Tag: 300-400

Park, Sangshin; Kwon, Hyukmin; Kang, Seokwoo; Park, Sunwoo; Jung, Hyocheol; Lee, Seungeun; Park, Jongwook published their research in Journal of Nanoscience and Nanotechnology in 2021. The article was titled 《Synthesis and electroluminescence property of anthracene green fluorescent derivatives based on optimized side groups》.Computed Properties of C14H8Br2 The article contains the following contents:

As new green fluorescent emitters, anthracenes I [R = 3-Me, 4-Me] were synthesized and the properties were evaluated. In solution state, photoluminescence (PL) maximum wavelength was 517 nm for I [R = 3-Me] and 529 nm for I [R = 4-Me] . In electroluminescence (EL) spectra, EL maximum wavelength of I [R = 3-Me] was 518 nm and I [R = 4-Me] was 533 nm. The doped device using I [R = 3-Me] as green fluorescent dopant exhibited current efficiency (CE) of 17.41 cd/A and external quantum efficiency (EQE) of 7.41%. The doped device with I [R = 4-Me] was optimized in order to achieve a green OLED with high efficiency. After reading the article, we found that the author used 9,10-Dibromoanthracene(cas: 523-27-3Computed Properties of C14H8Br2)

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.Computed Properties of C14H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Anisotropic Poisson Effect and Deformation-Induced Fluorescence Change of Elastic 9,10-Dibromoanthracene Single Crystals》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Hayashi, Shotaro; Ishiwari, Fumitaka; Fukushima, Takanori; Mikage, Shohei; Imamura, Yutaka; Tashiro, Motomichi; Katouda, Michio. Application of 523-27-3 The article mentions the following:

Elastic organic crystals have attracted considerable attention as next-generation flexible smart materials. However, the detailed information on both mol. packing change and macroscopic mech. crystal deformations upon applied stress is still insufficient. Herein, we report that fluorescent single crystals of 9,10-dibromoanthracene are elastically bendable and stretchable, which allows a detailed investigation of the deformation behavior. We clearly observed a Poisson effect for the crystal, where the short axes (b and c-axes) of the crystal are contracted upon elongation along the long axis (a-axis). Moreover, we found that the Poisson’s ratios along the b-axis and c-axis are largely different. Theor. mol. simulation suggests that the tilting motion of the anthracene may be responsible for the large deformation along the c-axis. Spatially resolved photoluminescence (PL) measurement of the bent elastic crystals reveals that the PL spectra at the outer (elongated), central (neutral), and inner (contracted) sides are different from each other. The experimental process involved the reaction of 9,10-Dibromoanthracene(cas: 523-27-3Application of 523-27-3)

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.Application of 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A novel finding of nalbuphine-6-glucuronide, an active opiate metabolite, possessing potent antinociceptive effects: Synthesis and biological evaluation》 were Liang, Ren-Jong; Lai, Yen-Hsun; Kao, Yu-Ting; Yang, Ting-Hsuan; Chen, Yen-Lun; Wang, Hong-Jaan. And the article was published in European Journal of Medicinal Chemistry in 2019. Related Products of 21085-72-3 The author mentioned the following in the article:

Nalbuphine, a partial agonist/antagonist opioid analgesic, is structurally related to morphine. It is equipotent to morphine and has no serious side effects. In the past few decades, studies focusing on morphine metabolism have indicated that one of its sugar-conjugated metabolites, morphine-6-glucuronide, exerts a higher analgesic effect than its parent drug. Considering that nalbuphine is a morphine analog that follows a similar metabolic scheme, nalbuphine glucuronides were synthesized in this study and their potential analgesic effects were assessed. Nalbuphine-3-glucuronide (N3G) and nalbuphine-6-glucuronide (N6G) were synthesized based on Schmidt’s glycosylation with OPiv protections on the glycosyl donor. In a pharmacodynamic study, paw pressure and cold-ethanol tail-flick tests were conducted in rats to evaluate the analgesic response after intracisternal and i.p. administrations of nalbuphine, N3G, or N6G. The antinociceptive response was evaluated for each compound by calculating the area under the curve and the duration spent at greater than 50% maximum possible analgesia. In conclusion, intracisternal administration of N6G exhibited a stronger analgesic response than nalbuphine in the pain tests after both cold and mech. stimuli, but N3G had no obvious effect. Similar to that of morphine, the glucuronide metabolite of nalbuphine at the 6-O-position exerted at least three-fold higher antinociceptive potency and five-fold longer analgesic duration than nalbuphine. In the experiment, the researchers used (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Related Products of 21085-72-3)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Related Products of 21085-72-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Intermolecular 1,4-Carboamination of Conjugated Dienes Enabled by Cp*RhIII-Catalyzed C-H Activation》 were Pinkert, Tobias; Wegner, Tristan; Mondal, Shobhan; Glorius, Frank. And the article was published in Angewandte Chemie, International Edition in 2019. Electric Literature of C19H18BrP The author mentioned the following in the article:

A protocol for the three-component 1,4-carboamination of dienes is described. Synthetically versatile Weinreb amides were coupled with 1,3-dienes and readily available dioxazolones as the nitrogen source using [Cp*RhCl2]2-catalyzed C-H activation to deliver the 1,4-carboaminated products. This transformation proceeds under mild reaction conditions and affords the products with high levels of regio- and E-selectivity. Mechanistic investigations suggest an intermediate RhIII-allyl species is trapped by an electrophilic amidation reagent in a redox-neutral fashion. The experimental part of the paper was very detailed, including the reaction process of Methyltriphenylphosphonium bromide(cas: 1779-49-3Electric Literature of C19H18BrP)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis. And it is used widely for methylenation via the Wittig reaction.Electric Literature of C19H18BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of the American Chemical Society included an article by Chen, Xiao-Wang; Zhu, Lei; Gui, Yong-Yuan; Jing, Ke; Jiang, Yuan-Xu; Bo, Zhi-Yu; Lan, Yu; Li, Jing; Yu, Da-Gang. Quality Control of Methyltriphenylphosphonium bromide. The article was titled 《Highly Selective and Catalytic Generation of Acyclic Quaternary Carbon Stereocenters via Functionalization of 1,3-Dienes with CO2》. The information in the text is summarized as follows:

A highly selective copper-catalyzed generation of chiral all-carbon acyclic quaternary stereocenters via functionalization of 1,3-dienes with CO2 is reported. A variety of readily available 1,1-disubstituted 1,3-dienes, as well as a 1,3,5-triene, undergo reductive hydroxymethylation with high chemo-, regio-, E/Z-, and enantioselectivities. The reported method features good functional group tolerance, is readily scaled up to at least 5 mmol of starting diene, and generates chiral products that are useful building blocks for further derivatization. Systemic mechanistic investigations using d. functional theory calculations were performed and provided the first theor. investigation for an asym. transformation involving CO2. These computational results indicate that the 1,2-hydrocupration of 1,3-diene proceeds with high π-facial selectivity to generate an (S)-allylcopper intermediate, which further induces the chirality of the quaternary carbon center in the final product. The 1,4-addition of an internal allylcopper complex, which differs from previous reports involving terminal allylmetallic intermediates, to CO2 kinetically determines the E/Z- and regioselectivity. The rapid reduction of a copper carboxylate intermediate to the corresponding silyl-ether in the presence of Me(MeO)2SiH provides the exergonic impetus and leads to chemoselective hydroxymethylation rather than carboxylation. These results provide new insights for guiding further development of asym. C-C bond formations with CO2. After reading the article, we found that the author used Methyltriphenylphosphonium bromide(cas: 1779-49-3Quality Control of Methyltriphenylphosphonium bromide)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis. And it is used widely for methylenation via the Wittig reaction.Quality Control of Methyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Angewandte Chemie, International Edition included an article by Meng, Qing-Yuan; Schirmer, Tobias E.; Katou, Kousuke; Koenig, Burkhard. Recommanded Product: 1779-49-3. The article was titled 《Controllable Isomerization of Alkenes by Dual Visible-Light-Cobalt Catalysis》. The information in the text is summarized as follows:

Thermodn. and kinetic isomerization of alkenes accomplished by the combination of visible light with Co catalysis is reported. Utilizing Xantphos as the ligand, the most stable isomers are obtained, while isomerizing terminal alkenes over one position can be selectively controlled by using DPEphos as the ligand. The presence of the donor-acceptor dye 4CzIPN accelerates the reaction further. Transformation of exocyclic alkenes into the corresponding endocyclic products could be efficiently realized by using 4CzIPN and Co(acac)2 in the absence of any addnl. ligands. Spectroscopic and spectroelectrochem. investigations indicate CoI being involved in the generation of a Co hydride, which subsequently adds to alkenes initiating the isomerization. After reading the article, we found that the author used Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Recommanded Product: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Akther, Thamina; Islam, Monarul Md.; Kowser, Zannatul; Matsumoto, Taisuke; Tanaka, Junji; Rahman, Shofiur; Alodhayb, Abdullah; Georghiou, Paris E.; Redshaw, Carl; Yamato, Takehiko published an article in European Journal of Organic Chemistry. The title of the article was 《Synthesis and Structures of [2.n]Metacyclophan-1-enes and their Conversion to Highly Strained [2.n]Metacyclophane-1-ynes》.Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide The author mentioned the following in the article:

The syntheses of syn-[2.n]metacyclophan-1-enes (n = 5, 6, 8) in good yields using the McMurry cyclization of 1,n-bis(3-formyl-4-methoxyphenyl)alkanes are reported. Conversion of syn-[2.6]- and [2.8]metacyclophan-1-enes to the corresponding highly strained syn-type [2.6]- and [2.8]metacyclophane-1-ynes was achieved by successive bromination and dehydrobromination reactions. An attempted trapping reaction of the putative corresponding [2.5]metacyclophane-1-yne by Diels-Alder reaction with 1,3-diphenylisobenzofuran failed due to its smaller ring size and strained structure. X-ray crystallog. analyses show that the triple bonds in syn-[2.6]- and [2.8]metacyclophane-1-ynes are distorted from linearity with bond angles of 156.7° and 161.4°, resp. A DFT (D. Functional Theory) computational study was conducted to determine the stabilities of different conformations of the target compoundsMono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide(cas: 111865-47-5Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide) was used in this study.

Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide(cas: 111865-47-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and inhibitory effect of cis-guggulsterone on lipopolysaccharide-induced production of nitric oxide in macrophages》 was written by Park, Jun Yeon; Lee, Jae Wook; Lee, Chang-Ho; Lee, Hae-Jeung; Kang, Ki Sung. Electric Literature of C20H20BrPThis research focused ontrans guggulsterone preparation antiinflammatory activity nitric oxide macrophage; COX-2; Guggulsterone; Inflammation; RAW264.7; iNOS. The article conveys some information:

Guggulsterone is a bioactive plant sterol naturally found in migratory plants. It exists in various forms, and its active compounds include the isomers cis-guggulsterone (I, E-GS) and trans-guggulsterone (Z-GS). In this study, the anti-inflammatory effects of these two isomeric pregnadienedione steroids were investigated against lipopolysaccharide-induced inflammatory reaction in RAW264.7 mouse macrophages. Our results showed that both guggulsterones inhibited the production of NO in macrophages treated with lipopolysaccharide, with IC50 values ranging from 3.0 to 6.7μM. E-GS exerted higher efficacy than Z-GS, and its anti-inflammatory effects was mediated through inhibition of iNOS and COX-2 expression. In the experimental materials used by the author, we found Ethyltriphenylphosphonium bromide(cas: 1530-32-1Electric Literature of C20H20BrP)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Electric Literature of C20H20BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of Ethyltriphenylphosphonium bromideIn 2020 ,《Unprecedented Selectivity of Ruthenium Iodide Benzylidenes in Olefin Metathesis Reactions》 was published in Angewandte Chemie, International Edition. The article was written by Nechmad, Noy B.; Phatake, Ravindra; Ivry, Elisa; Poater, Albert; Lemcoff, N. Gabriel. The article contains the following contents:

The development of selective olefin metathesis catalysts is crucial to achieving new synthetic pathways. Herein, we show that cis-diiodo/sulfur-chelated ruthenium benzylidenes do not react with strained cycloalkenes and internal olefins, but can effectively catalyze metathesis reactions of terminal dienes. Surprisingly, internal olefins may partake in olefin metathesis reactions once the ruthenium methylidene intermediate has been generated. This unexpected behavior allows the facile formation of strained cis-cyclooctene by the RCM reaction of 1,9-undecadiene. Moreover, cis-1,4-polybutadiene may be transformed into small cyclic mols., including its smallest precursor, 1,5-cyclooctadiene, by the use of this novel sequence. Norbornenes, including the reactive dicyclopentadiene (DCPD), remain unscathed even in the presence of terminal olefin substrates as they are too bulky to approach the diiodo ruthenium methylidene. The exptl. results are accompanied by thorough DFT calculations In addition to this study using Ethyltriphenylphosphonium bromide, there are many other studies that have used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Reference of Ethyltriphenylphosphonium bromide) was used in this study.

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Reference of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

McCurdy, Ryan D.; Jacobse, Peter H.; Piskun, Ilya; Veber, Gregory C.; Rizzo, Daniel J.; Zuzak, Rafal; Mutlu, Zafer; Bokor, Jeffrey; Crommie, Michael F.; Fischer, Felix R. published an article in 2021. The article was titled 《Synergetic Bottom-Up Synthesis of Graphene Nanoribbons by Matrix-Assisted Direct Transfer》, and you may find the article in Journal of the American Chemical Society.Product Details of 523-27-3 The information in the text is summarized as follows:

The scope of graphene nanoribbon (GNR) structures accessible through bottom-up approaches is defined by the intrinsic limitations of either all-on-surface or all-solution-based synthesis. Here, we report a hybrid bottom-up synthesis of GNRs based on a Matrix-Assisted Direct (MAD) transfer technique that successfully leverages tech. advantages inherent to both solution-based and on-surface synthesis while sidestepping their drawbacks. Critical structural parameters tightly controlled in solution-based polymerization reactions can seamlessly be translated into the structure of the corresponding GNRs. The transformative potential of the synergetic bottom-up approaches facilitated by the MAD transfer techniques is highlighted by the synthesis of chevron-type GNRs (cGNRs) featuring narrow length distributions and a nitrogen core-doped armchair GNR (N4-7-ANGR) that remains inaccessible using either a solution-based or an on-surface bottom-up approach alone. The results came from multiple reactions, including the reaction of 9,10-Dibromoanthracene(cas: 523-27-3Product Details of 523-27-3)

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.Product Details of 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary