Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 1073-06-9, name is 1-Bromo-3-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1073-06-9, HPLC of Formula: C6H4BrF

General procedure: In a typical run, a 5-mL vial equipped with a magnetic stirrer was charged with a mixture of phenyl bromide(78.5 mg, 0.5 mmol), styrene (62.5 mg, 0.6 mmol), Pd catalyst (0.0025 mmol), K3PO4 (212 mg, 1.0 mmol) and DMF (1 mL) under nitrogen. The mixture was heated at 100 C for 4 h and then cooled to room temperature. Brine was added, and the resulting mixture was extracted with ethyl acetate (3 x 5 mL). The GC-MS samples were prepared by diluting 10 lL of ethyl acetate solution to1 mL.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Du, Yufeng; Liang, Beibei; Yang, Fenglei; Shi, Yanhui; Li, Xiuling; Pang, Guangsheng; Cao, Changsheng; Transition Metal Chemistry; vol. 42; 3; (2017); p. 193 – 201;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7073-94-1, name is 1-Bromo-2-isopropylbenzene, A new synthetic method of this compound is introduced below., COA of Formula: C9H11Br

l-Bromo-2-/-propylbenzene (0.199 g, 1.00 mmol), (CyPF-Z-Bu)PdCl2 (7.30 mg, 1.00 x lO’2 mmol), and LiNH2 (0.230 g, 10.0 mmol) in 2.0 mL DME gave 0.109 g (81%) of 2-/-Propylaniline as a solid; Bromo-2-/-propylbenzene (1.99 g, 100 mmol) were weighed into a 100 mL round bottom flask with a stirring bar. DME (20.0 mL) was then added. The flask was sealed with a cap and wrapped tightly with electrical tape. The reaction mixture was stirred for 24 h at 90 0C. The reaction mixture was allowed to cool to room temperature before pouring into ice water (50.0 mL). To this mixture was added aqueous HCl (100 mL, 1.0 M). The mixture was stirred at room temperature for 5 min and was then neutralized with a saturated solution of NaHCO3 (50.0 mL). After extraction with CH2Cl2 (3 x 50.0 mL), the organic layer was separated and dried over MgSO4. The solvent was evaporated, and the crude product isolated by column chromatography, eluting with hexane/ethyl acetate (70/30) to give 1.11 g (82%) of 2-/-rhoropylaniline as a solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; YALE UNIVERSITY; WO2007/109365; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1003-98-1, These common heterocyclic compound, 1003-98-1, name is 2-Bromo-4-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 10: methyl [(lR)-6-fluoro-8-(methylsulfonyl)-2, 3,4, 9-tetrahydro-lH-carbazol-l- yl] acetate Step 1: 2-(2-bromo-4-fluorophenyl) hydraziniumchloride To a suspension of 2-bromo-4-fluoroaniline in concentrated HCI (1. 5M) at-10 C was slowly added a 10. 0M aqueous solution of NaNO2 (1.1 eq). The mixture was stirred at 0 C for 2.5 hrs. A cold (-30 C) solution of SnCl2 (3. 8M) in concentrated HCI was then slowly added while maintaining the internal temperature below 10 C. The resulting mixture was stirred mechanically for 20 min at 0, then at room temperature for 1 hr. The thick slurry was filtered and the solid was air dried overnight. The solid was resuspended in cold HCI and filtered again. The dried material was suspended in Et2O, stirred for 10 min, filtered and air dried overnight to give the title compound as a beige solid.

Statistics shows that 2-Bromo-4-fluoroaniline is playing an increasingly important role. we look forward to future research findings about 1003-98-1.

Reference:
Patent; MERCK FROSST CANADA & CO.; WO2005/56527; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 460-00-4, name is 1-Bromo-4-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 460-00-4, Product Details of 460-00-4

General procedure: A 10 mL vial was charged with CuI (9.5 mg, 0.05 mmol), PSAP (30 mg,0.05 mmol, > 100 mesh), K3PO4 (424 mg, 2 mmol), aryl bromides (1mmol), amines (1.5 mmol), DEG (2 mL), and a magnetic stir bar. The vessel was sealed with a septum and placed into a preheated oil batchat 70 C. The reaction mixture was held at this temperature for 14 hours. After cooling to r.t., the reaction mixture was filtered, and the precipitates were thoroughly washed with water and EtOAc (3 × 20mL). The combined organic phases were washed with water and brine, dried over anhydrous Na2SO4, and concentrated in vacuo. Theresidue was purified using flash column chromatography on silica gel(eluting with petroleum ether/EtOAc) to afford the desired products.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Yi, Zhou; Huang, Manna; Wan, Yiqian; Zhu, Xinhai; Synthesis; vol. 50; 19; (2018); p. 3911 – 3920;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 10269-01-9, A common heterocyclic compound, 10269-01-9, name is (3-Bromophenyl)methanamine, molecular formula is C7H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: HATU(1.00 g, 2.63 mmol, 1.05 equiv) was added to a stirred solution of the startingamine (2.50 mmol, 1.0 equiv), N,N-diisopropylethylamine(1.30 mL, 7.55 mmol, 3.0 equiv) and picolinic acid (325 mg, 2.63 mmol,1.05 equiv) in methylene chloride (25 ml) and the mixture was stirred at roomtemperature overnight. In the morning, the reaction mixture was transferred toseparating funnel with 25 mL H2O and extracted twice with methylenechloride (2 x 25 mL). The combined organic phase was dried over Na2SO4,filtered and solvents were removed invacuo. The residue was purified by column chromatography over silica gelusing gradient elution (40 to 100% Et2O in hexane).

The synthetic route of 10269-01-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; O’Donovan, Daniel H.; De Fusco, Claudia; Spring, David R.; Tetrahedron Letters; vol. 57; 27-28; (2016); p. 2962 – 2964;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 51437-00-4, name is 4-Bromo-1-fluoro-2-methylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51437-00-4, category: bromides-buliding-blocks

General procedure: An oven dried two-necked round bottom flask was charged with aryl halide (1mmol) and K3PO4 (2mmol), evacuated and backfilled with argon. The azole compound (1mmol) and 2mL of DMSO were added under argon. After that Cu-NP (1.6mmol) was added and the flask was again backfilled with argon. The flask was then immersed in a preheated oil bath at 80C until the conversion was completed (detected by TLC). The cooled mixture was partitioned between ethyl acetate (10mL) and saturated NH4Cl (10mL). The aqueous layer was extracted with ethyl acetate (2×10mL), the organic layer was washed with brine (20mL), dried over anhydrous Na2SO4 and concentrated in vacuum. The residue was purified by column chromatography on silica gel using ethyl acetate in hexane (1.5-10%) as eluent to afford the desired product. All the products have been characterized by 1H NMR, 13C NMR, and mass spectroscopy. For new products, FTIR data were also recorded.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-fluoro-2-methylbenzene, and friends who are interested can also refer to it.

Reference:
Article; Pai, Gita; Chattopadhyay, Asoke P.; Tetrahedron Letters; vol. 57; 29; (2016); p. 3140 – 3145;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 103-64-0, name is (2-Bromovinyl)benzene, A new synthetic method of this compound is introduced below., COA of Formula: C8H7Br

To a solution of an appropriate amount of an organic solvent (a mixture of N, N-dimethylformamide (DMF) and polyethylene glycol 200 (PEG-200) in a volume ratio of 4: 1)100 mmol of the compound of formula (I)40 mmol of the compound of formula (II)11 mmol of catalyst bis (triphenylphosphine) cyclopentadienyl ruthenium chloride,100 mmol Oxidant Bis (trifluoroacetic acid) iodobenzene (PhI (TFA) 2),20 mmol of organic ligands L1,60 mmol of base,5,7-triazabicyclo [4.4.0] dec-5-ene (TBD) and 10 mmol activator niobium pentachloride,Then the mixture was warmed to 70 C with stirring, and the reaction was stirred at that temperature for 12 hours;;After completion of the reaction, the reaction system is naturally cooled to room temperature and the pH is adjusted to neutral, filtered and the filtrate is saturated Washed with brine and extracted with ethyl acetate 2-3 times. The combined organic phases were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was passed through Silica gel column chromatography eluting with a 1: 2 by volume mixture of chloroform and petroleum ether to give a compound of the above formula (III) The yield was 89.5%.

The synthetic route of 103-64-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Huang Cheng; Bu Gonggaofamingren; (11 pag.)CN106278838; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74586-53-1, name is 3-Bromo-5-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H8BrN

To a solution of 3-bromo-5-nitrotoluene (1500g) in glacial acetic acid (11 I) in a nitrogen purged hydrogenation vessel was added 5% platinum on carbon (approx 50% water wet paste) and the mixture was hydrogenated under 4 bar hydrogen pressure at room temperature. On completion of hydrogen uptake the catalyst was removed by filtration and the filtrate split into two equal portions. Each portion was set to stir separately and a solution of potassium cyanate (500g) in water (1.25 I) was added to each over 15 min. After stirring for an additional 15 min water (10 I) was added and the precipitated solid isolated by filtration and washed with water. The water wet cakes were combined and dissolved in hot EtOAc (3 I) and the aqueous phase separated. The organic phase was cooled with stirring to crystallise the product, which was isolated by filtration and washed with fresh EtOAc (2 I) and air dried overnight. Recrystallisation from ETOH (2. 7 I) afforded the title compound. (565G) LC RT=3.9 mins.

According to the analysis of related databases, 74586-53-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/39766; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 59907-12-9, name is 1-Bromo-2-fluoro-3-methylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59907-12-9, Formula: C7H6BrF

General procedure: To an oven-dried 25 mL Schlenk tube containing a stirring bar was added 4.5 mg Pd(OAc)2 (0.02 mmol), 15.7mg nBuPAd2 (0.44 mmol), 2-bromofluorobenzene (0.50 mmol), salicylaldehyde (0.50 mmol), potassium carbonate (1.0 mmol). The Schlenk tube was vacuumed and then purged with argon before DMF (2.0 mL) was injected using a syringe. Afterwards the Schlenk tube in the ice bath was degassed by evacuation and back fillingwith argon three times. The reaction mixture was then stirred for 12 h at 120 C. After the reaction was complete,the reaction mixture was diluted with water (5 mL), extracted with ethyl acetate (3 x 10 mL) and dried withanhydrous Na2SO4. After filtration and addition of silica gel into the solution, the organic solvent was reduced evaporated. The crude product was purified by column chromatography using ethyl acetate/n-pentane.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-fluoro-3-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Shen, Chaoren; Wu, Xiao-Feng; Synlett; vol. 27; 8; (2016); p. 1269 – 1273;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 103-64-0,Some common heterocyclic compound, 103-64-0, name is (2-Bromovinyl)benzene, molecular formula is C8H7Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of thiophenols (0.5 mmol), 1-((E)-2-iodovinyl)benzenes (0.6 mmol), CuI (19 mg, 20 mol %), L5 (19 mg, 20 mol %), and Cs2CO3 (326 mg, 2 equiv) in DMSO (3 mL) was stirred in N2 at 100 C for 24 h., The mixture was quenched with saturated salt water (10 mL) after the reaction completion. The solution was extracted with ethyl acetate (3×10 mL). The organic layers were combined and dried by sodium sulfate. The product 2-(styrylthio)phenols was obtained by flash column chromatography on silica gel.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (2-Bromovinyl)benzene, its application will become more common.

Reference:
Article; Xu, Run-Sheng; Yue, Lei; Pan, Yuan-Jiang; Tetrahedron; vol. 68; 25; (2012); p. 5046 – 5052;,
Bromide – Wikipedia,
bromide – Wiktionary