Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2044-08-8, name is 1-Bromocyclohex-1-ene, A new synthetic method of this compound is introduced below., Formula: C6H9Br

To a solution of 1-bromocyclohexene6 (161 mg, 1.00 mmol) in Et2O (3 mL) at 78 C was addedtBuLi (6.0 mL, 1.46 M in pentane, 2.19 mmol). The resulting solution was stirred at 78 C for 0.5 h andRT for 20 min. After cooling to 78 C, MgBr2 solution (1.0 mL, 1.0 M in Et2O/benzene = 3:1, 1.00mmol) was added dropwise. The reaction mixture was stirred at 78 C for 10 min and a solution ofaldehyde 4a (150 mg, 0.48 mmol) in Et2O (4 mL) was added dropwise over 5 min. After stirring at78 C for 2 h, the reaction was quenched with sat. aq. NH4Cl (20 mL), and extracted with AcOEt (3 x20 mL). The organic layers were combined, washed with brine (20 mL), dried over MgSO4, andconcentrated in vacuo. The residue was purified by flash chromatography (silica gel, hexane/AcOEt =10:1) to afford 20g (161 mg, 85% yield) as a colorless oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Miyamoto, Hiroshi; Hirano, Tomohiro; Okawa, Yoichiro; Nakazaki, Atsuo; Kobayashi, Susumu; Tetrahedron; vol. 69; 45; (2013); p. 9481 – 9493;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 1647-26-3,Some common heterocyclic compound, 1647-26-3, name is 1-Bromo-2-cyclohexylethane, molecular formula is C8H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

STEP A:N-(lambda?r?-butoxycarbonyl)-D-valinol (1.0 g, 4.9 mmol) and (2-bromo-ethyl)-cyclohexane (1.53 mL, 9.8 mmol) were taken into DMF (10 mL). Crushed potassium hydroxide (0.55 g, 9.8 mmol) was added, and the reaction mixture was stirred at room temperature overnight. The reaction was quenched with water, and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium bicarbonate and brine, and then dried over sodium sulfate. The solvent was removed in vacuo to crude material which was used in the next step without further purification. MH+ 314.0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-cyclohexylethane, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/50612; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4117-09-3 as follows. Recommanded Product: 4117-09-3

To a suspension of 6 (40 mg, 0.075 mmol) and K2CO3 (51.2 mg, 0.373 mmol) in DMF (1 mL) was added 7-bromohept-1-ene (39.6 mg, 0.224 mmol). The reaction was stirred at 40 C for 5 h. The reaction mixture was cooled to rt and purified by flash chromatography (silica gel; linear gradient 0-10% MeOH-CH2Cl2) to provide S4f (42 mg, 77%).

According to the analysis of related databases, 4117-09-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Donnell, Andrew F.; Zhang, Yong; Stang, Erik M.; Wei, Donna D.; Tebben, Andrew J.; Perez, Heidi L.; Schroeder, Gretchen M.; Pan, Chin; Rao, Chetana; Borzilleri, Robert M.; Vite, Gregory D.; Gangwar, Sanjeev; Bioorganic and Medicinal Chemistry Letters; vol. 27; 23; (2017); p. 5267 – 5271;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 1422-54-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1422-54-4, name is 2-Bromo-6-fluorotoluene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step -I : Synthesis of Compound 3: [00113} Active magnesium (10 mrrtol) was added in a RB containing dry THF (10ml) and added a little iodine and stirred the reaction mixture and to this was added compound 1 (in 2 ml THF)slowly and stirred to generate the Grignard reagent The reaction mixture was cooled to 0 “C and added compound 2 (in THF) drop wise and stirred the reaction mixture at it for 2h. After 2h the reaction mixture was quenched with saturated ‘ CI solution and extracted with EtOAc. The organic layer washed with water, brine, dried over sodium sulphate and evaporated under reduced pressure to obtain compound 3

The synthetic route of 2-Bromo-6-fluorotoluene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KANDULA, Mahesh; WO2013/168022; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 460-00-4, A common heterocyclic compound, 460-00-4, name is 1-Bromo-4-fluorobenzene, molecular formula is C6H4BrF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An oven-dried Schlenk tube was charged with CuI (4 mg, 0.02 mmol), aryl bromide (1 mmol), L10 (9 mg, 0.04 mmol) and CsOH (504 mg, 3 mmol) (or KOH (168 mg, 3 mmol)). The tube was evacuated and backfilled with argon, and then DMSO (1 mL), t-BuOH (1 mL) and H2O (0.1 mL) were added. The reaction mixture was stirred at indicated temperatures until the starting material was completely converted (monitored by TLC). The cooled solution mixture was acidified to pH = 1-2 with 2 N HCl, and then extracted with EtOAc. The combined organic layers were washed with H2O and brine, dried over Na2SO4. After removal of the solvent in vacuo, the residue was purified with flash chromatography to give the corresponding phenol.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Jia, Jianhuan; Jiang, Chenglin; Zhang, Xiaojing; Jiang, Yongwen; Ma, Dawei; Tetrahedron Letters; vol. 52; 43; (2011); p. 5593 – 5595;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 7051-34-5,Some common heterocyclic compound, 7051-34-5, name is (Bromomethyl)cyclopropane, molecular formula is C4H7Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 4-fluoro-3-hydroxybenzonitrile (10.0 g, 78.74 mmol) in dry DMF (100 mL), K2C03 (21.73 g, 157.4 mmol) was added followed by addition ofcyclopropyl methyl bromide (12.85 g, 94.48 mmol). The reaction mixture was heated at 90C for 4 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with cold water and precipitated solid wasfiltered, washed with pentane to afford XII. Yield: 12 g, 94%; ?H NMR (400 MHz, CDC13) 7.28-7.11 (m, 3H), 3.90 (d, J= 7.1 Hz, 2H), 1.32-1.29 (m, 1H), 0.76-0.63 (m, 2H), 0.45-0.32 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (Bromomethyl)cyclopropane, its application will become more common.

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; LEWIS, Michael; (300 pag.)WO2018/98204; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 108-85-0, name is Bromocyclohexane, molecular formula is C6H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H11Br

General procedure: An alkyl halide (2 mmol) and HMDS (3 mmol) were addedto a solution of thiourea (2.2 mmol) in wet DMSO (2 mLDMSO + 0.05 mL H2O). The mixture was stirred magneticallyat 50 C for 10-24 h. Then, the mixture was dilutedwith water (2 mL) and extracted with 1:1 EtOAc/hexane(3 × 2 mL). The upper layers were decanted, combined,and concentrated. The crude product was purified by silicagel chromatography using low-boiling petroleum ether aseluent to provide the desired disulfide in high yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 108-85-0, its application will become more common.

Reference:
Article; Abbasi, Mohammad; Jabbari, Arida; Journal of the Iranian Chemical Society; vol. 13; 1; (2016); p. 81 – 86;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4117-09-3, name is 7-Bromo-1-heptene, A new synthetic method of this compound is introduced below., Formula: C7H13Br

Magnesium chips (0.24 g, 10.1 mmol) were protected with argon.And add 5mL of dry THF to take 7-bromo-1-heptene(1.5 mL, 9.6 mmol) in a disposable syringe,First, a small amount of 7-bromo-1-heptene (about 10% by volume)Infused into the reaction solution,Then add a small amount of 1,2-dibromoethane (about 0.1mL) to initiate the reaction, and then slowly add the remaining 7-bromo-1-heptene (added in 5min)Into the reaction solution, after the addition is complete,Heated back to reflux for 30 min (about 60 C),A freshly prepared Grignard reagent of 7-bromo-1-heptene was obtained.The nitrone formula (3-1) (2 g, 4.8 mmol) was dissolved in 20 mL of dry THF, argon-protected and cooled to 0 C.The above-mentioned new Grignard reagent (5mL)Add dropwise to the reaction solution (added in 2 minutes)The reaction was stirred for 1 h. The reaction was quenched with saturated aq.Dry over anhydrous MgSO 4, filtered and evaporated.2.5 g of the crude product of the product hydroxyamine (4-1) was obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Chinese Academy Of Sciences Chemical Institute; Yu Chuyi; Song Yingying; Jia Yuemei; Li Yixian; Jia Tengdun; (29 pag.)CN105085356; (2018); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 4333-56-6, These common heterocyclic compound, 4333-56-6, name is Bromocyclopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a microwave vial charged with Mg powder (2 equiv.) and THF was addedbromocyclopropane (2 equiv.). The resulting mixture was stirred for 30 min at rt before a solution of arylnitrile (1 equiv.) in THF was added. It was microwaved 10 min at 100 C, cooled to rt and added dropwise to a cold solution of NaBFL, (2 equiv.) in MeO at 0 C. The resulting mixture was stirred for 15 min at rt, quenched with H20, extracted with DCM and purified by Biotage Si02 column (gradient: MeOH/DCM 0-30%) to give the desired product.

The synthetic route of 4333-56-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY HEALTH NETWORK; PAULS, Heinz W.; LAUFER, Radoslaw; LIU, Yong; LI, Sze-Wan; FORREST, Bryan T.; LANG, Yunhui; PATEL, Narendra Kumar B.; EDWARDS, Louise G.; NG, Grace; SAMPSON, Peter Brent; FEHER, Miklos; AWREY, Donald E.; WO2013/53051; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 74586-53-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74586-53-1, name is 3-Bromo-5-methylaniline, This compound has unique chemical properties. The synthetic route is as follows.

Preparative Example 1.2 – N-(3- opropylpyrimidin-2-amine [00216] To a solution of 2-chloro-4-cyclopropyl-pyrimidine (12.5 g, 81 mmol) and 3- bromo-5-methylaniline (18.1 g, 97 mmol) in 1,4-dioxane (100 mL) was added pivalic acid (9.3 mL, 81 mmol). The resulting mixture was heated to reflux and left stirring for 10 hours. The mixture was allowed to cool to room temperature and hexanes were added (80 mL). The slurry was filtered and the filtrate was washed with MeOH to afford a portion of N-(3-bromo-5- methylphenyl)-4-cyclopropylpyrimidin-2-amine. The mother liquors were concentrated, absorbed on silica gel and purified by silica gel column chromatography (EtO Ac/Hex) to afford additional N-(3-bromo-5-methylphenyl)-4-cyclopropylpyrimidin-2-amine as a white solid. MS ESI calc’d for Ci4H15BrN3 [M+H]+ 304 and 306, found 304 and 306.

The chemical industry reduces the impact on the environment during synthesis 3-Bromo-5-methylaniline. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; HAIDLE, Andrew, M.; ALTMAN, Michael, D.; KATTAR, Solomon, D.; CHRISTOPHER, Matthew; ELLIS, John, Michael; FISCHER, Christian; NORTHRUP, Alan, B.; CHILDERS, Kaleen Konrad; WO2013/192088; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary