Tag: 400-500

Enantioselective allylation of imines catalyzed by newly developed (-)-β-pinene-based π-allylpalladium catalyst: an efficient synthesis of (R)-α-propylpiperonylamine and (R)-pipecolic acid was written by Fernandes, Rodney A.;Nallasivam, Jothi L.. And the article was included in Organic & Biomolecular Chemistry in 2012.Computed Properties of C23H26BrP This article mentions the following:

A newly developed π-allylpalladium with a (-)-β-pinene framework and an iso-Bu side chain catalyzed the enantioselective allylation of imines in good yields and enantioselectivities (20 examples, up to 98% ee). An efficient enantioselective synthesis of the (R)-α-Pr piperonylamine part of a human leukocyte elastase inhibitor and (R)-pipecolic acid have been achieved as a useful application of this methodol. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Computed Properties of C23H26BrP).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C23H26BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design and synthesis of an azobenzene-betaine surfactant for photo-rheological fluids was written by Butler, Calum S. G.;King, Joshua P.;Giles, Luke W.;Marlow, Joshua B.;Vidallon, Mark Louis P.;Sokolova, Anna;de Campo, Liliana;Tuck, Kellie L.;Tabor, Rico F.. And the article was included in Journal of Colloid and Interface Science in 2021.Application of 28322-40-9 This article mentions the following:

Morphol. of surfactant self-assemblies are governed by the intermol. interactions and packing constraints of the constituent mols. Therefore, rational design of surfactant structure should allow targeting of the specific self-assembly modes, such as wormlike micelles (WLMs). By inclusion of an appropriate photo-responsive functionality to a surfactant mol., light-based control of formulation properties without the need for additives can be achieved. A novel azobenzene-containing surfactant was synthesized with the intention of producing photo-responsive wormlike micelles. Aggregation of the mol. in its cis and trans isomers, and its concomitant flow properties, were characterised using UV-vis spectroscopy, small-angle neutron scattering, and rheol. measurements. Finally, the fluids capacity for mediating particle diffusion was assessed using dynamic light scattering. The trans isomer of the novel azo-surfactant was found to form a viscoelastic WLM network, which transitioned to inviscid ellipsoidal aggregates upon photo-switching to the cis isomer. This was accompanied by changes in zero-shear viscosity up to 16,000 x . UV-vis spectroscopic and rheo-SANS anal. revealed π – π interactions of the trans azobenzene chromophore within the micelles, influencing aggregate structure and contributing to micellar rigidity. Particles dispersed in a 1 wt% surfactant solution showed a fivefold increase in apparent diffusion coefficient after UV-irradiation of the mixture In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Application of 28322-40-9).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 28322-40-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intermolecular Radical C(sp³)-H Amination under Iodine Catalysis was written by Bosnidou, Alexandra E.;Muniz, Kilian. And the article was included in Angewandte Chemie, International Edition in 2019.Recommanded Product: 28322-40-9 This article mentions the following:

Alkanes and aryl alkanes such as ethylbenzene underwent regioselective amination with sulfonamides such as trifluoromethanesulfonamide in the presence of I₂ using iodobenzene bis(4-bromobenzoate) as the stoichiometric oxidant in anhydrous dichloromethane under blue LED irradiation to yield N-sulfonyl benzylic and alkyl amines such as PhCH(NHTf)Me. The method was used to prepare aminated amino acids and racemic arylglycinates and β-aryl-β-alaninates as well as memantine, rasagiline, and racemic sertraline. The method was also used to prepare trans-2,5-disubstituted pyrrolidines by iodine-catalyzed photochem. amination of phenylalkanes with methanesulfonamide followed by intramol. amination in the presence of I₂ using phenyliodine bis(3-chlorobenzoate) as the stoichiometric oxidant; the method was also used to prepare the dibenzoazabicyclooctane anticonvulsant MK-801. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Recommanded Product: 28322-40-9).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 28322-40-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of [1.1.1]propellanes by bridging of bicyclo[1.1.0]butanes was written by Werner, Markus;Stephenson, David S.;Szeimies, Guenter. And the article was included in Liebigs Annalen in 1996.SDS of cas: 28322-40-9 This article mentions the following:

Various [1.1.1]propellanes I [R = H, R¹ = alkyl or aryl; R, R¹ = Me, Et; RR¹ = (CH₂)₃, (CH₂)₄] were prepared by bridging the 1,3 positions of the corresponding bicyclo[1.1.0]butane. The synthesis of 1-bromo-3-(chloromethy)bicyclobutanes and the bridging were carried out in a 1-pot reaction by addition of 2 equivalent of MeLi to appropriate 1,1-dibromobis-2,2-(dichloromethyl)cyclopropanes II. Three routes to the cyclopropanes were investigated. The Wittig reaction of 1,3-dichlorocycloacetone leading to RR¹CC(CH₂Cl)₂, was with exception of RR¹CC(CH₂Cl)₂ [RR¹ = (CH₂)₃] successful only with Wittig reagents derived from primary alkyl halides. Reduction of alkylidenemalonates with LiAlH₄ in benzene afforded carbinols of type RR¹CC(CH₂OH)₂ which were converted into chlorides by reaction with N-chlorosuccinimide/Me₂S. The cyclopropanation of RR¹CC(CH₂Cl)₂ to cyclopropanes II was achieved by reaction with CHBr₃/NaOH under phase transfer catalysis conditions. Starting from alkylidenemalonates, the sequence of reduction and cyclopropanatioon was interchanged. Propellanes I (R = H; R¹ = Pr, CH₂CHMePr) were reduced with LiAlH₄ to give the corresponding bicyclo[1.1.1]pentanes. Very small coupling constants J(¹³C-¹³C) between the bridgehead positions (i.e. 0.47 and 0.53 Hz) were obtained by 2D inadequate NMR of I (R = H; R¹ = CH₂CHMeEt, CHMeEt). In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9SDS of cas: 28322-40-9).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.SDS of cas: 28322-40-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Exploitation of the Ability of γ-Tocopherol to Facilitate Membrane Co-localization of Akt and PHLPP1 to Develop PHLPP1-Targeted Akt Inhibitors was written by Yan, Ribai;Chuang, Hsiao-Ching;Kapuriya, Naval;Chou, Chih-Chien;Lai, Po-Ting;Chang, Hsin-Wen;Yang, Chia-Ning;Kulp, Samuel K.;Chen, Ching-Shih. And the article was included in Journal of Medicinal Chemistry in 2015.Product Details of 28322-40-9 This article mentions the following:

Previously, the authors reported that Akt inactivation by γ-tocopherol in PTEN-neg. prostate cancer cells resulted from its unique ability to facilitate membrane colocalization of Akt and PHLPP1 (PH domain leucine-rich repeat protein phosphatase isoform 1), a Ser473-specific Akt phosphatase, through pleckstrin homol. (PH) domain binding. This finding provided a basis for exploiting γ-tocopherol to develop a novel class of PHLPP1-targeted Akt inhibitors. Here, the authors used I (γ-VE5), a side chain-truncated γ-tocopherol derivative, as a scaffold for lead optimization. The proof-of-concept of this structural optimization was obtained by II, which exhibited higher antitumor efficacy than I in PTEN-neg. cancer cells through PHLPP1-facilitated Akt inactivation. Like I, II preferentially recognized the PH domains of Akt and PHLPP1, as its binding affinities for other PH domains, including those of ILK and PDK1, were an order-of-magnitude lower. Moreover, II was orally active in suppressing xenograft tumor growth in nude mice, which underlines the translational potential of this new class of Akt inhibitor in PTEN-deficient cancers. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Product Details of 28322-40-9).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 28322-40-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary