Tag: M.W=100-200

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3,4,5-Trichloropyridine, is researched, Molecular C5H2Cl3N, CAS is 33216-52-3, about Quantitative determination and validation of four ketones in Salvia miltiorrhiza bunge using quantitative proton nuclear magnetic resonance spectroscopy, the main research direction is tanshinone dihydrotanshinone cryptotanshinone Salvia root proton NMR spectroscopy; Salvia Miltiorrhiza Bunge; cryptotanshinone; dihydrotanshinone; qNMR; tanshinone I; tanshinone IIA.SDS of cas: 33216-52-3.

Salvia mltiorrhiza Bunge (SMB) is native to China, whose dried root has been used as medicine. A few chromatog.- or spectrometric-based methods have already been used to analyze the lipid-soluble components in SMB. However, the methodol. of qNMR on the extracts of fresh SMB root has not been verified so far. The purpose of this study was to establish a fast and simple method to quantify the tanshinone I, tanshinone IIA, dihydrotanshinone, and cryptotanshinone in fresh Salvia Miltiorrhiza Bunge root without any pre-purification steps using 1H-NMR spectroscopy. The process is as follows: first, 70% methanol aqueous extracts of fresh Salvia Miltiorrhiza Bunge roots were quant. analyzed for tanshinone I, tanshinone IIA, dihydrotanshinone, and cryptotanshinone using 1H-NMR spectroscopy. Different internal standards were tested and the validated method was compared with HPLC. 3,4,5-Trichloropyridine was chosen as the internal standard Twelve samples of Salvia Miltiorrhiza Bunge were quant. analyzed by qNMR and HPLC resp. Then, the results were analyzed by chemometric approaches. This NMR method offers a fast, stable, and accurate anal. of four ketones: tanshinone I, tanshinone IIA, dihydrotanshinone, and cryptotanshinone in fresh roots of Salvia Miltiorrhiza Bunge.

Here is a brief introduction to this compound(33216-52-3)SDS of cas: 33216-52-3, if you want to know about other compounds related to this compound(33216-52-3), you can read my other articles.

Reference:
Bromide – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chan, Laval; Jin, Haolun; Stefanac, Tomislav; Wang, Wei; Lavallee, Jean-Francois; Bedard, Jean; May, Suzanne researched the compound: Ethyl 3-Ethoxy-2-Propenoate( cas:1001-26-9 ).Formula: C7H12O3.They published the article 《Isoquinoline-6-carboxamides as potent and selective anti-human cytomegalovirus (HCMV) inhibitors》 about this compound( cas:1001-26-9 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: isoquinolinecarboxamide preparation cytomegalovirus inhibitor; antiviral agent isoquinolinecarboxamide preparation; naphthyridinecarboxamide preparation antiviral agent; virucide isoquinolinecarboxamide preparation. We’ll tell you more about this compound (cas:1001-26-9).

Structure-activity relationship studies on newly identified anti-HCMV compounds, the 1,6-naphthyridines led to the identification of isoquinoline-6-carboxamides as potent and selective anti-HCMV agents.

Here is a brief introduction to this compound(1001-26-9)Formula: C7H12O3, if you want to know about other compounds related to this compound(1001-26-9), you can read my other articles.

Reference:
Bromide – Wikipedia,
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Electric Literature of 583-75-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-75-5, name is 4-Bromo-2-methylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

6-bromo-8-methylquinoline. Glycerol (2.3 ml, 32.2 mmol) was added dropwise via syringe to a solution of 4-bromo-2-methylaniline (5.00 g, 26.8 mmol) and sodium iodide (52 mg, 0.349 mmol) in 75% aq H2SO4 (15.81 ml, 120 mmol) at 140 C. The mixture was held at this temperature for 3 hours. The reaction mixture was neutralized to a pH of 7 with aq NaOH. This mixture was extracted with EtOAc and the combined organics were washed with brine, dried over MgSO4 and concentrated. Column chromatography on silica gel (5-25% EtOAc in hexanes) afforded intermediate 11 (5.50 g, 24.7 mmol, 92%). 1H NMR (400 MHz, CDCl3) delta ppm 8.93 (dd, J=4.28, 1.76 Hz, 1H), 8.03 (dd, J=8.31, 1.76 Hz, 1H), 7.82 (d, J=2.01 Hz, 1H), 7.65 (d, J=1.01 Hz, 1H), 7.40 (dd, J=8.18, 4.15 Hz, 1H), 2.78 (s, 3H). Mass 221 [M+H]+.

The synthetic route of 4-Bromo-2-methylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Squibb Company; US2009/18163; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 399-94-0, name is 1-Bromo-2,5-difluorobenzene, A new synthetic method of this compound is introduced below., category: bromides-buliding-blocks

2.0 M Isopropyl magnesium chloride solution in THF (163mL, 324.3 mmol) was added to a solution of 2-bromo-l,4-difluorobenzene (62.5 g, 324.3 mmol) in THF (350mL) at -40C and stirring was continued at 5C for 1 h. tert- utyl 2- oxopyrrolidine-l-carboxylate(Step-l)(73 g, 392 mmol) in THF(150mL) was added dropwise to above reaction mixture at -40C and stirring was continued at 10C for 2 h. Reaction mixture was quenched with saturated NH4CI solution, extracted with EtOAc, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 76 g of the title compound.

The synthetic route of 399-94-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; SASMAL, Pradip Kumar; AHMED, Shahadat; TEHIM, Ashok; PRADKAR, Vidyadhar; DATTATREYA, Prasanna M.; MAVINAHALLI, Nanjegowda Jagadeesh; WO2013/88256; (2013); A1;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2924-09-6, name is 5-Bromo-2-fluoroaniline, A new synthetic method of this compound is introduced below., Formula: C6H5BrFN

98% of 2-fluoro-5-bromonitrobenzene (211 g, 0.96 mol) and iron powder (212 g, 3.8 mol) were mixed, 1200 ml of ethanol was added and glacial acetic acid (456 g, 7.6 mol) was added dropwise at room temperature. The reaction solution was treated with an oil bath at 60 CThe reaction solution was completed by a gas phase controlled reaction. The reaction solution was filtered through a Buchner funnel pad and the filtrate was evaporated to dryness and extracted with ethyl acetateN-heptane (volume ratio 1: 4) was purified by column and evaporated to give pure product 122.5 g, 98% GC, yield 62.5%

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Dalian Allychem Co., Ltd.; Wang, Xianxue; Zheng, Peng; (5 pag.)CN104530107; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7051-34-5, name is (Bromomethyl)cyclopropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 7051-34-5

a) 3-cyclopropylmethoxy-4-difluoromethoxy-benzaldehyde 4.70 g (24.98 mmol) 4-difluoromethoxy-3-hydroxybenzaldehyde are placed in 50 ml of dimethylformamide, 4.00 g (29.63 mmol) bromomethylcyclopropane and 3.50 g (25.32 mmol) potassium carbonate are added. The reaction mixture is heated to 100 C. for 20 hours, then the dimethylformamide is concentrated by evaporation. The residue is extracted with ethyl acetate and water, the organic phase is dried and evaporated to dryness. Yield: 5.83 g (96% of theoretical)

The synthetic route of 7051-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2006/116373; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 2550-36-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2550-36-9, name is (Bromomethyl)cyclohexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

20 g of bromomethyl cyclohexane,After 12.5 g of 1-naphthol was dissolved in 300 g of NMP in a three-necked flask,12g of potassium carbonate was added,14g potassium iodide was heated at 120 C for 8 hours.In the reaction solution was added 300g of water,Extraction was performed three times with 100 g of hexane,The resulting organic layers were combined,Washed once with 100 g of 1 N aqueous sodium hydroxide solution,Water 100g washed once,Brine 100g washed once,Concentration gave 13 g of compound 1.

The synthetic route of (Bromomethyl)cyclohexane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUJIFILM CORPORATION; SHIRAKAWA, MICHIHIRO; TANGO, NAOHIRO; SHIBUYA, AKINORI; YAMAGUCHI, SHUHEI; KATAOKA, SHOHEI; (175 pag.)TWI579263; (2017); B;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6911-87-1, name is 4-Bromo-N-methylaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 6911-87-1

Weigh BTC (58mg, 0.2mmol) in a 25mL two-neck bottle.Add 5 mL of anhydrous dichloromethane, magnetically stir, add equivalents of N-methyl-p-bromoaniline, triethylamine (0.25 mmol) and 5 mL of dichloromethane to a 25 mL constant pressure dropping funnel.Under ice bath, slowly add dropwise. After the addition, the ice salt bath was removed and stirred at room temperature for 4 h.HZA (40 mg, 0.1 mmol) was added to a 10 ml vial, and traces of DMAP, 5 mL of dichloromethane were added, and magnetically stirred at room temperature until completely dissolved.The solution was slowly added dropwise to the reaction liquid in the above step under an ice salt bath.At the end of the addition, the ice salt bath was removed and stirred at room temperature. After the reaction is completed, 3 to 6 times the volume of the reaction liquid is added to the above reaction liquid, and the mixture is extracted with ethyl acetate for 3-5 times. The organic layer is combined, washed with a saturated NaCI solution, dried over anhydrous Na2SO?Concentrate the crude product as a yellow oil, then the crude product was taken from petroleum ether:Ethyl acetate with a volume ratio of 20:1 mixed solvent elution, thin layer detection,Collecting an eluent that is strongly UV at 254 nm and less polar than HZA,The combined eluate and the product obtained by evaporating the solvent under reduced pressure are dried to obtain HZAM-17.The yield was 93%.

The synthetic route of 6911-87-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University of Technology; Zhan Zhajun; Shan Weiguang; Chen Yan; Shu Renhuan; Wang Jianwei; Ma Liefeng; (31 pag.)CN109956952; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 64248-56-2 as follows. COA of Formula: C6H3BrF2

Preparation 105 Preparation of tert-Butyl 9-(2,6-difluorophenyl)-1,4,5,6-tetrahydroazepino-[4,5-b]indole-3(2H)-carboxylate. A solution of 1-bromo-2,6-difluorobenzene (0.28 g, 1.5 mmol) in dioxane (12 mL) was added to a flask charged with 3-(tert-butyloxycarbonyl)-9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole (0.50 g, 1.2 mmol), Pd2(dba)3 (0.11 g, 0.12 mmol) and potassium phosphate(0.59 g, 2.8 mmol). Next, trimethylphosphite (0.045 mL, 0.38 mmol) was added and the mixture was heated to 95 C. After 28.5 h, the reaction was cooled to rt, diluted with H2O, and extracted with EtOAc (3*50 mL). The combined organic extracts were washed with brine, dried over Na2SO4, decanted, and concentrated. The crude product was purified by column chromatography (Biotage, 40M, SIM) with heptane/EtOAc (4:1) to give 0.38 g (80%) of a pale yellow solid: mp 225.5-226 C.; % water (KF): 0.10; melt solvate: 1.46% CH2Cl2; 0.19% EtOAc; Anal. Calcd for C23H24F2N2O2-0.10% H2O·1.46% CH2Cl2·0.19% EtOAc: C, 68.34; H, 6.19; N, 6.91; found: C, 68.34; H, 6.19; N, 6.81.

According to the analysis of related databases, 64248-56-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Frank, Kristine E.; Acker, Brad A.; Ennis, Michael D.; Fisher, Jed F.; Fu, Jian-min; Jacobsen, Eric Jon; McWhorter JR., William W.; Morris, Jeanette K.; Rogier, Donald Joseph; US2002/77318; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 108-85-0, name is Bromocyclohexane, molecular formula is C6H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 108-85-0

EXAMPLE 7; Entry No. 7-1 to Entry No. 7-6 Following the details given below, effects of various metallic reagents and halides on yield of the products were examined. A mixture of various aromatic zinc reagents shown by ArZnX (X = Br, I) (0.5 M THF solution, 4.0 mL, 2.0 mmol) and magnesium compounds shown by Me3SiCH2MgCl (1.1 M Et2O solution 1.8 mL, 2.0 mmol) was charged in a dry reactor and stirred at 0C for 0.5-1 hour. To the solution obtained, TMEDA (0.30 mL, 2.0 mmol), various halides (shown by “(FG)Ralkyl-X” in TABLE 6) (1.0 mmol) and then FeCl3 (0.1 M THF solution, 0.5 mL, 0.05 mmol) were added at 0C. The reaction mixture was stirred at 30C for 6 hours. Saturated NH4Cl aqueous solution was added to terminate the reaction. The mixture was filtered through a pad of Florisil (registered trademark) and concentrated in vacuum. The residue was purified by silica gel chromatography Entry No. 7-4 (4-Cyclohexylbenzonitrile) Halide: 3-bromocyclohexane (1.0 mmol) Aromatic zinc reagent: 4-cyanophenylzinc bromide (2.0 mmol) Reaction time: 6 hours Colorless oily substance (167 mg, 90%) FTIR (neat): cm-1 2925 (s), 2852 (m), 2227 (m), 1607 (m), 1505 (m), 1449 (m), 1415 (w), 1177 (w), 1000 (w), 823 (s); 1H NMR (500 MHz, CDCl3): delta 7.56 (d, J = 8.6 Hz, 2H), 7.30 (d, J = 8.6 Hz, 2H), 2.12-2.00 (m, 1H), 1.92-1.80 (m, 4H), 1.80-1.69 (m, 1H), 1.47-1.33 (m, 4H), 1.33-1.20 (m, 1H); 13C NMR (125 MHz, CDCl3): delta 153.4, 132.1 (2C), 127.6 (2C), 119.1, 109.5, 44.7, 33.9 (2C), 26.6 (2C), 25.9; Elemental analysis: Calcd. for C13H15N: C, 84.28; H, 8.16; N, 7.56. Found: C, 84.12; H, 8.36; N, 7.36.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 108-85-0, its application will become more common.

Reference:
Patent; Japan Science and Technology Agency; EP1724248; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary