Tag: M.W=100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-75-5, name is 4-Bromo-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H8BrN

EXAMPLE 192 1,2-Dihydro-6-(3-nitrophenyl-2,2,4,8-tetramethylquinoline (Compound 292, Structure 86 of Scheme XXII, where R1 =R3-5 =H, R2 -nitro) 4-Bromo-2-methylaniline (5.58 g, 30 mmol) was treated with iodine (0.2 g, 0.9 mmol) and acetone (150 mL) in a sealed tube at 80 C. for 24 h to provide 6-bromo-1,2-dihydro-8-methylquinoline (Compound 85 of Scheme XXII) in 9% yield as a yellow oil (0.70 g). Most of the aniline (>80%) was recovered.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 583-75-5.

Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5693646; (1997); A;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1003-99-2, name is 2-Bromo-5-fluoroaniline, A new synthetic method of this compound is introduced below., COA of Formula: C6H5BrFN

3-methyl-4-nitrobenzoyl chloride (5.496g, 27.62 mmol) dissolved in 2 mL of dry pyridine was added to a stirringsolution of 2-bromo-5-fluoroaniline (5.248 g, 27.62 mmol) in dry pyridine (10mL). The dark brown solution was heated under reflux for 2 hours, then pouredinto water (30 mL), forming a precipitate that was collected and washed withwater and methanol, to afford a white solid (8.128 g, 84percent yield). 1HNMR (400 MHz, DMSO-d6): 10.38 (bs, 1H, NH-CO)delta, 8.13 (d, J=8.6 Hz, 1H, H-5?), 8.07 (bs, 1H, H-2?), 8.00 (dd, J=2.3, 8.7 Hz, 1H, H-6?), 7.78 (dd, J=5.8, 9.0 Hz, 1H, H-3), 7.53 (dd, J= 3.2, 9.9 Hz, 1H, H-6), 7.18 (td, J=8.7 Hz, 3.32, 1H, H-4), 2.59 (s, 3H,CH3); 13C NMR (100 MHz, DMSO-d6): delta 164.43,162.78, 160.35, 151.29, 138.04, 134.35, 133.36, 132.57, 127.07, 125.10, 116.32,116.08, 115.70, 19.80. MS: m/z (HRMS)calcd. for C14H11BrFN2O3+352.9932, 354.9912 [M+H], MS found: 354.9938 [M+H].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Stone, Erica L.; Citossi, Francesca; Singh, Rajinder; Kaur, Balvinder; Gaskell, Margaret; Farmer, Peter B.; Monks, Anne; Hose, Curtis; Stevens, Malcolm F.G.; Leong, Chee-Onn; Stocks, Michael; Kellam, Barrie; Marlow, Maria; Bradshaw, Tracey D.; Bioorganic and Medicinal Chemistry; vol. 23; 21; (2015); p. 6891 – 6899;,
Bromide – Wikipedia,
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Application of 630-17-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 630-17-1 as follows.

To a solution of trans-N-(4-furo [3 ,2-b]pyridin-3 -ylcyclohexyl)- 1H-pyrazole-4-sulfonamide (20 mg, 1 equiv.) in DMF (1 mL), K2C03 (23.6 mg, 3 equiv.) was added, followed by 1- bromo-2,2-dimethyl-propane (10.8 tL, 1.5 equiv.). The reaction mixture was stirred for 30 mm at 150 C by using microwave irradiation, and was then purified by preparative HPLCMS to afford the expected product (8 mg). LCMS: MW (calc?d): 416.5; MS (ES, m/z):417.7 [M+H].

According to the analysis of related databases, 630-17-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; E-THERAPEUTICS PLC; KOLUND?IC, Filip; MILEK, Mateja; POLJAK, Tanja; RO?CIC, Maja; STUBBERFIELD, Colin; VADLAMUDI, Srinivasamurthy; (139 pag.)WO2019/43373; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1073-39-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1073-39-8, name is 3-Bromobicyclo[4.2.0]octa-1,3,5-triene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A four-neck flask was charged with aniline(2.79 g),3-Bromo-bicyclo [4,2,0] octa-1 (6), 2,4-triene(11.5 g),Tris (dibenzylideneacetone) dipalladium(0.549 g),Tri-tert-butylphosphonium tetrafluoroborate(0.696 g), sodiumTert-butoxide (8.55 g) and toluene (150 mL) were placed, and the mixture was heated at 110 for 2 hours. After cooling to room temperature (25 C), the insoluble material was filtered through celite. The solvent was distilled off the filtrate under reduced pressure, and the residue was purified by column chromatographyN- (bicyclo [4.2.0] octa-1,3,5-trien-3-yl)-N-phenyl-bicyclo[4.2.0] octa-1 (6), 2,4-triene-3-amine(9.16 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromobicyclo[4.2.0]octa-1,3,5-triene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Samsung Electronics Co., Ltd.; Kato, Fumiaki; Inayama, Satoshi; Numata, Masaki; (52 pag.)KR2016/93531; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 57951-72-1, name is 1-Bromo-2-cyclopropylethyne, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 57951-72-1

General procedure: The (E)-alpha-stannyl-alpha,beta-unsaturated ester 1 (1.0 mmol) and the alkynylbromide 2 (1.1 mmol) were dissolved in DMF (8 mL) under Ar at room temperature. Pd(PPh3)4 (0.05 mmol) and CuI (0.75 mmol) were then added. The mixture was stirred for 20-24 h at room temperature and monitored by TLC (SiO2) for the disappearance of the starting (E)-alpha-stannyl-alpha,beta-unsaturated ester 1. The reaction mixture was diluted with diethyl ether (30 mL), filtered and then treated with 20% aqueous KF(10 mL) for 30 min before being dried over MgSO4 and concentrated at 40 C under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: light petroleum ether (30-60 C)/EtOAc, 19:1).

The synthetic route of 1-Bromo-2-cyclopropylethyne has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Pingping; Huang, Bin; Xie, Shiyun; Tuo, Yuxin; Cai, Mingzhong; Journal of Chemical Research; vol. 39; 11; (2015); p. 627 – 630;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59907-12-9, name is 1-Bromo-2-fluoro-3-methylbenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-2-fluoro-3-methylbenzene

General Procedure 2 – Sonogashira coupling of 2-ethynyl-6,7-dihydroindolizin- 8(5H)-one with aryl bromides[00225]A solution of 2-ethynyl-6,7-dihydroindolizin-8(5H)-one, an appropriate aryl bromide (1 .1 eq.) and TEA (4 eq.) in dry DMF (2.5 mL) is flushed with argon for 10 min. PdCl2(Ph3P)2 (0.05 eq.) and copper(l)iodide (0.01 eq.) are added, and the reaction mixture is heated at 90 C for 30 min under microwave conditions. After cooling down to room temperature the mixture is diluted with EtOAc (50 mL), washed with brine (3×50 mL), dried over Na2SO and concentrated in vacuo. Purification by preparative TLC (silica, 50% EtOAc/heptane) and co-evaporation with Et2O (2×2 mL) provides the final compound.Example 622-((2-Fluoro-3-methylphenyl)ethynyl)-6,7-dihydroindolizin-8(5H)-one[00294] According to General Procedure 2, 2-ethynyl-6,7-dihydroindolizin-8(5H)-one (150 mg, 0.942 mmol) is reacted with 1 -bromo-2-fluoro-3-methylbenzene (129 mu, 1 .04 mmol) to provide the title compound (45 mg, 18%) as a light yellow powder. 1H NMR (CDCIs), deltaEta: 2.28-2.34 (m, 5H), 2.62 (t, 2H), 4.13 (t, 2H), 6.96-7.31 (m, 5H). LC/MS (M+H)+ = 268

The synthetic route of 59907-12-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERZ PHARMA GmbH & CO. KGaA; ZEMRIBO, Ronalds; FOTINS, Juris; ABEL, Ulrich; KUBAS, Holger; MEYER, Udo; WOLTER, Falko Ernst; HECHENBERGER, Mirko; WO2012/172093; (2012); A1;,
Bromide – Wikipedia,
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Synthetic Route of 2550-36-9, The chemical industry reduces the impact on the environment during synthesis 2550-36-9, name is (Bromomethyl)cyclohexane, I believe this compound will play a more active role in future production and life.

Synthesis of 9-(cyclohexylmethyl)-2-methoxy-6-methyl-9H-carbazole (Compound 42) Under argon atmosphere, a solution of 7-methoxy-3-methylcarbazole (Krahl et al., Organic & Biomolecular Chemistry 4:3215 (2006)) (600 mg, 2.84 mmol), bromomethylcyclohexane (635 muL, 4.55 mmol), and Cs2CO3 (1.8 g) in DMF (15 mL) was subjected to microwave irradiation at 140 C. for 1 h. The reaction mixture was cooled, diluted with ethyl acetate (150 mL), filtered, and extracted with diethyl ether. The organic layer was washed consecutively with concentrated sodium bicarbonate (150 mL*3), brine, dried over magnesium sulfate, filtered, and concentrated in vacuo. The obtained residue was purified by column chromatography on silica gel using heptanes/ethyl acetate in different proportions to afford the title compound as a brownish solid. Yield: 743 mg (85%), mp 136-137 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Bromomethyl)cyclohexane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Diaz, Philippe; Diaz, Fanny; Petrov, Ravil Rashitovich; US2012/39804; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 348-57-2, name is 1-Bromo-2,4-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Bromo-2,4-difluorobenzene

To a 0¡ã C. mixture of 1-bromo-2,4-difluorobenzene (20.0 g, 11.7 mL, 0.100 mol) and H2SO4 (76.8 mL) was added HNO3 (68.0 mL) over 45 min at such a rate that the internal temperature was <7¡ã C. The resulting mixture was stirred for 1 h at 0¡ã C., poured into ice water (400 mL), stirred vigorously for 2-3 min and extracted with CH2Cl2 (400 mL). The organic layers were washed with brine (1.x.500 mL), dried over Na2SO4, filtered and evaporated to give the product as a yellow oil (23.5 g, 95percent yield). 1H NMR (CDCl3) delta 8.39 (t, J=7.2 Hz, 1H), 7.14 (ddd, J=0.3, 7.8, 9.9 Hz, 1H). According to the analysis of related databases, 348-57-2, the application of this compound in the production field has become more and more popular. Reference:
Patent; H. Lundbeck A/S; US2006/79523; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 103-64-0, A common heterocyclic compound, 103-64-0, name is (2-Bromovinyl)benzene, molecular formula is C8H7Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of N, N-dimethylformamide (DMF) in a volume ratio of 4: 1 with polyethylene glycol 200(PEG-200)) was added 100 mmol of the compound of the above formula (I), 60 mmol of the compound of the above formula (II), 8 mmol of catalyst bis (triphenylphosphine) cyclopentadienyl ruthenium chloride,(TFA) 2), 15 mmol of organic ligand L1 and 80 mmol of base, 5,7-triazabicyclo [4.4.0] dec-5-ene (TBD), Then the mixture was warmed to 80 C with stirring, and the reaction was stirred at that temperature for 11 hours;After completion of the reaction, the reaction system is naturally cooled to room temperature and the pH is adjusted to neutral, filtered and the filtrate is saturatedWashed with brine, and extracted with ethyl acetate 2-3 times, combined with organic phase,Dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography eluting with a 1: 2 by volume mixture of chloroform and petroleum ether to give the compound of the above formula (III) in a yield of 76.6%.

The synthetic route of 103-64-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Huang, Cheng; No proclaimed inventor; (12 pag.)CN106278839; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 21120-91-2, A common heterocyclic compound, 21120-91-2, name is 7-Bromobicyclo[4.2.0]octa-1,3,5-triene, molecular formula is C8H7Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a 250 ml three necked round bottom flask equipped with a polytetraflouroethylene (Teflon polymer, Dupont, Wilmington, Del.) coated magnetic stir bar, potassium hydroxide (1.38 g, 1 eq) was dissolved in water (6.83 g). Then 4-acetoxy styrene (4 g, 1 eq) was added dropwise at room temperature, and the solution turned from colorless to pale orange. Potassium carbonate (6.82 g, 2 eq) was added portionwise, and the solution was stirred for one hour. The flask was equipped with a reflux condenser, then 1-bromobenzocyclobutene (4.06 g, 1 eq) was added dropwise in DMF (41 ml). The solution was then heated to 70 C. and allowed to reflux overnight. To the reaction was added water (50 ml) and ethyl acetate (50 ml). The aqueous residue was extracted four times with ethyl acetate (100 ml). The combined organics were extracted with sodium bicarbonate solution (1¡Á100 ml), lithium chloride aqueous solution (1¡Á100 ml) and brine (2¡Á100 ml). The organics were dried over sodium sulfate, filtered and concentrated in vacuo to give the product as a of white solid (3.36 g, 68% yield). Melting point 54-60 C. 1H NMR (600 MHz, Chloroform-d) delta 7.39 (d, J=8.6 Hz, 2H), 7.34 (td, J=7.3, 1.5 Hiz, 1H), 7.31-7.24 (m, 2H), 7.21-7.18 (m, 1H), 6.98 (d, J=8.6 Hz, 2H), 6.69 (dd, J=17.6, 10.9 Hz, 1H), 5.70 (dd, J=4.3, 1.9 Hz, 1H), 5.64 (dd, J=17.6, 0.9 Hz, 1H), 5.15 (dd, J=10.9, 0.9 Hz, 1H), 3.73 (dd, J=14.2, 4.3 Hz, 1H), 3.31 (d, J=14.2 Hz, 1H). 13C NMR (151 MHz, Chloroform-d) delta 157.79, 144.62, 142.57, 136.20, 130.87, 129.93, 127.50, 127.43, 123.48, 123.04, 115.06, 111.80, 74.28, 39.45. Yield from the above example was good and the resulting monomer was a stable solid which has a desirable ring opening cure temperature of 184 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Rohm and Haas Electronic Materials LLC; Hayes, Colin; Gallagher, Michael K.; Riener, Michelle; (10 pag.)US2019/169327; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary