Tag: 200-300

9,9-Dimethyl Dihydroacridine-Based Organic Photocatalyst for Atom Transfer Radical Polymerization from Modifying “Unstable” Electron Donor was written by Liu, Yiming;Chen, Qi;Tong, Yujie;Ma, Yuguo. And the article was included in Macromolecules (Washington, DC, United States) in 2020.Product Details of 162258-89-1 This article mentions the following:

Organic photocatalytic atom transfer radical polymerization (ATRP) has recently become a research highlight. Organic photocatalysts based on phenothiazine, phenoxazine and phenazine were reported and exhibited remarkable performance. All those structures contain two heteroatoms, which makes the oxidative state (i.e., the radical cation) of the photocatalysts stable enough to complete the catalytic cycle. However, despite for the similar structure, 9,9-di-Me dihydroacridine (DHA) was rarely used for constructing photocatalyst due to its unstable oxidative state. DHA is a weak electron donor that was widely applied in blue emitting thermally activated delayed fluorescence (TADF) mols. Its weaker electron donating ability will contribute to higher energy level of excited state. And also, the higher oxidation potential of its radical cation will contribute to better controllability due to fast reversible dormancy. In this study, we found that substitution on the active sites of DHA could make it stable enough to be the donor part of donor-acceptor (D-A) type photocatalyst for ATRP. Moreover, chem. modification is necessary for both stabilizing radical cation and improving the controllability in polymerization process. Further modification was made to construct rapid equilibrium between initiation and reversible dormancy, and polymerization with quant. initiator efficiencies was achieved with a polydispersity of 1.14. It is notable that such modification can probably apply to different kinds of electron donors, and various organic chromophores could thus be applied to construct organic photocatalyst with superior performance. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Product Details of 162258-89-1).

4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 162258-89-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Development of Tetrachlorophthalimides as Liver X Receptor β (LXRβ)-Selective Agonists was written by Nomura, Sayaka;Endo-Umeda, Kaori;Makishima, Makoto;Hashimoto, Yuichi;Ishikawa, Minoru. And the article was included in ChemMedChem in 2016.Recommanded Product: 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

Liver X receptor (LXR) agonists are candidates for the treatment of atherosclerosis via induction of ABCA1 (ATP-binding cassette A1) gene expression, which contributes to reverse cholesterol transport (RCT) and to cholesterol efflux from the liver and intestine. However, LXR agonists also induce genes involved in lipogenesis, such as SREBP-1c (sterol regulatory binding element protein 1c) and FAS (fatty acid synthase), thereby causing an undesirable increase in plasma and hepatic triglyceride (TG) levels. Recent studies indicate that LXRα contributes to lipogenesis in liver, and selective LXRβ activation improves RCT in mice. Therefore, LXRβ-selective agonists are promising candidates to improve atherosclerosis without increasing plasma or hepatic TG levels. However, the ligand-binding domains in the two LXR isoforms α/β share high sequence identity, and few LXR ligands show subtype selectivity. In this study the authors identified a tetrachlorophthalimide analog as an LXRβ-selective agonist. Structural development led to (E)-4,5,6,7-tetrachloro-2-(2-styrylphenyl)isoindoline-1,3-dione (I), which shows potent and selective LXRβ agonistic activity in reporter gene assays. In binding assays, compound I bound to LXRβ preferentially over LXRα. It also induced the expression of ABCA1 mRNA but not SREBP-1c mRNA in cells. Compound I appears to be a promising lead compound for therapeutic agents to treat atherosclerosis without the side effects induced by LXRα/β dual agonists. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Recommanded Product: 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Enamides by Ruthenium-Catalyzed Reaction of Alkyl Azides with Acid Anhydrides in Ionic Liquid was written by Pak, Han Kyu;Han, Junghoon;Jeon, Mina;Kim, Yongjin;Kwon, Yearang;Park, Jin Yong;Rhee, Young Ho;Park, Jaiwook. And the article was included in ChemCatChem in 2015.Product Details of 14425-64-0 This article mentions the following:

Enamides were synthesized by a ruthenium-catalyzed one-pot, one-step procedure from alkyl azides and acid anhydrides. The substrate scope includes not only secondary azides, but also primary aliphatic ones to give a wide range of enamides containing various functional groups. This one-step procedure was based on the newly discovered activity of Severin’s diruthenium complex ([CpR̂uCl₂]₂: Cp=̂η⁵-1-methoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl) for the transformation of alkyl azides into the corresponding N-H imine intermediates in ionic liquids The formation of ruthenium tetrazene complexes was observed in the stoichiometric reaction of Severin’s complex with alkyl azides, which acted as the catalyst for the formation of N-H imine intermediates. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Product Details of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Product Details of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A New TBAF Complex, Highly Stable, Facile and Selective Source for Nucleophilic Fluorination: Applications in Batch and Flow Chemistry was written by Said, Madhukar S.;Khonde, Nilesh S.;Thorat, Meghana N.;Atapalkar, Ranjit S.;Kulkarni, Amol A.;Gajbhiye, Jayant;Dastager, Syed G.. And the article was included in Asian Journal of Organic Chemistry in 2020.Product Details of 14425-64-0 This article mentions the following:

Natural polysaccharides supported tetrabutylammonium fluoride (TBAF) complexes were prepared and found to be highly stable and selective fluoride source for well-reowned nucleophilic (S_N2-type) substitution reaction for the first time. Bacterial cellulose, plant cellulose, pectin, and starch derived TBAF complexes were synthesized, characterized (using SEM, TEM, and NMR techniques) and studied for their stability and reactivity. Heterogeneous bacterial cellulose-TBAF complex (N-Bu₄(Bac-cell-OH)F) was found to be highly stable and non-hygroscopic among all complexes, which gave high yields of fluorinated products in multi-gram scale in shorter reaction time. The primarily developed batch protocol was extended to solid-solid continuous flow reaction using an inhouse built screw reactor, which furnished products in a few seconds of residence time (tR=20-25 s) and excellent yields. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Product Details of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Product Details of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer was written by Chen, Jinying;Sang, Zitai;Jiang, Youjun;Yang, Chao;He, Linhong. And the article was included in Chemical Biology & Drug Design in 2019.Related Products of 76437-44-0 This article mentions the following:

Fifty-eight quinazoline-based compounds were designed and synthesized based on the structural optimizations from the lead compound 23bb in an attempt to search for more potent dual HDAC1 and HDAC6 inhibitors. Among them, 32c (HDAC1, IC₅₀ = 31.10 ± 0.37 nM; HDAC6, IC₅₀ = 16.15 ± 0.62 nM) and 32d (HDAC1, IC₅₀ = 37.00 ± 0.24 nM; HDAC6, IC₅₀ = 35.00 ± 0.71 nM) were not only identified as potent dual-acting HDAC1 and HDAC6 inhibitors with over 10-fold selectivity to the other HDACs, but also displayed activities in tubulin acetylation and histone H₃ acetylation induction. Importantly, both of them displayed strong antiproliferative activities against various tumor cell lines in vitro with IC₅₀ values <40 nM, especially for hematol. tumors cells (U266 and RPMI8226, IC₅₀ < 1 nM), which were even better than 23bb and SAHA. Furthermore, 32c showed a significant tumor growth inhibition (antitumor rate = 63.98%, p < 0.05) in the resistant MCF-7/ADR xenograft model without any obvious body weight changes and abnormal behaviors. The authors’ findings validate that 32c is a potent dual inhibitor of HDAC1/6 that can be an efficacious treatment for breast cancer with Adriamycin resistance. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Related Products of 76437-44-0).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 76437-44-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Post-polymerization modification of a hydroxy monolith precursor. Part II. Epoxy biphenyl modified poly (hydroxyethyl methacrylate-co- pentaerythritol triacrylate) monolithic capillary columns for reversed-phase capillary electrochromatography based on π-π and hydrophobic interactions was written by Khadka, Shantipriya;Rassi, Ziad El. And the article was included in Electrophoresis in 2016.Product Details of 615-55-4 This article mentions the following:

In this second part of the series of investigations involving the post polymerization modification of a hydroxy monolith (OHM) capillary column, the surface hydroxyl groups were reacted with epoxy biphenyl thus yielding the so-called Biphenyl OHM capillary column. The modification involved the epoxy ring opening of the 2-biphenylyl glycidyl ether catalyzed by BF₃ and its subsequent reaction with the hydroxyl groups on the OHM precursor. The Biphenyl OHM capillary column thus obtained exhibited the typical reversed phase behavior by primarily hydrophobic interactions vis-a-vis the homologous series of alkyl benzenes and in addition by π-π interactions towards nitroalkane homologous series via their π-electron rich nitro groups. This dual retention mechanism was very distinctly observed with a set of polyaromatic hydrocarbon (PAH) solutes in the sense that the k values of the PAH solutes were comparable to those obtained on a more non polar stationary phase, namely the Epoxy OHM C-16 reported in the preceding article. Other aromatic solutes showed the dual retention mechanism on the Biphenyl OHM capillary including phenols, anilines derivatives and phenoxy acid herbicides. The Biphenyl OHM capillary exhibited good reproducibility from run-to-run, day-to-day and column-to-column. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Product Details of 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Separation of lanthanides and actinides using magnetic silica particles bearing covalently attached tetra-CMPO-calix[4]arenes was written by Boehmer, Volker;Dozol, Jean-Francois;Gruettner, Cordula;Liger, Karine;Matthews, Susan E.;Rudershausen, Sandra;Saadioui, Mohamed;Wang, Pingshan. And the article was included in Organic & Biomolecular Chemistry in 2004.Electric Literature of C13H14BrNO2 This article mentions the following:

Calix[4]arene tetraethers in the cone conformation bearing four -NH-CO-CH₂-P(O)Ph₂ (= CMPO) residues on their wide rim and one, two or four ω-amino alkyl residues of various lengths at the narrow rim were synthesized. Reaction with dichlorotriazinyl (DCT) functionalized magnetic particles led to complete coverage of the available surface by covalently linked CMPO-calix[4]arenes in all cases. Magnetically assisted removal of Eu(3+) and Am(3+) from acidic solutions was distinctly more efficient with these particles in comparison to analogous particles bearing the same amount of analogous single-chain CMPO-functions. The best result, an increase of the extraction efficiency by a factor of 140-160, was obtained for attachment via two Pr spacers. The selectivity Am/Eu was in the range of 1.9-2.8. No decrease of the extraction ability was observed, when the particles were repeatedly used, after simple back extraction with water. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Electric Literature of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Electric Literature of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 2,3′-spirobi[indolin]-2-ones enabled by a tandem nucleophilic benzylation/C(sp²)-N cross-coupling reaction sequence was written by Cui, Baodong;Shan, Jing;Yuan, Changlun;Han, Wenyong;Wan, Nanwei;Chen, Yongzheng. And the article was included in Organic & Biomolecular Chemistry in 2017.Product Details of 61150-57-0 This article mentions the following:

An efficient complementary strategy for the construction of spiro[pyrrolidin-3,2′-oxindole] derivatives has been described. With the sequential nucleophilic benzylation and copper-catalyzed intramol. C(sp²)-N cross-coupling reaction of 3-aminooxindoles with 2-bromobenzyl bromides, a wide range of 2,3′-spirobi[indolin]-2-ones, e.g., I (X-rays single crystal structure shown), were smoothly obtained in moderate to good yields. A plausible catalytic cycle for this tandem reaction process was proposed based on the control experiments This study represents a new perspective for the synthesis of structurally diverse spirocyclic oxindoles by employing 3-aminooxindole substrates. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Product Details of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Product Details of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Visible-Light-Enabled Decarboxylative Mono- and Difluoromethylation of Cinnamic Acids under Metal-Free Conditions was written by Tang, Wei-Ke;Feng, Yi-Si;Xu, Zhuo-Wei;Cheng, Zhi-Fei;Xu, Jun;Dai, Jian-Jun;Xu, Hua-Jian. And the article was included in Organic Letters in 2017.Electric Literature of C9H6BrFO2 This article mentions the following:

Several new mono- and difluoromethylation reactions of cinnamic acids using an Eosin Y catalytic system are reported. An efficient alkene fluoromethylation of α,β-unsaturated carboxylic acids, e.g., I, II, and III, was accomplished under ambient temperature and metal-free conditions, with a wide range of functional group tolerance. A mechanism that involves a radical process is proposed for this reaction. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1Electric Literature of C9H6BrFO2).

3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C9H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens was written by Wu, Yongqi;Wang, Bin;Lu, Haijia;Zhao, Hongyi;Yang, Beibei;Li, Li;Lu, Yu;Zhang, Dongfeng;Sun, Ning;Huang, Haihong. And the article was included in Journal of Medicinal Chemistry in 2021.Related Products of 4133-72-6 This article mentions the following:

A series of conformationally constrained novel benzo[1,3]oxazinyloxazolidinones were designed, synthesized, and evaluated on their activities against Mycobacterium tuberculosis, Gram-pos. bacteria, and Gram-neg. bacteria. The studies identified a new compound 20aa that displayed good to excellent antibacterial and antitubercular profiles against drug-resistant TB strains (MIC = 0.48-0.82μg/mL), MRSA (MIC = 0.25-0.5μg/mL), MRSE (MIC = 1μg/mL), VISA (MIC = 0.25μg/mL), and VRE (MIC = 0.25μg/mL) and some linezolid-resistant strains (MIC 1-2μg/mL). Compound 20aa was demonstrated as a promising candidate through ADME/T evaluation including microsomal stability, cytotoxicity, and inhibition of hERG and monoamine oxidase. Notably, 20aa showed excellent mouse PK profile with high plasma exposure (AUC_{0-âˆ?/sub> = 78 669 h·ng/mL), high peak plasma concentration (Cmax = 10 253 ng/mL), appropriate half-life of 3.76 h, and superior oral bioavailability (128%). The present study not only successfully provides a novel benzo[1,3]oxazinyloxazolidinone scaffold with superior druggability but also lays a good foundation for new antibacterial drug development. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-4-fluoro-2-hydroxybenzoate (cas: 4133-72-6Related Products of 4133-72-6).}

Methyl 5-bromo-4-fluoro-2-hydroxybenzoate (cas: 4133-72-6) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Related Products of 4133-72-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary