Tag: 300-400

Synthetic Route of C14H8Br2In 2020 ,《Switchable Conformational Isomerization of an Overcrowded Tristricyclic Aromatic Ene》 was published in Journal of Organic Chemistry. The article was written by Nishiuchi, Tomohiko; Ito, Ryuoh; Stratmann, Erik; Kubo, Takashi. The article contains the following contents:

We have prepared a new overcrowded tristricyclic aromatic ene (TAE) and investigated its external stimuli-responsive behavior for the interconversion between a closed-shell folded form and an open-shell twisted form. Upon photoirradiation, the folded form transforms into the biradical twisted form, whereas by keeping the twisted form in the dark, the reverse reaction gradually occurs at room temperature This switchable conformational change is analyzed by means of UV-Vis and ESR spectroscopies, cyclic voltammetry, d. functional theory (DFT) calculations, and kinetic studies. In the experimental materials used by the author, we found 9,10-Dibromoanthracene(cas: 523-27-3Synthetic Route of C14H8Br2)

9,10-Dibromoanthracene(cas: 523-27-3) is a dibrominated polycyclic aromatic hydrocarbon (PAH). 9,10-Dibromoanthracene is often used as an energy acceptor and activator in reactions that produce chemiluminescence.Synthetic Route of C14H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: Methyltriphenylphosphonium bromideIn 2022 ,《A Simple and Feasible Synthetic Strategy towards Poly(4-thiostyrene)》 appeared in Macromolecular Chemistry and Physics. The author of the article were Li, Jincai; Richardson, Joseph J.; Ejima, Hirotaka. The article conveys some information:

Poly(4-thiostyrene), a historically challenging to synthesize polymer, is synthesized herein via a feasible three-step protocol. Based on the newly developed protection-deprotection strategy, the precursor polymer containing thiomethyl groups is deprotected using Li/naphthalene to yield poly(4-thiostyrene) after acidification. This newly developed procedure is crucial for preventing crosslinking of the thiol groups and therefore the resulting polymer is soluble in common organic solvents (e.g., chloroform, tetrahydrofuran) and can be stored long-term, which has been challenging to accomplish over the past 60 years. The successful synthesis is confirmed by various characterization techniques including NMR, Fourier-transform IR spectroscopy, and Raman anal., which collectively are new and useful data that have generally been unavailable in previous reports. This work provides a robust approach for synthesizing this promising polymer and offers a new route to investigate thiol-containing polymers. In the experiment, the researchers used many compounds, for example, Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: Methyltriphenylphosphonium bromide)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Recommanded Product: Methyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Anselmi, Michele; Borbely, Adina; Figueras, Eduard; Michalek, Carmela; Kemker, Isabell; Gentilucci, Luca; Sewald, Norbert published an article in 2021. The article was titled 《Linker hydrophilicity modulates the anticancer activity of RGD-cryptophycin conjugates》, and you may find the article in Chemistry – A European Journal.SDS of cas: 21085-72-3 The information in the text is summarized as follows:

Most anticancer agents are hydrophobic and can easily penetrate the tumor cell membrane by passive diffusion. This may impede the development of highly effective and tumor-selective treatment options. A hydrophilic β-glucuronidase-cleavable linker was used to connect the highly potent antimitotic agent cryptophycin-55 glycinate with the αvβ3 integrin ligand c(RGDfK). Incorporation of the self-immolative linker containing glucuronic acid results in lower cytotoxicity than that of the free payload, suggesting that hydrophilic sugar linkers can preclude passive cellular uptake. In vitro drug-release studies and cytotoxicity assays demonstrated the potential of this small mol.-drug conjugate, providing guidance for the development of therapeutics containing hydrophobic anticancer drugs. The experimental part of the paper was very detailed, including the reaction process of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3SDS of cas: 21085-72-3)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.SDS of cas: 21085-72-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wei, Xianzhe; Hao, Mengjiao; Hu, Xiao-Xiao; Song, Zhiling; Wang, Yan; Sun, Ronghuan; Zhang, Jing; Yan, Mei; Ding, Biyan; Yu, Jinghua published an article in 2021. The article was titled 《A near-infrared fluorescent probe with large stokes shift for accurate detection of β-glucuronidase in living cells and mouse models》, and you may find the article in Sensors and Actuators, B: Chemical.Quality Control of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate The information in the text is summarized as follows:

β-Glucuronidase (GLU) plays a vital role in the growth, migration, angiogenesis, and metastasis of tumors. The reliable detection of GLU is an effective approach for early diagnosis of numerous disease such as cholelithiasis and colorectal cancer. In this work, a near-IR fluorescent probe (DP-GLU) with a large Stokes shift was rationally designed for accurate detection of GLU in living cells and mouse models. DP-GLU was composed of two moieties: dicyanoisophorone as NIR fluorophore and enzyme substrate as GLU recognizable group. Upon reaction with GLU, DP-GLU rapidly displayed a strong emission at 676 nm and the Stokes shift could reach 131 nm. DP-GLU also exhibited high sensitivity toward GLU, and the linearity was fitted in the concentration range of 0-100 μg/L with the detection limit as low as 1.45 x 10-2 μg/L. Furthermore, DP-GLU was used for distinguishing GLU-overexpression tumor cells from normal cells and revealed functions of noninvasive tracking GLU levels in mouse tumor models. Remarkably, DP-GLU was great potential application for cancer imaging in the early diagnoses and therapies of pathologies, which could obtain a comprehensive of the physiol. functions of GLU. The experimental process involved the reaction of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Quality Control of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Quality Control of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《One-Pot Synthesis of Dithioacetals and Diselenoacetals: An Indium-Catalyzed Reductive Insertion into Disulfides and Diselenides with Orthoesters as a Methylene Source》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Sakai, Norio; Adachi, Shunpei; Ogawa, Sho; Takahashi, Kenshiro; Ogiwara, Yohei. Synthetic Route of Br3In The article mentions the following:

A variety of dithioacetal derivatives were synthesized effectively via indium(III) catalyzed reductive insertion into either diaryl or dialkyl disulfides with orthoesters. This method was also adapted to the diselenoacetalization of diselenides. During a series of reductive insertions using this method, its noteworthy that an orthoester functions as a masked methylene moiety. The experimental process involved the reaction of Indium(III) bromide(cas: 13465-09-3Synthetic Route of Br3In)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Synthetic Route of Br3In

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Design, synthesis and biological activity evaluation of novel carbazole-benzylpiperidine hybrids as potential anti Alzheimer agents》 was published in Journal of Molecular Structure in 2020. These research results belong to Sadeghian, Batool; Sakhteman, Amirhossein; Faghih, Zeinab; Nadri, Hamid; Edraki, Najmeh; Iraji, Aida; Sadeghian, Issa; Rezaei, Zahra. SDS of cas: 6825-20-3 The article mentions the following:

In this study a series of novel carbazole-benzylpiperidine hybrids was designed, synthesized and evaluated as acetylcholinesterase and butyrylcholinesterase inhibitors. Moreover, some of these compounds were evaluated for anti β-secretase (BACE1) activity and metal chelation properties. Among the synthesized compounds, I (n = 2) (IC50 = 16.5μM for AChE and IC50 = 0.59μM for BuChE) and I (n = 3) (IC50 = 26.5μM for AChE and IC50 = 0.18μM for BuChE) showed highest inhibitory activity against acetylcholinesterase and butyrylcholinesterase. Furthermore, these compounds I (n = 2, 3) displayed interaction with Zn2+ ion and compound I (n = 3) showed moderate inhibitory activity against BACE1 (24.5% at 50μM). Kinetic and docking studies exhibited that these compounds likely acts as non-competitive inhibitors, able to interact with the catalytic active site (CAS) and peripheral anionic site (PAS) of acetylcholinesterase simultaneously. The experimental process involved the reaction of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3SDS of cas: 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent. And it has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.SDS of cas: 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Reaction of Vinyl Aziridines with Arynes: Synthesis of Benzazepines and Branched Allyl Fluorides》 was published in Chemistry – A European Journal in 2020. These research results belong to Kaldas, Sherif J.; Kran, Eva; Mueck-Lichtenfeld, Christian; Yudin, Andrei K.; Studer, Armido. Recommanded Product: 1779-49-3 The article mentions the following:

The cycloaddition between vinyl aziridines I [R1 = benzyl, cyclohexyl, (4-methoxyphenyl)methyl; R2 = H, Me; R3 = H, Me; R4 = H, Ph] and arynes R5OS(O)2Ar (R5 = 2-iodophenyl, 4-fluoro-3-iodophenyl, 2-iodo-6-methoxyphenyl, etc.; Ar = trifluoromethyl, 4-chlorophenyl, 4-fluorophenyl, 4-iodophenyl) was reported. Depending on the reaction conditions and the choice of the aryne precursor, the aziridinium intermediate can be trapped through two distinct mechanistic pathways. The first one proceeds through a formal [5+2] cycloaddition to furnish valuable multi-substituted benzazepines II (R6 = H, 6-OMe, 6,8-(CH3)2, 6-F, etc.). In the second pathway, the aziridinium is intercepted by a fluoride ion to afford allylic fluorides R7N(R8)CH(R9)CH(F)C(=CH2)R10 (R7 = Ph, 3-methoxyphenyl, 3,4-difluorophenyl, etc.; R8 = benzyl, cyclohexyl, (4-methoxyphenyl)methyl; R9 = H, Me; R10 = H, Me) in good yields. Both reactions proceed stereospecifically and furnish enantiopure benzazepines II and allylic fluorides. After reading the article, we found that the author used Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Recommanded Product: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Side-Chain Polymers as Dopant-Free Hole-Transporting Materials for Perovskite Solar Cells-The Impact of Substituents’ Positions in Carbazole on Device Performance》 were Wu, Jianchang; Liu, Chang; Li, Bo; Gu, Fenglong; Zhang, Luozheng; Hu, Manman; Deng, Xiang; Qiao, Yuan; Mao, Yongyun; Tan, Wenchang; Tian, Yanqing; Xu, Baomin. And the article was published in ACS Applied Materials & Interfaces in 2019. Synthetic Route of C12H7Br2N The author mentioned the following in the article:

Side-chain polymers have the potential to be excellent dopant-free hole-transporting materials (HTMs) for perovskite solar cells (PSCs) because of their unique characteristics, such as tunable energy levels, high charge mobility, good solubility, and excellent film-forming ability. However, there has been less research focusing on side-chain polymers for PSCs. Here, two side-chain polystyrenes with triphenylamine substituents on carbazole moieties were designed and characterized. The properties of the side-chain polymers were tuned finely, including the photophys. and electrochem. properties and charge mobilities, by changing the positions of triphenylamine substituents on carbazole. Owing to the higher mobility and charge extraction ability, the polymer P2 with the triphenylamine substituent on the 3,6-positions of the carbazole unit showed higher performance with power conversion efficiency (PCE) of 18.45%, which was much higher than the PCE (16.78%) of P1 with 2,7-positions substituted. These results clearly demonstrated that side-chain polymers can act as promising HTMs for PSC applications and the performance of side-chain polymers could be optimized by carefully tuning the structure of the monomer, which provides a new strategy to design new kinds of side-chain polymers and obtain high-performance dopant-free HTMs. The experimental part of the paper was very detailed, including the reaction process of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Synthetic Route of C12H7Br2N)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Synthetic Route of C12H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Selective synthesis of N-protected exo-spiro[oxirane-3,2′-tropanes]》 were Mandzhulo, Aleksandr; Vashchenko, Iryna; Gerasov, Andrii; Vovk, Mykhaylo; Rusanov, Eduard; Fetyukhin, Volodymyr; Lukin, Oleg; Shivanyuk, Alexander. And the article was published in Organic Chemistry Frontiers in 2019. HPLC of Formula: 1779-49-3 The author mentioned the following in the article:

N-Cbz- and N-Boc-protected exo-spiro[oxirane-3,2′-tropanes] were obtained in 62-75% yield via either epoxidation or hydroxybromination/dehydrobromination of the corresponding alkenes. Deprotection of the Cbz-exo-epoxide afforded the corresponding tropane containing an exo-oxirane fragment and a secondary amino group. In the experimental materials used by the author, we found Methyltriphenylphosphonium bromide(cas: 1779-49-3HPLC of Formula: 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis. And it is used widely for methylenation via the Wittig reaction.HPLC of Formula: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of Br3InIn 2021 ,《Indium-Catalyzed Deoxygenation of Sulfoxides with Hydrosilanes》 was published in Asian Journal of Organic Chemistry. The article was written by Sakai, Norio; Shimada, Retsu; Ogiwara, Yohei. The article contains the following contents:

Described herein was that a novel InBr3/PhSiH3 reducing system in a 1,4-dioxane solution smoothly and effectively undertook deoxygenation of a variety of sulfoxides led to the facile preparation of sulfide derivatives R1SR2 [R1 = Ph, cyclohexyl, n-Bu, etc.; R2 = Ph, Me, Bn, etc.; R1R2 = (CH2)4]. Also, it was demonstrated that the reducing system showed a higher reactivity toward sulfoxides than that toward commonly reducible functional groups, such as carboxylic acids, esters, amides and sulfones. The experimental part of the paper was very detailed, including the reaction process of Indium(III) bromide(cas: 13465-09-3Electric Literature of Br3In)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Electric Literature of Br3In

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary