Tag: 200-300

Palladium-Catalyzed Desilylative Acyloxylation of Silicon-Carbon Bonds on (Trimethylsilyl)arenes: Synthesis of Phenol Derivatives from Trimethylsilylarenes was written by Gondo, Keisuke;Oyamada, Juzo;Kitamura, Tsugio. And the article was included in Organic Letters in 2015.HPLC of Formula: 35065-86-2 This article mentions the following:

A strategy for desilylative acetoxylation of (trimethylsilyl)arenes has been developed in which (trimethylsilyl)arenes are converted into acetoxyarenes. The direct acetoxylation is performed in the presence of 5 mol % of Pd(OAc)₂ and PhI(OCOCF₃)₂ (1.5 equiv) in AcOH at 80 °C for 17 h. The acetoxyarenes are obtained in good to high yields (67-98%). The synthetic utility is demonstrated with a one-pot transformation of (trimethylsilyl)arenes to phenols by successive acetoxylation and hydrolysis. Furthermore, desilylative acyloxylation of 2-(trimethylsilyl)naphthalene using several carboxylic acids has been conducted. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2HPLC of Formula: 35065-86-2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 35065-86-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

syn-Selective alkylarylation of terminal alkynes via the combination of photoredox and nickel catalysis was written by Guo, Lei;Song, Fan;Zhu, Shengqing;Li, Huan;Chu, Lingling. And the article was included in Nature Communications in 2018.Reference of 179232-29-2 This article mentions the following:

An intermol., regio- and syn-stereoselective alkylarylation of terminal alkynes with tertiary alkyl oxalates via photoredox-Ni dual catalysis was described. This catalytic protocol, synergistically combining Ir/Ni-catalyzed alkyne difunctionalization with photoinduced alkene isomerization, afforded trisubstituted alkenes, e.g., I with excellent efficiency and syn-stereoselectivity. The mild conditions tolerated many functional groups, allowing for a broad scope with respect to terminal alkynes, aryl bromides, and alkyl oxalates. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Reference of 179232-29-2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 179232-29-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A theoretical study on vibration frequencies of some aniline derivatives and correlations with experimental data was written by Rezaei-Sameti, M.. And the article was included in Asian Journal of Chemistry in 2010.Recommanded Product: 615-55-4 This article mentions the following:

A theor. study on the vibrational frequencies of all possible isomers of some aniline derivatives C₆H_5-nX_nNH₂ (n = 1-5; X = F, Cl, Br) is reported. Calculations were done at B3LYP employing the 6-31G(d), 6-31G(d,p), 6-31++G(d,p) and 6-311++G(d,p) levels of theory. The optimized structures were used for calculation of vibrational frequencies at B3LYP/6-311++G(d,p) level of theory. The resulting data were scaled by 0.952 for N-H stretching bond and 0.981 for C-N, C-X (X = F, Cl, Br), C=C, N-H (bending) bonds. There is a good agreement between the scaled theor. frequencies and exptl. data for this type of compounds In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Recommanded Product: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Total synthesis of dictyodendrins B and E, and formal synthesis of dictyodendrin C was written by Tao, Pengyu;Liang, Jingjing;Jia, Yanxing. And the article was included in European Journal of Organic Chemistry in 2014.Product Details of 14425-64-0 This article mentions the following:

A full account of the concise total syntheses of dictyodendrins B and E, and the formal synthesis of dictyodendrin C are described. A palladium-catalyzed Larock indole synthesis was used to form the highly substituted indole core, and a palladium-mediated one-pot consecutive Buchwald-Hartwig amination/C-H activation reaction was used to construct the key pyrrolo[2,3-c]carbazole core. Unsuccessful synthetic strategies are also discussed. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Product Details of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Practical, Highly Convergent, Asymmetric Synthesis of a Selective PPARγ Modulator was written by Maligres, Peter E.;Humphrey, Guy R.;Marcoux, Jean-Francois;Hillier, Michael C.;Zhao, Dalian;Krska, Shane;Grabowski, Edward J. J.. And the article was included in Organic Process Research & Development in 2009.Related Products of 95668-20-5 This article mentions the following:

A practical, highly convergent, asym. synthesis of a selective PPARγ modulator (I) is described. The inhibitor contains two key components, a 6-trifluoromethoxy-3-acylindole (II) and (R)-α-aryloxybutanoic acid derivative (10). Two methods were developed to overcome the regioselectivity issues encountered in the preparation of the II-substituted indole. The first involved an intramol. Heck reaction of an iodoaryl enamine. The second involved application of a catalytic Meerwein arylation reaction between 2-nitro-4-trifluoromethoxyaniline and isopropenyl acetate and subsequent reductive cyclization. The α-aryloxybutanoic acid was prepared via an asym. hydrogenation of the corresponding α-aryloxy-α,β-unsaturated acid. Tetrabutylammonium iodide-catalyzed coupling of the two fragments and ester hydrolysis completed the convergent synthesis. The described convergent synthesis was used to prepare >3 kg of drug substance I in 50% overall yield and with >99.5% ee. In the experiment, the researchers used many compounds, for example, 3-Nitro-4-(trifluoromethoxy)bromobenzene (cas: 95668-20-5Related Products of 95668-20-5).

3-Nitro-4-(trifluoromethoxy)bromobenzene (cas: 95668-20-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Related Products of 95668-20-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Twisted olefinic building blocks for low bandgap polymers in solar cells and ambipolar field-effect transistors was written by Chiu, Chien-Yang;Wang, Hengbin;Phan, Hung;Shiratori, Kazuya;Nguyen, Thuc-Quyen;Hawker, Craig J.. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2016.SDS of cas: 653-92-9 This article mentions the following:

A series of polymers based on 8,8′-biindeno[2,1-b]thiophenylidene for use in photovoltaic devices and field-effect transistors are reported. These structurally twisted olefins are effective building blocks for preparation of low bandgap polymers with optical bandgaps of 1.2-1.5 eV. Device performance, such as V_oc and J_sc, in solar cell devices could be successfully modulated by incorporation of a variety of comonomers. Ambipolar properties in field-effect transistors using Au electrodes were also studied, with PtBTPDPP exhibiting balanced charge transport properties with hole and electron mobilities of 0.09 and 0.12 cm²·V^-1·s^-1, resp. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9SDS of cas: 653-92-9).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.SDS of cas: 653-92-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Conjugated or Broken: The Introduction of Isolation Spacer ahead of the Anchoring Moiety and the Improved Device Performance was written by Chai, Zhaofei;Wan, Sushu;Zhong, Cheng;Xu, Ting;Fang, Manman;Wang, Jinfeng;Xie, Yujun;Zhang, Yu;Mei, Anyi;Han, Hongwei;Peng, Qian;Li, Qianqian;Li, Zhen. And the article was included in ACS Applied Materials & Interfaces in 2016.Application In Synthesis of 2,5-Dibromo-1,3-dimethylbenzene This article mentions the following:

Acceptors in traditional dyes are generally designed closed to TiO₂ substrate to form a strong electronic coupling with each other (e.g., cyanoacrylic acid) to enhance the electron injection for the high performance of the corresponding solar cells. However, some newly developed dyes with chromophores or main acceptors isolated from anchoring groups also exhibit comparable or even higher performances. To investigate the relatively untouched electronic coupling effect in dye-sensitized solar cells, a relatively precise method is proposed in which the strength is adjusted gradually by changing isolation spacers between main acceptors and anchoring groups to partially control the electronic interaction. After an anal. of 3 different groups of 11 sensitizers, it is inferred that the electronic coupling should be kept at a suitable level to balance the electron injection and recombination. Based on a reference dye LI-81 possessing a cyanoacrylic acid as acceptor and anchoring group, both photocurrent and photovoltage are synergistically improved after the properties of isolation spacers were changed through the adjustment of the length, steric hindrance, and push-pull electronic characteristic. Accordingly, the rationally designed dye LI-87 with an isolation spacer of thiophene ethylene gives an efficiency of 8.54% and further improved to 9.07% in the presence of CDCA, showing a new way to develop efficient sensitizers. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2Application In Synthesis of 2,5-Dibromo-1,3-dimethylbenzene).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application In Synthesis of 2,5-Dibromo-1,3-dimethylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ni-Catalyzed Larock Indenone Annulation with Aliphatic- and Silyl-Substituted Alkynes Supported by Mechanistic Analysis was written by Hynds, Hannah M.;Lemons, Holli E.;Willis, Jasmine D.;Bell, MarKayla J.;Bottcher, Sydney E.;Dye, Mei Lin N.;Echols, Emily T.;Garner, Edward L.;Hutchinson, Lauren E.;Phillips, Caleb M.;Stephens, Claudia P.;Gilbert, Thomas M.;Wilger, Dale J.. And the article was included in Organometallics in 2022.Product Details of 653-92-9 This article mentions the following:

A Ni-catalyzed annulation reaction to synthesize indenones is reported. The reaction provides high yields and regioselectivities when aliphatic- and silyl-substituted alkynes are employed. Both were challenging and underused substrate classes. Several mechanistic observations aided in the development of this reaction, including that β-hydride elimination is turnover-limiting for ortho-halogenated aldehyde substrates and that alkyne dissociation is rate-limiting for internal aliphatic alkynes. The authors anticipate that these methods will be rapidly adopted due to their synthetic ease and inherent versatility. The authors also anticipate that the mechanistic conclusions will inform further reaction development. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Product Details of 653-92-9).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 653-92-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

New caffeic acid phenylethyl ester analogs bearing substituted triazole: synthesis and structure-activity relationship study towards 5-lipoxygenase inhibition was written by Roy, Pierre-Philipe;Faye, Diene;Blanchard, Sebastien;Cormier, Marc;Doiron, Jeremie A.;Surette, Marc E.;Touaibia, Mohamed. And the article was included in Journal of Chemistry in 2017.SDS of cas: 14425-64-0 This article mentions the following:

Sixteen new CAPE analogs bearing substituted triazole were synthesized by copper catalyzed Huisgen 1,3-dipolar cycloaddition Compound I (R = 4-CF₃C₆H₄) was equivalent to CAPE but clearly surpassed Zileuton, the only approved 5-LO inhibitor. Substitution of the phenethyl moiety by cyclohexylethyl, as with I (R = cyclohexyl), clearly increased 5-LO inhibition which confirms the importance of hydrophobic interactions. Mol. docking revealed new hydrogen bonds and π-π interactions between the enzyme and some of the investigated compounds In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0SDS of cas: 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.SDS of cas: 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chiral Cp-Rhodium(III)-Catalyzed Asymmetric Hydroarylations of 1,1-Disubstituted Alkenes was written by Ye, Baihua;Donets, Pavel A.;Cramer, Nicolai. And the article was included in Angewandte Chemie, International Edition in 2014.Name: Methyl 3-bromo-5-hydroxybenzoate This article mentions the following:

A metal-catalyzed functionalization at the ortho position of a directing group have become an efficient bond-forming strategy. A wide range of transformations that employ Cp*Rh^III catalysts have been described, but despite their synthetic potential, enantioselective variants that use chiral versions of the Cp* ligand remain scarce (Cp* = pentamethylcyclopentadiene). Cyclopentadiene compounds with an atropchiral biaryl backbone are shown to be suitable ligands for the efficient intramol. enantioselective hydroarylation of aryl hydroxamate derivatives Dihydrofuran derivatives that bear methyl-substituted quaternary stereocenters are thus obtained by carbon-hydrogen bond (C-H bond) functionalization under mild conditions. Under optimized conditions the synthesis of the target compounds was achieved using [(3a,4,5,6,6a-η)-(13cR)-3,7-dihydro-2,8-dimethoxy-3aH-cyclopenta[6,7]cycloocta[2,1-a:3,4-a‘]dinaphthalen-3a-yl]bis(η²-ethene)rhodium as catalyst. A chiral ligand was (13bR)-5,7-dihydro-2,8-dimethoxy-3H-cyclopenta[6,7]cycloocta[2,1-a:3,4-a’]dinaphthalene. The title compounds thus formed included a benzofuran derivative (I) and related substances, such as an indole derivative Reactants included hydroxamate derivatives, such as N-methoxy-3-[[3-[(phenylmethoxy)methyl]-2-propenyl]oxy]benzamide derivatives In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Name: Methyl 3-bromo-5-hydroxybenzoate).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Name: Methyl 3-bromo-5-hydroxybenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary