Tag: 300-400

In 2022,Meng, Shuai; Hettiarachchi, Ishani Lakshika; Bhetuwal, Bishwa Raj; Thapa, Prakash; Zhu, Jianglong published an article in Journal of Organic Chemistry. The title of the article was 《Stereoselective Synthesis of β-D-Manno-heptopyranoside via Cs2CO3-Mediated Anomeric O-Alkylation: Synthesis of a Tetrasaccharide Repeating Unit of Bacillus thermoaerophilus Surface-Layer Glycoprotein》.Formula: C19H18BrP The author mentioned the following in the article:

Stereoselective synthesis of D-glycero- and L-glycero-β-D-mannoheptosides has been achieved by cesium carbonate-mediated β-selective anomeric O-alkylation of the corresponding D-mannoheptoses. In addition, this method has been utilized in the total synthesis of a tetrasaccharide repeat unit of Bacillus thermoaerophilus surface-layer glycoprotein. The results came from multiple reactions, including the reaction of Methyltriphenylphosphonium bromide(cas: 1779-49-3Formula: C19H18BrP)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Formula: C19H18BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Hole Transport Materials Based on 6,12-Dihydroindeno[1,2-b]fluorine with Different Periphery Groups: A New Strategy for Dopant-Free Perovskite Solar Cells》 were Liu, Fan; Wu, Fei; Tu, Zongxiao; Liao, Qiuyan; Gong, Yanbin; Zhu, Linna; Li, Qianqian; Li, Zhen. And the article was published in Advanced Functional Materials in 2019. Product Details of 111865-47-5 The author mentioned the following in the article:

Although several hole-transporting materials (HTMs) have been designed to obtain perovskite solar cells (PSCs) devices with high performance, the dopant-free HTMs for efficient and stable PSCs remain rare. Herein, a rigid planar 6,12-dihydroindeno[1,2-b]fluorine (IDF) core with different numbers of bulky periphery groups to construct dopant-free HTMs of IDF-SFXPh, IDF-DiDPA, and IDF-TeDPA is modified. Thanks to the contributions of the planar IDF core and the twisted SFX periphery groups, the dopant-free IDF-SFXPh-based PSCs device achieves a device performance of 17.6%, comparable to the doped 2,2′,7,7′-tetrakis(N,N-di-p-methoxyphenylamine)-9,9′-spirobifluorene (spiro-OMeTAD)-based device (17.6%), with much enhanced device stability under glovebox and ambient conditions. In the experiment, the researchers used Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide(cas: 111865-47-5Product Details of 111865-47-5)

Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide(cas: 111865-47-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Product Details of 111865-47-5 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Determining sub-cooled liquid vapor pressures and octanol-air partition coefficients for chlorinated and brominated polycyclic aromatic hydrocarbons based on gas chromatographic retention times: Application for gas/particle partitioning in air》 was written by Vuong, Quang Tran; Thang, Phan Quang; Ohura, Takeshi; Choi, Sung-Deuk. SDS of cas: 523-27-3This research focused onvapor pressure octanol air partition coefficient PAH GCRT partitioning. The article conveys some information:

Halogenated polycyclic aromatic hydrocarbons (Halo-PAHs) are a new group of PAH derivatives and are reported to be more toxic than their parent PAHs. However, limited research has been undertaken on their physicochem. properties. In this study, subcooled liquid vapor pressures (PL) and octanol-air partition coefficients (KOA) of 24 chlorinated and 11 brominated PAHs (ClPAHs and BrPAHs) were determined using the gas chromatog. retention time (GC-RT) technique. The temperature dependences of PL and KOA for the Halo-PAHs were determined by the slopes and intercepts of the linear regressions. The GC-RT method also provided the enthalpies of vaporization (ΔHL) and internal energies of phase transfer (ΔUOA) for all interested compounds The activity of Halo-PAHs in octanol (γoct) ranging from 18 to 87, indicated the non-ideal solution behavior. The number of the chlorine atoms in the PAH rings could influence the interaction of ClPAHs with the organic matter, whereas this interaction for BrPAHs could not be studied due to the limited number of target BrPAHs. The measured values of PL and KOA were applied to investigate the gas/particle partition behaviors of Halo-PAHs in Ulsan, South Korea. This study is so far the first one to report the linear regression coefficients, which can be used to estimate the PL and KOA values of Halo-PAHs at any temperature The experimental part of the paper was very detailed, including the reaction process of 9,10-Dibromoanthracene(cas: 523-27-3SDS of cas: 523-27-3)

9,10-Dibromoanthracene(cas: 523-27-3) is a dibrominated polycyclic aromatic hydrocarbon (PAH). 9,10-Dibromoanthracene is often used as an energy acceptor and activator in reactions that produce chemiluminescence.SDS of cas: 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Luomo; Hilt, Gerhard published their research in Chemistry – A European Journal in 2021. The article was titled 《Indium Tribromide-Catalysed Transfer-Hydrogenation: Expanding the Scope of the Hydrogenation and of the Regiodivergent DH or HD Addition to Alkenes》.Recommanded Product: Indium(III) bromide The article contains the following contents:

The transfer-hydrogenation as well as the regioselective and regiodivergent addition of H-D from regiospecific deuterated dihydroarom. compounds to a variety of 1,1-di- and trisubstituted alkenes was realized with InBr3 in dichloro(m)ethane. In comparison with the previously reported BF3·Et2O-catalyzed process, electron-deficient aryl-substituents was applied reliably and thereby several restrictions would be lifted, and new types of substrates would be transformed successfully in hydrodeuterogenation as well as deuterohydrogenation transfer-hydrogenation reactions. The experimental process involved the reaction of Indium(III) bromide(cas: 13465-09-3Recommanded Product: Indium(III) bromide)

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Recommanded Product: Indium(III) bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Organic & Biomolecular Chemistry included an article by Sun, Wan; Chen, Chen; Qi, Yuan; Zhao, Jinghui; Bao, Yinwei; Zhu, Bolin. Recommanded Product: Methyltriphenylphosphonium bromide. The article was titled 《Palladium-catalyzed cascade reactions of alkene-tethered carbamoyl chlorides with N-tosyl hydrazones: synthesis of alkene-functionalized oxindoles》. The information in the text is summarized as follows:

A palladium-catalyzed cascade reaction of alkene-tethered carbamoyl chlorides 4-R-5-R1-6-R2-2-R3C(=CH2)C6HN(R4)C(O)Cl (R = H, CH3, t-Bu, OCH3, 4-F, 4-Cl, 4-NO2; R2 = H, CH3; R1R2 = -CH=CHCH=CH-; R3 = CH3, C6H5, 4-FC6H4, 4-ClC6H4, 2-FC6H4; R4 = benzyl, p-methoxybenzyl, cyclopentyl) with N-tosyl hydrazones R5HC=NNHTs (R5 = C6H5, naphthalen-1-yl, thiophen-2-yl, etc.) is described. It provided a new way to synthesize various alkene-functionalized oxindoles I bearing an all-carbon quaternary center. The olefin moieties could serve as versatile handles for further elaboration. This transformation was highly efficient and showed good functional group tolerance. After reading the article, we found that the author used Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: Methyltriphenylphosphonium bromide)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Recommanded Product: Methyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: Ethyltriphenylphosphonium bromideIn 2021 ,《Highly efficient and reversible low-concentration SO2 absorption in flue gas using novel phosphonium-based deep eutectic solvents with different substituents》 was published in Journal of Molecular Liquids. The article was written by Zhao, Yongqi; Dou, Jinxiao; Wei, Aoran; Khoshkrish, Salman; Yu, Jianglong. The article contains the following contents:

Four hydrogen bond acceptors (HBAs) with different carbon chain length substituents, including methyl-triphenyl phosphonium bromide (MTPB), ethyl-tri-Ph phosphonium bromide (ETPB), propyl-triphenyl phosphonium bromide (PTPB), and butyl-tri-Ph phosphonium bromide (BTPB), combined with ethylene glycol (EG) were developed to synthesize four low-viscosity deep eutectic solvents (DESs). In this study, the effect of different substituents in DESs on low-concentration SO2 absorption was systematically studied at 30-70°C. Exptl. results show that the EG-MTPB DES has a higher SO2 absorption capacity and a lower viscosity than other DESs. The reason for the higher SO2 absorption capacity of EG-MTPB DES was described by viscosity experiments and quantum chem. calculations It was shown that the strong polarization ability of the CH3- group promotes the absorption of SO2 by DESs. 1H NMR and FTIR results indicated that chem. interactions primarily exist between the S of SO2 and Br, and the O of SO2 and the H atom of EG form hydrogen bonds. The d. functional theory (DFT) results also confirm that the charge of the Br atom migrated to the S atom. Also, thermostability and regeneration experiments showed that the EG-MTPB DES exhibits good stability and can thus be used for industrial flue gas desulfurization. In the part of experimental materials, we found many familiar compounds, such as Ethyltriphenylphosphonium bromide(cas: 1530-32-1Name: Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Name: Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetateIn 2019 ,《Synthesis and characterization of stanozolol N-glucuronide metabolites》 was published in Monatshefte fuer Chemie. The article was written by Kratena, Nicolas; Enev, Valentin; Gmeiner, Guenter; Gaertner, Peter. The article contains the following contents:

The preparation, separation, and anal. of two regioisomeric N-glucuronides of the common doping agent stanozolol are described in this manuscript. Glucuronidation was carried out using modified Koenigs-Knorr conditions developed specifically for pyrazoles. After preparative HPLC separation both isomers could be isolated in a pure form. Global cleavage of protecting groups furnished the putative human phase II metabolites STN1 and STN2 which were compared with human excretion studies. The results came from multiple reactions, including the reaction of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Recommanded Product: (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Recommanded Product: (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C12H7Br2NIn 2022 ,《Effects of 3,6-Dibromocarbazole on Soil Health-Based on Soil Enzymes and the Biolog-ECO Test》 was published in Water, Air, & Soil Pollution. The article was written by Du, Zhongkun; Zhang, Ji; Cheng, Chao; Shi, Baihui; Zhu, Lusheng; Wang, Jun; Wang, Jinhua; Li, Bing. The article contains the following contents:

Polyhalogenated carbazoles (PHCZs) are a kind of emerging contaminants with doxin-like toxicity, potential bioaccumulation capability, and persistence. Data about the risks of PHCZs on soil ecosystem are scarce to date, although PHCZs have been detected with high concentrations in the soil. The present study performed a preliminary investigation of 3,6-dibromocarbazole (36-DBCZ, a PHCZ with a high detection rate, and concentration in the environment) at concentrations of 0.1, 1.0, 10, and 100 mg/kg on the soil health, based on soil enzyme test and Biolog-ECO assay. Results showed that 36-DBCZ could inhibit the activity and diversity of soil microbes, even at the environment-relevant concentration (0.1 mg/kg). But, the inhibition lasted only about 10 days. As time passed, slight increases in microbe activity and diversity were found in 36-DBCZ-treated groups. We hypothesized that the degradation products of 36-DBCZ provided extra nutrients to the soil microbes, which required further verification. Activities of urease, β-glucosidase, and acid phosphatase were increasingly increased, in contrast to the microbial activity. The present study provides valuable data on the effects of PHCZs on the soil ecosystem, and we suggest that the degradation of PHCZs, as well as their influences on the structure and functions of the soil microbial community, should be investigated in future studies. In the experiment, the researchers used many compounds, for example, 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Synthetic Route of C12H7Br2N)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Synthetic Route of C12H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 21085-72-3In 2021 ,《Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates》 appeared in Bioconjugate Chemistry. The author of the article were Chuprakov, Stepan; Ogunkoya, Ayodele O.; Barfield, Robyn M.; Bauzon, Maxine; Hickle, Colin; Kim, Yun Cheol; Yeo, Dominick; Zhang, Fangjiu; Rabuka, David; Drake, Penelope M.. The article conveys some information:

Although peptide motifs represent the majority of cleavable linkers used in clin.-stage antibody-drug conjugates (ADCs), the sequences are often sensitive to cleavage by extracellular enzymes, such as elastase, which leads to systemic release of the cytotoxic payload. This action reduces the therapeutic index by causing off-target toxicities that can be dose-limiting. For example, a common side-effect of ADCs made using peptide-cleavable linkers is myelosuppression, including neutropenia. Only a few reports describe methods for optimizing peptide linkers to maintain efficient and potent tumor payload delivery while enhancing circulating stability. Herein, the authors address these critical limitations through the development of a tandem-cleavage linker strategy, where two sequential enzymic cleavage events mediate payload release. The authors prepared dipeptides that are protected from degradation in the circulation by a sterically encumbering glucuronide moiety. Upon ADC internalization and lysosomal degradation, the monosaccharide is removed and the exposed dipeptide is degraded, which liberates the attached payload inside the target cell. The authors used CD79b-targeted monomethyl auristatin E (MMAE) conjugates as the model system and compared the stability, efficacy, and tolerability of ADCs made with tandem-cleavage linkers to ADCs made using standard technol. with the vedotin linker. The results, where rat studies showed dramatically improved tolerability in the hematopoietic compartment, highlight the role that linker stability plays in efficacy and tolerability and also offer a means of improving an ADC’s therapeutic index for improved patient outcomes. The experimental part of the paper was very detailed, including the reaction process of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Application of 21085-72-3)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Application of 21085-72-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wu, Lipeng; Zhang, Kaiming; Shi, Jiaoyan; Wu, Fan; Zhu, Xufei; Dong, Wei; Xie, Aming published an article in Composites, Part B: Engineering. The title of the article was 《Metal/nitrogen co-doped hollow carbon nanorods derived from self-assembly organic nanostructure for wide bandwidth electromagnetic wave absorption》.HPLC of Formula: 523-27-3 The author mentioned the following in the article:

Converting carbonaceous material into heteroatom-doped hollow nanomaterial is a promise route to realize lightweight and high-performance electromagnetic wave absorption (EMA). In this work, a series of metal/nitrogen co-doped hollow carbon nanorods (M-NHCRs, M represent as Fe, Co, Ni) were successfully fabricated via a facile self-assembly template strategy, which refers to self-assembling of 9,10-dibromoanthracene (DBA), surficial modification with polydopamine (PDA) and metal ions, and controlled pyrolysis. Among these M-NHCRs, Co-NHCR exhibits remarkable EMA performance, where the optimal reflection loss (RL) reaches -58.6 dB at a loading ratio of 5 wt%. Moreover, the effective absorption bandwidth (EAB) gets to 7.65 GHz. It is considered that the high-performance EMA should be attributed to the unique hollow structure, excellent conductance loss and improved polarization relaxation. This research not only provides a new idea for the design of lightweight electromagnetic absorbents with broadband efficient absorption, but also broadens the way of synthesizing hollow nanomaterials.9,10-Dibromoanthracene(cas: 523-27-3HPLC of Formula: 523-27-3) was used in this study.

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.HPLC of Formula: 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary