Tag: M.W=150-200

Xu, Miaomiao; Chen, Liang; Yan, Qiang published the artcile< Gas-Constructed Vesicles with Gas-Moldable Membrane Architectures>, SDS of cas: 576-83-0, the main research area is vesicle membrane carbon dioxide frustrated Lewis pair nanomaterial; carbon dioxide; frustrated Lewis pair; gas-bridged bond; nanomaterial; vesicle.

Integrating gas as a main building block into nanomaterial construction is a challenging mission that remains elusive. Herein, we report a gas-constructed vesicular system formed by CO2 gas and frustrated Lewis pairs (FLPs). Two mol. triads bearing three bulky borane and phosphine groups are designed as trivalent disk-like FLP monomers. CO2, as a gas cross-linker, can drive the two-dimensional polymerization of these two FLP monomers, leading to the generation of planar FLP networks that further transform into a thermodynamically favored membranous vesicle structure. Gas-guided vesicle formation is also applicable to other inert but FLP-activatable gases. Different gas linkages can form vesicles with distinct architectures, sizes, and morphologies. We envisage that this study would suggest a new concept that exploits gases to fabricate tunable nanomaterials.

Angewandte Chemie, International Edition published new progress about Electrospray ionization mass spectra. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, SDS of cas: 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Haihong; Zhao, Ning; Matus, Ekaterina V.; Ismagilov, Zinfer R.; Li, Lei; Xiao, Fukui published the artcile< Preparation and modulation of Cu-BTC-(n)Br/MCFs with water stability and its application for CO2 capture>, Quality Control of 576-83-0, the main research area is copper trimesic acid bromine MCF water carbon dioxide capture.

In this study, a novel composite Cu-BTC-(n)Br/MCFs was successfully synthesized by solvothermal method. The composites were characterized by XRD, N2 adsorption and desorption, SEM, FT-IR, TG, and water vapor adsorption technologies. Meanwhile, the CO2 adsorption isotherms were obtained using the static adsorption instrument which could be well fitted by the Langmuir-Freundlich model. The Cu-BTC-0.05Br/MCFs exhibited a good CO2 adsorption capacity of 2.44 mmol/g which was basically maintained after five adsorption-desorption cycles. More importantly, the Cu-BTC-0.05Br/MCFs also showed remarkable adsorption effectivity that was an increase of 8.7% than the Cu-BTC/MCFs at 35 °C and 1 bar after water treatment. The Cu-BTC-(n)Br/MCFs were promising candidate materials for effectively CO2 capture in practical application.

Journal of Environmental Chemical Engineering published new progress about Adsorption. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Quality Control of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Bingxiao; Xu, Jiao; Song, Jinliang; Wu, Haihong; Mei, Xuelei; Zhang, Kaili; Han, Wanying; Wu, Wei; He, Mingyuan; Han, Buxing published the artcile< Nanoparticles and single atoms of cobalt synergistically enabled low-temperature reductive amination of carbonyl compounds>, Category: bromides-buliding-blocks, the main research area is primary amine preparation; aldehyde ketone reductive amination cobalt catalyst.

Herein, authors designed several Co-based catalysts (denoted as Co@C-N(x), where x represents the pyrolysis temperature) by the pyrolysis of the metal-organic framework ZIF-67 at different temperatures Very interestingly, the prepared Co@C-N(800) could efficiently catalyze the reductive amination of various aldehydes/ketones to synthesize the corresponding primary amines with high yields at 35°C. Besides non-noble metal and mild temperature, the other unique advantage of the catalyst was that the substrates with different reduction-sensitive groups could be converted into primary amines selectively because the Co-based catalyst was not active for these groups at low temperature Systematic anal. revealed that the catalyst was composed of graphene encapsulated Co nanoparticles and atomically dispersed Co-Nx sites. The Co particles promoted the hydrogenation step, while the Co-Nx sites acted as acidic sites to activate the intermediate (Schiff base). The synergistic effect of metallic Co particles and Co-Nx sites is crucial for the excellent performance of the catalyst Co@C-N(800). To the best of knowledge, this is the first study on efficient synthesis of primary amines via reductive amination of carbonyl compounds over earth-abundant metal-based catalysts at low temperature (35°C).

Chemical Science published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Perez-Castillo, Yunierkis; Montes, Ricardo Carneiro; da Silva, Cecilia Rocha; Neto, Joao Batista de Andrade; Dias, Celidarque da Silva; Brunna Sucupira Duarte, Allana; Junior, Helio Vitoriano Nobre; de Sousa, Damiao Pergentino published the artcile< Antifungal Activity of N-(4-Halobenzyl)amides against Candida spp. and Molecular Modeling Studies>, SDS of cas: 3959-07-7, the main research area is Candida halobenzyl amide mol modeling antifungal activity; Candida auris; anticandidal drugs; antimicrobial activity; benzoic acid; candidiasis; cinnamic acid; fungi; molecular docking; natural products; plants.

Fungal infections remain a high-incidence worldwide health problem that is aggravated by limited therapeutic options and the emergence of drug-resistant strains. Cinnamic and benzoic acid amides have previously shown bioactivity against different species belonging to the Candida genus. Here, 20 cinnamic and benzoic acid amides were synthesized and tested for inhibition of C. krusei ATCC 14243 and C. parapsilosis ATCC 22019. Five compounds inhibited the Candida strains tested, with compound 16 (MIC = 7.8 μg/mL) producing stronger antifungal activity than fluconazole (MIC = 16 μg/mL) against C. krusei ATCC 14243. It was also tested against eight Candida strains, including five clin. strains resistant to fluconazole, and showed an inhibitory effect against all strains tested (MIC = 85.3-341.3 μg/mL). The MIC value against C. krusei ATCC 6258 was 85.3 mcg/mL, while against C. krusei ATCC 14243, it was 10.9 times smaller. This strain had greater sensitivity to the antifungal action of compound 16. The inhibition of C. krusei ATCC 14243 and C. parapsilosis ATCC 22019 was also achieved by compounds 2, 9, 12, 14 and 15. Computational experiments combining target fishing, mol. docking and mol. dynamics simulations were performed to study the potential mechanism of action of compound 16 against C. krusei. From these, a multi-target mechanism of action is proposed for this compound that involves proteins related to critical cellular processes such as the redox balance, kinases-mediated signaling, protein folding and cell wall synthesis. The modeling results might guide future experiments focusing on the wet-lab investigation of the mechanism of action of this series of compounds, as well as on the optimization of their inhibitory potency.

International Journal of Molecular Sciences published new progress about Candida albicans. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Takeda, Mitsumi; Maejima, Saki; Yamaguchi, Eiji; Itoh, Akichika published the artcile< Iodine-mediated direct α-amination of dimethyl methylmalonate using non-protected amines>, SDS of cas: 3959-07-7, the main research area is dimethyl methylmalonate amine iodine regioselective amination; alkylamino dimethyl methylmalonate preparation.

In this study, direct C-N bond formation was achieved via the reaction of a di-Me methylmalonate with various amines in the presence of mol. iodine to produce α-aminocarbonyl compounds This versatile methodol. of the α-amination of a carbonyl-containing compound involves the in situ iodination of the di-Me methylmalonate, thus promoting the formation of its enolate isomer, which then facilitates its nucleophilic substitution reaction with an amine. This strategy is highly practical and can be used in industry due to its requirement of only readily available reagents without any pre-preparation of the amines and other substrates.

Tetrahedron Letters published new progress about Amination, regioselective. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gupta, Priyanka; Siewert, Jan-Erik; Wellnitz, Tim; Fischer, Malte; Baumann, Wolgang; Beweries, Torsten; Hering-Junghans, Christian published the artcile< Reactivity of phospha-Wittig reagents towards NHCs and NHOs>, Synthetic Route of 576-83-0, the main research area is phosphaWittig reagent reaction heterocyclic carbene olefin; crystal structure carbene phosphinidene phosphinoimidazolylidene adduct; mol structure carbene phosphinidene phosphinoimidazolylidene adduct; optimized geometry carbene phosphinidene phosphinoimidazolylidene adduct DFT.

Phospha-Wittig reagents, RPPMe3 (R = Mes* 2,4,6-tBu3-C6H2; MesTer 2,6-(2,4,6-Me3C6H2)-C6H3; DipTer 2,6-(2,6-iPr2C6H3)-C6H3), can be considered as phosphine-stabilized phosphinidenes. PMe3 can be displaced by NHCs or NHOs. Phosphinidene-like reactivity results in a subsequent C(sp2)-H activation of the exocyclic CH2 group in NHOs. This concept was further extended to allyl-appended NHOs, which resulted in phosphine-substituted allyl species.

Dalton Transactions published new progress about Crystal structure. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Synthetic Route of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sheng, Wenlong; Shi, Ji-Long; Hao, Huimin; Li, Xia; Lang, Xianjun published the artcile< Polyimide-TiO2 hybrid photocatalysis: Visible light-promoted selective aerobic oxidation of amines>, Computed Properties of 3959-07-7, the main research area is visible light promoted selective aerobic oxidation amine; Polyimide titania hybrid photocatalysis.

Polyimides are a class of high-performance polymers with good thermal and chem. stability. One specific polyimide can be formed via thermal polymerization of melamine (MA) and pyromellitic dianhydride (PMDA) precursors. Herein, polyimide-TiO2 hybrids were straightforwardly synthesized with a mixture of MA, PMDA and TiO2 by annealing at 325 °C. The crystal phase of anatase TiO2 can be preserved and polyimide can be formed on the surface of TiO2 to enable visible light absorption and high sp. surface areas for the polyimide-TiO2 hybrid. Next, this polyimide-TiO2 hybrid as a photocatalyst were successfully applied for visible light-promoted selective aerobic oxidation of amines into imines under irradiation of 460 nm blue light-emitting diodes (LEDs). With 4 mol% of (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) as the co-catalyst, polyimide-TiO2 hybrid photocatalyst reached 8 times of that of pristine TiO2 for the selective aerobic oxidation of benzylamine. Overall, the cooperative photocatalysis of polyimide-TiO2 hybrid and TEMPO was demonstrably efficient for visible light-promoted selective oxidation of amines with aerial O2 as the oxidant. Moreover, by means of reactive oxygen species (ROS) quenching experiments and in-situ ESR spectroscopy, superoxide anion radical (O·-2) was certified as the crucial ROS in coupling polyimide-TiO2 hybrid photocatalysis and TEMPO catalysis. This work suggests that hybridization of metal oxide semiconductor with polymer like polyimides is viable to forge visible light photocatalysts.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Lingyun; Zhang, Jian; Si, Lianghui; Han, Li; Zhang, Bo; Ma, Hui; Xing, Junhao; Zhao, Leilei; Zhou, Jinpei; Zhang, Huibin published the artcile< Synthesis and biological evaluation of GPR40/FFAR1 agonists containing 3,5-dimethylisoxazole>, Reference of 188813-04-9, the main research area is dimethylisoxazolyl benzyloxy fluorophenylpropanoic acid preparation antidiabetic activity SAR; 3,5-Dimethylisoxazole; Diabetes; GPR40 agonist; Oral glucose tolerance test.

GPR40 is an attractive target due to its glucose-stimulated insulin secretion effect with low risk of causing hypoglycemia, which also can be seen from the clin. studies using TAK-875 (fasiglifam). 3,5-Dimethylisoxazolyl-substituted arylmethoxy fluorobenzenepropanoic acids such as I (R = Me, Et, n-Pr, i-Pr, Bu, i-Bu, cyclopropylmethyl, cyclopentyl; R1 = H, Me, F, Cl, CF3, RO; R2 = F, Cl, MeO; R3 = F, R4 = F, Cl, MeO) were prepared as GPR40 agonists; I (R1 = R2 = R3 = H; R4 = Cl) (II) was a GPR40 agonist with an EC50 value of 15.9 nM. Moreover, II reduced glucose excursion to 23.1% in ICR mice and 29.5% in type 2 diabetic C57BL/6 mice at 30 mg/kg and exhibited satisfactory pharmacokinetics profile. Mol. docking studies of I (R1 = R2 = R3 = R4 = H) with GPR40 were conducted to explain the interaction mode of this series. II with robust efficacy in vitro and in vivo constitutes a promising antidiabetic drug candidate.

European Journal of Medicinal Chemistry published new progress about Antidiabetic agents. 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Reference of 188813-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cao, Dawei; Yan, Chaoxian; Zhou, Panpan; Zeng, Huiying; Li, Chao-Jun published the artcile< Hydrogen bonding promoted simple and clean photo-induced reduction of C-X bond with isopropanol>, Recommanded Product: 2,4,6-Trimethylbromobenzene, the main research area is hydrogen bonding photoinduced reductive dehalogenation isopropanol.

We herein report a simple and clean photo-induced metal-free reduction of C-X bond under an atm. of air at room temperature Isopropanol is used as both the reducing reagent and solvent [e.g., Me 4-iodobenzoate → Me benzoate (96%) under UV irradiation in isopropanol]. Various functional groups (acids, esters, alcs., anilines, phenols, indoles, pyridines, cyano and trifluoromethyl groups) and other heterocyclic compounds are tolerated. Different organic halides (including C-I, C-Br and C-Cl bonds) can be dehalogenated with moderate to excellent yields. Polyhalides are also reduced chemoselectively and efficiently. DFT calculation suggests a six-membered ring transition state via C-X···H-O hydrogen bonding to decrease the activation energy.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl halides Role: POL (Pollutant), RCT (Reactant), OCCU (Occurrence), RACT (Reactant or Reagent) (and heteroaryl halides and polyhalides). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Recommanded Product: 2,4,6-Trimethylbromobenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gao, Chao; Li, Jian; Yin, Sheng; Sun, Junliang; Wang, Cheng published the artcile< Twist Building Blocks from Planar to Tetrahedral for the Synthesis of Covalent Organic Frameworks>, Synthetic Route of 576-83-0, the main research area is twist building planar tetrahedral covalent organic framework.

Rational construction of covalent organic frameworks (COFs) with novel structures still remains a challenge. Herein, we report the designed synthesis of two COFs, 2D-BPTA-COF and 3D-BMTA-COF, starting from biphenyl-based precursors but with different groups at the ortho positions. Both COFs exhibited high crystallinity and large surface area, and interestingly, 2D-BPTA-COF crystallizes into 2D sheets with AB stacking mode while 3D-BMTA-COF adopts a 7-fold interpenetrated structure with pts topol. This structural difference could be ascribed to the introduction of Me groups in the building blocks, as the dihedral angle of biphenyl rings in 2D-BPTA-COF is ∼0° while in 3D-BMTA-COF it is ∼60°. Therefore, it is possible to synthesize COFs with different structures by twisting building blocks from planar to tetrahedral with steric hindrance. We believe this result represents a general and straightforward way to expand the diversity of tetrahedral nodes for constructing 3D COFs in the future, and moreover, a new tetrahedral node for constructing 3D COFs is now available.

Journal of the American Chemical Society published new progress about Aminoplasts, polyazomethine- Role: PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), PREP (Preparation), USES (Uses). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Synthetic Route of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary