Tag: M.W=150-200

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Synthetic Route of 4897-84-1

Donoghue, Craig;Cubillos-Rojas, Monica;Gutierrez-Prat, Nuria;Sanchez-Zarzalejo, Carolina;Verdaguer, Xavier;Riera, Antoni;Nebreda, Angel R. research published 《 Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation》, the research content is summarized as follows. We report the design of hetero-bifunctional small mols. that selectively target p38α and p38β for degradation These proteolysis targeted chimeras (PROTACs) are based on an ATP competitive inhibitor of p38α and p38β, which is linked to thalidomide analogs to recruit the Cereblon E3 ubiquitin ligase complex. Compound synthesis was facilitated by the use of a copper catalyzed “click” reaction. We show that optimization of the linker length and composition is crucial for the degradation-inducing activity of these PROTACs. We provide evidence that these chem. compounds can induce degradation of p38α and p38β but no other related kinases at nanomolar concentrations in several mammalian cell lines. Accordingly, the PROTACs inhibit stress and cytokine-induced p38α signaling. Our compounds contribute to understanding the development of PROTACs, and provide a useful tool to investigate functions of the p38 MAPK pathway and its involvement in diseases.

Synthetic Route of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline, Product Details of C7H8BrN

Du, Chongyang;Chen, Yaofeng research published 《 Zinc Powder Catalysed Formylation and Urealation of Amines Using CO₂ as a C1 Building Block》, the research content is summarized as follows. The zinc powder catalyzed formylation and urealation of secondary amines e.g., N-methylaniline and primary aromatic amines RNH₂ (R = Ph, 2,4,6-trimethylphenyl, cyclohexyl, etc.) with CO₂ and (EtO)₃SiH under solvent-free condition were reported. Using 2 mol% zinc powder as the catalyst, a series of secondary amines, both the aromatic ones and the aliphatic ones can be formylated into formamides e.g., N-methyl-N-phenylformamide. When primary aromatic amines were used as the substrates, the reactions produce urea derivatives RNHC(O)NHR. The electronic and steric effects from the substrates on the formylation and urealation reactions were observed and discussed. The recovery and reusability of zinc powder were investigated, showing that zinc powder can be reused in the formylation reaction without loss of catalytic activity. The anal. on the reactants/products mixture after filtering out the zinc powder showed that zinc concentration in the mixture is low to 1 ppm. The pathways for the formylation and urealation of amines with this catalytic system were also investigated and related to the different substrates.

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Product Details of C7H8BrN

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Horrer, Guenther; Krummenacher, Ivo; Mann, Sophie; Braunschweig, Holger; Radius, Udo published the artcile< N-Heterocyclic carbene and cyclic (alkyl)(amino)carbene complexes of vanadium(III) and vanadium(V)>, Category: bromides-buliding-blocks, the main research area is vanadium cAAC NHC complex preparation oxidation paramagnetism magnetic moment.

[VCl3(THF)3] offers a convenient entrance point into the chem. of carbene stabilized V(III) complexes. Herein we report the paramagnetic mono- and biscarbene complexes [VCl3(cAAC)] (1, cAAC = 1-Dipp-3,3,5,5-tetramethyl-2-pyrrolidinylidene), [VCl3(cAAC)(THF)] (1-thf), [VCl3(IMes)] (2), [{VCl2(IiPrMe)(μ-Cl)}2] (3, IiPrMe = 1,3-diisopropyl-4,5-dimethyl-2-imidazolylidene), [VCl3(IDipp)] (4) [VCl3(SIDipp)] (5), [VCl3(SIDipp)(THF)] (5-thf), [VCl3(ItBu)] (6, ItBu = 1,3-di-tert-butyl-2-imidazolylidene), [VCl3(cAAC)2] (7) and [VCl3(IiPrMe)2] (8). Reaction of 1 with MesMgCl, MesLi and LiNPh2 afforded the complexes [VCl2(Mes)(cAACMe)] (9), [cAAC-H]+[VCl2Mes2]- (10) and [VCl2(NPh2)(cAAC)] (11). The vanadium(V) complexes [V(O)Cl3(IDipp)] (12) and [V(O)Cl3(SIDipp)] (13) were selectively prepared from oxygen oxidation of 4 and 5. The complex 12 and [V(O)Cl3(IMes)] react with isocyanates ArNCO to yield the NHC-ligated imido complexes [V(:NAr1)Cl3(IDipp)] (14, Ar1 = 4-MeC6H4), [V(:NAr2)Cl3(IDipp)] (15, Ar2 = 4-FC6H4), [V(:NAr1)Cl3(SIDipp)] (16), [V(:NAr2)Cl3(SIDipp)] (17), [V(:NAr1)Cl3(IMes)] (18) and [V(:NAr2)Cl3(IMes)] (19).

Dalton Transactions published new progress about Amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (imido complexes). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Anbardan, Soheil Zamani; Mokhtari, Javad; Yari, Ahmad; Bozcheloei, Abolfazl Hassani published the artcile< Direct synthesis of amides and imines by dehydrogenative homo or cross-coupling of amines and alcohols catalyzed by Cu-MOF>, Synthetic Route of 3959-07-7, the main research area is amine benzyl alc copper MOF catalyst dehydrogenative cross coupling; benzamide preparation green chem; benzyl amine copper MOF catalyst dehydrogenative homo coupling; benzylphenyl methanimine preparation green chem.

Oxidative dehydrogenative homo-coupling of amines to imines and cross-coupling of amines with alcs. to amides were achieved with high to moderate yields at room temperature in THF using Cu-MOF as an efficient and recyclable heterogeneous catalyst under mild conditions. Different primary benzyl amines and alcs. were utilized for the synthesis of a wide variety of amides and imines. The Cu-MOF catalyst was recycled and reused four times without loss of catalytic activity.

RSC Advances published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Weibo; Li, Zhixinyi; Gao, Wei; Liu, Xiaoyu; Lv, You; Hao, Zesheng; Tang, Liangfu; Li, Kun; Zhao, Bin; Fan, Zhijin published the artcile< Design, Synthesis, and Evaluation of Novel Isothiazole-Purines as a Pyruvate Kinase-Based Fungicidal Lead Compound>, HPLC of Formula: 3959-07-7, the main research area is isothiazole purine preparation pyruvate kinase inhibitor fungicide phytopathogenic fungi; fungicidal activity; molecular docking; pyruvate kinase inhibitors.

Target identification is one of the most important bases for novel pesticide development; pyruvate kinase (PK) was discovered as a potent fungicide target in our previous studies. To continue the PK-based fungicide development, novel isothiazole-purine derivatives were rationally designed and synthesized. Bioassay results showed that compound 5ai displayed excellent in vitro activity against Rhizoctonia solani with an EC50 of 1.5μg/mL, which was superior to those of pos. controls diflumetorim with its EC50 of 19.8μg/mL and PK-based lead YZK-C22 with its EC50 of 4.2μg/mL. Compounds (I) (5.2μg/mL) and (II) (4.5μg/mL) displayed better activities against Gibberella zeae with their EC50s falling between 4.0 and 5.5μg/mL, while YZK-C22 showed an EC50 of 6.4μg/mL. In addition, (III) exhibited promising in vivo activity against Erysiphe graminis and Puccinia sorghi Schw. with 100% efficacy at 10μg/mL and 90% efficacy at 2μg/mL against P. sorghi Schw. Compound (IV) showed good PK inhibitory activity with an IC50 of 38.8μmol/L, and it was well docked into the active site of the target enzyme PK, which was slightly more active than YZK-C22 with its IC50 of 42.4μmol/L. Our studies discovered that isothiazole-purines were PK-based fungicidal leads deserving of further study.

Journal of Agricultural and Food Chemistry published new progress about Agrochemical fungicides. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, HPLC of Formula: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bouz, Ghada; Bouz, Sarah; Jandourek, Ondrej; Konecna, Klara; Barta, Pavel; Vinsova, Jarmila; Dolezal, Martin; Zitko, Jan published the artcile< Synthesis, biological evaluation, and in silico modeling of N-substituted quinoxaline-2-carboxamides>, Application In Synthesis of 3959-07-7, the main research area is N substituted quinoxaline 2 carboxamides synthesis; Mycobacterium tuberculosis; antimycobacterial; cytotoxicity; molecular docking; pyrazinamide; quinoxaline; tuberculosis.

Despite the established treatment regimens, tuberculosis remains an alarming threat to public health according to WHO. Novel agents are needed to overcome the increasing rate of resistance and perhaps achieve eradication. As part of our long-term research on pyrazine derived compounds, we prepared a series of their ortho fused derivatives, N-phenyl- and N-benzyl quinoxaline-2-carboxamides, and evaluated their in vitro antimycobacterial activity. In vitro activity against Mycobacterium tuberculosis H37Ra (represented by min. inhibitory concentration, MIC) ranged between 3.91-500μg/mL, with most compounds having moderate to good activities (MIC < 15.625μg/mL). The majority of the active compounds belonged to the N-benzyl group. In addition to antimycobacterial activity assessment, final compounds were screened for their in vitro cytotoxicity. N-(naphthalen-1-ylmethyl)quinoxaline-2-carboxamide (compound 29) was identified as a potential antineoplastic agent with selective cytotoxicity against hepatic (HepG2), ovarian (SK-OV-3), and prostate (PC-3) cancer cells lines. Mol. docking showed that human DNA topoisomerase and vascular endothelial growth factor receptor could be potential targets for 29. Pharmaceuticals published new progress about Antimycobacterial agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Gaozhan; Brosius, Victor; Han, Jie; Rominger, Frank; Dreuw, Andreas; Freudenberg, Jan; Bunz, Uwe H. F. published the artcile< Stable Radical Cations of N,N'-Diarylated Dihydrodiazapentacenes>, Reference of 576-83-0, the main research area is diaryla dihydrodiazapentacene radical cation crystal structure UV EPR spectra; N,N′-diaryldiazapentacenes; oxidation; radical cation; single crystal structure.

A series of quinoidal N,N’-diaryldiaza-N,N’-dihydropentacenes (Quino) was prepared in a two-step reaction, starting from quinacridone. Oxidation of Quino furnishes stable radical cations, isoelectronic to the radical anions of the azaacenes, whereas the dicationic species are isoelectronic to neutral azapentacenes. The spectroscopic properties of the diaryldiazapentacenes and their oxidized mono- and dications are equivalent to that of the dianion of tetraazapentacene (TAP), its radical anion and the neutral TAP.

Chemistry – A European Journal published new progress about Aromaticity. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Reference of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Betori, Rick C.; May, Catherine M.; Scheidt, Karl A. published the artcile< Combined Photoredox/Enzymatic C-H Benzylic Hydroxylations>, HPLC of Formula: 2725-82-8, the main research area is photoredox chemoenzymic benzylic hydroxylation; C−H oxidation; chemoenzymatic catalysis; chiral alcohols; ketoreductase; photoredox catalysis.

Chem. transformations that install heteroatoms into C-H bonds are of significant interest because they streamline the construction of value-added small mols. Direct C-H oxyfunctionalization, or the one step conversion of a C-H bond to a C-O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcs. in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymic process for direct C-H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymic catalysis synergy and enables chemoenzymic processes for powerful and selective oxidative transformations.

Angewandte Chemie, International Edition published new progress about Biochemical reaction kinetics. 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, HPLC of Formula: 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Abazid, Ayham H.; Clamor, Nils; Nachtsheim, Boris J. published the artcile< An Enantioconvergent Benzylic Hydroxylation Using a Chiral Aryl Iodide in a Dual Activation Mode>, Synthetic Route of 2725-82-8, the main research area is alkylarene triazolylmethyl iodoanisole catalyst enantioselective hydroxylation; benzyl alc preparation.

The application of a triazole-substituted chiral iodoarene in a direct enantioselective hydroxylation of alkyl arenes was reported. This method allows the rapid synthesis of chiral benzyl alcs. in high yields and stereocontrol, despite its nontemplated nature. In a cascade activation consisting of an initial irradiation-induced radical C-H-bromination and a consecutive enantioconvergent hydroxylation, the iodoarene catalyst has a dual role. It initiates the radical bromination in its oxidized state through an in-situ-formed bromoiodane and in the second, Cu-catalyzed step, it acts as a chiral ligand. This work demonstrates the ability of a chiral aryl iodide catalyst acting both as an oxidant and as a chiral ligand in a highly enantioselective C-H-activating transformation. Furthermore, this concept presents an enantioconvergent hydroxylation with high selectivity using a synthetic catalyst.

ACS Catalysis published new progress about Alkylarenes Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Synthetic Route of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shi, Ji-Long; Hao, Huimin; Lang, Xianjun published the artcile< Phenol-TiO2 complex photocatalysis: visible light-driven selective oxidation of amines into imines in air>, Product Details of C7H8BrN, the main research area is phenol titania photocatalyst amine imine oxidation air.

Strong interfacial charge-transfer (ICT) has been observed between phenol and TiO2. It was demonstrated that a single Ph-O-Ti linkage could induce ICT transitions in the visible light region. By utilizing the surface complexation of phenol with TiO2, we, herein, present a new photocatalytic protocol for the selective oxidation of amines to imines in air. Our success depended on merging the phenol-TiO2 complex photocatalyst with (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO), so called cooperative photocatalysis, which improved stability of the surface-complexed phenol under the oxidative circumstance and promoted the selective conversion of amines. With 5 mol% of TEMPO as a co-catalyst and phenol-TiO2 complex (containing 0.8 mol% of phenol) as a photocatalyst, amines could be efficiently oxidized into imines with atm. O2 under blue light-emitting diode (LED) irradiation In addition, a mechanism is proposed to explain the visible-light photocatalytic performance of the present system.

Sustainable Energy & Fuels published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary