Tag: 200-300

Consequences of the nonmonotonic variation of XH frequencies with ionic character on the frequency-Hammett constant relation was written by Laurence, Christian;Berthelot, Michel. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 1978.Reference of 6515-58-8 This article mentions the following:

A nonmonotonic variation of XH stretching frequencies with ionic character is illustrated for RC₆H₄XH (X = O, CH₂O, NH, NMe, CH₂NH, and S) where m– and p-substituents are expected to affect the polarity of the XH bond. It is explained why ν(XH)-Hammett constant relations are not always linear. Attempts to make the relations linear are unsuccessful. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Reference of 6515-58-8).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Reference of 6515-58-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regiocontrolled and Stereoselective Syntheses of Tetrahydrophthalazine Derivatives using Radical Cyclizations was written by Zhang, Wei;Mo, Jia Yi;He, Weiying;Kennepohl, Pierre;Sammis, Glenn M.. And the article was included in Chemistry – A European Journal in 2019.Product Details of 653-92-9 This article mentions the following:

Tetrahydrophthalazine derivatives found important applications in pharmaceutical research, but existing synthetic methods are unable to access them regio- and stereoselectively. Here, a new approach is presented that addresses these challenges by using a 6-endo-trig radical cyclization in the key step. The desired tetrahydrophthalazines can be accessed in high yields (55-98 %) and high diastereoselectivities for the trans-product (>95:5) starting either from readily accessible hydrazones, or from the corresponding aldehydes and substituted Boc-hydrazides in a one-pot process. The synthetic versatility of the tetrahydrophthalazine core was demonstrated by its straightforward conversion to dihydro-phthalazines, phthalazines, or pyrazolo dione derivatives Furthermore, the N-N bond was reduced to afford a new route to 1,4-diamines. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Product Details of 653-92-9).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Product Details of 653-92-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Double C-H amination by consecutive SET oxidations was written by Evoniuk, Christopher J.;Hill, Sean P.;Hanson, Kenneth;Alabugin, Igor V.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Related Products of 14425-64-0 This article mentions the following:

A new method for intramol. C-H oxidative amination is based on a FeCl₃-mediated oxidative reaction of anilines with activated sp³ C-H bonds. The amino group plays multiple roles in the reaction cascade: (1) as the activating group in single-electron-transfer (SET) oxidation process, (2) as a directing group in benzylic/allylic C-H activation at a remote position, and (3) internal nucleophile trapping reactive intermediates formed from the C-H activation steps. These multielectron oxidation reactions proceed with catalytic amounts of Fe(III) and inexpensive reagents. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Related Products of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Related Products of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and evaluation of anti-microbial and analgesic activity of some (4Z)-3-methyl-1-[(2-oxo-2H-chromen-4-yl) carbonyl]-1H-pyrazole-4,5-dione substitutedphenyl) hydrazone] was written by Sivakumar, K. K.;Rajasekaran, A.;Ponnilavarasan, I.;Somasundaram, A.;Sivasakthi, R.;Kamalaveni, S.. And the article was included in Pharmacia Lettre in 2010.Application of 615-55-4 This article mentions the following:

A series of (4Z)-3-methyl-1-[(2-oxo-2H-chromen-4-yl) carbonyl]-1H-pyrazole-4,5-dione 4-[(4-substitutedphenyl)hydrazone] (5a-i) have been synthesized. All the synthesized compounds were characterized on the basis of elemental anal. and spectral data (IR, ¹HNMR). The titled compounds were screened for their anti-inflammatory and analgesic activity. Among the synthesized compounds, compound 5a, 5c, 5g and 5h exhibited significant anti-microbial activity and compound 5a, 5b, 5d, 5h, and 5i exhibited significant analgesic activity compared with the standard drug (indomethacin 5 mg/kg) at the dose level of 50 mg/kg on oral administration. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Application of 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, Synthesis, and Biological Evaluation of a Novel Class of γ-Secretase Modulators with PPARγ Activity was written by Hieke, Martina;Ness, Julia;Steri, Ramona;Dittrich, Michaela;Greiner, Christine;Werz, Oliver;Baumann, Karlheinz;Schubert-Zsilavecz, Manfred;Weggen, Sascha;Zettl, Heiko. And the article was included in Journal of Medicinal Chemistry in 2010.Name: 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

We present a novel class of dual modulators of γ-secretase and peroxisome proliferator-activated receptor γ (PPARγ) based on the structure of 2-(bis(phenethoxy)pyrimidin-2-ylthio)hexanoic acid (I, IC₅₀(Aβ42) = 22.8 μM, EC₅₀(PPARγ) = 8.3 μM). The modulation of both targets with approved drugs (i.e., amyloid-β 42 (Aβ42)-lowering NSAIDs for γ-secretase and glitazones for PPARγ) has demonstrated beneficial effects in in vitro and in vivo models of Alzheimer’s disease (AD). However, although NSAIDs and PPARγ agonists share similar structural features, no druglike compounds with dual activities as γ-secretase modulators (GSMs) and PPARγ agonists have been designed so far. On the basis of our initial lead structure I, we present the structure-activity relationships (SARs) of broad structural variations. A significant improvement was reached by the introduction of p-trifluoromethyl substituents at the Ph residues yielding compound 2-(4,6-bis(4-(trifluoromethyl)phenethoxy)pyrimidin-2-ylthio)hexanoic acid (II, IC₅₀(Aβ42) = 6.0 μM, EC₅₀(PPARγ) = 11.0 μM) and the replacement of the two Ph residues of I by cyclohexyl yielding a compound with IC₅₀(Aβ42) = 5.1 μM and EC₅₀(PPARγ) = 6.6 μM. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Name: 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Name: 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A two-photon turn-on probe for glucose uptake was written by Lim, Chang Su;Chung, Chul;Kim, Hwan Myung;An, Myung Jin;Tian, Yu Shun;Chun, Hoon Jai;Cho, Bong Rae. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2012.HPLC of Formula: 166821-88-1 This article mentions the following:

The authors report a two-photon turn-on probe (AS1) that can be excited by 780 nm femto-second pulses and visualize glucose uptake and the changes in the intracellular glucose concentration in live cells and tissue by two-photon microscopy. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1HPLC of Formula: 166821-88-1).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.HPLC of Formula: 166821-88-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular Alkene-Alkene Coupling via Rh(III)-Catalyzed Alkenyl sp² C-H Functionalization: Divergent Pathways to Indene or α-Naphthol Derivatives was written by Maraswami, Manikantha;Diggins, Thomas;Goh, Jeffrey;Tio, Raymond;Ong, Wan Qing Renee;Hirao, Hajime;Loh, Teck-Peng. And the article was included in ACS Catalysis in 2021.Electric Literature of C10H11BrO2 This article mentions the following:

Highly selective synthesis of either indene or 1-naphthol derivatives through intramol. alkene-alkene cross-coupling is reported. The reaction works with different alkene pairs that couple to give the corresponding products in good to satisfactory yields. The indene products of authors reaction also allow further derivatization. The reaction pathway is dependent on alkene functionalities. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Electric Literature of C10H11BrO2).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C10H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction was written by Tan, Wei;Jansch, Niklas;Ohlmann, Tina;Meyer-Almes, Franz-Josef;Jiang, Xuefeng. And the article was included in Organic Letters in 2019.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

An efficient and practical thiocarbonyl surrogate via combination of potassium sulfide and chloroform was established. A variety of dithiocarbamates were afforded along with four new chem. bond formations in a one-pot reaction in which the thiocarbonyl motif was generated in situ. Furthermore, these readily accessed mols. showed promising activity against HDAC8, opening a potential gateway to discover a new type of nonhydroxamate and isoenzyme-selective HDAC inhibitors. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors was written by Kuo, Gee-Hong;Prouty, Catherine;Wang, Aihua;Emanuel, Stuart;DeAngelis, Alan;Zhang, Yan;Song, Fengbin;Beall, Lawrence;Connolly, Peter J.;Karnachi, Prahba;Chen, Xin;Gruninger, Robert H.;Sechler, Jan;Fuentes-Pesquera, Angel;Middleton, Steven A.;Jolliffe, Linda;Murray, William V.. And the article was included in Journal of Medicinal Chemistry in 2005.Synthetic Route of C6H5BrN2O2 This article mentions the following:

There is much evidence that direct inhibition of the kinase activity of vascular endothelial growth factor receptor-2 (VEGFR-2) will result in the reduction of angiogenesis and the suppression of tumor growth. Palladium-catalyzed C-C bond, C-N bond formation reactions were used to assemble various pyrazine-pyridine biheteroaryls as potent VEGFR-2 inhibitors. Among them, I [R = NH(CH₂)₄OH, NH(CH₂)₂NMe₂] exhibited the highest kinase selectivity against fibroblast growth factor receptor kinase, platelet-derived growth factor receptor kinase, and glycogen synthase kinase-3. All of these compounds showed good cellular potency to inhibit VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) but with modest effects on the unstimulated growth of HUVEC. The low inhibition of these compounds to the growth of tumor cell lines, such as HeLa, HCT-116, and A375 further confirms that these VEGFR-2 inhibitors are not cytotoxic agents. The in vivo antitumor activity of I were demonstrated in the A375 human melanoma xenograft nude mice model. Mol. modeling (QSAR anal.) was conducted in an attempt to rationalize the observed structure-activity relationship. In the experiment, the researchers used many compounds, for example, 6-Amino-5-bromonicotinic acid (cas: 180340-69-6Synthetic Route of C6H5BrN2O2).

6-Amino-5-bromonicotinic acid (cas: 180340-69-6) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C6H5BrN2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lewis Acid-Catalyzed Intramolecular [3+2] Cross-Cycloaddition of Donor-Acceptor Epoxides with Alkenes for Construction of Oxa-[n.2.1] Skeletons was written by Chen, Lu;Tian, Jun;Zhan, Yizhou;Ren, Jun;Wang, Zhong-Wen. And the article was included in Chinese Journal of Chemistry in 2019.COA of Formula: C8H4BrF3O This article mentions the following:

The first LA-catalyzed [3+2] intramol. cross-cycloaddition of GDA-epoxides with carbon-carbon double bonds was developed for construction of bridged oxa-[n.2.1] skeletons I [R¹ = H, 7-F, 7-Me, etc.; R² = R³ = Me, OMe]. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7COA of Formula: C8H4BrF3O).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.COA of Formula: C8H4BrF3O

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary