Tag: M.W=100-200

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Liquid-phase process for acetylene reactions, published in 1962, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, Synthetic Route of C7H12O3.

Vinylation of mono- and polyhydric alcs., of mercaptans and lactams, as well as ethynylation of ketones and reaction of C2H2 with alkyl carbonates, is carried out by a liquid-phase technique having advantages with respect to safety, economy, productivity, and versatility. Reactions are carried out under pressure in the complete absence of a gas phase. Under pressure and at low temperature, C2H2 is dissolved in the reactants, and the reaction mixture is passed through a tubular reactor under pressure high enough to prevent desorption of C2H2. After lowering the pressure to atm., the product is isolated by distillation The critical feature of the process is the use of good C2H2 solvents, e.g., N-methylpyrrolidinone, methylal, dimethoxyethane, dioxane, tetraethylene glycol dimethyl ether, and pyrrolidinone. The preparation of the following compounds is described: 1,2,3-tris(vinyloxy)propane (≤50% conversion) from glycerol, together with 2-methyl-4-vinyloxymethyl-1,3-dioxolane, 2-methyl-4-hydroxymethyl-1,3-dioxolane, and the monovinyl ether of glycerol; N-vinylpyrrolidinone (50-60% conversion, 90-95% yield) from pyrrolidinone (caprolactam and substituted pyrrolidinones have been vinylated similarly); 1-ethynyl-1-cyclohexanol (51% conversion, 72% yield) from cyclohexanone, together with the glycol, 1,2-bis(1-hydroxy-1-cyclohexyl)ethyne (7.5% conversion, 11% yield); from Et2CO3, a mixture of Et 3-ethoxyacrylate, Et 3,3′-diethoxypropionate, di-Et ethoxymaleate, and di-Et α,α-diethoxysuccinate (54% conversion, 72% yield of acrylate-propionate mixture) was obtained. No specific example for the reaction of mercaptans (RSH) with C2H2 is given, but yields of RSCH:CH2 are usually 85-90%, and the major by-product is RSCH2CH2SR.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Ring-chain tautomerism in the reaction products of aminophenol and some ethoxymethyleneacetates》. Authors are Nozoe, Tetsuo; Doi, Kozo.The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).Application of 1001-26-9. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

o-Aminophenol (I) (1.1 g.) and 2.2 g. di-Et (ethoxymethylene)malonate was heated at 130° 30 min. and crystallized to give quant. yield of 2-(ω,ω-diethoxyearbonylmethyl)benzoxazoline (II), prisms, m. 1401° (EtOH). II did not show coloration with alc. FeCl3 and was inert to the action of CH2N2. II (5.6 g.) was pyrolyzed at 250° and fractions b. 175-185° (A) (1.6 g.) and 195-9° (B) (2.7 g.) were collected. Redistillation of A gave benzoxazole (III), b. 180-2°, m. 30-1°; B was identified as di-Et malonate. Similar condensation of I with Et (ethoxymethylene)acetoacetate and di-Et (ethoxymethylene)cyanoacetate gave, resp., 2-(ω-acetyl-ω-ethoxycarbonylmethyl)benzoxazoline (IV), prisms, m. 146-7° (MeOH), and 2(ω-ethoxycarbonyhnethyl-ω-cyanomethyl)benzoxazoline (V), needles, m. 191-2° (MeOH). Pyrolysis of IV gave Et acetoacetate and III, and V similarly gave Et cyanoacetate and III.

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Formula: C5H2Cl3N. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3,4,5-Trichloropyridine, is researched, Molecular C5H2Cl3N, CAS is 33216-52-3, about The halogen bond made visible: experimental charge density of a very short intermolecular Cl···Cl donor-acceptor contact. Author is Wang, Ruimin; Dols, Thomas S.; Lehmann, Christian W.; Englert, Ulli.

[ZnCl2(3,4,5-trichloropyridine)2] features short intermol. Cl···Cl contacts between halogen atoms of different nature, and a charge d. study provides exptl. evidence for the accepted model of the halogen bonds: an arene-bonded Cl atom acts as a donor of electron d. towards the sigma hole of a chlorido ligand attached to a neighboring Zn(II) cation.

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Wang, Haiying; Han, Hongjing; Sun, Enhao; Zhang, Yanan; Li, Jinxin; Chen, Yanguang; Song, Hua; Zhao, Hongzhi; Kang, Yue published an article about the compound: Ethyl 3-Ethoxy-2-Propenoate( cas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC ).Computed Properties of C7H12O3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1001-26-9) through the article.

To realize the resource and high-value utilization, a new approach, named bagasse lignin (BL) used to produce aryl oxygen-containing compounds by catalytic pyrolysis over perovskite, was proposed. LaTi0.2Fe0.8O3 (LTF) samples prepared by the sol-gel method (SG) and the solid-state reaction method (SS) were characterized. The catalytic action on BL pyrolysis was performed by the test of TG-DTG and the evaluation of the fixed bed micro-reactor, the components and contents of the products were determined The results show that LTF samples have cubic perovskite phase, LTF prepared by SG (LTF-SG) is porous with larger sp. surface area than LTF prepared by SS (LTF-SS). During the pyrolysis of BL, the addition of LTF lowers the pyrolysis temperature and the activation energy, the contents of CO2 and CO in gaseous products reduce by 4.6%-8.0% and 30.7%-34.3%, resp., the total content of aryl oxygen-containing compounds (including phenolics, guaiacols, syringols and phenylates) in liquid products increases from 62 wt% to more than 72 wt%, and LTF-SG shows better catalytic performance. LTF samples have nice phase and catalytic stabilities for BL pyrolysis after five successive redox cycles.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Evaluation of a series of bicyclic CXCR2 antagonists》. Authors are Walters, Iain; Austin, Caroline; Austin, Rupert; Bonnert, Roger; Cage, Peter; Christie, Mark; Ebden, Mark; Gardiner, Stuart; Grahames, Caroline; Hill, Steven; Hunt, Fraser; Jewell, Robert; Lewis, Shirley; Martin, Iain; Nicholls, David; Robinson, David.The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).Formula: C7H12O3. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

The CXCR2 SAR of a series of bicyclic antagonists such as the 2-aminothiazolo[4,5-d]pyrimidine 3b was investigated by systematic variation of the fused pyrimidine-based heterocyclic cores. Replacement of the aminothiazole ring with a 2-thiazolone alternative led to a series of thiazolo[4,5-d]pyrimidine-2(3H)-one antagonists with markedly improved biol. and pharmacokinetic properties, which are suitable pharmacol. tools to probe the in vivo effects of CXCR2 antagonism combined with the associated CCR2 activity.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Vibration and electronic spectra of esters of polyenecarboxylic acids》. Authors are Kogan, G. A.; Ivanova, T. M.; Yanovskaya, L. A.; Kucherov, V. F.; Popov, E. M..The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).Formula: C7H12O3. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

The frequencies and integral intensities of bands in the ir and uv spectra and Raman spectra of polyene compounds X(CH:CH)nCOOEt (X = Me, OEt, COH, NO2, and CO2Et; n = 1-5) were investigated in a study of the mutual effect of functional groups of atoms through a system of conjugate bonds. Causes of changes in these parameters in the spectra of compounds in the basic and excited states were determined from an analysis of the data.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1001-26-9, is researched, SMILESS is O=C(OCC)/C=C/OCC, Molecular C7H12O3Journal, Heterocycles called Palladium-catalyzed cross-coupling of aryl iodides with ethyl 2-ethoxy- and 3-ethoxyacrylate, Author is Sakamoto, Takao; Kondo, Yoshinori; Kashiwagi, Yoshitomo; Yamanaka, Hiroshi, the main research direction is coupling iodoquinoline acrylate catalyst; iodopyridine coupling acrylate catalyst; iodobenzene coupling acrylate catalyst; quinolinylacrylic acid; cinnamate ester.Quality Control of Ethyl 3-Ethoxy-2-Propenoate.

The reaction of 3-iodoquinoline with R1CH:CR2CO2Et (one at R1 and R2 is OEt and the other is H), Pd, and K2CO3 in MeCN gave Et 3-quinolylacrylates I. Similarly prepared were pyridylacrylate esters II and 4-R3C6H4CR1:CR2CO2Et (R3 = H, OMe).

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor, published in 2020-12-15, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, HPLC of Formula: 1001-26-9.

Casein kinase 2 (CK2) is a constitutively expressed serine/threonine kinase that has a large diversity of cellular substrates. Thus, CK2 has been associated with a plethora of regulatory functions and dysregulation of CK2 has been linked to disease development in particular to cancer. The broad implications in disease pathol. makes CK2 an attractive target. To date, the most advanced CK2 inhibitor is silmitasertib, which has been investigated in clin. trials for treatment of various cancers, albeit several off-targets for silmitasertib have been described. To ascertain the role of CK2 inhibition in cancer, other disease and normal physiol. the development of a selective CK2 inhibitor would be highly desirable. In this study we explored the pyrazolo [1,5-a]pyrimidine hinge-binding moiety for the development of selective CK2 inhibitors. Optimization of this scaffold, which included macrocyclization, led to IC20 (31) a compound that displayed high in vitro potency for CK2 (KD = 12 nM) and exclusive selectivity for CK2. X-ray anal. revealed a canonical type-I binding mode for IC20 (31). However, the polar carboxylic acid moiety that is shared by many CK2 inhibitors including silmitasertib was required for potency but limits the cellular activity of IC20 (31) and the cellular IC50 dropped to the low micromolar range. In summary, IC20 (31) represents a highly selective and potent inhibitor of CK2, which can be used as a tool compound to study CK2 biol. and potential new applications for the treatment of diseases.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Efficient Synthesis of a Trisubstituted 1,6-Naphthyridone from Acetonedicarboxylate and Regioselective Suzuki Arylation, published in 2005-12-09, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, Related Products of 1001-26-9.

An efficient five-step synthesis of 1,6-naphthyridone I, a p38 mitogen-activated protein (MAP) kinase inhibitor intermediate, in 32% overall yield starting from acetonedicarboxylate (ADC) is described. The synthesis began with a selective monoamidation of ADC di-Me ester enolate. A novel concomitant enamine formation and an imide cyclization afforded the nitrogen differentially protected enamide imide. Treatment of this with KOCMe3 and 3-ethoxyacrylate produced lactam quant., which was converted to tetrachloronaphthyridone via a one-pot p-methoxybenzyl deprotection and bischlorination. A highly regioselective Pd(OAc)2/IMes-catalyzed Suzuki coupling completed the synthesis.

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Recommanded Product: 3,4,5-Trichloropyridine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3,4,5-Trichloropyridine, is researched, Molecular C5H2Cl3N, CAS is 33216-52-3, about A simple and efficient method for the preparation of pyridine N-oxides. II. Author is Coperet, Christophe; Adolfsson, Hans; Chiang, Jay P.; Yudin, Andrei K.; Sharpless, K. Barry.

Oxidation of pyridines with bis(trimethylsilyl) peroxide in the presence of catalytic amounts of inorganic Re derivatives gives high yields of their anal. pure N-oxides by simple work-ups, typically a filtration or a Kugelrohr distillation

If you want to learn more about this compound(3,4,5-Trichloropyridine)Recommanded Product: 3,4,5-Trichloropyridine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(33216-52-3).

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