Tag: M.W=150-200

Hahn, G.; Kunnas, P.; de Jonge, N.; Kempe, R. published the artcile< General synthesis of primary amines via reductive amination employing a reusable nickel catalyst>, Electric Literature of 3959-07-7, the main research area is gamma alumina supported nickel salen complex nanocatalyst preparation reusable; amine hydrochloride preparation; primary amine preparation hydrochloric acid salt formation; aldehyde ammonia reductive amination alumina supported nickel complex catalyst; ketone ammonia reductive amination alumina supported nickel complex catalyst.

A nanostructured nickel catalyst was reported for the general and selective synthesis of primary amines via reductive amination, employing ammonia dissolved in water. The catalyst, which operated at low temperature and pressure, was highly active, reusable and easy to handle. The synthesis from a specific nickel complex and γ-Al2O3 was straightforward, with the ligand-metal combination of this complex being crucial. Aldehydes (including purely aliphatic ones), aryl-alkyl, dialkyl and diaryl ketones could all be converted smoothly into primary amines. In addition, the amination of pharmaceuticals, bioactive compounds and natural products was demonstrated. Many functional groups-including hydrogenation-sensitive examples-were tolerated.

Nature Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Electric Literature of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Muraoka, Takako; Ishii, Yasuhisa; Siti, Nursaliha; Nasu, Masahiro; Wahida, Nurul Ain; Ueno, Keiji published the artcile< Syntheses and Structures of Gallyliron Complexes with Pyridine Ligands and Their Reactions with Methyl Acrylate>, Recommanded Product: 2,4,6-Trimethylbromobenzene, the main research area is photolysis dichloro gallyl iron complex pyridine; crystal structure mol gallium iron pyridine complex preparation; gallyl iron pyridine complex preparation coordinative substitution methyl acrylate.

Reactions of gallyliron complexes Cp*(OC)2FeGaR2 (R = Cl (1), Mes (2); Cp*, η5-C5Me5; Mes, 2,4,6-Me3C6H2) with pyridine in C6D6 afforded pyridine-stabilized gallyl complexes Cp*(OC)2Fe{GaR2(py)} (R = Cl (3), Mes (5a); py, pyridine). Photoirradiation of dichlorogallyl complex 3 in the presence of excess pyridine in benzene proceeded via the substitution of a CO ligand with another pyridine to give Cp*(OC)(py)Fe{GaCl2(py)} (4). However, photoirradiation of dimesitylgallyl complex 2 in the presence of excess pyridine gave gallane(pyridyl)iron complex Cp*(OC)Fe{(η1-HGaMes2)(η1-2-C5H4N)} (6a) via CO elimination and oxidative addition of the C-H bond at the 2-position of the gallium-coordinated pyridine. X-ray crystal structure anal. of 6a revealed the formation of a 3-center-2-electron (3c2e) bond in the Fe-H-GaMes2 fragment. Reaction of 4 with Me acrylate in toluene at 50°C resulted in substitution of the pyridine ligand on the iron atom with the C:C bond, giving Cp*(OC)(η2-CH2:CHCO2Me)Fe{GaCl2(py)} (7). In contrast, the reaction of 6a with Me acrylate in toluene at 100°C afforded vinyl iron complex Cp*(OC)2Fe(CH:CH2) (8) and 4-membered Ga2O2 cyclic gallane compound [Mes2GaOMe]2 (9) via cleavage of the Fe-Ga, C-O, and C-C bonds.

Organometallics published new progress about Bond cleavage. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Recommanded Product: 2,4,6-Trimethylbromobenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yeung, Jason; Becker, Matthias; Stephan, Douglas W. published the artcile< Towards macrocyclic frustrated Lewis pairs>, Safety of 2,4,6-Trimethylbromobenzene, the main research area is crystal structure mol boron macrocycle frustrated Lewis pair preparation; macrocyclic frustrated Lewis pair boron nitrogen bond macrocycle preparation.

Macrocycles with and without B-N bonds were prepared from reaction of C6F5BH2·SMe2 or MesBH2 with the 2,6-pyridinedimethanol derivatives Both classes of macrocycle reacted with B(C6F5)3 but were unreactive to small mols. These observations provide insights for the subsequent design of macrocyclic FLPs for multi-electron reactions.

Dalton Transactions published new progress about B-N bond. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Safety of 2,4,6-Trimethylbromobenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Xu-Lin; Tao, Xiao-Dong; Wei, Zhuangzhuang; Meng, Lingyi; Lin, Fu-Lin; Zhang, Dong-Hai; Jing, Yan-Yun; Lu, Can-Zhong published the artcile< Thermally Activated Delayed Fluorescence Amorphous Molecular Materials for High-Performance Organic Light-Emitting Diodes>, HPLC of Formula: 576-83-0, the main research area is thermally activated delayed fluorescence amorphous mol material high performance; OLEDs; amorphous molecular materials; bimesitylene; film quality; stability; thermally activated delayed fluorescence.

Small-mol. thermally activated delayed fluorescence (TADF) materials have been extensively developed to actualize efficient organic LEDs (OLEDs). However, organic small mols. generally compromise thin film quality and stability due to the tendency of crystallization, aggregation, and phase separation, which hence degrade the efficiency and long-term stability of the OLEDs. Here, for the first time, we exploit the unique mol. configuration of the bimesitylene scaffold to design two highly efficient TADF amorphous mol. materials with excellent thermal and morphol. stabilities. The twisted and rigid bimesitylene scaffold thwarts regular mol. packing and crystallization, thereby guaranteeing homogeneous and stable amorphous thin films. Meanwhile, the highly twisted geometry of the bimesitylene scaffold efficiently breaks the mol. conjugation and thus conserves the high energies of the lowest locally excited triplet states (3LE) above the lowest charge transfer states (1CT and 3CT), leading to small singlet-triplet energy splitting and fast reverse intersystem crossing. These TADF emitters exhibit high photoluminescence quantum yields of 0.90 and 0.69 and short TADF lifetimes of 4.94 and 1.44μs in doped films, based on which the greenish-blue and greenish-yellow OLEDs achieve external quantum efficiencies of 23.2 and 16.2%, resp., with small efficiency roll-off rates and perfect color stability.

ACS Applied Materials & Interfaces published new progress about Crystallinity. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, HPLC of Formula: 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fricke, Christoph; Deckers, Kristina; Schoenebeck, Franziska published the artcile< Orthogonal Stability and Reactivity of Aryl Germanes Enables Rapid and Selective (Multi)Halogenations>, SDS of cas: 576-83-0, the main research area is fluorination iodination bromination aryl germane; chemoselectivity; germanium; halogenation; reaction mechanisms; synthetic methods.

While halogenation is of key importance in synthesis and radio-imaging, the currently available repertoire is largely designed to introduce a single halogen per mol. This report makes the selective introduction of several different halogens accessible. Showcased here is the privileged stability of nontoxic aryl germanes under harsh fluorination conditions (that allow selective fluorination in their presence), while displaying superior reactivity and functional-group tolerance in electrophilic iodinations and brominations, out-competing silanes or boronic esters under rapid and additive-free conditions. Mechanistic experiments and computational studies suggest a concerted electrophilic aromatic substitution as the underlying mechanism.

Angewandte Chemie, International Edition published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (chemoselective germane functionalization over boronic acids, boronic esters and silanes). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, SDS of cas: 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Alam, Ryan M.; Keating, John J. published the artcile< An Expedient Approach to Pyrazolo[3,4-b]pyridine-3-carboxamides via Palladium-Catalyzed Aminocarbonylation>, Recommanded Product: 4-Bromobenzylamine, the main research area is iodo fluorobenzyl pyrazolopyridine formic acid amine palladium catalyst aminocarbonylation; fluorobenzyl pyrazolopyridine carboxamide preparation.

A series of novel 1,3-disubstituted pyrazolo[3,4- b]pyridine-3-carboxamide derivatives was prepared by introducing the 3-carboxamide moiety using palladium-catalyzed aminocarbonylation methodol. and employing CO gas generated ex-situ using a two-chamber reactor (COware ). The functional group tolerance of this optimized aminocarbonylation protocol was highlighted through the synthesis of a range of diversely substituted C-3 carboxamide pyrazolo[3,4- b]pyridines in excellent yields of up to 99%.

Synthesis published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas published the artcile< Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis>, Quality Control of 188813-04-9, the main research area is palladium catalyzed hydroxycarbonylation heteroaryl halide DNA encoded library synthesis.

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets.

Bioconjugate Chemistry published new progress about Carbonylation. 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Quality Control of 188813-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Doobary, Sayad; Sedikides, Alexi T.; Caldora, Henry P.; Poole, Darren L.; Lennox, Alastair J. J. published the artcile< Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-rich Substrates>, Reference of 3959-07-7, the main research area is vicinal difluoroalkane preparation difluorination unactivated alkene hypervalent iodine mediator; electrochem difluorination unactivated alkene hypervalent iodine mediator; electrochemistry; fluorination; green chemistry; hypervalent iodine; oxidation.

Fluorinated alkyl groups are important motifs in bioactive compounds, pos. influencing pharmacokinetics, potency and conformation. The oxidative difluorination of alkenes represents an important strategy for their preparation, yet current methods are limited in their alkene-types and tolerance of electron-rich, readily oxidized functionalities, as well as in their safety and scalability. Herein, we report a method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving products that are otherwise unattainable. Key to success is the electrochem. generation of a hypervalent iodine mediator using an “”ex-cell”” approach, which avoids oxidative substrate decomposition The more sustainable conditions give good to excellent yields in up to decagram scales. Of note, when handling HF reagents, personal protection is of utmost importance.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (unactivated). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gopalaiah, Kovuru; Tiwari, Ankit; Choudhary, Renu; Mahiya, Kuldeep published the artcile< Straightforward Access to 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides and Quinazolines via Iron-Catalyzed Aerobic Oxidative Condensation of Amines>, Application In Synthesis of 3959-07-7, the main research area is aminobenzenesulfonamide primary amine iron catalyst oxidative cyclocondensation; dihydrobenzothiadiazine dioxide preparation; aminobenzylamine primary amine iron catalyst oxidative cyclocondensation; quinazoline preparation.

A novel and straightforward approach for constructing 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxides from 2-aminobenzenesulfonamide and benzylamines via oxidative condensation was explored. Abundant and cheap iron salt as a catalyst and air as an oxidant were employed, which makes the process more practical and economical. This reaction protocol was further applied to synthesize diverse functionalized quinazolines through oxidative condensation of 2-aminobenzylamines with benzylamines. Besides this, the use of amino acid such as phenylglycine as benzylamine surrogate was tested for the construction of 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide and quinazoline derivatives The proposed mechanistic pathway was validated by isolating the key intermediates.

ChemistrySelect published new progress about Benzothiadiazines Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Le; Mao, Junjie; Guo, Shuangxi; Zhang, Qi; Cai, Shuangfei; He, Wei published the artcile< PtAu bimetallic nanocatalyst for selective hydrogenation of alkenes over aryl halides>, Application of C8H9Br, the main research area is platinum gold nanocatalyst hydrogenation chemoselectivity enantioselectivity.

Herein, we present a new strategy that for the first time achieved chemo- and enantio-selective hydrogenation of alkenes over arylhalides. Key to the success is that instead of using external poisons, we use the composition of the bimetallic nanocrystal catalysts to control chemoselectivity (hydrogenation of C=C bonds without cleavage of Ar-X bonds). We further show that this system combined with surface modifying chiral ligands can control the enantioselectivity. Thus, after synthesizing and screening a series of easily accessible MxAuy (M = Pd, Pt; x, y = 1, 3, 5) bimetallic nanocrystals (9-10 nm) supported on activated carbon, we identified that Pt1Au1/C is a recyclable and generally applicable catalyst for the chemoselective hydrogenation of alkenes without cleaving aryl halogen bonds. Furthermore, cinchonidine modified Pt1Au1/C is shown to be capable of enantioselective hydrogenation, as illustrated by the rapid and enantio-enriched synthesis of RIP1 inhibitor analog 7-Br-O-Nec1.

Nano Research published new progress about Binding energy. 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Application of C8H9Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary