Tag: M.W=100-200

Related Products of 4117-09-3,Some common heterocyclic compound, 4117-09-3, name is 7-Bromo-1-heptene, molecular formula is C7H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a round-bottom flask, tetrabutylammonium iodide(0.02 eq.) and potassium phthalimide (2.0 eq.) were suspended in acetonitrile. 17 (1.0 eq.) was addeddropwise and the resulting mixture was heated up to 80C for exactly 24 hours. Once the mixturereached room temperature, it was diluted with diethyl ether and passed through a celite plug. Thefiltrate was concentrated in vacuo and the yellow residue was purified by column chromatography(hexane/ethyl acetate 95/5) giving the desired product as a white solid (83% yield).

The synthetic route of 4117-09-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Czescik, Joanna; Zamolo, Susanna; Darbre, Tamis; Mancin, Fabrizio; Scrimin, Paolo; Molecules; vol. 24; 15; (2019);,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 1003-99-2, name is 2-Bromo-5-fluoroaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1003-99-2, Safety of 2-Bromo-5-fluoroaniline

N-(2-Bromo-5-fluorophenyl)pivalamide. Trimethylacetyl chloride (4.2 mL, 34.1 mL) was fast dropwise added to a solution of 2-bromo-5-fluorobenzenamine (4.31 g, 22.7 mmol) in CH2Cl2 (50 mL) at room temperature, followed by the addition of DIEA (7.9 mL, 45.4 mmol). The resulting mixture was stirred at room temperature for 2 hrs, and then partitioned between HCl (1N, 200 mL) and EtOAc (250 mL). After separation, the organic phase was washed with brine (50 mL), dried on MgSO4, concentrated on rotary vacuum, and purified on flash chromatography eluting with 2040percent EtOAc/hexanes (1200 mL) to afford the expected product, as a colorless oil (6.07 g, 98percent yield); 1H NMR (400 MHz, CDCl3) delta ppm 1.33 (s, 9H), 6.69 (ddd, J=8.81, 7.55, 3.02 Hz, 1H), 7.45 (dd, J=8.81, 5.79 Hz, 1H), 8.04 (s, 1H), 8.28 (dd, J=11.08, 3.02 Hz, 1H); Mass spec. 274.04 (MH+), Calc. for C11H13BrFNO 273.02

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5-fluoroaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chaturvedula, Prasad V.; Mercer, Stephen E.; Fang, Haiquan; US2006/94707; (2006); A1;,
Bromide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 57951-72-1, name is 1-Bromo-2-cyclopropylethyne, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57951-72-1, Formula: C5H5Br

General procedure: Dissolved aryl halide (1.0 equiv) in dry DMF and subjected to degassing with a gaseous mixture of (H2+ N2) balloon for three times. Added PdCl2(PPh3)2(10 mol %) followed by Cul (8 mol%) at r.t. Added terminal alkyne (1.0 equiv. followed by TEA. The reaction mixture stirred at 50 C or 90 C. After cooling to room temperature, the resulting solution was subjected to rotary evaporation and partitioned between EtOAc and D.I. water. Aqueous layer was extracted with EtOAc 20 mL (3x). Combined organic layers were given water, brine washes and dried over anhydrous Na2S04. After evaporation of the solvent, column chromatography on silica gel afforded the desired product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-cyclopropylethyne, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THORPE, Steven Brandon; SANTOS, Webster L.; LYNCH, Kevin R.; (375 pag.)WO2017/172989; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 51437-00-4, name is 4-Bromo-1-fluoro-2-methylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51437-00-4, Recommanded Product: 51437-00-4

Example 96 Preparation of 3-Methyl-2-(1H-1,2,4-triazol-1-yl)-5-vinylbenzonitrile (DI70) Step 1. 5-Bromo-2-fluoro-3-methylbenzaldehyde To a stirred solution of di-isopropyl amine (4.01 g, 39.88 mmol) in THF (20 mL) was added n-butyl lithium (1.6 M in hexane) (19.9 mL, 31.91 mmol) at -78 C. slowly dropwise over the period of 10 min, the reaction mixture was stirred at -78 C. for 30 min. A solution of 4-bromo-1-fluoro-2-methylbenzene (5.0 g, 26.6 mmol) in THF (30.0 mL) was added at -78 C., and the reaction mixture was stirred for 1 h at the same temperature. DMF (5.0 mL) was added and stirred at -78 C. for another 30 min. The reaction was monitored by TLC; then the reaction mixture was quenched with 1N HCl solution (aq) at 0 C. The aqueous layer was extracted with diethyl ether, washed with water and saturated brine solution. The combined organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the crude compound purified by flash column chromatography (SiO2, 100-200 mesh; eluting with 5% ethyl acetate/pet ether) to afford the title compound as a white solid (3.6 g, 64%); mp 48-50 C.: 1H NMR (400 MHz, CDCl3) delta 8.33 (s, 1H), 8.22 (s, 1H), 7.67 (s, 1H), 7.60 (s, 1H), 6.75 (dd, J=17.6, 10.8 Hz, 1H), 5.92 (dd, J=17.6, 10.8 Hz, 1H), 5.52 (d, J=17.6 Hz, 1H), 2.21 (s, 3H); ESIMS m/z 211.35 ([M-H]-).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Dow AgroSciences LLC; Lo, William C.; Hunter, James E.; Watson, Gerald B.; Patny, Akshay; Iyer, Pravin S.; Boruwa, Joshodeep; US9211280; (2015); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 10269-01-9,Some common heterocyclic compound, 10269-01-9, name is (3-Bromophenyl)methanamine, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1B (100 mg, 0.40 mmol),3-bromobenzylamine (74 mg, 0.40 mmol) and potassium carbonate (50 mg, 0.36 mmol)DMF was distilled off under reduced pressure. Separated with DCM-MeOH (40:1) as eluent,A white solid (41 mg, 27.9%) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (3-Bromophenyl)methanamine, its application will become more common.

Reference:
Patent; Shanghai Jiao Tong University; Mao Zhenmin; Wang Yaolin; Zhan Xiaoping; (15 pag.)CN109593066; (2019); A;,
Bromide – Wikipedia,
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Synthetic Route of 38573-88-5, The chemical industry reduces the impact on the environment during synthesis 38573-88-5, name is 1-Bromo-2,3-difluorobenzene, I believe this compound will play a more active role in future production and life.

Then 2,3-difluorobromobenzene (T-10) (115.2 g) was dissolved in DryTHF (600 ml), and the resultant solution was cooled to -70°C. In a nitrogen atmosphere, n-BuLi (364 ml) was added dropwise, and agitation was carried out at -70°C for 2 hours. Then, a DryTHF solution of cyclohexanedione monoethylene ketal (T-3) (93.6 g) was slowly added dropwise at -70°C, and the resultant solution was heated to room temperature and agitated for 16 hours. After completion of the reaction, 2N-HCl (200 ml) was added, extraction was carried out with toluene, an organic layer was washed with water and a saturated aqueous solution of sodium chloride, and then the resultant solution was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and thus a light brown solid was obtained. The resultant material was dissolved in toluene (400 ml), p-TsOH (4.74 g) was added, and heating reflux was carried out for 4 hours while performing dehydration. After completion of the reaction, extraction was carried out with toluene, an organic layer was washed with water and a saturated aqueous solution of sodium chloride, and then the resultant solution was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and thus a light brown solid was obtained. The resultant material was subjected to silica gel column chromatography (heptane:ethyl acetate = 20:1 in a volume ratio) and recrystallization (Solmix), and thus (T-11) was obtained as a colorless crystal (121.0 g, yield: 80percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2,3-difluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JNC Corporation; JNC Petrochemical Corporation; EP2484658; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 7745-91-7,Some common heterocyclic compound, 7745-91-7, name is 3-Bromo-4-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

C. (l,3-Dihvdw-l-hvdwxy-2,l-benzoxabowl-6-yl)-phenyl-carbamic acid t- butvl ester (59); (3-Bromo-4-methyl-phenyl)-phenyl-amine (54); [0321] To a mixture of iodobenzene (4.4 g, 21.56 mmol), 3-bromo-4- methylbenzamine (4.0 g, 21.56 mmol) and DMSO (50 mL) were added in sequence copper (I) iodide (0.82 g, 4.31 mmol), L-proline (0.99 g, 8.61 mmol) and NaOBu-t (4.14 g, 43.13 mmol) under N2. The mixture was stirred at 50 0C for 48 hbefore poured onto ice (100 g) and extracted with EtOAc (100 mL x 3). The extracts were dried over Na2SO4 and the residue after rotary evaporation was purified by column chromatography to give 1.2 g of compound 54 (21.2%). 1HNMR (300 MHz, DMSO): delta 8.19 (s, 1 H), 7.27-7.15 (m, 4 H), 7.05-7.01 (m, 2 H), 6.97 (dd, Ji = 8.4, J2 = 2.4 Hz, 1 H), 6.85 (m, 1 H) and 2.23 (s, 3 H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-4-methylaniline, its application will become more common.

Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; ORR, Matthew; JENKS, Matthew; WO2011/19612; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5433-01-2, name is 1-Bromo-3-isopropylbenzene, A new synthetic method of this compound is introduced below., SDS of cas: 5433-01-2

1-Bromo-3-isopropylbenzene 13 (1.5 g, 7.5 mmol, 1.0 eq.), acrolein-diethylacetal (3.57g, 23.43 mmol, 3.1 eq.), Bu4NOAc (5.0 g, 16.6 mmol, 2.2 eq.), potassium carbonate (1.56 g, 11.3 mmol, 1.5 eq.), potassium chloride (0.75 g, 7.6 mmol, 1.01 eq.) and palladium(II) acetate (50 mg, 0.22 mmol, 0.029 eq.) were suspended in DMF (32 mL) and heated for 24 h at 90C. The reaction mixture was cooled to room temperature, diluted with water (25 mL) and acidified with HCl 2M. After extraction with methyl-tert-butyl ether, the organic phase was washed with water and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by chromatography on silica gel (hexane/EtOAc 19/1) to give 14 (928 mg, 71% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Goncalves-Contal, Sylvie; Gremaud, Ludovic; Palais, Laetitia; Babel, Lucille; Alexakis, Alexandre; Synthesis; vol. 48; 19; (2016); p. 3301 – 3308;,
Bromide – Wikipedia,
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Synthetic Route of 17247-58-4, These common heterocyclic compound, 17247-58-4, name is (Bromomethyl)cyclobutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0079] Step G: l-[2-(2,4-Dichloro-phenyl)-ethyl]-8-(3-methoxy-phenyl)-l,3- diaza-spiro[4.5]decane-2,4-dione 86 (0.52 g, 1.16 mmol), bromomethylcyclobutane (0.175 mL, 1.56 mmol) and potassium carbonate (0.32 g, 2.32 mmol) in dry DMSO (5.0 mL) are stirred for 3 h at 500C. The mixture is cooled to rt, diluted with water and extracted with DCM (3x). The combined extracts are washed with 1 N HCl, H2O (3x) and brine, dried over MgSO4, and concentrated to afford 3-cyclobutylmethyl-l-[2-(2,4-dichloro-phenyl)-ethyl]-8- (3-methoxy-phenyl)-l,3-diaza-spiro[4.5]decane-2,4-dione 87 (0.65 g, quant.) as a clear, thick oil: MS calcd. for C28H33Cl2N2O3 (MH-H+) 515.1, found 515.1; 1H-NMR (400 MHz, CDCl3) delta = 7.40 (d, J= 1.7 Hz, IH), 7.21 (m, 3H), 6.88 (d, J = 7.9 Hz, IH)5 6.83 (t, J= 2.2 Hz, IH)5 6.75 (dd, J= 2.2, 7.9 Hz, IH), 3.80 (s, 3H)5 3.54 (d, J= 7.4 Hz5 2H), 3.41 (t, J= 7.2 Hz5 2H), 3.13 (t, J= 7.2 Hz, 2H)5 2.71 (septet, J= 7.7 Hz, IH), 2.38 (m, 3H), 2.02 (m5 2H), 1.88 (m, 2H)5 1.77 (m, 6H)5 1.62 (m, 2H).

The synthetic route of 17247-58-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IRM LLC; WO2007/87448; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 51376-06-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51376-06-8, name is 5-Bromobenzo[c][1,2,5]oxadiazole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

l-(2-((2S,4R)-4-Fluoro-2-((2-fluoro-3-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenyl)carbamoyl)pyrrolidin-l-yl)-2-oxoethyl)-lH-indazole-3-carboxamide, 5- bromobenzo[c][l,2,5]oxadiazole, Pd(dppf)Cl2 and potassium carbonate were taken up in a pressure tube under argon. To this mixture, 8 mL of dioxane and 2 mL of water were added. The mixture was bubbled with argon for 5 min and the vial was stoppered and subjected to microwave irradiation at 100 C for 45 min. The volatiles were removed under reduced pressure and the residue was purified by ISCO (0-5 % MeOH in CH2CI2) to afford compound 68. 1HNMR (400 MHz, DMSO) (major rotamer) delta 2.10 – 2.20 (m, 1H), 2.57-2.63 (m, 1H), 3.89 – 4.04 (m, 1H), 4.24 (dd, J = 12.7, 21.8 Hz, 1H), 4.78 (t, J = 8.3 Hz, 1H), 5.47 (d, J= 17.2 Hz, 1H), 5.55 (d, J = 52.4 Hz, 1H), 5.67 (d, j = 17.2 Hz, 1H), 7.23-7.31 (m, 2H), 7.36 (s, 1H), 7.39 – 7.46 (m, 2H), 7.59 – 7.64 (m, 2H), 7.74 (d, J= 9.3 Hz, 1H), 7.98 (t, J= 7.8 Hz, 1H), 8.11 – 8.25 (m, 3H), 10.05 (s, 1H). 19F- MR (DMSO-de ) (major rotamer): delta -128.8, -175.9.

The synthetic route of 5-Bromobenzo[c][1,2,5]oxadiazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (447 pag.)WO2017/35408; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary