Tag: 200-300

Pd/C-Catalyzed Hydrogenolysis of Dibenzodioxocin Lignin Model Compounds Using Silanes and Water as Hydrogen Source was written by Subbotina, Elena;Galkin, Maxim V.;Samec, Joseph S. M.. And the article was included in ACS Sustainable Chemistry & Engineering in 2017.Application of 14425-64-0 This article mentions the following:

A mild Pd/C-catalyzed hydrogenolysis of the C-O bond of model compounds representing the dibenzodioxocin motif in lignin using polymethylhydrosiloxane (PMHS) and water as hydrogen sources was developed. The efficiency of the reaction is highly dependent on both water concentration and the addition of a base. The results from mechanistic studies showed that the benzylic C-O bond is cleaved faster than the terminal C-O bond, which only cleaves upon the presence of the neighboring phenol. We propose a hydrogen bond formation between an oxygen atom of an ether group and a proton of a neighboring phenol under the employed mild reaction conditions, which facilitates cleavage of the C-O bond. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological activity of novel 2,5-disubstituted-1,3,4-oxadiazoles was written by Shailaja, M.;Anitha, M.;Manjula, A.;Rao, B. Vittal. And the article was included in Indian Journal of Chemistry in 2010.Electric Literature of C8H6BrFO2 This article mentions the following:

A new mol. framework of 1,3,4-oxadiazoles incorporating halopyridines was synthesized. The derivatives were synthesized starting from (pyridinyloxy)benzaldehydes, by conversion into the corresponding aroyl hydrazides followed by oxidative cyclization to the title compounds using chloramine-T. The 2,5-disubstituted 1,3,4-oxadiazoles were tested for antimicrobial activity. Many compounds showed a high degree of activity against Staphylococcus aureus and Escherichia coli at 250 μg/mL. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Electric Literature of C8H6BrFO2).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of two photolabile benzyl manganese derivatives incorporating a geometrically inaccessible radical trap was written by Keana, John F. W.;Pou, Sovitj. And the article was included in Organic Preparations and Procedures International in 1989.Quality Control of 3-(Bromomethyl)benzoic acid This article mentions the following:

Synthesis of 2 title compounds I and II are described. Oxidation of 3,5-(BrCH₂)₂C₆H₃CO₂Me with (Bu₄N)₂Cr₂O₇ in CHCl₃ gave 31% monoformylated derivative which on 2 stepwise condensations with Me₃CNHOH and NaMn(CO)₅ gave I. Chlorination of 3-BrCH₂C₆H₄CO₂H with SOCl₂ followed by 2 stepwise condensations with 2,2,6,6-tetramethyl-4-amino-1-piperidinyloxy and MeMn(CO)₅ gave II. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Quality Control of 3-(Bromomethyl)benzoic acid).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 3-(Bromomethyl)benzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Self-Healing Heterometallic Supramolecular Polymers Constructed by Hierarchical Assembly of Triply Orthogonal Interactions with Tunable Photophysical Properties was written by Zhang, Qian;Tang, Danting;Zhang, Jinjin;Ni, Ruidong;Xu, Luonan;He, Tian;Lin, Xiongjie;Li, Xiaopeng;Qiu, Huayu;Yin, Shouchun;Stang, Peter J.. And the article was included in Journal of the American Chemical Society in 2019.Application of 108940-96-1 This article mentions the following:

Here, the authors present a method for the building of new bicyclic heterometallic cross-linked supramol. polymers by hierarchical unification of three types of orthogonal noncovalent interactions, including Pt(II)-pyridine coordination-driven self-assembly, Zn-terpyridine complex, and host-guest interactions. The Pt-pyridine coordination provides the primary driving force to form discrete rhomboidal metallacycles. The assembly does not interfere with the Zn-terpyridine complexes, which link the discrete metallacycles into linear supramol. polymers, and the conjugation length is extended upon the formation of the Zn-terpyridine complexes, which red shifts the absorption and emission spectra. Finally, host-guest interactions via bis-ammonium salt binding to the benzo-21-crown-7 (B21C7) groups on the Pt acceptors afford the cross-linked supramol. polymers. By continuous increase of the concentration of the supramol. polymer to a relatively high level, supramol. polymer gel was obtained, which exhibits self-healing properties and reversible gel-sol transitions stimulated by various external stimuli, including temperature, K⁺, and cyclen. Also, the photophys. properties of the supramol. polymers could be effectively tuned by varying the substituents of the precursor ligands. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Application of 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A General Catalyst for Site-Selective C(sp³)-H Bond Amination of Activated Secondary over Tertiary Alkyl C(sp³)-H Bonds was written by Scamp, Ryan J.;Jirak, James G.;Dolan, Nicholas S.;Guzei, Ilia A.;Schomaker, Jennifer M.. And the article was included in Organic Letters in 2016.Recommanded Product: 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

The discovery of transition metal complexes capable of promoting general, catalyst-controlled and selective carbon-hydrogen (C-H) bond amination of activated secondary C-H bonds over tertiary alkyl C(sp³)-H bonds is challenging, as substrate control often dominates when reactive nitrene intermediates are involved. In this letter, we report the design of a new silver complex, [(Py₅Me₂)AgOTf]₂, that displays general and good-to-excellent selectivity for nitrene insertion into propargylic, benzylic, and allylic C-H bonds over tertiary alkyl C(sp³)-H bonds. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Recommanded Product: 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of potent, non-carbonyl inhibitors of fatty acid amide hydrolase (FAAH) was written by Gowlugari, Sumithra;DeFalco, Jeff;Nguyen, Margaret T.;Kaub, Carl;Chi, Candace;Duncton, Matthew A. J.;Emerling, Daniel E.;Kelly, Michael G.;Kincaid, John;Vincent, Fabien. And the article was included in MedChemComm in 2012.Electric Literature of C9H11BrO This article mentions the following:

Fatty acid amide hydrolase (FAAH) inhibition is a promising target for the treatment of pain, anxiety and depression. The vast majority of FAAH inhibitors contain an electrophilic moiety and are known to react covalently with the enzyme. Herein we present the discovery of potent inhibitors, such as RN-450 29, which are based upon a novel tetrahydropyridopyridine scaffold lacking an obvious electrophilic site, and which appear to inhibit FAAH in a reversible and non-covalent manner. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Electric Literature of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, Synthesis, and Structure-Activity Relationship of a Novel Series of GluN2C-Selective Potentiators was written by Zimmerman, Sommer S.;Khatri, Alpa;Garnier-Amblard, Ethel C.;Mullasseril, Praseeda;Kurtkaya, Natalie L.;Gyoneva, Stefka;Hansen, Kasper B.;Traynelis, Stephen F.;Liotta, Dennis C.. And the article was included in Journal of Medicinal Chemistry in 2014.Synthetic Route of C8H6BrFO2 This article mentions the following:

NMDA receptors are tetrameric complexes composed of GluN1 and GluN2A-D subunits that mediate a slow Ca²⁺-permeable component of excitatory synaptic transmission. NMDA receptors have been implicated in a wide range of neurol. diseases and thus represent an important therapeutic target. We herein describe a novel series of pyrrolidinones, e.g., I, that selectively potentiate only NMDA receptors that contain the GluN2C subunit. The most active analogs tested were over 100-fold selective for recombinant GluN2C-containing receptors over GluN2A/B/D-containing NMDA receptors as well as AMPA and kainate receptors. This series represents the first class of allosteric potentiators that are selective for diheteromeric GluN2C-containing NMDA receptors. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Synthetic Route of C8H6BrFO2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of aminopiperidine-based Smac mimetics as IAP antagonists was written by Hennessy, Edward J.;Saeh, Jamal C.;Sha, Li;MacIntyre, Terry;Wang, Haiyun;Larsen, Nicholas A.;Aquila, Brian M.;Ferguson, Andrew D.;Laing, Naomi M.;Omer, Charles A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Electric Literature of C9H11BrO This article mentions the following:

A series of structurally unique Smac mimetics that act as antagonists of inhibitor of apoptosis proteins (IAPs) has been discovered. While most previously described Smac mimetics contain the proline ring (or a similar cyclic motif) found in Smac, a key feature of the compounds described herein is that this ring has been removed. Despite this, compounds in this series potently bind to cIAP1 and elicit the expected phenotype of cIAP1 inhibition in cancer cells. Marked selectivity for cIAP1 over XIAP is observed for these compounds, which is attributed to a slight difference in the binding groove between the two proteins and the resulting steric interactions with the inhibitors. XIAP binding can be improved by constraining the inhibitor so that these unfavorable steric interactions are minimized. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Electric Literature of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Oxidation for unsymmetrical bromo-1,10-phenanthrolines and subsequent hydroxylation, decarbonylation and chlorination reactions was written by Peng, Yu-Xin;Hu, Bin;Huang, Wei. And the article was included in Tetrahedron in 2018.Synthetic Route of C12H7BrN2 This article mentions the following:

Systematic investigation on the oxidation of unsym. bromo-phens is presented, where the reaction temperature is found to be the key parameter to generate oxidation or oxidation-bromination products. The regioselective C3-brominated compounds are produced in moderate yields in the cases of 2-bromo-phen and 4-bromo-phen. Subsequent hydroxylation and decarbonylation for bromo-phds are also studied, where a series of bromo-diazafluorenones and phen-triones have been isolated. Furthermore, various chlorination products have been obtained by treating bromo-phds or bromo-phts with excess POCl₃. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Synthetic Route of C12H7BrN2).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C12H7BrN2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological evaluation of α-1-C-4′-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors was written by Natori, Yoshihiro;Sakuma, Toshihiro;Yoshimura, Yuichi;Kinami, Kyoko;Hirokami, Yuki;Sato, Kasumi;Adachi, Isao;Kato, Atsushi;Takahata, Hiroki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Recommanded Product: 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:

A series of α-1-C-4′-arylbutyl-L-arabinoiminofuranoses, e.g. I, with functional groups attached to the Ph ring, which are potential α-glycosidase inhibitors, was designed and synthesized by using a Negishi cross-coupling reaction as the key reaction. Arylbutyl derivatives, e.g. I, showed potent inhibitory activities against intestinal maltase. Among them, difluorophenylbutyl derivative I showed good inhibition activities against intestinal isomaltase and sucrase as compared to com. drugs. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Recommanded Product: 1-(3-Bromopropyl)-4-methoxybenzene).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 1-(3-Bromopropyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary