Tag: 300-400

In 2022,Zhang, Wei; Luo, Yang; Jia, Meng-Hao; Ni, Xin-Long; Tao, Zhu; Xiao, Chao-Da; Xiao, Xin published an article in Sensors and Actuators, B: Chemical. The title of the article was 《An efficient supramolecular artificial light-harvesting system based on twisted cucurbit[15]uril and cucurbit[10]uril for live cell imaging》.Electric Literature of C14H8Br2 The author mentioned the following in the article:

The construction of highly efficient artificial light-harvesting systems in aqueous solutions is still challenging. Herein, we reported a new light-harvesting system based on the supramol. combination of twisted cucurbit[15]uril (tQ[15]), cucurbit[10]uril (Q[10]), and an anthracene derivative (APy) with aggregation-induced emission (AIE) properties. The Q[n]-based linear supramol. polymer, APy@tQ[15]@Q[10], was constructed through a two-step assembly strategy. Subsequently, a highly efficient artificial light-harvesting system with relatively high antenna effect and energy transfer efficiency was successfully constructed through non-covalent interactions between Rhodamine B (RB, acceptor) and the APy@tQ[15]@Q[10] (donor). The resulting system was compatible with HeLa cells and could be used for live-cell imaging in the red channel. This supramol. assembly strategy has not only produced a highly efficient light-harvesting system but also expands the application of Q[n]s in the biomedical field. After reading the article, we found that the author used 9,10-Dibromoanthracene(cas: 523-27-3Electric Literature of C14H8Br2)

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.Electric Literature of C14H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Zhenyu; Li, Xinke; Zhao, Yu; Li, Yi; Wei, Kaiqiang; Shi, Hong; Zhang, Tianyang; Huang, Hui; Liu, Yang; Kang, Zhenhui published an article in 2021. The article was titled 《Organic Semiconductor/Carbon Dot Composites for Highly Efficient Hydrogen and Hydrogen Peroxide Coproduction from Water Photosplitting》, and you may find the article in ACS Applied Materials & Interfaces.COA of Formula: C14H8Br2 The information in the text is summarized as follows:

Coprodn. of hydrogen (H2) and hydrogen peroxide (H2O2) from water splitting is one of the most promising ways to alleviate the energy crisis and environmental pollution. Here, we first show the synthesis and photocatalytic property of an organic semiconductor (DAnTMS compound) from 9,10-dibromoanthracene and trimethylsilylacetylene. Then, a metal-free photocatalyst of a DAnTMS/carbon dot (DAnTMS/CD) composite was designed and fabricated, which achieved the efficient photocatalytic production of H2 and H2O2 without usage of any organic solvents and sacrificial agents. Under visible light, the DAnTMS/CD composite could produce H2O2 with a maximum rate of 396.7 μmol g-1 h-1 and H2 with a maximum rate of 365.0 μmol g-1 h-1 in pure water. Transient photovoltage tests showed that CDs changed the interface electron transfer kinetics and served as the active site for highly efficient H2 evolution. This work provided a deep insight into the function of CDs in regulating the catalytic property of organic photocatalysts. After reading the article, we found that the author used 9,10-Dibromoanthracene(cas: 523-27-3COA of Formula: C14H8Br2)

9,10-Dibromoanthracene(cas: 523-27-3) is a dibrominated polycyclic aromatic hydrocarbon (PAH). 9,10-Dibromoanthracene is often used as an energy acceptor and activator in reactions that produce chemiluminescence.COA of Formula: C14H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Reconfigurable Flow Platform for Automated Reagent Screening and Autonomous Optimization for Bioinspired Lignans Synthesis》 were Aka, Ehu Camille; Wimmer, Eric; Barre, Elvina; Vasudevan, Natarajan; Cortes-Borda, Daniel; Ekou, Tchirioua; Ekou, Lynda; Rodriguez-Zubiri, Mireia; Felpin, Francois-Xavier. And the article was published in Journal of Organic Chemistry in 2019. Quality Control of Ethyltriphenylphosphonium bromide The author mentioned the following in the article:

Naturally occurring benzoxanthenones, which belong to the vast family of lignans, are promising biol. relevant targets. They are biosynthetically produced by the oxidative dimerization of 2-propenyl phenols. In this manuscript, we disclose a powerful automated flow-based strategy for identifying and optimizing a cobalt-catalyzed oxidizing system for the bioinspired dimerization of 2-propenyl phenols. We designed a reconfigurable flow reactor associating online monitoring and process control instrumentation. Our machine was first configured as an automated screening platform to evaluate a matrix of 4 catalysts (plus the blank) and 5 oxidants (plus the blank) at two different temperatures, resulting in an array of 50 reactions. The automated screening was conducted on micromole scale at a rate of one fully characterized reaction every 26 min. After having identified the most promising cobalt-catalyzed oxidizing system, the automated screening platform was straightforwardly reconfigured to an autonomous self-optimizing flow reactor by implementation of an optimization algorithm in the closed-loop system. The optimization campaign allowed the determination of very effective exptl. conditions in a limited number of experiments, which allowed us to prepare the natural products carpanone and polemannone B as well as synthetic analogs. The experimental part of the paper was very detailed, including the reaction process of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Quality Control of Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Quality Control of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Guowei; Jiang, Timing; Li, Sen; Hou, Huijie; Xiao, Keke; Hu, Jingping; Liang, Sha; Liu, Bingchuan; Yang, Jiakuan published an article in 2021. The article was titled 《Occurrence and exposure risk evaluation of polyhalogenated carbazoles (PHCZs) in drinking water》, and you may find the article in Science of the Total Environment.Related Products of 6825-20-3 The information in the text is summarized as follows:

Although polyhalogenated carbazoles (PHCZs) can be generated and detected in drinking water, their occurrence and potential health risks to humans via drinking water ingestion are not well known. In this study, 11 PHCZs were screened in drinking water samples from Wuhan, the most populous city in central China. The total concentration of PHCZs could be up to 53.48 ng/L with a median level of 8.19 ng/L, which was comparable to polychlorinated biphenyls and poly- and perfluoroalkyl substances reported in the literatures for drinking water. Composition profiles revealed that 3,6-dichlorocarbazole, 3-chlorocarbazole, 3-bromocarbazole and 3,6-dibromocarbazole were the predominant PHCZ congeners in the tested samples. Regional differences in the levels and patterns of PHCZs suggested that anthropogenic releases should be the dominant source compared to natural generation. Potential health risks associated to the levels of PHCZs in drinking water were assessed using the toxic equivalent (TEQs) method. The estimated daily intake of PHCZs via drinking water ingestion is up to 0.38 pg-TEQ/kg body weight/day for infants, nearly 4.5 times higher than that for adults, and appears to reach the maximum permissible concentration set by certain authority agencies. Overall, drinking water ingestion represents an important exposure pathway for PHCZs. This is the first comprehensive study on the abundance and health risks of PHCZs in drinking water. In the experiment, the researchers used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Related Products of 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Related Products of 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Guojun; Ren, Qiqiong; Molokeev, Maxim S.; Zhou, Yayun; Zhang, Jian; Zhang, Xian-Ming published an article in 2021. The article was titled 《Unraveling the Ultrafast Self-assembly and Photoluminescence in Zero-Dimensional Mn2+-Based Halides with Narrow-Band Green Emissions》, and you may find the article in ACS Applied Electronic Materials.Application of 1530-32-1 The information in the text is summarized as follows:

The discovery of narrow-band luminescent materials remains an immense challenge to optimize the performance of white light-emitting diodes (LEDs). So far, the zero-dimensional (0D) Mn2+-based halides with near-unity narrow-band emissions have emerged as a class of promising phosphors in solid-state displays, but the related large-scale synthesis strategies have not been proposed and evaluated. Herein, we report an in situ synthetic process of 0D Mn2+-based halides and utilize (C20H20P)2MnBr4 as a case to investigate the photoluminescence characteristics and the structural essence of ultrafast self-assembly. The bright green emission peak at 523 nm with a full width at half maximum of 48 nm for (C20H20P)2MnBr4 is attributed to the d-d transition (4T1-6A1) of tetrahedrally coordinated [MnBr4]2- centers, and the fabricated white LED device shows a wide color gamut of 103.7% National Television System Committee (NTSC) standard Remarkably, the exptl. and theor. results indicate that there are hydrogen bonding of C-H···Br and weak van der Waals interactions between [C20H20P]+ and [MnBr4]2-, resulting in the root for the realization of ultrafast self-assembly in 0D Mn2+-based halides. This work reveals a feasible and general synthesis method for preparing 0D Mn2+-based halides, thereby providing a possibility for their industrial application in solid-state displays. The experimental part of the paper was very detailed, including the reaction process of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Application of 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Application of 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Leitch, Jamie A.; Smallman, Harry R.; Browne, Duncan L. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Solvent-Minimized Synthesis of 4CzIPN and Related Organic Fluorophores via Ball Milling》.COA of Formula: C12H7Br2N The article contains the following contents:

The mechanochem. synthesis of 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile and related organic fluorophores/photocatalysts via a solvent-minimized four-fold SNAr pathway is herein described. Employing sodium tert-butoxide as base, and negating the need for any air/moisture-sensitive reaction set-ups, a selection of organic dyes was synthesized in just 1 h using this ball-milling technique. Furthermore, the transformation was then showcased on a multigram scale. In addition to this study using 3,6-Dibromo-9H-carbazole, there are many other studies that have used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3COA of Formula: C12H7Br2N) was used in this study.

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.COA of Formula: C12H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Navarro, Gemma; Gonzalez, Angel; Sanchez-Morales, Adria; Casajuana-Martin, Nil; Gomez-Ventura, Marc; Cordomi, Arnau; Busque, Felix; Alibes, Ramon; Pardo, Leonardo; Franco, Rafael published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB2 Receptor Derived from the Natural Product Cannabidiol》.COA of Formula: C20H20BrP The article contains the following contents:

Cannabidiol (CBD), the second most abundant of the active compounds found in the Cannabis sativa plant, is of increasing interest because it is approved for human use and is neither euphorizing nor addictive. Here, we design and synthesize novel compounds taking into account that CBD is both a partial agonist, when it binds to the orthosteric site, and a neg. allosteric modulator, when it binds to the allosteric site of the cannabinoid CB2 receptor. Mol. dynamic simulations and site-directed mutagenesis studies have identified the allosteric site near the receptor entrance. This knowledge has permitted to perform structure-guided design of neg. and pos. allosteric modulators of the CB2 receptor with potential therapeutic utility. The experimental part of the paper was very detailed, including the reaction process of Ethyltriphenylphosphonium bromide(cas: 1530-32-1COA of Formula: C20H20BrP)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.COA of Formula: C20H20BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of 3,6-Dibromo-9H-carbazoleIn 2021 ,《Occurrence and distribution of polyhalogenated carbazoles (PHCs) in sediments from the northern South China Sea》 appeared in Science of the Total Environment. The author of the article were Zhou, Wenxiu; Chen, Weifang; Li, Peng; Gu, Zhaoyang; Peng, Jinghe; Lin, Kunde. The article conveys some information:

Polyhalogenated carbazoles (PHCs) have been frequently detected in various environments and have gained increasing attention due to their dioxin-like toxicity. In this study, 28 surface sediments and three sediment cores were collected from the northern South China Sea (SCS) to investigate the spatial and temporal distribution trends of PHCs. The total concentrations of PHCs in the surface sediments ranged from 0.25 ng/g to 3.10 ng/g, with a median concentration of 1.50 ng/g. The composition profiles of PHCs in the surface sediments were dominated by 3,6-dichlorocarbazole (36-CCZ), 3,6-dibromocarbazole (36-BCZ), and 1,3,6,8-tetrabromocarbazole (1368-BCZ). The total organic carbon (TOC) based concentrations of 36-CCZ, 1-bromo-3,6-dichlorocarbazole, 1,3,6,8-tetrachlorocarbazole, and 1368-BCZ showed significant pos. correlation with water depth (r = 0.58-0.88, p values < 0.01). On the contrary, the TOC based concentration of 2,3,6,7-tetrachlorocarbazole displayed a significant neg. correlation with the water depth (r = -0.52, p < 0.01). However, no significant correlation was observed for 3-chlorocarbazole, 36-BCZ, and 1,3,6-tribromocarbazole (p values > 0.05). PHCs in sediment cores showed that congener profiles and concentrations of PHCs remained largely stable throughout the 1890s and 2010s. In addition, all the detected PHCs displayed a significant pos. correlation with TOC content of the sediments. These unique spatial and temporal distribution patterns suggest that both terrigenous and natural marine sources contributed the observed PHCs in sediments of the northern SCS. In the experimental materials used by the author, we found 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Application In Synthesis of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Application In Synthesis of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Jiang, Ben-Jie; Zhang, Song-Lin published an article in Advanced Synthesis & Catalysis. The title of the article was 《Synthesis of Quinolines and 2-Functionalized Quinolines by Difluorocarbene Incorporation》.Computed Properties of C20H20BrP The author mentioned the following in the article:

A general method was developed to allow de novo construction of quinolines I [R = Me, cyclopropyl, Ph, etc.] and C2-functionalized quinolines II [R1 = Me, cyclopentyl, Ph; R2 = Ph, Bn, 1-naphthyl, etc.; R3 = H, Me] from ortho-alkenyl anilines in the presence of a difluorocarbene precursor. This method exploited a crucial reactivity of in-situ generation of isocyanides from condensation of primary aniline with difluorocarbene. Subsequent α-addition of isocyanide by neighboring alkenyl group constructs the quinoline ring. Furthermore, when a combination of difluorocarbene precursor and Se are present, selenoisocyanate intermediates were tentatively generated that upon nucleophilic addition by ortho-alkenyl produce 2-SeH quinolines. In the presence of a second nucleophile such as anilines, competing nucleophilic addition of anilines to the selenoisocyanate was preferred, generating selenourea intermediate. Further nucleophilic addition of the ortho-alkenyl to selenourea followed by elimination of H2Se produces 2-aminoquinolines. This allows one-step multi-component modular preparation of various C2-functionalized quinolines from readily available starting compounds This method showed good yields, scope and chemoselectivity. It was operationally convenient and friendly without manipulating unpleasant isocyanides. The difluorocarbene-enabled primary amine to isocyanide conversion may be exploited to develop other interesting reactions. In the experiment, the researchers used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Computed Properties of C20H20BrP)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Computed Properties of C20H20BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Du, Zhongkun; Hou, Kaixuan; Zhou, Tongtong; Shi, Baihui; Zhang, Cheng; Zhu, Lusheng; Li, Bing; Wang, Jinhua; Wang, Jun published an article in Science of the Total Environment. The title of the article was 《Polyhalogenated carbazoles (PHCZs) induce cardiotoxicity and behavioral changes in zebrafish at early developmental stages》.Recommanded Product: 6825-20-3 The author mentioned the following in the article:

Polyhalogenated carbazoles (PHCZs) are widely present in the environment, and their health risks are of increasing concern. Available studies primarily confirm their dioxin-like toxicity mechanism based on biomarkers, such as aryl hydrocarbon receptor (AHR) and CYP1A1, while few studies have investigated their actual toxic effects at the level of individual organisms. In the present study, the developmental toxicity of two typical PHCZs with a high detection rate and high concentration in the environment (3,6-dichlorocarbazol (3,6-DCCZ) and 3,6-dibromocarbazole (3,6-DBCZ)) was investigated based on a fish embryo acute toxicity test (FET, zebrafish) and transcriptomics anal. The 96 h LC50 values of 3,6-DCCZ and 3,6-DBCZ were 0.636 mg/L and 1.167 mg/L, resp. Both tested PHCZs reduced the zebrafish heart rate and blocked heart looping at concentrations of 0.5 mg/L or higher. The swimming/escaping behavior of zebrafish larvae was more vulnerable to 3,6-DBCZ than 3,6-DCCZ. Transcriptomics assays showed that multiple pathways linked to organ development, immunization, metabolism and protein synthesis were disturbed in PHCZ-exposed fish, which might be the internal mechanism of the adverse effects. The present study provides evidence that PHCZs cause cardiac developmental toxicity and behavioral changes and improves our understanding of their health risks. In addition to this study using 3,6-Dibromo-9H-carbazole, there are many other studies that have used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Recommanded Product: 6825-20-3) was used in this study.

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Recommanded Product: 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary