Tag: M.W=100-200

Application of 630-17-1, A common heterocyclic compound, 630-17-1, name is 1-Bromo-2,2-dimethylpropane, molecular formula is C5H11Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: (3 mL) was added the electron-deficient alkene (6 mmol) at room temperature. Under vigorous stirring, NiCl2*6H2O (475 mg,2 mmol) was added to the above mixture. The temperature thenrose to 50 C, and stirring was continued for 20 min. The resulting red-brown Ni(0) complex was cooled to room temperature, and a solution of the alkyl bromide (2 mmol) in pyridine (1 mL) was added dropwise. The mixture was stirred for 0.5 h, and then filtered with a short plug (elution with 50 mL of Et2O) and washed with HCl(1N), water and brine, dried over MgSO4, filtered and concentrated. The crude product was purified by flash chromatography on silicagel to afford desired ester products.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Ouyang, Yan; Peng, Yu; Li, Wei-Dong Z.; Tetrahedron; vol. 75; 33; (2019); p. 4486 – 4496;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, molecular formula is C6H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H11Br

General procedure: A 50-mL Schlenk flask equipped with a magnetic stirring bar and a rubber septum was charged with 1H-indole substrate 1 (1.00 mmol), norbornene (188 mg, 2.00 mmol), the base [K2CO3 (276 mg, 2.00mmol), KHCO3 (300 mg, 3.00 mmol), or K2HPO4 (522 mg, 3.00mmol) as indicated], and PdCl2(MeCN)2 (25.9 mg, 0.100 mmol). A 0.5 M solution of H2O in DMA (5 mL) was added. The alkyl bromide 2 (2.00 mmol) was then added from a syringe, and the resulting mixture was degassed by three freeze-pump-thaw cycles with liquid nitrogen under high vacuum. The flask was then placed in an oil bath preheated to 70 C or 90 C, as indicated, and the mixture was stirred vigorously under balloon pressure of argon. Upon completion of the reaction (TLC), the mixture was cooled to r.t., diluted with Et2O (30 mL), and filtered. The filtrate was concentrated in arotary evaporator (60 C water bath, 8-10 mbar) to remove the Et2O and most of the DMA. The residue was purified directly by flash column chromatography [silica gel (dry loading)] to give the alkylation product 3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2270-59-9, its application will become more common.

Reference:
Article; Jiao, Lei; Bach, Thorsten; Synthesis; vol. 46; 1; (2014); p. 35 – 41;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38573-88-5, name is 1-Bromo-2,3-difluorobenzene, A new synthetic method of this compound is introduced below., SDS of cas: 38573-88-5

1,3-Dimethyl-5-phenyl-7,8-dihydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione (Intermediate I) (180 mg, 0.586 mmol), 1-bromo-2,3-difluorobenzene (commercially available) (0.085 mL, 0.761 mmol) and N-cyclohexyl-N-methylcyclohexanamine (commercially available) (0.251 mL, 1.171 mmol) were combined in DMA (2.5 mL) and the mixture sparged with nitrogen for 30 min. [1,1?-Bis(di-tert-butylphosphino)ferrocene]dichloropalladium(II) (commercially available) (38.2 mg, 0.059 mmol) was then added and the mixture heated at 110° C. for 1 hour under microwave irradiation. After cooling to room temperature, the mixture was heated at 110° C. for a further 6 hours. Further portions of 1-bromo-2,3-difluorobenzene (0.085 mL, 0.761 mmol) and [1,1?-Bis(di-tert-butylphosphino)ferrocene]dichloropalladium( II) (38.2 mg, 0.059 mmol) were added, and the mixture heated at 110° C. for a further 5 h. Further [ 1,1?-Bis(di-tert-butylphosphino) ferrocene]dichloropalladium(II) (38.2 mg, 0.059 mmol) and 1-bromo-2,3-difluorobenzene (0.085 mL, 0.761 mmol) were added and the mixture heated 110° C. for a further 6 hours. Further [1,1?-Bis(di-tert-butylphosphino)ferrocene]dichloropalladium(II) (38.2 mg, 0.059 mmol) was added and the mixture heated at 110° C. for a further 6 h. The reaction mixture was diluted with EtOAc and washed with water and brine. The organic phase was dried over sodium sulphate and evaporated under reduced pressure. Purification by chromatography on silica, eluting with 15percent EtOAc in iso-hexane afforded the title compound, which was used without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPHERD, Jon; WRIGHT, Paul; US2014/171417; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1647-26-3, The chemical industry reduces the impact on the environment during synthesis 1647-26-3, name is 1-Bromo-2-cyclohexylethane, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of 3-methyl-hypoxanthine (0.59 mmol, 89 mg) and anhydrous potassium carbonate (amounts, see Tables in the article) in dry DMSO (23 mL) was stirred under N2 at ambient temperature for 1 h. Alkyl halide (amounts, see Tables in the article) in dry DMSO (5 mL) was added over 5 min by a syringe pump (rate 60 mL/h). The reaction mixture was stirred for at ambient temperature for the time given in the article. The mixture was filtered, the filtrate concentrated in vacuo and the residue was purified by flash chromatography on SiO2. In cases where the product was not completely pure after chromatography, the material isolated was cooled to 5 C in a 50 mL round bottom flask, and stirred moderately for 2 h in distilled hexane (50 mL). The solid was allowed to settle (1 h) and most of the hexane was removed carefully by a pipette, leaving a small volume, so as not to remove the fine particles of product at the bottom. The remaining hexane was removed by concentration in vacuo.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-cyclohexylethane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chamgordani, Elahe Jafari; Paulsen, Jan; Gundersen, Lise-Lotte; Tetrahedron Letters; vol. 57; 44; (2016); p. 4926 – 4929;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57951-72-1, name is 1-Bromo-2-cyclopropylethyne belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H5Br

To a solution of (bromoethynyl)cyclopropane (60 g, 414 mmol) in piperidine (345 ml) at 0 C. was added ethynyltrimethylsilane (44.7 g, 455 mmol) and CuI (7.88 g, 41.4 mmol). The solution was then stirred at rt for 2 hours. The reaction was quenched by adding sat. aq. NH4Cl solution and then extracted with TBME. The organic layer was washed with water, brine, dried over MgSO4 and concentrated. The crude material was purified by silica gel column chromatography, heptane as eluant to give product (42 g, 62% yield). 1H NMR (400 MHz, CDCl3) 0.13-0.24 (m, 9H) 0.72-0.91 (m, 4H) 1.25-1.36 (m, 1H)

The synthetic route of 57951-72-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Novartis AG; FU, Jiping; JIANG, Siyi; KORDIKOWSKI, Andreas; SWEENEY, Zachary Kevin; (21 pag.)US2017/355684; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 586-61-8,Some common heterocyclic compound, 586-61-8, name is 1-Bromo-4-isopropylbenzene, molecular formula is C9H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A sealable reaction tube was charged with azole (0.75 mmol),aryl bromide (0.50 mmol), [(NHC)Pd(h3-allyl)]2(m2-N-heterocycle)(BF4)2 (0.0025 mmol), LiOtBu (1.0 mmol) and DME (4.0 mL).The mixture was stirred at 100 C for 12 h. After completion of thereaction, the filtrate was concentrated and the residue was subjectedto purification via column chromatography to give the correspondingproduct.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-isopropylbenzene, its application will become more common.

Reference:
Article; Yang, Jin; Tetrahedron; vol. 75; 14; (2019); p. 2182 – 2187;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1159977-65-7 as follows. COA of Formula: C6H4BrN3

To a mixture of 2,4-difluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide (2.13 g, 5.0 mmol), 6-bromoimidazo[1,2-b]pyridazine (1 g, 0.79 mmol), Pd(dppf)Cl2.CH2Cl2 (408 mg, 0.5 mmol) and Na2CO3 (1.32 g, 12.5 mmol) were added DME (120 mL) and water (30 mL). The mixture was stirred at 70 C. under N2 atmosphere for 4 hours, then cooled to rt, quenched with H2O (500 mL), and then extracted with EtOAc (500 mL*3). The combined organic phases were concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/MeOH (v/v)=200/3) to give the title compound as a light brown solid (1.28 g, 61.4%). MS (ESI, pos. ion) m/z: 418.0 [M+H]+.

According to the analysis of related databases, 1159977-65-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Calitor Sciences, LLC; Xi, Ning; US2014/134133; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17247-58-4, name is (Bromomethyl)cyclobutane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: (Bromomethyl)cyclobutane

Step 1. EPO A stirred solution of the ketimime 1a’ (50 g, 187.1 mmol, available from Aldrich Chemical Company, Milwaukee, Wisconsin) under N2 in dry THF (400 ml_) was cooled to -780C and treated with 1 M solution of K-4BuO (220 ml_, 1.15 equiv.) in THF. The reaction mixture was warmed to 0 C and stirred for 1 h and treated with bromomethylcyclobutane (28 mL, 249 mmol). The reaction mixture was stirred at room temperature for 48 h and concentrated in vacuo. The residue was dissolved in Et2O (300 mL) and treated with aq. HCI (2 M, 300 mL) The resulting solution was stirred at room temperature for 5 h and extracted with Et2O (1 L). The aqueous layer was made basic to pH -12-14 with aq. NaOH (50 %) and extracted with CH2CI2 (3×300 mL). The combined organic layers were dried (MgSO4), filtered, and concentrated to give pure amine (1b’, 18 g) as a colorless oil

The synthetic route of 17247-58-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2006/130688; (2006); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 630-17-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 630-17-1, name is 1-Bromo-2,2-dimethylpropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

N- (benzyloxycarbonyl) acetamide potassium salt(231 mg, 1.00 mmol) and 18-crown-6 (264 mg, 1.00 mmol)Was dissolved in dimethylformamide (1 mL).After adding 1-bromo-2-chloroethane (83 mL, 1.00 mmol)And the mixture was stirred at room temperature for 19.5 hours.The reaction was terminated by adding saturated aqueous ammonium chloride solution (about 3 mL)The reaction mixture was extracted with ethyl acetate.After washing the organic layer with water and saturated brine,And dried over anhydrous magnesium sulfate.Flash silica gel chromatography(20% ? 40% ethyl acetate / n-hexane)N- (benzyloxycarbonyl) -N- (2-chloroethyl) acetamide(137 mg, 54%) of a colorless oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2,2-dimethylpropane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; School corporation Meijo University; Mori, Yuji; Sakai, Takeo; Fukuda, Ayumi; Kasai, Satomi; (28 pag.)JP2018/95576; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 55289-36-6, name is 3-Bromo-2-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-Bromo-2-methylaniline

To a vigorously stirred solution of 3-bromo-2-methylaniline (5.0 g, 26.9 mmol) in a 1 :1 mixture of dichloromethane (67.2 mL) and sodium bicarbonate (80.6 mL, 1 .15 M) was added dropwise a solution of triphosgene (2.79 g, 9.41 mmol, 0.35 equiv) in (15 mL) at 0C. The reaction mixture was stirred until no more gas formation was observed. The organic and water phases were separated. The aqueous phase was extracted with dichloromethane, and the combined organic layer was washed with brine, dried over Na2S04 and concentrated under reduced pressure to give 1-bromo-3- isocyanato-2-methyl-benzene (5.70 g, 98 %) as a brown liquid that was used in the next step without further purification. NMR (400 MHz, CDCIs) delta 7.40 (dd, J = 7.9, 1.5 Hz, 1 H), 7.05 (dd, J = 8.0, 1.5 Hz, 1 H), 7.00 (t, J = 7.9 Hz, 1 H), 2.43 (s, 3H). LC (method A): 0.99 min.

The synthetic route of 3-Bromo-2-methylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; QUARANTA, Laura; BOU HAMDAN, Farhan; POULIOT, Martin; RENDINE, Stefano; (94 pag.)WO2018/114541; (2018); A2;,
Bromide – Wikipedia,
bromide – Wiktionary