Tag: 200-300

Synthesis of 3-phenylethynylphenol. (A novel high-temperature phenyl acetylene endcapper for arylene ethers) was written by Jayaraman, S.;Srinivasan, R.;McGrath, J. E.. And the article was included in Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) in 1993.Safety of 3-Bromophenyl acetate This article mentions the following:

PhCCH was condensed with m-XC₆H₄OAc (X = Br, I) to give 3-(phenylethynyl)phenyl acetate, which was methanolyzed to provide 3-(phenylethynyl)phenol, an endcapping agent for aromatic polyethers. 3-Ethynylphenol was similarly obtained. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Safety of 3-Bromophenyl acetate).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of 3-Bromophenyl acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and gas permeation properties of poly(diarylacetylene)s having substituted and twisted biphenyl moieties was written by Hu, Yanming;Shimizu, Toshiyuki;Hattori, Kyohei;Shiotsuki, Masashi;Sanda, Fumio;Masuda, Toshio. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2010.Computed Properties of C16H17Br This article mentions the following:

Diarylacetylene monomers containing substituted biphenyl (1a-f) and anthryl (1g) groups were synthesized and then polymerized with TaCl₅-n-Bu₄Sn catalyst to produce the corresponding poly(diarylacetylene)s (2a-g). Polymers 2a-f were soluble in common organic solvents such as cyclohexane, toluene, and chloroform. According to thermogravimetric anal., the onset temperatures of weight loss of the polymers were over 400° in air, indicating considerably high thermal stability. Free-standing membranes 2a and 2c-e were prepared by the solution casting method. Desilylation of Si-containing membrane 2c was carried out with trifluoroacetic acid to afford 3c. All the polymer membranes, especially those having twisted biphenyl groups, exhibited high gas permeability; for example, their oxygen permeability (PO₂) values ranged from 130 to 1400 barriers. Membrane 2d having two chlorine atoms in the biphenyl group showed the highest gas permeability (PO₂ = 1400 barriers) among the present polymers. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Computed Properties of C16H17Br).

4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C16H17Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Polysubstituted 2-Naphthols by Palladium-Catalyzed Intramolecular Arylation/Aromatization Cascade was written by Cai, Jinhui;Wang, Zhen-Kai;Zhang, Yun-Hao;Yao, Fei;Hu, Xu-Dong;Liu, Wen-Bo. And the article was included in Advanced Synthesis & Catalysis in 2020.Reference of 61150-57-0 This article mentions the following:

A palladium-catalyzed intramol. α-arylation and defluorinative aromatization strategy for the synthesis of polysubstituted 2-naphthols, e.g., 1-(3-hydroxynaphthalen-2-yl)ethan-1-one, is reported. With ortho-bromobenzyl-substituted α-fluoroketones RCH₂C(F)(C(O)R²)C(O)R¹ (R = 2-bromophenyl, 2-bromopyridin-3-yl, 6-bromo-2H-1,3-benzodioxol-5-yl, etc., R¹ = Me, Et, Ph, R² = Et, OMe, OEt, Ot-Bu) as the substrates and palladium acetate/triphenylphosphine as the catalyst system, this method features good functional group tolerance, readily available catalyst and starting materials, and high yields. The applications of the strategy are demonstrated by the synthesis of useful building blocks, such as naphtha[2,3-b]furan, naphthol AS-D, and ligands/catalysts. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Reference of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors was written by Soliman, Beatrice;Wang, Ning;Zagotto, Giuseppe;Pockes, Steffen. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2019.Related Products of 954-81-4 This article mentions the following:

Imidazolylbutyl cyanoguanidines, such as N-cyano-N’-4-(4-imidazolyl)butyl-N”-2-(phenylthio)ethylguanidine, previously identified as highly potent agonists at the human histamine H₄ receptor (hH₄R), display certain drawbacks in pharmacokinetics, which led to the attempt to replace the heteroaromatic cycle by nonaromatic six-membered heterocycles (piperidine, morpholine, thiomorpholine, and N-methylpiperazine) as potential bioisosteres. Besides these changes, a variation of the spacer length (C₃-C₅) connecting the heterocycle and the cyanoguanidine moiety was made to possibly trigger the selectivity towards the resp. HRs. Investigations in radioligand-binding assays of the synthesized compounds I [X = CH₂, O, S, NMe; Y = CH₂, S; Z = (CH₂)_n; n = 1-3] exhibited only very weak activity at the hH₁R and hH₃R, while nearly all compounds were inactive at the hH₂R and hH₄R. In the case of piperidine-containing compounds, moderate affinities at the hH₃R over the single-digit micromolar range were detected. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Related Products of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and study of the antioxidant activity of symmetrical and unsymmetrical sulfides based on 3-[4-hydroxy(methoxy)aryl]-1-bromopropanes was written by Prosenko, A. E.;Terakh, E. I.;Gorokh, E. A.;Khomchenko, A. S.;Panferov, M. A.. And the article was included in Neftekhimiya in 2003.Category: bromides-buliding-blocks This article mentions the following:

Synthesis of structural analogs of bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl]sulfide (stabilizer SO-3) – sym. and unsym. sulfides with different number of tert-Bu ortho-substituents in the structure of phenol fragments. A comparative study of the antioxidant activity of the synthesized compounds in model reactions of the autoxidation of lard and vaseline oil was carried out. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Category: bromides-buliding-blocks).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Macrocyclic 2,2′-Bibenzimidazole Ruthenium(II) Chromophore as a Versatile Building Block for Supramolecular Devices was written by Sorsche, Dieter;Rau, Sven. And the article was included in European Journal of Inorganic Chemistry in 2014.Computed Properties of C7H7BrN2O2 This article mentions the following:

The authors present the synthesis of a macrocyclic Ru(II) complex I(PF₆)₂ that combines the versatile photophysics and supramol. chem. of biimidazole Ru(II) chromophores with a macrocyclic geometry that allows for its introduction into mech. interlocked frameworks. Structural information on the core framework was gained from a solid-state structure. The new supramol. building block shows that the principal photophysics of the Ru chromophore, i.e., the cation-driven light-switch effect, are retained during the formation of the macrocycle. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Computed Properties of C7H7BrN2O2).

2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C7H7BrN2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Direct and Efficient Total Synthesis of the Tubulin-Binding Agents Ceratamine A and B; Use of IBX for a Remarkable Heterocycle Dehydrogenation was written by Coleman, Robert S.;Campbell, Erica L.;Carper, Daniel J.. And the article was included in Organic Letters in 2009.HPLC of Formula: 108940-96-1 This article mentions the following:

The total synthesis of the tubulin-binding agents (no biol. testing data presented) ceratamines A and B I (R = Me, H, resp., R¹ = Me) was reported, along with des-Me analogs I (R = Me, H, R¹ = H), via a synthetic route that is high-yielding and operationally efficient. The synthetic route involved a Beckmann rearrangement to form an azepine ring precursor, a Knoevenagel condensation to install the benzylic side chain, and an effective imidazole annulation onto an α-aminoketone precursor with a protected S-methylisothiourea. Final dehydrogenation proved remarkably facile using IBX. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1HPLC of Formula: 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Improved Flavodoxin Inhibitors with Potential Therapeutic Effects against Helicobacter pylori Infection was written by Galano, Juan J.;Alias, Miriam;Perez, Reyes;Velazquez-Campoy, Adrian;Hoffman, Paul S.;Sancho, Javier. And the article was included in Journal of Medicinal Chemistry in 2013.Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:

A variety of electron-deficient chromenes and styrenes and nitrobenzooxadiazolyl thioethers and other compounds were tested (and in some cases prepared) as selective inhibitors of flavodoxin in Helicobacter pylori for potential use in the treatment of gastric ulcer and prevention of stomach cancer with fewer side effects and reduced susceptibilities to drug resistance; their inhibition of flavodoxin and of Helicobacter pylori and their cytotoxicities were determined For example, (E)-ArCH:CHNO₂ (Ar = 2-F-5-F₃CC₆H₃, 4-Cl-2,6-F₂C₆H₂) inhibited H. pylori with IC₅₀ values of 0.53 μM and therapeutic indexes of 38 and 15, resp. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and Radiosynthesis of Prospective 2-Nitroimidazole Hypoxia PET Tracers via Thiazolidine Ligation with 5-Fluorodeoxyribose (FDR) was written by Musolino, M.;Dall’Angelo, S.;Zanda, M.. And the article was included in SynOpen in 2017.Quality Control of N-(5-Bromopentyl)phthalimide This article mentions the following:

The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation. The resulting compounds, e.g., I were submitted to thiazolidine-ring-forming ligation reaction with the fluorinated carbohydrate L-5-fluoro-5-deoxy-ribose (FDR), affording the desired candidate PET tracers, e.g., II in variable yields. The same ligation reactions performed on L-ribose – a byproduct of [18F]FDR radiosynthesis – under conditions mimicking a radiochem. production and showed that the fluorinated adducts can be efficiently purified and isolated by HPLC. Finally, one of the prospective hypoxia tracers was successfully produced in radiolabeled form in 29.2% radiochem. yield from [18F]FDR. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Quality Control of N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Quality Control of N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Two bicyclic dinuclear complexes generated from 3,3′-[1,3,4-thiadiazole-2,5-diyldi(thiomethylene)]dibenzoic acid (L) and dimethylformamide (DMF): [Cu(L)(DMF)]₂ and [Zn(L)(DMF)]₂ was written by Wang, Ping;Ma, Jian-Ping;Li, Xiao-Yan;Huang, Ru-Qi;Dong, Yu-Bin. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2009.Category: bromides-buliding-blocks This article mentions the following:

A new 1,3,4-thiadiazole bridging ligand, 3,3′-[1,3,4-thiadiazole-2,5-diyldi(thiomethylene)]dibenzoic acid (L), was used to create the novel isomorphous complexes bis{μ-3,3′-[1,3,4-thiadiazole-2,5-diyldi(thiomethylene)]dibenzoato}bis[(DMF)copper(II)], [Cu₂(C₁₈H₁₂N₂O₄S₃)₂(C₃H₇NO)₂], (I), and bis{μ-3,3′-[1,3,4-thiadiazole-2,5-diyldi(thiomethylene)]dibenzoato}bis[(DMF)zinc(II)], [Zn₂(C₁₈H₁₂N₂O₄S₃)₂(C₃H₇NO)₂], (II). Crystallog. data are given. Both exist as centrosym. bicyclic dimers constructed through the syn-syn bidentate bridging mode of the carboxylate groups. The two rings share a metal-metal bond and each of the metal atoms possesses a square-pyramidal geometry capped by the DMF mol. The 1,3,4-thiadiazole rings play a critical role in the formation of a π-π stacking system that expands the dimensionality of the structure from zero to one. The TGA of (I) indicates decomposition of the coordinated ligands on heating. Compared with the fluorescence of L in the solid state, the fluorescence intensity of (II) is relatively enhanced with a slight red shift, while that of (I) is quenched. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Category: bromides-buliding-blocks).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary