Tag: 300-400

In 2018,Miranda, Silvia; Gomez, Ana M.; Lopez, J. Cristobal published 《Diversity-Oriented Synthetic Endeavors of Newly Designed Ferrier and Ferrier-Nicholas Systems Derived from 1-C-Alkynyl-2-deoxy-2-C-Methylene Pyranosides》.European Journal of Organic Chemistry published the findings.Recommanded Product: Indium(III) bromide The information in the text is summarized as follows:

Novel pyranose derivatives that display Ferrier- and Ferrier-Nicholas-like reactivity have been designed. These systems: 1-C-alkynyl-2-deoxy-2-C-methylene pyranosides (Ferrier), and their corresponding dicobalthexacarbonyl alkenyl derivatives (Ferrier-Nicholas), which can be accessed by a concise synthetic route from com. available tri-O-acetyl-D-glucal, allow the incorporation of two nucleophiles (at positions C-3 and C-2′) in the pyranose ring. The study of these systems has resulted in the discovery of novel reaction patterns that allow, among others, access to open-chain derivatives, branched pyranosides, 1,6-anhydro derivatives and, when reacting with indole, access to a new family of tetracyclic indole-containing carbohydrate derivatives, namely, cyclohepta[b]indole-fused glycals. The latter are, most likely, formed by a bis Ferrier-type rearrangement followed by an unusual intramol. 7-endo-dig Friedel-Crafts alkenylation of one of the indole moieties by the C-1 alkyne.Indium(III) bromide(cas: 13465-09-3Recommanded Product: Indium(III) bromide) was used in this study.

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Recommanded Product: Indium(III) bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vang, Zoua Pa; Reyes, Albert; Sonstrom, Reilly E.; Holdren, Martin S.; Sloane, Samantha E.; Alansari, Isabella Y.; Neill, Justin L.; Pate, Brooks H.; Clark, Joseph R. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Copper-Catalyzed Transfer Hydrodeuteration of Aryl Alkenes with Quantitative Isotopomer Purity Analysis by Molecular Rotational Resonance Spectroscopy》.Name: Ethyltriphenylphosphonium bromide The article contains the following contents:

A copper-catalyzed alkene transfer hydrodeuteration reaction that selectively incorporates one hydrogen and one deuterium atom across an aryl alkene was described. The transfer hydrodeuteration protocol was selective across a variety of internal and terminal alkenes and was also demonstrated on an alkene-containing complex natural product analog. Beyond using 1H, 2H, and 13C NMR anal. to measure reaction selectivity, six transfer hydrodeuteration products were analyzed by mol. rotational resonance (MRR) spectroscopy. The application of MRR spectroscopy to the anal. of isotopic impurities in deuteration chem. was further explored through a measurement methodol. that was compatible with high-throughput sample anal. In the first step, the MRR spectroscopy signatures of all isotopic variants accessible in the reaction chem. were analyzed using a broadband chirped-pulse Fourier transform microwave spectrometer. With the signatures in hand, measurement scripts were created to quant. analyze the sample composition using a com. cavity enhanced MRR spectrometer. The sample consumption was below 10 mg with anal. times on the order of 10 min using this instrument-both representing order-of-magnitude reduction compared to broadband MRR spectroscopy. To date, these measurements represent the most precise spectroscopic determination of selectivity in a transfer hydrodeuteration reaction and confirm that product regioselectivity ratios of >140:1 were achievable under this mild protocol. In the part of experimental materials, we found many familiar compounds, such as Ethyltriphenylphosphonium bromide(cas: 1530-32-1Name: Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Name: Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pomogaeva, Anna V.; Timoshkin, Alexey Y. published their research in Journal of Computational Chemistry in 2021. The article was titled 《Influence of the solvent on the Lewis acidity of antimony pentahalides and group 13 Lewis acids toward acetonitrile and pyridine》.Related Products of 13465-09-3 The article contains the following contents:

Energetic effects of solvation of SbF5, SbCl5, and 21 group 13 Lewis acids (LA) and their mol. complexes with acetonitrile and pyridine are evaluated using SMD approach. Compared to the gas phase, solvation increases the stability of boron- and aluminum-containing complexes but decreases the stability of gallium and indium-containing homologs due to larger solvation energies of free LA. New Lewis acidity scales, based on the Gibbs energy of dissociation of the mol. complexes LA·pyridine and LA·acetonitrile in the gas phase, in benzene and acetonitrile solutions, are proposed. The experimental process involved the reaction of Indium(III) bromide(cas: 13465-09-3Related Products of 13465-09-3)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Related Products of 13465-09-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Harnessing Applied Potential: Selective β-Hydrocarboxylation of Substituted Olefins》 was published in Journal of the American Chemical Society in 2020. These research results belong to Alkayal, Anas; Tabas, Volodymyr; Montanaro, Stephanie; Wright, Iain A.; Malkov, Andrei V.; Buckley, Benjamin R.. Safety of Methyltriphenylphosphonium bromide The article mentions the following:

The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, β-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochem. approaches. The reported method allows unprecedented direct access to carboxylic acids derived from β,β-trisubstituted alkenes, in a highly regioselective manner.Methyltriphenylphosphonium bromide(cas: 1779-49-3Safety of Methyltriphenylphosphonium bromide) was used in this study.

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis. And it is used widely for methylenation via the Wittig reaction.Safety of Methyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Asymmetric Total Synthesis of (+)-Waihoensene》 was published in Journal of the American Chemical Society in 2020. These research results belong to Qu, Yongzheng; Wang, Zheyuan; Zhang, Zhongchao; Zhang, Wendou; Huang, Jun; Yang, Zhen. Category: bromides-buliding-blocks The article mentions the following:

The asym. total synthesis of (+)-waihoensene (I), which has a cis-fused [6,5,5,5] tetracyclic core bearing an angular triquinane, a cis-fused six-membered ring, and four contiguous quaternary carbon atoms, was achieved through a sequence of chem. reactions in a stereochem. well-defined manner. The total synthesis features the following: (1) Cu-catalyzed asym. conjugated 1,4-addition; (2) diastereoselective Conia-ene type reaction; (3) diastereoselective intramol. Pauson-Khand reaction; (4) Ni-catalyzed diastereoselective conjugated 1,4-addition; and (5) radical-initiated intramol. hydrogen atom transfer (HAT). Control experiments and d. functional theory calculations support the proposed HAT process.Methyltriphenylphosphonium bromide(cas: 1779-49-3Category: bromides-buliding-blocks) was used in this study.

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Scope, Kinetics, and Mechanism of “”On Water”” Cu Catalysis in the C-N Cross-Coupling Reactions of Indole Derivatives》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Malavade, Vrunda; Patil, Manish; Patil, M.. Product Details of 6825-20-3 The article mentions the following:

In the presence of CuI and 1,10-phenanthroline, indoles and carbazoles underwent cross-coupling reactions with aryl iodides in (on) aqueous DME at 95° to yield N-aryl indoles and carbazoles. The reaction was accelerated significantly in aqueous DME over with DME or water alone. The kinetics and mechanism of the copper-catalyzed cross-coupling were studied; the mechanism, transition state structures and activation barriers, and effect of water on the oxidative addition and reductive elimination steps were studied using DFT calculations The water accelerated the cross-coupling rate acceleration by stabilizing the transition state of oxidative addition of iodobenzene to a copper phenanthroline complex (the rate-limiting step of reaction) through hydrogen bonding. The experimental part of the paper was very detailed, including the reaction process of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Product Details of 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent. And it has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Product Details of 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Copper-Catalyzed 1,2-Methoxy Methoxycarbonylation of Alkenes with Methyl Formate》 were Budai, Balazs; Leclair, Alexandre; Wang, Qian; Zhu, Jieping. And the article was published in Angewandte Chemie, International Edition in 2019. Formula: C19H18BrP The author mentioned the following in the article:

Reported here is a copper-catalyzed 1,2-methoxy methoxycarbonylation of alkenes by an unprecedented use of Me formate as a source of both the methoxy and the methoxycarbonyl groups. This reaction transforms styrene and its derivatives into value-added β-methoxy alkanoates and cinnamates, as well as medicinally important five-membered heterocycles, such as functionalized tetrahydrofurans, γ-lactones, and pyrrolidines. These findings suggest that pre-coordination of electron-rich alkenes to copper might play an important role in accelerating the addition of nucleophilic radicals to electron-rich alkenes, and could have general implications in the design of novel radical-based transformations.Methyltriphenylphosphonium bromide(cas: 1779-49-3Formula: C19H18BrP) was used in this study.

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Formula: C19H18BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of Methyltriphenylphosphonium bromideIn 2019 ,《Regio- and Enantioselective C-H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis》 appeared in Journal of the American Chemical Society. The author of the article were Zhang, Wu-Bin; Yang, Xin-Tuo; Ma, Jun-Bao; Su, Zhi-Ming; Shi, Shi-Liang. The article conveys some information:

Annulated pyridines are ubiquitous scaffolds in many bioactive mols. A highly regio- and enantioselective Ni(0)-catalyzed endo-selective C-H cyclization of pyridines with alkenes was developed. An unprecedented enantioselective C-H activation at pyridyl 3- or 4-positions was enabled by bulky chiral N-heterocyclic carbene ligands. This protocol provides expedient access to a series of optically active 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines, compounds otherwise accessed with difficulty, in moderate to high yields (up to 99% yield) and enantioselectivities (up to 99% ee). To the authors’ knowledge, this is the first example of enantioselective C-H cyclization of pyridines to chiral annulated products.Methyltriphenylphosphonium bromide(cas: 1779-49-3Application In Synthesis of Methyltriphenylphosphonium bromide) was used in this study.

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Application In Synthesis of Methyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 1779-49-3In 2019 ,《Chiral Bronsted Acid Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes》 appeared in Angewandte Chemie, International Edition. The author of the article were Lin, Jin-Shun; Li, Tao-Tao; Jiao, Guan-Yuan; Gu, Qiang-Shuai; Cheng, Jiang-Tao; Lv, Ling; Liu, Xin-Yuan. The article conveys some information:

The first highly efficient and practical chiral Bronsted acid catalyzed dynamic kinetic asym. hydroamination (DyKAH) of racemic allenes and asym. hydroamination of unactivated dienes with both high E/Z selectivity and enantioselectivity are described herein. The transformation proceeds through a new catalytic asym. model involving a highly reactive π-allylic carbocationic intermediate, generated from racemic allenes or dienes through a proton transfer mediated by an activating/directing thiourea group. This method affords expedient access to structurally diverse enantioenriched, potentially bioactive alkenyl-containing aza-heterocycles and bicyclic aza-heterocycles. In the part of experimental materials, we found many familiar compounds, such as Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Recommanded Product: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 13465-09-3In 2020 ,《Synthesis, properties and structures of gallium(III) and indium(III) halide complexes with neutral pnictine coordination》 appeared in Journal of Organometallic Chemistry. The author of the article were Cairns, Kelsey R.; Greenacre, Victoria K.; Grose, Laura A.; Levason, William; Reid, Gillian; Robinson, Fred. The article conveys some information:

A series of Group 13 halide complexes of SbnBu3, [GaX3(SbnBu3)] and [InX3(SbnBu3)] (X = Cl, Br, I) have been prepared by reaction of the appropriate trihalide with SbnBu3 in n-hexane or CH2Cl2 solution, and characterized by microanal., IR, 1H, 13C{1H} and 71Ga NMR spectroscopy. X-ray crystal structures are reported for [InX3(SbnBu3)] (X = Cl, Br) and [GaX3(SbnBu3)]. Similar pseudo-tetrahedral complexes of AsEt3, [GaCl3(AsEt3)], [InCl3(AsEt3)] and the five-coordinate [InCl3(AsEt3)2] were also obtained and their structures determined Attempts to use [InCl3(SbR3)] and [GaCl3(SbR3)] (R = nBu, Et) as single source precursors for low pressure CVD growth of InSb or GaSb films were unsuccessful, instead producing elemental antimony, while [GaCl3(AsEt3)] and [InCl3(AsEt3)] failed to produce any deposition under similar conditions. In the part of experimental materials, we found many familiar compounds, such as Indium(III) bromide(cas: 13465-09-3Product Details of 13465-09-3)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Product Details of 13465-09-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary