Tag: M.W=100-200

Reference of 583-75-5,Some common heterocyclic compound, 583-75-5, name is 4-Bromo-2-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-bromo-2-methylaniline (5.0 g, 27 mmol) was added to a mixture of water (12.3 ml) and HBF4 (48% by weight in water, 12.3 ml, 67 mmol) in a Nalger reaction vessel cooled in an ice water bath. Then, NaNO2 (1.85 g, 27 mmol) in water (3.8 ml) was added while maintaining the temperature of the reaction around 10 C. After 15 minutes, the was then recooled in an ice water bath and filtered via a Buchner funnel. The solid was washed with cold 5% aqueous HBF4, cold MeOH (20 ml) and diethyl ether (3 x 10 ml). The solid was dried on a Buchner funnel for 1 hour and then added to a flask containing KOAc (5.3 g, 54 mmol, dried in vacuo overnight) and 18-C-6 (0.35 g, 1,3 mmol) suspended in chloroform (250 ml). The reaction was stirred at room temperature for 2 hours and then filtered, and the solid was washed with chloroform. The filtrate was washed with water and brine, dried over sodium sulfate, filtered, concentrated, and diluted with water (250 ml). The suspension was filtered, and the solid was washed with hexanes (50 ml) and diethyl ether (50 ml), collected, and dried in vacuo to give title compound (3.6 g, 68%). MS (ESI pos. ion) m/z: 197 (M+H). Calc’d Exact Mass for C7H5BrN2: 196.

The synthetic route of 583-75-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; WO2007/5668; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17247-58-4, name is (Bromomethyl)cyclobutane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of (Bromomethyl)cyclobutane

Example 5; Preparation of N-cyclobutylmethyl-6,14~endoethano-7-(2-hydroxy-2-cyclobutyl-2-ethyl)-tetrahydronorthebaine (compound (VI); R1 and R2= cyclobutyl); 596 mg (4 mmol) of bromomethyl cyclobutane, 1 g (7.2 mmol) of potassium carbonate and 1 g (2.5 mmol) of the compound of formula (V) obtained in Example 4 were added slowly to 10 ml of dimethylformamide. The resulting mixture was heated to 135 C and stirred for 3 hours. The excess potassium carbonate was removed by filtration, and the solvent was removed by vacuum distillation. The remaining solid was filtered and vacuum dried to obtain the title compound (0.94 g, 81%).

The synthetic route of 17247-58-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HANMI PHARM. CO., LTD.; WO2006/25710; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 55289-36-6, A common heterocyclic compound, 55289-36-6, name is 3-Bromo-2-methylaniline, molecular formula is C7H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 32C: N-(3-Bromo-2-methylphenyl)-2-(3-methoxypyridin-2-yl)acetamide A mixture of sodium 2-(3-methoxypyridin-2-yl)acetate (0.166 g, 0.871 mmol), 3-bromo-2-methylaniline (0.118 mL, 0.958 mmol), DIEA (0.608 mL, 3.48 mmol) and HATU (0.397 g, 1.05 mmol) in DMF (4.0 mL) was stirred at room temperature. After 1 h, the mixture was diluted with EtOAc and washed twice with 10% aqueous LiCl, then with brine, dried and concentrated. The residue was purified by column chromatography on silica gel to provide N-(3-bromo-2-methylphenyl)-2-(3-methoxypyridin-2-yl)acetamide as a pale yellow solid (0.213 g, 73% yield). Mass spectrum m/z 335, 337 (M+H)+.

The synthetic route of 55289-36-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Batt, Douglas G.; Bertrand, Myra Beaudoin; Delucca, George; Galella, Michael A.; Ko, Soo Sung; Langevine, Charles M.; Liu, Qingjie; Shi, Qing; Srivastava, Anurag S.; Tino, Joseph A.; Watterson, Scott Hunter; US2014/378475; (2014); A1;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 766-46-1, name is 2′-Bromophenylacetylene, A new synthetic method of this compound is introduced below., name: 2′-Bromophenylacetylene

General procedure: All reactions were carried out under aerobic conditions. A mixture of aromatic alkyne (1.0 mmol), AgNO3 (0.075 mmol), Cs2CO3 (1.0 mmol), catalyst compound 1 (0.5 mol %), and n-butyl alcohol/H2O (in 1:2 proportion, 3 mL) was stirred at 60 C for 24 h and then extracted three times with ethyl acetate (3 x 15 mL). The combined organic phase was dried with MgSO4, filtrated, and then solvent was removed on a rotary evaporator. The product was isolated by thin-layer chromatography. The purified products were identified by 1H-NMR and 13C-NMR spectroscopy (Figures S1-S10).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Guo, Mengping; Chen, Bo; Lv, Meiyun; Zhou, Xiuling; Wen, Yongju; Shen, Xiuli; Molecules; vol. 21; 5; (2016);,
Bromide – Wikipedia,
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Synthetic Route of 4333-56-6, A common heterocyclic compound, 4333-56-6, name is Bromocyclopropane, molecular formula is C3H5Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 2-bromo-5-fluorophenol (1.0 g) in DMF (15 mL) in a microwave tube was added cesium carbonate (5.0 g), potassium iodide (130 mg) and bromocyclopropane (1.82 g). The mixture was heated in a microwave oven to 180 C for 1 h, to 200 C for 1 h and to 220 C for 1 h. Ethyl acetate was added and the mixture was washed with water. The organic phase was washed with saturated sodium chloride solution, dried (sodium sulfate) and the solvent was removed in vacuum. Silica gel chromatography gave 1.14 g of the title compound. 1H-NMR (300MHz, DMSO-d6): delta [ppm]= 0.62 – 0.88 (m, 4H), 3.90 – 4.00 (m, 1 H), 6.77 (td, 1 H), 7.23 (dd, 1 H), 7.48 – 7.63 (m, 1 H).

The synthetic route of 4333-56-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; KOSEMUND, Dirk; WENGNER, Antje Margret; SIEMEISTER, Gerhard; STOeCKIGT, Detlef; BRUENING, Michael; WO2013/87579; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 626-88-0, name is 1-Bromo-4-methylpentane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-88-0, category: bromides-buliding-blocks

To a solution of Magnesium turning (46 mg, 1.9 mmol) with catalytic amount of iodine indiethylether (1 mL) was added 1-bromo-4-methyl pentane(0.345 mL, 2.37 mmol). The reaction mixture was stirred under argon gas until complete consumption of the Magnesium turning at ambient temperature. To a reaction mixture was added 9 (500 mg,1.58 mmol) in diethylether (1 mL) at ambient temperature. The reaction mixture was stirred until the bubbling was over at ambient temperature. The reaction mixture was quenched with 2 N HCl, and diluted with EtOAc. The organic phase was washed with H2O and brine, dried over MgSO4, and concentrated in vacuo. Purification of the residue via flash column chromatography on silica gel (EtOAc:n-Hexane 1:10 to 1:5) afforded 96 mg (15%) of the desired alcohol11: 1H NMR (CDCl3, 300 MHz) d 5.35 (d, J 5.3 Hz, 1H), 3.53 (m, 1H),2.32-2.24 (m, 2H), 2.11-0.86 (m, 42H). LR-MS (FAB) m/z 425(M Na)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Kim, Kyeojin; Maharjan, Sony; Lim, Changjin; Kim, Nam-Jung; Agrawal, Vijayendra; Han, Young Taek; Lee, Sujin; An, Hongchan; Yun, Hwayoung; Choi, Hyun-Jung; Kwon, Young-Guen; Suh, Young-Ger; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 184 – 194;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-70-0, name is 2,4-Dimethylbromobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H9Br

General procedure: By using 3,6-di-tert-butyldimethylsilyloxy-Si-xanthone obtained in Example 1, the step (6), Compounds (a) to (e) were synthesized by the following procedures. (0134) A bromobenzene derivative (1.0 mmol) and anhydrous tetrahydrofuran (THF, 5 mL) were added to a sufficiently dried flask under an argon atmosphere. The mixture was cooled to -78 C., and then 1 M sec-butyllithium (0.5 mmol) was added thereto, and the mixture was stirred for 20 minutes. 3,6-Di-tert-butyldimethylsilyloxy-Si-xanthone (0.015 to 0.019 mmol) dissolved in anhydrous THF (5 mL) was slowly added to the mixture at the same temperature, and the mixture was brought to room temperature. The mixture was stirred at room temperature for 1 hour, and then 2 N hydrochloric acid (5 mL) was added thereto, and the mixture was stirred for 20 minutes. The reaction mixture was extracted with dichloromethane, and the organic layer was washed with brine, and dried over anhydrous sodium sulfate. The solvent was removed, and then the residue was purified by HPLC to obtain the objective substance.

The synthetic route of 583-70-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF TOKYO; Nagano, Tetsuo; Hanaoka, Kenjiro; Koide, Yuichiro; Egawa, Takahiro; US9170266; (2015); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 399-94-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 399-94-0, name is 1-Bromo-2,5-difluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The reaction flask were sequentially added Compound 8 (386mg, 2.0mmol), Pd (OAc)2(18mg,4mol)dppp(66mg,8mol)DMSO(2mL)[bmim][BF 4] (2mL), allyl alcohol (0.27mL, 4.0mmol) and NEt3(0.42mL, 3mmol). The reaction mixture was stirred at 115 C 15 hours. After the reaction system was cooled to room temperature and extracted with dichloromethane, dried and the solvent was evaporated. Mixture was purified by column chromatography to give compound 9.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2,5-difluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Jiao Tong University; Zhang, yongjian; A, MAER; (10 pag.)CN104370939; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7073-94-1, name is 1-Bromo-2-isopropylbenzene, A new synthetic method of this compound is introduced below., Computed Properties of C9H11Br

1-Br-2-isopropylbenzene (1.306 g, 6.561 mmol, 2.7 eq)Was added THF (13.122 mL) and t-BuLi (8.36 mL) was added at -78 C. This was reacted for 2 hours and then heated to room temperature to prepare lithium cumene. The ligand precursor prepared above N-(2,6-diisopropylphenyl)-1-(6-(2-methyl-1,2,3,4-tetrahydroquinolin-8-yl)pyridin-2-yl)methanimine(1 g, 2.43 mmol, 1 eq) was added diethyl ether (24.3 mL), and the lithium cumene was added dropwise at -78 C. The reaction was allowed to warm to room temperature overnight, quenched with 1 N NH4Cl and worked up with Ether / H2O. The water was dried with Na2SO4 and the solvent was vacuum dried with a rotary evaporator. Yellow oil, 1.48 g, was obtained in quantitative yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LG Chemical Co., Ltd.; Han, Hyo Jung; Han, Ki Won; Jang, Jae Kwon; Lee, Eun Jung; Lee, Chung Hoon; (59 pag.)KR2017/95036; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 51376-06-8, The chemical industry reduces the impact on the environment during synthesis 51376-06-8, name is 5-Bromobenzo[c][1,2,5]oxadiazole, I believe this compound will play a more active role in future production and life.

A solution of 5-bromobenzo[c][1,2,5]oxadiazole (3 g , 15.0 mmol, Combiblocks ) in toluene (10 mL) was degassed for 30 min. 1 -Ethoxy vinyl tributyltin (6.01 mL, 16.5 mole, Frontier Scientific) and bis(triphenylphosphine)palladium(ll) dichloride (1.16 g, 1 .65 mmol) were added at rt and the resulting mixture was stirred at 90 C overnight. It was cooled to rt and filtered through celite. HCl aqueous solution (20 mL, 6N) was added and the mixture was stirred for 1 hour at rt. It was concentrated and neutralized with sat. NaHCO3 solution (25 mL). The product was extracted with DCM (100 mL), dried over Na2SO4 and concentrated. The crude product was purified by flash column chromatography to afford the title compound. Yield: 60% (1 .5 g, pale yellow solid). 1 H NMR (400 MHz, DMSO-d6): delta 8.90 (s, 1H), 8.14 (d, J = 9.6 Hz, 1H), 7.98-7.39 (m, 1H), 2.72 (s, 3H). LCMS: (Method B) 162.0 (M+H), Rt. 4.6 min, 98.01 % (Max).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromobenzo[c][1,2,5]oxadiazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASCENEURON SA; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (243 pag.)WO2016/30443; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary