Tag: M.W=150-200

Deng, Qinfei published the artcileSynthesis of 6-Fluoroalkyl 6H-Benzo[c]chromenes via Visible-Light-Promoted Radical Addition/Cyclization of Biaryl Vinyl Ethers, SDS of cas: 401-55-8, the publication is Journal of Organic Chemistry (2018), 83(11), 6151-6161, database is CAplus and MEDLINE.

A novel visible-light-promoted cascade cyclization reaction for the synthesis of 6-fluoroalkyl 6H-benzo[c]chromenes has been successfully realized, which was initiated by intermol. radical addition to biaryl vinyl ethers using easily available fluoroalkylated reagents BrCF₂CO₂Et or 2-bromo-2,2-difluoroamides as the sources of fluorinated radicals, followed by the cyclization onto an aromatic ring process. This protocol tolerated a wide range of functional groups and provided the desired products in moderate to good yields.

Journal of Organic Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fujiki, Michiya published the artcileThermo-driven chiroptical switching polysilane featuring 2-cyclopentylethyl side group, Recommanded Product: (2-Bromoethyl)cyclopentane, the publication is Silicon Chemistry (2002), 1(1), 67-72, database is CAplus.

A new rod-like helical polysilane, poly{(S)-3,7-dimethyloctyl(2-cyclopentylethyl)silane}, was found to undergo a thermo-driven, helix-helix transition at -33°C in isooctane associated with the discontinuous changes in the Siσ-Siσ* transition energy and intensity in the transition temperature region. This is the first example of a helix-helix transition polysilane with a cycloalkyl group. A similar rod-like polysilane derivative, poly{(S)-3,7-dimethyloctyl(1-cyclopentylmethyl)silane}, however, did not undergo any helix-helix transition between -61 and 80°C.

Silicon Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Recommanded Product: (2-Bromoethyl)cyclopentane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nobili, Alberto published the artcileSimultaneous Use of in Silico Design and a Correlated Mutation Network as a Tool To Efficiently Guide Enzyme Engineering, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is ChemBioChem (2015), 16(5), 805-810, database is CAplus and MEDLINE.

In order to improve the efficiency of directed evolution experiments, in silico multiple-substrate clustering was combined with an anal. of the variability of natural enzymes within a protein superfamily. This was applied to a Pseudomonas fluorescens esterase (PFE I) targeting the enantioselective hydrolysis of 3-phenylbutyric acid esters. Data reported in the literature for nine substrates were used for the clustering meta-anal. of the docking conformations in wild-type PFE I, and this highlighted a tryptophan residue (W28) as an interesting target. Exploration of the most frequently, naturally occurring amino acids at this position suggested that the reduced flexibility observed in the case of the W28F variant leads to enhancement of the enantioselectivity. This mutant was subsequently combined with mutations identified in a library based on anal. of a correlated mutation network. By interrogation of <80 variants, a mutant with 15-fold improved enantioselectivity was found.

ChemBioChem published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Recommanded Product: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hu, Essa published the artcileDiscovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit, Related Products of bromides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2008), 51(11), 3065-3068, database is CAplus and MEDLINE.

Inhibition of c-Kit has the potential to treat mast cell associated fibrotic diseases. We report the discovery of several aminoquinazoline pyridones that are potent inhibitors of c-Kit with greater than 200-fold selectivity against KDR, p38, Lck, and Src. In vivo efficacy of pyridone 16 (I)by dose-dependent inhibition of histamine release was demonstrated in a rodent pharmacodynamic model of mast cell activation.

Journal of Medicinal Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Uno, Misae published the artcileSynthesis of 4,4-Difluoroalkenes by Coupling of α-Substituted α,α-Difluoromethyl Halides with Allyl Sulfones under Photoredox Catalyzed Conditions, Computed Properties of 401-55-8, the publication is Journal of Organic Chemistry (2019), 84(14), 9330-9338, database is CAplus and MEDLINE.

Photoredox-catalyzed allylation of α-gem-difluorinated organohalides with allyl sulfones proceeded smoothly under visible light irradiation to give 4,4-difluoroalkenes in good yields. In the presence of catalytic Ru(bpy)₃Cl₂, Hantzsch ester, and diisopropylethylamine, the reaction was complete within 2 h. Using the same methodol., three-component cascade reactions to give 6,6-difluoroalkenes were carried out successfully.

Journal of Organic Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C19H14Cl2, Computed Properties of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fischer, J. published the artcileSynthesis of N-(2-hydroxy-5-methylphenyl)-substituted amino acids, Category: bromides-buliding-blocks, the publication is Magyar Kemiai Folyoirat (1997), 103(7), 331-335, database is CAplus.

N-(2-hydroxy-5-methylphenyl)-substituted amino acids were prepared from 2-amino-4-methylphenol by (1) nucleophilic substitution with halogenated carboxylic acids, (2) condensation with α-keto carboxylic acid derivatives, and (3) reductive alkylation with α-keto esters. The advantages and disadvantages of these methods depend on the target mols.

Magyar Kemiai Folyoirat published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ladanyi, L. published the artcileDetermination of the enantiomeric composition of chiral carboxylic acids using chiral derivatization and HPLC, Product Details of C4H7BrO2, the publication is Chromatographia (1987), 477-81, database is CAplus.

The enantiomers of chiral carboxylic acids were separated as their diastereomeric amides with (1R,2R)-(-)-1-(4-nitrophenyl)-2-amino-1,3-propanediol (levo-base) and with dextrobase (the enantiomer of levobase) by high-performance liquid chromatog. using a conventional C-18 column and various solvent systems containing MeCN, MeOH, H₂O, and phosphoric acid.

Chromatographia published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Product Details of C4H7BrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kabir, Shahriar published the artcileNear-infrared organic photodetectors with a soluble Alkoxy-Phthalocyanine derivative, Formula: C8H17Br, the publication is Optical Materials (Amsterdam, Netherlands) (2022), 112209, database is CAplus.

The condition of the bulk-heterojunction (BHJ) is an important factor for photodetectors as it significantly influences the efficiency of exciton dissociation from bound exciton pairs inside the active layer. In this study, we realized near-IR (NIR) photodetectors with the BHJ system of a soluble donor organic semiconductor, 1,4,8,11,15,18,22,25-octaoctyloxy-phthalocyanine, and phenyl-C61-butyric acid Me ester. By experimenting with the blend ratio of the organic materials, we observed substantial change of device performance owing to the change in the crystalline condition and morphol. of the active layer. Our organic photodiodes with optimized BHJ active layer reached shot noise limited specific detectivity of 2.1 x 10¹² Jones and external quantum efficiency of 18% with a bias of -0.5 V at the NIR wavelength of 770 nm. We attributed this improvement to the decrease in grain size inside the BHJ which resulted in an increased exciton dissociation efficiency at the donor-acceptor interface.

Optical Materials (Amsterdam, Netherlands) published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Formula: C8H17Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Cao, Qun published the artcileA Ball-Milling-Enabled Reformatsky Reaction, Product Details of C4H6BrFO2, the publication is ChemSusChem (2019), 12(12), 2554-2557, database is CAplus and MEDLINE.

An operationally simple one-pot one-step mechanochem. Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre-activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39-82 % yield) and is effective irresp. of the initial morphol. of the zinc source.

ChemSusChem published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Product Details of C4H6BrFO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Eubanks, Lisa M. published the artcileIdentification of α₂ Macroglobulin as a Major Serum Ghrelin Esterase, Application of 7-Bromohept-1-yne, the publication is Angewandte Chemie, International Edition (2011), 50(45), 10699-10702, S10699/1-S10699/23, database is CAplus and MEDLINE.

Ghrelin is an appetite-stimulating hormone secreted from endocrine cells in the stomach. Ghrelin is synthesized as a 117-residue polypeptide (preproghrelin) which undergoes proteolytic cleavage to produce the 94-residue proghrelin. Subsequent post-translational processing events include cleavage of proghrelin at residue Arg28 and octanoylation at the hydroxyl group of Ser3; these modifications generate the mature 28-residue ghrelin peptide. In serum, the inactivation of ghrelin is thought to occur primarily by deacylation of Ser3. In order to capture serum-based serine hydrolase enzymes that participate in the deacylation of circulating ghrelin, the present work describes the synthesis of a ghrelin-like “bait” mol. (probe 1) that contains a phosphonofluoridate warhead. The interaction of probe 1 with α₂-macroglobulin (α₂M) lead to addnl. studies which indicate that α₂M possesses ghrelin esterase activity and plays an important role in ghrelin metabolism

Angewandte Chemie, International Edition published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Application of 7-Bromohept-1-yne.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary