Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 766-96-1, name is 1-Bromo-4-ethynylbenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-4-ethynylbenzene

To a 50 mL test tube was added the crude product from above (0.306 g, 1.69 mmol), 1-bromo-4-iodobenzene(0.478 g, 1.69 mmol), Pd(PPh3)4 (0.057 g, 0.05 mmol), and CuI (0.019 g, 0.10 mmol). To a separate test tubewas added tetrahydrofuran (20 mL), and triethylamine (5 mL). Each tube was sealed with a rubber septumand purged with a continuous stream of argon (5 min). The contents of the liquids tube were transferred tothe solids tube via cannula under argon. The resulting mixture was stirred at 50C under argon for 24 h. Theresulting suspension was extracted between dichloromethane and 5% NH4OH (aq). The organic layer wasseparated and dried over MgSO4. After filtration to remove the drying agent, the solvent was removed viarotary evaporation to give a brown-orange powder. 1H NMR spectrum matched that previously described.8This crude 4,4?-dibromotolane product was used directly in the next step without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Christensen, Joseph A.; Fletcher, James T.; Tetrahedron Letters; vol. 55; 33; (2014); p. 4612 – 4615;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5910-12-3, name is 3-Bromopyrazolo[1,5-a]pyridine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-Bromopyrazolo[1,5-a]pyridine

4i4)4′)4’i5i5,5,,5′-Octamethyl-2,2′-bi(1 ,3,2-dioxaborolane) (1.27 g, 5.0 mmol), palladium (II) acetate (0.050 g, 0.228 mmol), tricyclohexylphosphine (0.127 g, 0.46 mmol), potassium carbonate (0.945 g, 6.84 mmol) and water (0.05 mL) were added to a solution of 3-bromopyrazolo[1 ,5-a]pyridine (Preparation 22c, 0.90 g, 4.56 mmol)) in diglyme (10 mL) and the resulting mixture was heated at 100 C for 2h. After cooling, the reaction mixture was filtered through Celite, eluting with methanol. The filtrate was evaporated and the crude product was used with no further purification in the next synthetic step.LRMS (m/z): 245 (M+1)+.

According to the analysis of related databases, 5910-12-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALMIRALL, S.A.; BACH TA?A, Jordi; PAGES SANTACANA, Lluis, Miquel; TALTAVULL MOLL, Joan; EASTWOOD, Paul, Robert; GONZALEZ RODRIGUES, Jacob; GIULIO MATASSA, Victor; WO2011/101161; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 35354-37-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35354-37-1 as follows.

Example 44 (+-)-4-(3-Methanesulfonylaminophenyl)-trans-3,4-dimethyl-N-(5-methylhexyl)piperidine To a stirred solution of (+-)-4-(3-methanesulfonylaminophenyl)-trans-3,4-dimethylpiperidine (Preparation 10, 25 mg, 0.088 mmol) in N,N-dimethylformamide (2 ml) was added sodium hydrogen carbonate (11 mg, 0.13 mmol) and 1-bromo-5-methylhexane (20 mg, 0.11 mmol). The reaction was heated to 90° C. for 24 h and then cooled to room temperature. The reaction mixture was diluted with water (40 ml) and extracted with diethyl ether (2*20 ml). The combined extracts were dried (MgSO4), filtered and concentrated in vacuo to give the crude product. This was purified by silica (5 g) column chromatography eluding with ethyl acetate:hexane (4:1) to give the title compound as a light brown gum (11 mg, 32percent). NMR (CDCl3, selected data for the free base): 0.75 (d, 3H), 0.8 (m, 6H), 1.2 (m, 3H), 2.55 (m, 2H), 3.0 (s, 3H), 7.0-7.4 (m, 4H). MS (thermospray): M/Z [MH+] 381.3; C21H36N2O2S+H requires 381.3.

According to the analysis of related databases, 35354-37-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Armer, Richard Edward; Dutton, Christopher James; Gethin, David Morris; Gibson, Stephen Paul; Smith, Julian Duncan; Tommasini, Ivan; US2003/78282; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1159977-65-7, name is 6-Bromoimidazo[1,2-b]pyridazine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H4BrN3

To a solution of intermediate 26B (100 mg, 0.246 mmol) in 1,4-dioxane (3 mL) was added BisPin (94 mg, 0.3 70 mmol) and potassium acetate (72.6 mg, 0.73 9 mmol). The solution was purged with argon for 2 mm. and PdC12(dppf)-CH2C12 adduct (10.06mg, 0.0 12 mmol) was added. The reaction mixture was heated at 90 C for 3 h and cooled to RT. 6-Bromoimidazo[1,2-bjpyridazine (48.8 mg, 0.246 mmol), aqueous 3M K3P04 solution (0.370 mL, 0.739 mmol) and PdC12(dppf)-CH2C12 adduct (10.06 mg, 0.012 mmol) were added. The reaction mixture was heated at 90 C for 16 h, cooled to RT and concentrated in vacuo. The crude product was purified by silica gelchromatography (12 g RediSep column, eluting with a gradient of 40-100 % EtOAc in petroleum ether). Fractions containing the desired product were combined and evaporated under reduced pressure to afford intermediate 26B (30 mg, 27.4 % yield). MS (ES): m/z = 444.5 [M+Hj HPLC Ret. Time 1.25 mm. (HPLC Methods B).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1159977-65-7.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; LIU, Peiying; TEBBEN, Andrew J.; VELAPARTHI, Upender; RAHAMAN, Hasibur; TONUKUNURU, Gopikishan; WARRIER, Jayakumar Sankara; (264 pag.)WO2018/17633; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 3959-05-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3959-05-5, name is (2-Bromophenyl)methanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 47 Part A. (2-Bromo-benzyl)-methyl-amine A solution of 2-bromobenzylamine (9 g, 36.1 mmol) in MeOH (60 ml) was added dropwise over 30 min. to a solution of methylamine in MeOH (200 mL of a 2.0 M solution, 0.4 mol). The resulting solution was stirred at rt for 2 h and concentrated. The residue obtained was dissolved in DCM (100 mL) and successively washed with saturated aqueous sodium carbonate, dried over sodium sulphate, and concentrated. The resulting oil was distilled to afford the title compound (7 g, 95%) as a colorless oil (b.p. 110 C. at 0.1 mm Hg, LC/MS retention time=1.22 min.; M+=201.92 Column: Phenominex 4.6 mm*50 mm.

The synthetic route of (2-Bromophenyl)methanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Squibb Company; US6596747; (2003); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 3959-05-5,Some common heterocyclic compound, 3959-05-5, name is (2-Bromophenyl)methanamine, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Part A. (2-Bromo-benzyl)-methyl-amine A solution of 2-bromobenzylamine (9 g, 36.1 mmol) in MeOH (60 ml) was added dropwise over 30 min. to a solution of methylamine in MeOH (200 mL of a 2.0 M solution, 0.4 mol). The resulting solution was stirred at rt for 2 h and concentrated. The residue obtained was dissolved in DCM (100 mL) and successively washed with saturated aqueous sodium carbonate, dried over sodium sulphate, and concentrated. The resulting oil was distilled to afford the title compound (7 g, 95%) as a colorless oil (b.p. 110 C. at 0.1 mm Hg, LC/MS retention time=1.22 min.; M+=201.92 Column: Phenominex 4.6 mm*50 mm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (2-Bromophenyl)methanamine, its application will become more common.

Reference:
Patent; Liu, Chunjian; Dhar, T.G. Murali; Gu, Henry H.; Iwanowicz, Edwin J.; Leftheris, Katerina; Pitts, William J.; Herpin, Timothy F.; Pi, Zulan; Bisacchi, Gregory S.; US2002/143176; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 35354-37-1, name is 1-Bromo-5-methylhexane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35354-37-1, Safety of 1-Bromo-5-methylhexane

(a) Methyl 1-(5-methylhexyl)cyclopentanecarboxylate To a solution of methyl cyclopentanecarboxylate (300 mg, 2.3 mmol) in THF (20 ml) at -78¡ã C. was added LHMDS (4.6 mL, 4.6 mmol) and stirred for 30 min, and followed by 1-bromo-5-methylhexane (626 mg, 3.5 mmol). The mixture was stirred from -78¡ã C. to rt over 16 hr, before 30 ml of H2O was added and then was extracted with CH2Cl2 (2*30 mL). The combined extracts were washed with water, dried over MgSO4, filtered and concentrated, then purified using flash chromatography to give an oil (110 mg, 21percent). MS [M+H]+333.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Yang, Michael G.; Liu, Hong; US2002/61874; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In an article, author is Dong, Xiao-Yang, once mentioned the application of 111-83-1, Recommanded Product: 111-83-1, Name is 1-Bromooctane, molecular formula is C8H17Br, molecular weight is 193.1246, MDL number is MFCD00000276, category is bromides-buliding-blocks. Now introduce a scientific discovery about this category.

Copper-Catalyzed Asymmetric Coupling of Allenyl Radicals with Terminal Alkynes to Access Tetrasubstituted Allenes

In contrast to the wealth of asymmetric transformations for generating central chirality from alkyl radicals, the enantiocontrol over the allenyl radicals for forging axial chirality represents an uncharted domain. The challenge arises from the unique elongated linear configuration of the allenyl radicals that necessitates the stereo-differentiation of remote motifs away from the radical reaction site. We herein describe a copper-catalyzed asymmetric radical 1,4-carboalkynylation of 1,3-enynes via the coupling of allenyl radicals with terminal alkynes, providing diverse synthetically challenging tetrasubstituted chiral allenes. A chiral N,N,P-ligand is crucial for both the reaction initiation and the enantiocontrol over the highly reactive allenyl radicals. The reaction features a broad substrate scope, covering a variety of (hetero)aryl and alkyl alkynes and 1,3-enynes as well as radical precursors with excellent functional group tolerance.

If you are interested in 111-83-1, you can contact me at any time and look forward to more communication. Recommanded Product: 111-83-1.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 927-58-2, Name is 4-Bromobutyryl chloride, SMILES is O=C(Cl)CCCBr, in an article , author is Yang, Ze-Yong, once mentioned of 927-58-2, COA of Formula: https://www.ambeed.com/products/927-58-2.html.

An appropriate level of autophagy reduces emulsified isoflurane-induced apoptosis in fetal neural stem cells

Autophagy plays essential roles in cell survival. However, the functions and regulation of the autophagy-related proteins Atg5, LC3B, and Beclin 1 during anesthetic-induced developmental neurotoxicity remain unclear. This study aimed to understand the autophagy pathways and mechanisms that affect neurotoxicity, induced by the anesthetic emulsified isoflurane, in rat fetal neural stem cells. Fetal neural stem cells were cultured, in vitro, and neurotoxicity was induced by emulsified isoflurane treatment. The effects of pretreatment with the autophagy inhibitors 3-methyladenine and bafilomycin and the effects of transfection with small interfering RNA against ATG5 (siRNA-Atg5) were observed. Cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and apoptosis was assessed using flow cytometry. Ultrastructural changes were analyzed through transmission electron microscopy. The levels of the autophagy-related proteins LC3B, Beclin 1, Atg5, and P62 and the pro-apoptosis-related protein caspase-3 were analyzed using western blot assay. The inhibition of cell proliferation and that of apoptosis rate increased after treatment with emulsified isoflurane. Autophagolysosomes, monolayer membrane formation due to lysosomal degradation, were observed. The autophagy-related proteins LC3B, Beclin 1, Atg5, and P62 and caspase-3 were upregulated. These results confirm that emulsified isoflurane can induce toxicity and autophagy in fetal neural stem cells. Pre-treatment with 3-methyladenine and bafilomycin increased the apoptosis rate in emulsified isoflurane-treated fetal neural stem cells, which indicated that the complete inhibition of autophagy does not alleviate emulsified isoflurane-induced fetal neural stem cell toxicity. Atg5 expression was decreased significantly by siRNA-Atg5 transfection, and cell proliferation was inhibited. These results verify that the Atg5 autophagy pathway can be regulated to maintain appropriate levels of autophagy, which can inhibit the neurotoxicity induced by emulsified isoflurane anesthetic in fetal neural stem cells.

Interested yet? Read on for other articles about 927-58-2, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/927-58-2.html.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 95-56-7, Name is 2-Bromophenol, molecular formula is C6H5BrO, belongs to bromides-buliding-blocks compound, is a common compound. In a patnet, author is Wang, Tingting, once mentioned the new application about 95-56-7, SDS of cas: 95-56-7.

Radiation-Resistant CsPbBr3 Nanoplate-Based Lasers

The use of nanoscale lasers in new space technologies can enable a variety of applications. Metal lead halide perovskites have emerged and been verified to possess many unique properties for optoelectronic applications, which are key elements for the space mission system. However, the basic knowledge of radiation damage of perovskite materials and the in-depth experimental irradiation testing on their lasing properties are still lacking. Here, the performance of a CsPbBr3 nanoplate (NP) laser is measured to be maintained after exposure to 150 keV proton beam with fluence up to 1 x 10(15) p/cm(2), an extremely high level of collision that destroys CdS NPs with similar shapes and emission wavelengths. Lasing characteristics and carrier dynamics of the CsPbBr(3 )and CdS NPs have been studied and compared in detail before and after proton irradiation with different beam fluences. Concurrently, simulation results manifest that negligible atomic displacement damage is caused by proton bombardment in CsPbBr3, ensuring its high resistance to proton irradiation. The findings of the high radiation resistance of the CsPbBr3 NP lasers and the insights into the underlying mechanism are conceivably important, which might make recommendations for the development of perovskite coherent light sources for new space applications.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 95-56-7. The above is the message from the blog manager. SDS of cas: 95-56-7.