Tag: 200-300

Silica-supported boron trifluoride (BF₃-SiO₂), an efficient, environment friendly and recyclable catalyst for the one-pot synthesis of 4(3H)-quinazolinones was written by Wu, Liqiang;Ma, Weiwei;Yang, Limin;Yan, Fulin. And the article was included in Asian Journal of Chemistry in 2010.Application In Synthesis of 3,4-Dibromoaniline This article mentions the following:

A simple and efficient synthesis of 4(3H)-quinazolinones was accomplished by the one-pot condensation of anthranilic acid, tri-Et orthoformate and primary amines under solvent-free conditions in the presence of BF₃-SiO₂. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Application In Synthesis of 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application In Synthesis of 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Expeditious synthesis of 1-aminoindane derivatives achieved by [1,4]-hydride shift mediated C(sp³)-H bond functionalization was written by Mori, Keiji;Kurihara, Kazuki;Akiyama, Takahiko. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Name: 2-Bromo-4-fluorobenzylbromide This article mentions the following:

Described herein is a [1,4]-hydride shift mediated expeditious synthesis of 1-aminoindane derivatives A wide variety of substrates could be employed in this reaction to afford various indane derivatives in good to excellent chem. yields. E.g., The desired [1,4]-hydride shift process was realized when benzylidenemalonate (I) was employed as the substrate. Upon treatment of I with 5 mol% Yb(OTf)₃ in refluxing ClCH₂CH₂Cl, the desired reaction proceeded smoothly to afford indane derivative II in a quant. yield with a short reaction time (0.5 h). Examination of the amine moiety revealed that the sterically hindered amine is the key to achieving both low catalyst loading and excellent chem. yields. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Name: 2-Bromo-4-fluorobenzylbromide).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 2-Bromo-4-fluorobenzylbromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Neighboring-group effects on the rate of metal ion catalyzed decarboxylation of dimethyloxalacetic acid was written by Claus, Kenneth G.;Rund, John V.. And the article was included in Inorganic Chemistry in 1969.Application of 22426-14-8 This article mentions the following:

Some rates of the metal ion catalyzed reaction of dimethyloxalacetic acid to give 2-oxo-3-methylbutanoic acid and CO2 are reported. The catalysts are 1:1 complexes of 2-substituted 1,10-phenanthrolines with zinc (II) and manganese (II). In the complexes, the substituents are quite close to the metal ions and could affect the reaction rate by several modes of interaction with the metal or the substrate. The principal effect in zinc complexes is the result of the electron-donating power of the substituent. For manganese complexes, steric inhibition of the approach of the substrate to the metal ion seems to be more important. Some amine substituents are examined to see whether they may be able to react directly with the substrate. The syntheses for some new phenanthroline derivatives are reported. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Application of 22426-14-8).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 22426-14-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and antibacterial activities of cadiolides A, B and C and analogues was written by Boulange, Agathe;Parraga, Javier;Galan, Abraham;Cabedo, Nuria;Leleu, Stephane;Sanz, Maria Jesus;Cortes, Diego;Franck, Xavier. And the article was included in Bioorganic & Medicinal Chemistry in 2015.Application of 108940-96-1 This article mentions the following:

A one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogs has been realized. An antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils. The synthesis of the target compounds was achieved using 6-(4-methoxyphenyl)-2,2-dimethyl-4H-1,3-dioxin-4-one derivatives and 6-(2-furanyl)-2,2-dimethyl-4H-1,3-dioxin-4-one as key intermediates. The title compounds thus formed included (5Z)-3-(4-hydroxybenzoyl)-4-(4-hydroxyphenyl)-5-[(4-hydroxyphenyl)methylene]-2(5H)-furanone derivatives, (5Z)-3-(3,5-dibromo-4-hydroxybenzoyl)-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2(5H)-furanone (i.e., cadiolide B). In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Application of 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application of 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines was written by Hunt, Thomas;Atherton-Watson, Hazel C.;Axford, Jake;Collingwood, Stephen P.;Coote, Kevin J.;Cox, Brian;Czarnecki, Sarah;Danahay, Henry;Devereux, Nick;Howsham, Catherine;Hunt, Peter;Paddock, Victoria;Paisley, Derek;Young, Alice. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Computed Properties of C10H13BrO This article mentions the following:

We report the identification of a novel series of human epithelial sodium channel (ENaC) blockers that are structurally distinct from the pyrazinoyl guanidine chemotype found in prototypical ENaC blockers such as amiloride. Following a rational design hypothesis a series of quaternary amines were prepared and evaluated for their ability to block ion transport via ENaC in human bronchial epithelial cells (HBECs). Compound 11 has an IC₅₀ of 200 nM and is efficacious in the Guinea-pig tracheal p.d. (TPD) model of ENaC blockade with an ED₅₀ of 44 μg kg^-1 at 1 h. As such, pyrazinoyl quaternary amines represent the first examples of a promising new class of human ENaC blockers. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Computed Properties of C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Computed Properties of C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A chemoselective Reformatsky-Negishi approach to α-haloaryl esters was written by Wong, Brian;Linghu, Xin;Crawford, James J.;Drobnick, Joy;Lee, Wendy;Zhang, Haiming. And the article was included in Tetrahedron in 2014.Recommanded Product: 2178-24-7 This article mentions the following:

A practical synthesis of α-haloaryl esters was achieved via a chemoselective Negishi coupling of poly-halogenated aromatics and Reformatskii reagents in the presence of catalytic Pd(dba)₂ and Xantphos. This chem. tolerates a variety of aryl halides and was successfully applied to the synthesis of Ibuprofen. The α-haloaryl ester products, exemplified by Et 2-(4-bromo-2-chlorophenyl)acetate , can be further functionalized via palladium or copper catalysis to afford an array of α-aryl esters. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Recommanded Product: 2178-24-7).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 2178-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary