Tag: 300-400

《Zinc/Indium Bimetallic Lewis Acid Relay Catalysis for Dehydrogenative Silylation/Hydrosilylation Reaction of Terminal Alkynes with Bis(hydrosilane)s》 was written by Tani, Tomohiro; Sohma, Yudai; Tsuchimoto, Teruhisa. Reference of Indium(III) bromideThis research focused onzinc indium Lewis acid catalyst dehydrogenative silylation alkyne hydrosilane; disilanaphthalene preparation; disilaindane preparation; disilylalkene preparation; hydrosilylation intramol dehydrogenative silylation zinc indium catalyst; bismuth catalyzed Hiyama cross coupling ether formation iododesilylation. The article conveys some information:

When mixed with two different Lewis acid catalysts of Zn and In, terminal alkynes react with bis(hydrosilane)s to selectively provide 1,1-disilylalkenes from among several possible products, by way of a sequential dehydrogenative silylation/intramol. hydrosilylation reaction. Adding a pyridine base is crucial in this reaction; a switch as a catalyst of the Zn Lewis acid is turned on by forming a Zn-pyridine-base complex. A range of the 1,1-disilylalkenes can be obtained by a combination of aryl and aliphatic terminal alkynes plus aryl-, heteroaryl-, and naphthyl-tethered bis(hydrosilane)s. The 1,1-disilylalkene prepared here is available as a reagent for further transformations by using its C-Si or C:C bond. The former includes Hiyama cross-coupling, Bi-catalyzed ether formation, and iododesilylation; the latter includes double alkylation and epoxidation Mechanistic studies clarified the role of the two Lewis acids: the Zn-pyridine-base complex catalyzes the dehydrogenative silylation as a 1st stage, and, following on this, the In Lewis acid catalyzes the ring-closing hydrosilylation as a 2nd stage, thus leading to the 1,1-disilylalkene. The experimental part of the paper was very detailed, including the reaction process of Indium(III) bromide(cas: 13465-09-3Reference of Indium(III) bromide)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Reference of Indium(III) bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Passive air sampling of halogenated polycyclic aromatic hydrocarbons in the largest industrial city in Korea: Spatial distributions and source identification》 was written by Vuong, Quang Tran; Kim, Seong-Joon; Nguyen, Tuyet Nam Thi; Thang, Phan Quang; Lee, Sang-Jin; Ohura, Takeshi; Choi, Sung-Deuk. Recommanded Product: 9,10-Dibromoanthracene And the article was included in Journal of Hazardous Materials in 2020. The article conveys some information:

Some halogenated polycyclic aromatic hydrocarbons (Halo-PAHs) are known to be more toxic than their corresponding parent PAHs, but studies on Halo-PAHs have been somewhat limited. In this study, passive air samplers were used to monitor Halo-PAH and PAH contamination at 20 sampling sites in Ulsan, one of the largest industrial cities in South Korea. The mean concentrations of Σ24 ClPAHs, Σ11 BrPAHs, and Σ13 PAHs were 207 pg/m3, 84 pg/m3, and 26 ng/m3, resp. Industrial areas displayed higher concentrations of both Halo-PAHs and PAHs than urban and rural areas. Strong correlations between energetically unfavorable Halo-PAHs and their corresponding parent PAHs suggest that the main formation mechanism of Halo-PAHs is not direct halogenation of PAHs. Low mol. weight Halo-PAHs with one halogen atom and their parent PAHs were dominant. The profiles of ClPAHs and BrPAHs in petrochem., automobile, shipbuilding, and non-ferrous industrial complexes were distinguished. The toxicity equivalency quantities (TEQs) of ClPAHs, BrPAHs, and PAHs at the industrial sites also showed the highest values of 4.2, 0.5, and 18.3 pg-TEQ/m3, resp., reflecting the high toxicity of Halo-PAHs. To the best of our knowledge, this is the first study reporting atm. levels of both ClPAHs and BrPAHs using passive air samplers. The results came from multiple reactions, including the reaction of 9,10-Dibromoanthracene(cas: 523-27-3Recommanded Product: 9,10-Dibromoanthracene)

9,10-Dibromoanthracene(cas: 523-27-3) is a dibrominated polycyclic aromatic hydrocarbon (PAH). 9,10-Dibromoanthracene is often used as an energy acceptor and activator in reactions that produce chemiluminescence.Recommanded Product: 9,10-Dibromoanthracene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Off-on fluorogenic substrate harnessing ESIPT and AIE features for in situ and long-term tracking of β-glucuronidase in Escherichia coli》 was published in Sensors and Actuators, B: Chemical in 2020. These research results belong to Wei, Xianhu; Wu, Qingping; Feng, Ying; Chen, Minling; Zhang, Shuhong; Chen, Moutong; Zhang, Jumei; Yang, Guangzhu; Ding, Yu; Yang, Xiaojuan; Ye, Qinghua; Zhang, Youxiong; Gu, Qihui; Wang, Juan; Wu, Shi; Pang, Rui; Li, Ying. Quality Control of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate The article mentions the following:

Detection and isolation of both O157:H7 and non-O157:H7 Escherichia coli are essential for the evaluation and surveillance of the associated foodborne disease risk. However, the development of a chromogenic/fluorogenic culture medium for detection and isolation is challenging yet urgent. β-Glucuronidase (GUS) serves as an important biomarker in E. coli. A novel and simple off-on fluorogenic substrate (BTBP-Gluc) was developed, based on a solid-state fluorophore (BTBP) with excited-state intramol. proton transfer (ESIPT) and aggregation-induced emission (AIE) effects. BTBP-Gluc could be well-suited for visually detecting GUS activity under acidic conditions. It was successfully applied for detection of endogenous intracellular GUS activity in living E. coli and could produce the in situ and long-term localization of the target colonies and cell imaging of living E. coli. Addnl., it showed high selectivity, little toxicity, excellent cell permeability and sensitivity. BTBP-Gluc was combined with two tightly localizing chromogenic substrates, Magenta-Gal and X-Glu. These combinations were applied to the development of a new chromogenic-fluorogenic culture medium. On this new agar simultaneous visual detection and isolation of O157:H7 and non-O157:H7 E. coli with relatively high accuracy was achieved. C-F E. coli agar shows potential in serving as a simple sensitive tool for detecting and isolating O157:H7 and non-O157:H7 E. coli in food samples such as milk. In the experiment, the researchers used (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Quality Control of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Quality Control of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Photochemical degradation of polyhalogenated carbazoles in hexane by sunlight》 were Zhou, Shanshan; Pan, Xiaoxue; Tang, Qiaozhi; Zhu, Hongbin; Zhou, Jiayi; Zhao, Lu; Guo, Jiehong; Wang, Zunyao; Liu, Weiping; Li, An. And the article was published in Science of the Total Environment in 2019. Quality Control of 3,6-Dibromo-9H-carbazole The author mentioned the following in the article:

Polyhalogenated carbazoles (PHCZs) are a class of halogenated dibenzopyrrole, which have been increasingly detected in the environment and found to be bioaccumulative and potentially toxic. However, their environmental transformation potential is largely unknown. In this study, UV absorption spectra of carbazole (CZ) and 10 PHCZs were obtained with wavelength range 290-400 nm, and three peaks were identified in most cases with the highest occurring around 300 nm. Hexane solutions of CZ, 10 individual PHCZs, and a sediment extract containing nine other PHCZs were sep. irradiated under natural sunlight in order to investigate their photodegradation kinetics and pathways. The pseudo-first-order reaction rate constants (k) of these PHCZs varied from 0.183 h-1 to 2.394 h-1, and increased exponentially with increasing numbers of chlorines and bromines in PHCZ mols. Contribution to ln k from each bromine atom is more than doubling of that from each chlorine atom. Stepwise reduction debromination was confirmed to be one of the photodegradation mechanisms for both brominated and mixed halogenated (containing both bromine and chlorine) carbazoles. Only sporadic dechlorinated products were found during the photolysis of chlorinated carbazoles. By adopting a simplified kinetic approach, we estimated that dehalogenation contributed approx. 20% to 51% of the total loss of the parent PHCZs. In the experiment, the researchers used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Quality Control of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Quality Control of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Determination of carbazole and halogenated carbazoles in human serum samples using GC-MS/MS》 were Fang, Li; Qiu, Fengmei; Li, Ying; Wang, Shizhong; DeGuzman, Josephine; Wang, Jun; She, Jianwen. And the article was published in Ecotoxicology and Environmental Safety in 2019. Computed Properties of C12H7Br2N The author mentioned the following in the article:

Carbazole and halogenated carbazoles have been widely detected throughout the environment in soil, river deposits, and lake sediments. Human exposure to these compounds may occur through inhalation, drinking water, dietary intake and/or skin contact, and exposure levels in the body may be evaluated by measuring them in serum or blood. This paper reports the method development and validation for the anal. of carbazole and 11 halogenated carbazoles in human blood and/or serum samples. A small sample size of 100μL of blood or serum was employed for the anal. The samples were prepared through salting-out liquid-liquid extraction (LLE) by using hexane/ethyl acetate (4:1, volume/volume) as the extraction solvent and aqueous MgSO4 (37.5 wt%) as the salting-out regent, resp. Sample anal. was performed using gas-chromatog. (GC) coupled with a tandem mass spectrometer (MS/MS) in an electron impact (EI) mode. The developed method demonstrated low detection limits in the range of 0.02-0.27 ng/mL, intra-day accuracy ranging from 81.2% to 125%, and inter-day accuracy from 91.0% to 117%. The intra- and inter-day precisions, calculated by relative standard deviations (RSDs), were in the ranges of 1.0-16.0% and 1.8-16.4%, resp. The developed method was applied to the anal. of 50 human serum samples collected from pregnant women in Southern California in 2012. Low concentrations of carbazole were measured in 18 samples, while halogenated carbazoles were not detected in any of the samples. In the experimental materials used by the author, we found 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Computed Properties of C12H7Br2N)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Computed Properties of C12H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemistry – A European Journal included an article by Richter, Sven C.; Oestreich, Martin. Category: bromides-buliding-blocks. The article was titled 《Bioinspired Metal-Free Formal Decarbonylation of α-Branched Aliphatic Aldehydes at Ambient Temperature》. The information in the text is summarized as follows:

A sequence of a Baeyer-Villiger oxidation and a Lewis acid-promoted reduction of the resulting formate with Et3SiH enabled the metal-free formal decarbonylation of tertiary and secondary aliphatic aldehydes. The new methodol. mimics the biosynthetic decarbonylation pathway through oxidative C-C bond cleavage rather than the C(O)-H bond activation known from conventional Tsuji-Wilkinson-type reactions. The substrate scope is complementary to existing transition-metal-catalyzed protocols. In the experiment, the researchers used many compounds, for example, Ethyltriphenylphosphonium bromide(cas: 1530-32-1Category: bromides-buliding-blocks)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Environmental Science & Technology included an article by Ji, Chenyang; Shen, Chao; Zhou, Yixi; Zhu, Kongyang; Sun, Zhe; Zuo, Zhenghong; Zhao, Meirong. Related Products of 6825-20-3. The article was titled 《AhR Agonist Activity Confirmation of Polyhalogenated Carbazoles (PHCZs) Using an Integration of in Vitro, in Vivo, and in Silico Models》. The information in the text is summarized as follows:

Polyhalogenated carbazoles (PHCZs) are a kind of rising environmental pollutants that have been reported to pose high risk to human beings and natural environment. PHCZs are of a similar mol. structure with of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and exhibited some dioxin-like toxicity. Dioxin-like compounds (DLCs) are required to be banned by the Stockholm Convention due to their potential adverse impacts to the environment and public health. However, few efforts have been done towards the regulation of PHCZs. Herein, we initiated multi-models to systematically determine and validate the dioxin-like effects of PHCZs in a large scale. Transgenic zebrafish line-Tg(cyp1a-12DRE:EGFP) and stably transfected HepG2 cell line with luciferase reporter plasmids were used to screen and evaluate the aryl hydrocarbon receptor (AhR) agonist effects of the target PHCZs, which were then verified by application of mol. docking and expression levels of AhR downstream genes. Results of the two bioassays showed that most of the tested PHCZs could pose dioxin-like AhR agonist effects, change the expression levels of AhR downstream genes, and interact with AhR in accordance with TCDD. In summary, data presented here can help to guide the safe use and regulation of PHCZs. The results came from multiple reactions, including the reaction of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Related Products of 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent. And it has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Related Products of 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Lin; Zhang, Chun; Xu, Lei; Ye, Changqing; Chen, Shuoran; Wang, Xiaomei; Song, Yanlin published an article in 2021. The article was titled 《Luminescence Ratiometric Nanothermometry Regulated by Tailoring Annihilators of Triplet-Triplet Annihilation Upconversion Nanomicelles》, and you may find the article in Angewandte Chemie, International Edition.Quality Control of 9,10-Dibromoanthracene The information in the text is summarized as follows:

Triplet-triplet annihilation (TTA) upconversion is a special non-linear photophys. process that converts low-energy photons into high-energy photons based on sensitizer/annihilator pairs. Here, we constructed a novel luminescence ratiometric nanothermometer based on TTA upconversion nanomicelles by encapsulating sensitizer/annihilator mols. into a temperature-sensitive amphiphilic triblock polymer and obtained good linear relationships between the luminescence ratio (integrated intensity ratio of upconverted luminescence peak to the downshifted phosphorescence peak) and the temperature We also found chem. modification of annihilators would rule out the interference of the polymer concentration and stereochem. engineering of annihilators would readily regulate the thermal sensitivity. In addition to this study using 9,10-Dibromoanthracene, there are many other studies that have used 9,10-Dibromoanthracene(cas: 523-27-3Quality Control of 9,10-Dibromoanthracene) was used in this study.

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.Quality Control of 9,10-Dibromoanthracene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Multi-fold Sonogashira coupling: a new and convenient approach to obtain tetraalkynyl anthracenes with tunable photophysical properties》 was written by Islam, Khadimul; Narjinari, Himani; Bisarya, Akshara; Kumar, Akshai. Computed Properties of C14H8Br2 And the article was included in Organic & Biomolecular Chemistry in 2021. The article conveys some information:

For the first time, a direct single-step one-pot route to access nine new sym. tetraalkynylated anthracenes via Pd(CH3CN)2Cl2/cataCXiumA catalyzed tetra-fold Sonogashira coupling was reported. Five of these tetraalkynylated anthracenes was crystallog. characterized, with two of them exhibiting multiple interactions that significantly shorten the inter-planar distances in the solid-state structure. The rich photophys. properties exhibited by these mols. hold immense promise for future applications in sensors and optoelectronic devices. Two of the considered tetraalkynylated anthracenes comprising a D-π-A-π-D motif demonstrate solvatochromism and halochromism, with one of them showing a low bandgap of 1.79 eV. The remaining compounds demonstrate bandgaps in the range of 1.79-2.04 eV. In addition to this study using 9,10-Dibromoanthracene, there are many other studies that have used 9,10-Dibromoanthracene(cas: 523-27-3Computed Properties of C14H8Br2) was used in this study.

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.Computed Properties of C14H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization》 was written by Peng, Wan-Ling; Jhang, Yin-Jia; Chang, Chieh-Yu; Peng, Po-Kai; Zhao, Wei-Ting; Wu, Yen-Ku. SDS of cas: 1530-32-1This research focused ontotal synthesis racemic mersicarpine radical cyclization. The article conveys some information:

Described is a total synthesis of racemic mersicarpine (I)from di-Et 4-oxopimelate. The synthetic route takes advantage of a 2-indolyl radical cyclization to construct the pyrido[1,2-a]indole scaffold bearing the all-carbon quaternary stereocenter. After reading the article, we found that the author used Ethyltriphenylphosphonium bromide(cas: 1530-32-1SDS of cas: 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.SDS of cas: 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary