation of the diastereoisomeric 2-hydroxybenzocarbacephem-4′-carboxylate (I, R = OH) afforded I (R=Cl) as racemic diastereoisomers or I (R = F) as a single racemic diastereoisomer. The free carboxylic acids of I (R = Cl, F) were inactivators of β-lactamases. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Product Details of 2178-24-7).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 2178-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hNE) inhibitors was written by Xu, Yanzhao;Qi, Na;Wen, Hui;Zhang, Gang;Wang, Yuchen;Cui, Huaqing. And the article was included in Medicinal Chemistry Research in 2021.Name: 3-Bromobenzene-1-sulfonyl fluoride This article mentions the following:

Herein we report our investigation concerning the development of Human neutrophil elastase (hNE) inhibitors for the treatment of Acute Respiratory Distress Syndrome (ARDS). Various benzenesulfonic acid derived compounds were synthesized and evaluated as competitive inhibitors of hNE. Biol. screening revealed that compound 4f shows moderate inhibitory activity (IC50 = 35.2μM) against hNE. Compound 4f was also superimposed onto the active center of hNE to understand the binding mode. In the experiment, the researchers used many compounds, for example, 3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9Name: 3-Bromobenzene-1-sulfonyl fluoride).

3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 3-Bromobenzene-1-sulfonyl fluoride

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents was written by Huang, Jian;Yuan, Yafei;Zhao, Na;Pu, Debing;Tang, Qingxuan;Zhang, Shuo;Luo, Shuchen;Yang, Xikang;Wang, Nan;Xiao, Yu;Zhang, Tuan;Liu, Zhuoyi;Sakata-Kato, Tomoyo;Jiang, Xin;Kato, Nobutaka;Yan, Nieng;Yin, Hang. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2021.Recommanded Product: N-(5-Bromopentyl)phthalimide This article mentions the following:

Artemisinin-resistant malaria parasites have emerged and have been spreading, posing a significant public health challenge. Antimalarial drugs with novel mechanisms of action are therefore urgently needed. In this report, we exploit a ‘selective starvation’ strategy by inhibiting Plasmodium falciparum hexose transporter 1 (PfHT1), the sole hexose transporter in P. falciparum, over human glucose transporter 1 (hGLUT1), providing an alternative approach to fight against multidrug-resistant malaria parasites. The crystal structure of hGLUT3, which shares 80% sequence similarity with hGLUT1, was resolved in complex with C3361, a moderate PfHT1-specific inhibitor, at 2.3-Å resolution Structural comparison between the present hGLUT3-C3361 and our previously reported PfHT1-C3361 confirmed the unique inhibitor binding-induced pocket in PfHT1. We then designed small mols. to simultaneously block the orthosteric and allosteric pockets of PfHT1. Through extensive structure-activity relationship studies, the TH-PF series was identified to selectively inhibit PfHT1 over hGLUT1 and potent against multiple strains of the blood-stage P. falciparum. Our findings shed light on the next-generation chemotherapeutics with a paradigm-shifting structure-based design strategy to simultaneously target the orthosteric and allosteric sites of a transporter. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Recommanded Product: N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Borylation of Unactivated C(sp³)-H Bonds with Bromide as a Traceless Directing Group was written by Zhang, Ge;Li, Meng-Yao;Ye, Wen-Bo;He, Zhi-Tao;Feng, Chen-Guo;Lin, Guo-Qiang. And the article was included in Organic Letters in 2021.Electric Literature of C10H11BrO2 This article mentions the following:

A Pd-catalyzed alkyl C-H borylation of aryl bromides with bromide as a traceless directing group is described, providing a convenient approach to access alkyl boronates bearing a β-all-C quaternary stereocenter. The protocol features a broad substrate scope, excellent site selectivity, and good functional group tolerance. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Electric Literature of C10H11BrO2).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C10H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-catalyzed three-component reaction of arylhydrazine hydrochloride, DABSO, and NFSI for the synthesis of arenesulfonyl fluorides was written by Pan, Qijun;Liu, Yongan;Pang, Wan;Wu, Jingjing;Ma, Xiaoyu;Hu, Xiaojun;Guo, Yong;Chen, Qing-Yun;Liu, Chao. And the article was included in Organic & Biomolecular Chemistry in 2021.Name: 3-Bromobenzene-1-sulfonyl fluoride This article mentions the following:

This paper reports a convenient copper-catalyzed three-component conversion of arylhydrazine hydrochlorides RNHNH₂.HCl (R = 4-bromophenyl, naphthalen-2-yl, quinolin-7-yl, etc.) to arenesulfonyl fluorides RS(O)₂F in good yields under mild conditions, using 1,4-diazabicyclo [2.2.2]octane bis(sulfur dioxide) (DABSO) as a sulfonyl source and N-fluorobenzenesulfonimide (NFSI) as a fluorine source based on a radical sulfur dioxide insertion and fluorination strategy. Notably, arylhydrazine hydrochloride is used as a safe precursor of aryl radicals. In the experiment, the researchers used many compounds, for example, 3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9Name: 3-Bromobenzene-1-sulfonyl fluoride).

3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 3-Bromobenzene-1-sulfonyl fluoride

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cu²⁺ ion crosslinked carboxymethylcellulose/diatomite composite beads as an efficient catalyst for CuAAC reactions was written by Zeng, Fang;Zhang, Mingjuan;Li, Yiqun. And the article was included in Polymers for Advanced Technologies in 2021.Application of 76437-44-0 This article mentions the following:

Cu²⁺-crosslinked CM-cellulose/diatomite composite beads (CuII@CMC/DE) were prepared in simple and efficient way using ionic crosslinking techniques. In CuII@CMC/DE beads, diatomite serves as a reinforcing filler, and divalent copper cation acts as crosslinking agent. The chem. structure and morphol. of as-fabricated CuII@CMC/DE beads were well characterized using various techniques such as ICP, FT-IR, XRD, SEM, EDS, elemental mapping, TEM, XPS, and TGA. The CuII@CMC/DE beads exerted superior catalytic performance in CuAAC reactions of benzyl halides, sodium azide, and alkynes to yield regioselective 1,4-disubstituted-1,2,3-triazoles in excellent yields under green conditions. In these resultant catalytic composite beads, Cu²⁺ was used not only as a crosslinking agent but also as a metal catalyst for CuAAC reaction. The composite beads can be easily separated by filter and reused at least four times without any significant decrease on its activity and selectivity. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Application of 76437-44-0).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 76437-44-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular Pd-Catalyzed Formal anti-Carboalkoxylation of Alkynes: Access to Tetrasubstituted Enol Ethers was written by Schitter, Theresa;Jones, Peter G.;Werz, Daniel B.. And the article was included in Chemistry – A European Journal in 2018.Computed Properties of C7H5Br2F This article mentions the following:

An intramol. Pd-catalyzed formal anti-carboalkoxylation reaction is presented that provides access to tetrasubstituted enol ethers. The key to success is a cascade consisting of a formal anti-carbopalladation of a carbon-carbon triple bond followed by a nucleophilic attack of a hydroxy group at the emerging vinyl organopalladium species. The desired transformation proceeded smoothly with primary, secondary, and tertiary alcs., and even with phenols. Depending on the substitution pattern of the enol ethers, a further Tsuji-Trost-type step may occur resulting in oligocyclic ketals. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Computed Properties of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary