Tag: 200-300

Substituent effects on the mass spectra of substituted phenyl acetates was written by Gamble, A. A.;Gilbert, J. R.;Tillett, J. G.. And the article was included in Organic Mass Spectrometry in 1971.Category: bromides-buliding-blocks This article mentions the following:

The mass spectra of a series of meta- and para-substituted phenyl acetates were examined Substituent effects were correlated with Δ(AP-IP) values (AP = appearance potential; IP = ionization potential) and by using the Harrison and Chin approach. The bond-cleavage and rearrangement reactions of Ph acetates are compared with the corresponding reactions of acetanilides and the differences attributed to the degree of transmission of polar effects in the 2 systems. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Category: bromides-buliding-blocks).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and evaluation of aryl boronic acids as fluorescent artificial receptors for biological carbohydrates was written by Craig, Sandra. And the article was included in Bioorganic Chemistry in 2012.HPLC of Formula: 166821-88-1 This article mentions the following:

Carbohydrates in various forms play a vital role in numerous critical biol. processes. The detection of such saccharides can give insight into the progression of such diseases such as cancer. Boronic acids react with 1,2 and 1,3 diols of saccharides in non-aqueous or basic aqueous media. Herein, we describe the design, synthesis and evaluation of three bisboronic acid fluorescent probes, each having about ten linear steps in its synthesis. Among these compounds that were evaluated, 9b was shown to selectively label HepG2, liver carcinoma cell line within a concentration range of 0.5-10 μM in comparison to COS-7, a normal fibroblast cell line. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1HPLC of Formula: 166821-88-1).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 166821-88-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

De Novo Synthesis of Phenols and Naphthols through Oxidative Cycloaromatization of Dienynes was written by Rong, Ming-Guang;Qin, Tian-Zhu;Liu, Xin-Rui;Wang, Hong-Fa;Zi, Weiwei. And the article was included in Organic Letters in 2018.Related Products of 85118-24-7 This article mentions the following:

In this work, a rhodium-catalyzed oxidative cycloaromatization of dienynes, which provides a highly straightforward and efficient way to access polysubstituted naphthols and phenols under mild conditions, is described. Challenged electron-withdrawing groups are well tolerated in this protocol, and late-stage Ph ring formation is demonstrated. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Related Products of 85118-24-7).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 85118-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. design, synthesis, and enzymatic BACE-1 and cell assays was written by Garino, Cedrik;Tomita, Taisuke;Pietrancosta, Nicolas;Laras, Younes;Rosas, Roselyne;Herbette, Gaetan;Maigret, Bernard;Quelever, Gilles;Iwatsubo, Takeshi;Kraus, Jean-Louis. And the article was included in Journal of Medicinal Chemistry in 2006.Computed Properties of C13H14BrNO2 This article mentions the following:

Twenty novel β-secretase inhibitors containing biarylpiperazine moieties belonging to naphthyl and coumarinyl series were designed for their potential use in Alzheimer’s disease therapy. Enzymic and cell-based assays have been carried out. The biol. results clearly demonstrate that specific substituents located at the N₄-position of the piperazine ring result in excellent in vitro inhibitory potency (IC₅₀ values ranging between 40 and 70 nM). Variable temperature NMR and modeling studies are consistent with the obtained biol. data, since these studies confirmed that introduction at the N₄-position of the piperazine ring allows productive interactions within the BACE-1 active site, which appear to be determinative for high BACE-1 inhibitory activity. These results are of particular interest since some of the new analogs belonging to the naphthyl series are almost one log more active than the best inhibitor of the similar family recently reported. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Computed Properties of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of the Hammett relation to tetrasubsituted thiophenes. Kinetics of piperidino-debromination of 5-substituted 2-bromo-3-nitrothiophenes and 2-bromo-4-methyl-3-nitrothiophenes in methanol was written by Spinelli, D.;Consiglio, G.;Corrao, A.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1972.SDS of cas: 38239-45-1 This article mentions the following:

The kinetics of piperidino-debromination of six 5-substituted 2-bromo-3-nitrothiophenes and six 2-bromo-4-methyl-3-nitrothiophenes in MeOH were determined The results were correlated with σp- values (ρ = 3.21 for the trisubstituted and 3.24 for the tetrasubstituted thiophenes). In the experiment, the researchers used many compounds, for example, 5-Bromo-3-methylthiophene-2-carboxylic acid (cas: 38239-45-1SDS of cas: 38239-45-1).

5-Bromo-3-methylthiophene-2-carboxylic acid (cas: 38239-45-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. SDS of cas: 38239-45-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and anti-proliferative activity evaluation of N3-acyl-N5-aryl-3,5-diaminoindazole analogues as anti-head and neck cancer agent was written by Lee, Jinho;Kim, Jina;Hong, Victor Sukbong;Park, Jong-Wook. And the article was included in Daru, Journal of Pharmaceutical Sciences in 2014.Product Details of 1130165-74-0 This article mentions the following:

Head and neck squamous cell carcinoma (HNSCC) is the 11th leading cancer by incidence worldwide. Surgery and radiotherapy were the major treatment for patients with HNSCC while chemotherapy become an important treatment option for locally advanced HNSCC. Understanding of the mol. mechanisms underlying HNSCC impelled the development of targeted therapeutic agents. The development and combinations of targeted therapies in different cellular pathways may be needed to fulfill the unmet needs of current HNSCC chemotherapy. A series of N3-acyl-N5-aryl-3,5-diaminoindazoles were synthesized and their antiproliferative activities were evaluated against human cancer cell lines, Caki, A549, AMC-HN1, AMC-HN3, AMC-HN4, AMC-HN6, and SNU449. The cellular selectivity of compound was obtained by the modification of substituent at N5-aryl group of 3,5-diaminoindazole. The compounds 2-(4-ethoxyphenyl)-N-{5-[2-fluoro-4-(morpholine-4-carbonyl)phenylamino]-1H-indazol-3-yl}acetamide and 2-(4-ethoxyphenyl)-N-{5-[2-fluoro-4-(4-methylpiperazine-1-carbonyl)phenylamino]-1H-indazol-3-yl}acetamide showed more than 7-fold selectivity for AMC-HN4 and AMC-HN3, resp. 3-Acylamino-N-arylaminoindazole analogs were used as hits in the development of anticancer drug for HNSCC. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromo-3-fluorobenzoate (cas: 1130165-74-0Product Details of 1130165-74-0).

Ethyl 4-bromo-3-fluorobenzoate (cas: 1130165-74-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 1130165-74-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological evaluation of coumarin linked fluoroquinolones, phthalimides and naphthalimides as potential DNA gyrase inhibitors was written by Kamal, A.;Satyanarayana, M.;Devaiah, V.;Rohini, V.;Yadav, J. S.;Mullick, B.;Nagaraja, V.. And the article was included in Letters in Drug Design & Discovery in 2006.Category: bromides-buliding-blocks This article mentions the following:

A hybrid mol. synthesis strategy is employed to develop new mols. with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Category: bromides-buliding-blocks).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Highly stereoselective synthesis of aryl/heteroaryl-C-nucleosides via the merger of photoredox and nickel catalysis was written by Ma, Yingying;Liu, Shihui;Xi, Yifan;Li, Hongrui;Yang, Kai;Cheng, Zhihao;Wang, Wei;Zhang, Yongqiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Recommanded Product: 179232-29-2 This article mentions the following:

A photoredox/nickel dual-catalyzed decarboxylative cross-coupling reaction of anomeric ribosyl/deoxyribosyl acids with aryl/heteroaryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the using of cost-effective and easily handled catalysts and starting materials, which allows the highly stereoselective synthesis of diverse aryl/heteroaryl-C-nucleosides in moderate to high yields. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Recommanded Product: 179232-29-2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 179232-29-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Selective Electron Transfer Reduction of Urea-Type Carbonyls was written by Huang, Huan-Ming;Procter, David J.. And the article was included in European Journal of Organic Chemistry in 2019.Reference of 14425-64-0 This article mentions the following:

Urea-type carbonyls in barbiturates undergo a highly chemoselective electron transfer reduction upon treatment with SmI₂/H₂O/LiBr. The process involves the formation, and further reduction, of unusual ketyl-type radical anions under mild conditions. Cyclic aminal products are obtained in good to excellent yield without recourse to pre-activation of the substrate or the use of metal hydride reagents. Furthermore, varying the protic additive used in conjunction with SmI₂ allows intermediate hemiaminals to be obtained. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Reference of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Effect of intermolecular interaction on the reaction of bromination in the binary system benzene-nitrobenzene was written by Cheshko, F. F.;Novikova, L. N.;Shevchenko, O. I.. And the article was included in Zhurnal Obshchei Khimii in 1957.Synthetic Route of C10H13BrO This article mentions the following:

Bromination of a 2:5 molar mixture of C₆H₆ and PhNO₂ 4 hrs. on a steam bath with 0.3 mole Br per 0.36 mole C₆H₆ occurred rapidly and in 90 min. gave 33.1% PhBr without any Br₂C₆H₄; a kinetic curve of the reaction was shown. In CCl₄ the reaction failed to take place after 4 hrs. When the solvent was omitted, the reaction was very slow for 1.5 hrs., then proceeded at an appreciable rate and gave 10.3% PhBr in 4 hrs. The reaction in PhBr was less rapid than in PhNO₂ but more rapid than without a solvent and gave 15.3% PhBr in 4 hrs. The solvating or complexing action of PhNO₂ on C₆H₆ accounted for the activation of the reaction described above. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Synthetic Route of C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Synthetic Route of C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary