Tag: 300-400

Hou, Chao-Ping; Chen, Xin-Lun; Huang, Zhi-Jian; Lei, Yang; Xiao, Li-Min; Huang, Jian-Feng; Li, Shao-Yong; Liu, Jun-Min published an article in 2021. The article was titled 《Robust Heterogeneous Photocatalyst for Visible-Light-Driven Hydrogen Evolution Promotion: Immobilization of a Fluorescein Dye-Encapsulated Metal-Organic Cage on TiO2》, and you may find the article in ACS Applied Materials & Interfaces.SDS of cas: 6825-20-3 The information in the text is summarized as follows:

The design of artificial photocatalytic devices that simulates the ingenious and efficient photosynthetic systems in nature is promising. Herein, a metal-organic cage [Pd6(NPyCzPF)12]12+ (MOC-PC6) integrating 12 organic ligands NPyCzBP and 6 Pd2+ catalytic centers is designed, which is well defined to include organic dye fluorescein (FL) for constructing a supramol. photochem. mol. device (SPMD) FL@MOC-PC6. Photoinduced electron transfer (PET) between MOC-PC6 and the encapsulated FL has been observed by steady-state and time-resolved emission spectroscopy. FL@MOC-PC6 is successfully heterogenized with TiO2 by a facile sol-gel method to achieve a robust heterogeneous FL@MOC-PC6-TiO2. The close proximity between the Pd2+ catalytic site and FL included in the cage enables PET from the photoexcited FL to Pd2+ sites through a powerful intramol. pathway. The photocatalytic hydrogen production assessments of the optimized 4 wt % FL@MOC-PC6-TiO2 demonstrate an initial H2 production rate of 2402 μmol g-1 h-1 and a turnover number of 4356 within 40 h, enhanced by 15-fold over that of a homogeneous FL@MOC-PC6. The effect of the MOC content on photocatalytic H2 evolution (PHE) is investigated and the inefficient comparison systems, such as MOC-PC6, MOC-PC6-TiO2, FL-sensitized MOC-PC6/FL-TiO2, and analog FL/MOC-PC6-TiO2 with free FL, are evaluated. This study provides a creative and distinctive approach for the design and preparation of novel heterogeneous SPMD catalysts based on MOCs. In the experiment, the researchers used many compounds, for example, 3,6-Dibromo-9H-carbazole(cas: 6825-20-3SDS of cas: 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.SDS of cas: 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Total Synthesis of Viridin and Viridiol》 was written by Ji, Yang; Xin, Zhengyuan; He, Haibing; Gao, Shuanhu. Electric Literature of C19H18BrPThis research focused onviridin viridiol total asym synthesis cycloaddition radical cyclization. The article conveys some information:

The asym. total syntheses of (-)-viridin (I) and (-)-viridiol (II), antifungal metabolites, were achieved in 17 and 18 steps, resp., from a com. available starting material. An intramol. [3+2]-cycloaddition was applied to an easily available L-ribose derivative in order to construct the highly substituted D ring containing the key chiral cis-triol fragment. Co-catalyzed metal-hydride H atom transfer (MHAT) radical cyclization was utilized to form the C-ring and the all-carbon quaternary center at C-10. This convergent strategy provides a scalable approach to prepare viridin and viridiol for biol. studies. In the experiment, the researchers used Methyltriphenylphosphonium bromide(cas: 1779-49-3Electric Literature of C19H18BrP)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Electric Literature of C19H18BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C19H18BrPIn 2020 ,《Fitting of experimental viscosity to temperature data for deep eutectic solvents》 was published in Journal of Molecular Liquids. The article was written by Al-Dawsari, Jiyad N.; Bessadok-Jemai, Abdelbasset; Wazeer, Irfan; Mokraoui, Salim; AlMansour, Muath A.; Hadj-Kali, Mohamed K.. The article contains the following contents:

Seven new deep eutectic solvents based on tetrabutylammonium bromide and tetraethylammonium p-toluene sulfonate were prepared and their viscosity determined between 298.15 and 323.15 K. The effect of temperature was modeled using an appropriate fitting procedure, proposed in this work, with a coefficient of determination R2 > 0.99 for all DES. The fitting procedure used of pre-existing exptl. data in which 70 DESs were collected from the literature and refined on the basis of R2 and root mean square error (RMSE); ∼10% of the data was rejected. Furthermore, about half of the refined data was fitted with a three-parameter Vogel-Fulcher-Tammann (VFT) equation with an R2 higher than 0.99. The remaining data were more adequately fitted with a two-parameter Arrhenius equation. The adjusted parameters of both models for 62 DESs were determined to estimate the viscosity. Based on R2, the VFT model was more accurate than the Arrhenius model. Moreover, addnl. in-lab experiments were performed for model validation at six temperatures In some cases, the exptl. measurements were different from those in the literature with an R2 below 0.95 indicating a large scatter in the viscosity data. Most of the highly viscous DESs considered in this study showed a rapid decay when temperature increases. Hence, the limitation of using these solvents for applications such as absorption could be overcome by operating at slightly higher temperature (i.e., 313.15 to 333.15 K). After reading the article, we found that the author used Methyltriphenylphosphonium bromide(cas: 1779-49-3Computed Properties of C19H18BrP)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Computed Properties of C19H18BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2021 ,《Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid》 was published in European Journal of Medicinal Chemistry. The article was written by Liu, Liu; Li, Haobin; Hu, Kaiwen; Xu, Qinglong; Wen, Xiaoan; Cheng, Keguang; Chen, Caiping; Yuan, Haoliang; Dai, Liang; Sun, Hongbin. The article contains the following contents:

Pentacyclic triterpenes (PTs) are the active ingredients of many medicinal herbs and pharmaceutical formulations, and are well-known for their anti-inflammatory activity. Recently, the anti-inflammatory effects of AMP-activated protein kinase (AMPK) have also drawn much attention. In this study, the authors found that a variety of naturally occurring PTs sapogenins and saponins could stimulate the phosphorylation of AMPK, and identified δ-oleanolic acid as a potent AMPK activator. Based on these findings, 23 saponin derivatives of δ-oleanolic acid were synthesized in order to find more potent anti-inflammatory agents with improved pharmacokinetic properties. The results of cellular assays showed that saponin I significantly inhibited LPS-induced secretion of pro-inflammatory factors TNF-α and IL-6 in THP1-derived macrophages. Preliminary mechanistic studies showed that I stimulated the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC). The bioavailability of I was significantly improved in comparison with its aglycon. More importantly, I showed significant anti-inflammatory and liver-protective effects in LPS/D-GalN-induced fulminant hepatic failure mice. Taken together, PTs saponins hold promise as therapeutic agents for inflammatory diseases. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Category: bromides-buliding-blocks)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and Structure of Organyltriphenylphosphonium and Stibonium Hexabromoplatinates》 was written by Zykova, A. R.; Sharutin, V. V.; Sharutina, O. K.; Senchurin, V. S.. Related Products of 1530-32-1 And the article was included in Russian Journal of General Chemistry in 2020. The article conveys some information:

Organyltriphenylphosphonium and -stibonium hexabromoplatinates were synthesized by the reaction of potassium hexabromoplatinate with organyltriphenylphosphonium and -stibonium bromides in acetonitrile or water. The complexes [Ph3PC2H5]2[PtBr6] and [Ph3PCH2Ph]2[PtBr6] were obtained by recrystallization from DMSO; the complexes [Ph3PCH2Ph][PtBr5(Et2SO-S)] and [Ph4Sb·Et2SO-O]2[PtBr6], by recrystallization of benzyltriphenylphosphonium and tetraphenylstibonium hexabromoplatinates from di-Et sulfoxide. According to the x-ray data, phosphorus atoms in cations have a distorted tetrahedral coordination and antimony atoms, a distorted trigonal-bipyramidal coordination due caused by the Sb···O:SEt2 interaction. In the experiment, the researchers used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Related Products of 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Related Products of 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor》 was written by Bartolini, Desiree; De Franco, Francesca; Torquato, Pierangelo; Marinelli, Rita; Cerra, Bruno; Ronchetti, Riccardo; Schon, Arne; Fallarino, Francesca; De Luca, Antonella; Bellezza, Guido; Ferri, Ivana; Sidoni, Angelo; Walton, William G.; Pellock, Samuel J.; Redinbo, Matthew R.; Mani, Sridhar; Pellicciari, Roberto; Gioiello, Antimo; Galli, Francesco. Recommanded Product: 21085-72-3 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Pregnane X receptor (PXR) is a master xenobiotic-sensing transcription factor and a validated target for immune and inflammatory diseases. The identification of chem. probes to investigate the therapeutic relevance of the receptor is still highly desired. In fact, currently available PXR ligands are not highly selective and can exhibit toxicity and/or potential off-target effects. In this study, we have identified garcinoic acid as a selective and efficient PXR agonist. The properties of this natural mol. as a specific PXR agonist were demonstrated by the screening on a panel of nuclear receptors, the assessment of the phys. and thermodn. binding affinity, and the determination of the PXR-garcinoic acid complex crystal structure. Cytotoxicity, transcriptional, and functional properties were investigated in human liver cells, and compound activity and target engagement were confirmed in vivo in mouse liver and gut tissue. In conclusion, garcinoic acid is a selective natural agonist of PXR and a promising lead compound toward the development of new PXR-regulating modulators. The experimental part of the paper was very detailed, including the reaction process of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Recommanded Product: 21085-72-3)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Recommanded Product: 21085-72-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and Analgesic Activity Assessment of Furanolabdanoid Conjugates with Glucuronic Acid》 was written by Brusentseva, O. I.; Kharitonov, Yu. V.; Dolgikh, M. P.; Tolstikova, T. G.; Shul’ts, E. E.. Category: bromides-buliding-blocks And the article was included in Chemistry of Natural Compounds in 2020. The article conveys some information:

Phlomisoic acid reacted with methyl-1-deoxy-2,3,4-tri-O-acetyl-1-bromo-α-D-glucopyranuronate to form the 18-O-β-D-(glucuronopyranoside)-6′-O-Me ester of 15,16-epoxylabda-8(9),13,14-triene. Reductive amination of Me 16-formyl-15,16-epoxylabda-8(9),13,14-trienoate or this β-D-glucuronopyranoside of 16-formyl-15,16-epoxylabda-8(9),13,14-triene by propargylamine in the presence of NaBH4 gave the corresponding 16-propargylaminomethyl-15,16-epoxylabda-8(9),13,14-trienes. Copper-catalyzed azide-alkyne cycloaddition of the new terpenoid alkynes and the propargylamide of phlomisoic acid with Me 1-deoxy-2,3,4-tri-O-acetyl-1-azido-α-D-glucopyranuronate synthesized the corresponding labdanoid glucuronides and diglucuronide. Selective screening of the labdanoid triazolylglucuronides identified compounds with analgesic activity in chem. and thermal irritation tests. In the experiment, the researchers used (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Category: bromides-buliding-blocks)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Blue Light-Promoted N-H Insertion of Carbazoles, Pyrazoles and 1,2,3-Triazoles into Aryldiazoacetates》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Stivanin, Mateus L.; Fernandes, Alessandra A. G.; da Silva, Amanda F.; Okada, Celso Y. Jr.; Jurberg, Igor D.. Product Details of 6825-20-3 The article mentions the following:

Blue light irradiation of aryldiazoacetates led to the formation of free carbenes, which reacted with carbazoles, pyrazoles and 1,2,3-triazoles to afford the corresponding N-H inserted products. These reactions were performed under air and at room temperature, allowing the mild preparation of a variety of motifs found in biol. relevant targets. In the part of experimental materials, we found many familiar compounds, such as 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Product Details of 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Product Details of 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Unlocking the 5-exo Pathway with the AuI-Catalyzed Alkoxycyclization of 1,3-Dien-5-ynes》 was published in Chemistry – A European Journal in 2020. These research results belong to Virumbrales, Cintia; Suarez-Pantiga, Samuel; Marin-Luna, Marta; Silva Lopez, Carlos; Sanz, Roberto. Recommanded Product: 1530-32-1 The article mentions the following:

The first general regio- and stereoselective 5-exo gold(I)-catalyzed alkoxycyclization of a specific class of 1,5-enynes such as 1,3-dien-5-ynes was described, despite 1,5-enynes being known to almost invariably proceed via endo cyclizations under gold-catalysis. The configuration of the terminal alkene in the starting 1,3-dien-5-yne played a crucial role on the regiochem. outcome of the reaction. A wide variety of interesting alkoxy-functionalized alkylidenecyclopentenes was synthesized from 1-monosubstituted (E)-1,3-dien-5-ynes. On the contrary, the corresponding Z isomers evolve affording formal 6-endo cyclization products. In addition, mechanistic exploration supports a highly stabilized carbocation as a key intermediate instead of a highly constrained cyclopropyl gold carbene from E isomers, and also accounts for the well differentiated reactivity observed between both E/Z geometrical isomers as well as for the stereochem. outcome of the reaction. In the experiment, the researchers used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Recommanded Product: 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Recommanded Product: 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Sequential Cross-Coupling/Annulation of ortho-Vinyl Bromobenzenes with Aromatic Bromides for the Synthesis of Polycyclic Aromatic Compounds》 were Wei, Dong; Li, Meng-Yao; Zhu, Bin-Bin; Yang, Xiao-Di; Zhang, Fang; Feng, Chen-Guo; Lin, Guo-Qiang. And the article was published in Angewandte Chemie, International Edition in 2019. Electric Literature of C19H18BrP The author mentioned the following in the article:

A sequential cross-coupling/annulation of ortho-vinyl bromobenzenes with aromatic bromides was realized, providing a direct and modular approach to access polycyclic aromatic compounds A vinyl-coordinated palladacycle was proposed as the key intermediate for this sequential process. Excellent chemoselectivity and regioselectivity were observed in this transformation. The practicability of this method is highlighted by its broad substrate scope, excellent functional group tolerance, and rich transformations associated with the obtained products. In addition to this study using Methyltriphenylphosphonium bromide, there are many other studies that have used Methyltriphenylphosphonium bromide(cas: 1779-49-3Electric Literature of C19H18BrP) was used in this study.

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Electric Literature of C19H18BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary