Tag: M.W=100-200

Related Products of 7745-91-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7745-91-7, name is 3-Bromo-4-methylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(d) 3-Bromo-4-methylphenol 25 g (134 mmol) of 2-bromo-4-aminotoluene are placed in 400 ml of 1M sulfuric acid in a round-bottomed flask, and the mixture is then cooled to 0 C. 13 g (190 mmol) of sodium nitrite dissolved in 30 ml of water are added, followed by addition of 21 ml of concentrated sulfuric acid. The mixture is refluxed for 4 hours. It is then extracted with ethyl ether. The organic phase is dried over magnesium sulfate, filtered and then evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a mixture of heptane and ethyl acetate (90/10) to give 12.1 g (48%) of the expected product in the form of a brown oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-4-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bernardon, Jean-Michel; Biadatti, Thibaud; US2003/195259; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 5469-19-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5469-19-2, name is 1-Bromo-2,4,5-trimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 8 3-diethylamino-6-methyl-7-(2′,4′,5′-trimethylanilino)fluoran STR17 30 g. of 3-methoxy-6-acetylaminotoluene, 40 g. of 2,4,5-trimethylbromobenzene, 15 g. of potassium carbonate, 1 g. of copper powder and 0.1 g. of iodine were reacted for 75 hours at 220 to 230 C. Then 15 g. of potassium hydroxide and 30 ml. of iso-propylalcohol were added and refluxed for 24 hours. The resultant was poured into 200 ml. of water and precipitate was filtered off, distilled in a vacuum to obtain 35.5 g. (83 percent of theoretical yields) of 4-methoxy-2,2′,4′,5′-tetramethyldiphenylamine as a light brown crystal having a melting point of 87 to 88 C., and boiling point of 165 to 168 C./3 mmHg.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2,4,5-trimethylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Yamamoto Kagaku Gosei Kabushiki Kaisha; US4330473; (1982); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 399-94-0, name is 1-Bromo-2,5-difluorobenzene, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-2,5-difluorobenzene

THF (25 mL) was added to Magnesium metal (2.55g, 105 mmol), and then 2-bromo-1,4-difluorobenzene (19.70g, 100mmol) was addedslowly to prepare a Grignard reagent. To separately prepared THF (10mL)solution of diethyl oxalate (15.34g, 105mmol), Grignard reagent preparedearlier was added dropwise at -40 below. After completion of the addition, it was stirred for 1 hour at thereaction temperature of 0 . saturated aqueous solution of ammonium chlorideand water (200 mL) were added to the reaction solution, and extracted with ethyl acetate (200mL ×2). The organic layer was dried over magnesium sulfate, filtered, and thesolvent was evaporatedunder reduced pressure, and by distillation under reducedpressure, colorless liquid of 2- (2,5-difluorophenyl) -2- oxo-ethyl acetate(14.82g, yield: 62%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SAGAMI CHEMICAL RESEARCH INSTITUTE; KAKEN PHARMACEUTICAL COMPANY LIMITED; KOBAYASHI, OSAMU; TAKATSUNA, REIKO; NIIKURA, NAOKO; MATSUKAWA, TOMOKO; NAKAMURA, SHINJI; HIRAI, KENJI; KOCHI, SHINICHIRO; KAWANISHI, NAOKI; YAMADA, OSAMU; (75 pag.)JP2016/56157; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 583-75-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 583-75-5 name is 4-Bromo-2-methylaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a 100 niL RBF, 4-bromo-2-methylaniline (3.7 g, 20 mmol) and DIPEA (6.95 mL, 40 mmol) were combined with DMF (40 mL). The reaction was cooled to 0 C in an ice bath and cyclopropanecarbonyl chloride (2.1 g, 20 mmol) was added. The mixture was stirred at 0 C for 1 h. Water and EtO Ac were added to separate the phases and the aqueous phase was extracted with EtO Ac. The organic layers were combined, dried over Na2S04, filtered, and concentrated under reduced pressure to give the title compound as a white solid (4.76 g, 94%). NMR (400 MHz, CDCl3) delta ppm 7.85-7.72 (m, 1H), 7.38-7.28 (m, 2H), 7.15-7.02 (m, 1H), 2.27 (s, 3H), 1.57-1.48 (m, 1H), 1.10 (quint, J = 3.9 Hz, 2 H), 0.92-0.79 (m, 2H); MS ESI [M + H]+ 253.9, calcd for [CnHi2BrNO + H]+ 254.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-methylaniline, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITY HEALTH NETWORK; LAUFER, Radoslaw; NG, Grace; LI, Sze-Wan; PAULS, Heinz W.; LIU, Yong; PATEL, Narendra Kumar B.; WO2015/70349; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53078-85-6, name is 2-Bromo-5-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 53078-85-6

3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester (0.05 mmol) was added to the reaction flask.2-bromo-5-methylaniline (0.05 mmol),4-phenyl-1,3-cyclohexanedione (0.05 mmol),(R)-3,3,3′,3′-tetramethylspirophosphoric acid (0.005 mmol) represented by the formula (V),Anhydrous Na2SO4 (200 mg) was poured into 1 mL of dichloromethane, and the mixture was reacted at 65 C for 16 hours. After completion of the reaction, the column was directly subjected to silica gel column chromatography, and the eluent was ethyl acetate / petroleum ether = 1:30.Corresponding optically active 1-arylindole derivative (I-7), yield 73%;

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 53078-85-6.

Reference:
Patent; Zhejiang University; Lin Xufeng; Wang Lei; Zhong Jialing; (14 pag.)CN110183373; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 111721-75-6, A common heterocyclic compound, 111721-75-6, name is 2-Bromo-3-fluoroaniline, molecular formula is C6H5BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 50 mL microwave tube, to a solution of 20 mL of 1 ,4-dioxane and 3 mL of water degassed with argon for 15 minutes, were successively added, 900 mg (4.73 mmol) of 2-bromo-3-fluoroaniline, 2.64 g (11.84 mmol) of 3-fluoro-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridine, 1798 mg (11.84 mmol) of cesium fluoride, 216 mg (0.237 mmol) of tris(dibenzylideneacetone)pailadium(0) and 194 mg (0.474 mmol) of S-Phos. The reaction mixture was heated under microwave at 150 C for 1 hour. The cooled reaction mixture was diluted with ethyl acetate and filtered over a pad of Celite. The organic phase was washed by brine and dried over magnesium sulfate. The organic phase was concentrated under vacuo and purified by column chromatography on silica gel (40 g cartridge – gradient n-heptane/ethyl acetate) to yield 775 mg (72%) of 2-(3-fluoropyridin-4-yl)aniline. LogP = 2.38. Mass (M+H) = 207.

The synthetic route of 111721-75-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; CRISTAU, Pierre; DESBORDES, Philippe; DUFOUR, Jeremy; GOURGUES, Mathieu; LAMPRECHT, Sybille; LOQUE, Dominique; MEISSNER, Ruth; NAUD, Sebastien; THOMAS, Vincent; (90 pag.)WO2020/79173; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 1073-39-8, name is 3-Bromobicyclo[4.2.0]octa-1,3,5-triene, molecular formula is C8H7Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H7Br

The synthesis of a tetracene brominated in the 2-position is shown by way of example in the following illustration: In a first step, alpha-chloro-o-xylene 1 was subjected to pyrolysis at approximately 800 C. and 0.5 mbar. Benzocyclobutene 2 was obtained in a 45% yield. The selective bromination thereof was carried out by treating benzocyclobutene, dissolved in acetic acid, with a mixture of bromine and iodine at room temperature, resulting in 4-bromobenzocyclobutene 3. Dissolving in toluene and heating with a slight molar excess of 1,4-dihydro-1,4-epoxynaphthalene 4 at 220 C. for 20 hours resulted in an 80% yield of a pure endo/exo mixture of the Diels-Alder addition product 5, a colorless crystalline material. This material was heated at reflux in acetic anhydride in the presence of concentrated hydrochloric acid, thus forming 9-bromo-6,11-dihydrotetracene 6. The Yamamoto coupling then resulted in 2-(5,12-dihydrotetracene-2-yl)-5,12-dihydrotetracene 7. The coupling reaction was carried out in an approximately 80% yield in a mixture of dimethylformamide and toluene at 80 C., using bis(cyclooctadienyl) nickel(0) in stoichiometric quantities. After recrystallization from o-dichlorobenzene, compound 7 was dehydrogenated by treatment with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) in boiling o-xylene. After purification by repeated vacuum sublimation, orange-red crystals of 2-(tetracene-2-yl) tetracene 8 were obtained in a yield of 75%. All intermediate products were characterized by 1H and 13C NMR spectroscopy and mass spectroscopy. Compound 8 was characterized by UV-visible spectroscopy.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1073-39-8, its application will become more common.

Reference:
Patent; Rehahn, Matthias; Roth, Michael; Von Seggern, Heinz; Schmechel, Roland; Ahles, Marcus; US2008/214838; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1073-39-8, name is 3-Bromobicyclo[4.2.0]octa-1,3,5-triene, A new synthetic method of this compound is introduced below., name: 3-Bromobicyclo[4.2.0]octa-1,3,5-triene

4-bromobenzocyclobutene[4-bromobenzocyclobutene] (4.23 mL, 34 mmol) was dissolved in tetrahydrofuran[THF] (100 mL) and then charged into a dry ice / acetone bath [dry ice/acetone bath] to lower the furnace temperature.n-BuLi (13 mL, 32 mmol, 2.5 M in hexane) was slowly added and stirred for 1 hour.Then 9-fluorenone [9-fluorenone](3.6 g, 20 mmol) was added thereto, followed by stirring overnight.The reaction was stopped with water and extracted with ethyl acetate water.After the organic layer was collected, the organic layer was dried and filtered using MgSO4.The filtrate was dried with a vacuum rotary concentrator to remove the organic solvent,The residue was column purified to give 4.32 g (76% yield) of intermediate 1-1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LG Chem, Ltd.; Seo Min-seop; Lee Jae-cheol; Kim Jin-seok; Bae Jae-sun; Kim Byeong-jae; (47 pag.)KR2019/60484; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 51376-06-8, name is 5-Bromobenzo[c][1,2,5]oxadiazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 51376-06-8

General procedure: Methyl 5-boronofuran-2-carboxylate (8, 1.3mmol), the appropriate bromo derivatives (10, or 12, or 13, 1.0mmol) and bis(triphenylphosphine)palladium (II) dichloride (5% mol) were dissolved in dry 1,4-dioxane (10mL), under nitrogen atmosphere. A 2M sodium carbonate solution (2mmol) was then added and the resulting mixture was stirred in a microwave synthesizer (Biotage Initiator Classic) for 1hat 60C. After completion, the solution was cooled to room temperature and then filtered on a celite pad. The filtrate was diluted with water and extracted with ethyl acetate (3×4mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo.

The synthetic route of 5-Bromobenzo[c][1,2,5]oxadiazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chiarelli, Laurent R.; Mori, Matteo; Barlocco, Daniela; Beretta, Giangiacomo; Gelain, Arianna; Pini, Elena; Porcino, Marianna; Mori, Giorgia; Stelitano, Giovanni; Costantino, Luca; Lapillo, Margherita; Bonanni, Davide; Poli, Giulio; Tuccinardi, Tiziano; Villa, Stefania; Meneghetti, Fiorella; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 754 – 763;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 202865-83-6, name is 1-Bromo-3-fluoro-5-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 202865-83-6

Example AAA00110 Synthesis of 4-(thiazol-2-yl)-1-(3-(3-fluoro-5-methylphenyl)-propiolyl)piperazine 4-(Thiazol-2-yl)-1-(3-(3-fluoro-5-methylphenyl)propiolyl)piperazine was obtained by the reaction of 4-(thiazol-2-yl)-1-propiolylpiperazine [Precursor BBB2] with 3-bromo-5-fluorotoluene under the conditions described in the case of Example AAA35.

The synthetic route of 1-Bromo-3-fluoro-5-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gruenenthal GmbH; US2007/112011; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary