Tag: M.W=150-200

Zhang, Feng; Ma, Jun; Tan, Ya; Yu, Gang; Qin, Hongxin; Zheng, Lirong; Liu, Hongbo; Li, Run published the artcile< Construction of Porphyrin Porous Organic Cage as a Support for Single Cobalt Atoms for Photocatalytic Oxidation in Visible Light>, Synthetic Route of 3959-07-7, the main research area is construction porphyrin porous organic cage support single cobalt atom; oxidative coupling reaction catalyst benzylamine.

The construction of an appropriate support for a single atom catalyst plays an important role in delivering a high catalytic performance. However, most reported host materials suffer the drawbacks of low photostability and limited visible light absorption. Herein, we report a porous organic cage as a high-quality support for single metal atoms by a facile stepwise nucleophilic substitution approach. Thanks to its intrinsic advantages of extended visible light absorption, suppressed charge recombination, and improved electron transfer, the obtained single Co atoms anchored organic cage (CoP@POC) demonstrates a prominent photocatalytic efficiency for oxidation of amines into imines in visible light. An excellent reaction conversion and selectivity up to 99%, associated with a turnover frequency (TOF) of 1389 h-1 and 22 989 mmol g-1 h-1 are achieved based on organic cage and single Co atoms, resp., which outperforms most reported photocatalysts. Moreover, a negligible conversion decrease in 5 repeating cycles and no photobleaching after the reaction was detected, implying a remarkable photostability of CoP@POC.

ACS Catalysis published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Belov, Dmitry S.; Mathivathanan, Logesh; Beazley, Melanie J.; Martin, William Blake; Bukhryakov, Konstantin V. published the artcile< Stereospecific Ring-Opening Metathesis Polymerization of Norbornene Catalyzed by Iron Complexes>, Synthetic Route of 576-83-0, the main research area is stereospecific ring opening metathesis polymerization norbornene catalyzed iron; iron; metathesis; norbornene; ring-opening polymerization; syndiotactic.

Developing well-defined iron-based catalysts for olefin metathesis would be a breakthrough achievement in the field not only to replace existing catalysts by inexpensive metals but also to attain a new reactivity taking advantage of the unique electronic structure of the base metals. Here, we present a two-coordinate homoleptic iron complex, Fe(HMTO)2 [HMTO=O-2,6-(2,4,6-Me3C6H2)2C6H3], that is capable of performing ring-opening metathesis polymerization of norbornene to produce highly stereoregular polynorbornene (99% cis, syndiotactic). The use of heteroleptic Fe(HMTO)(RO) [RO=(CH3)2CF3CO, CH3(CF3)2CO, or Ph(CF3)2CO] prepared in situ significantly increases the polymerization rate while preserving selectivity. The resulting polymers were characterized by 1H and 13C NMR spectroscopy and gel-permeation chromatog.

Angewandte Chemie, International Edition published new progress about Electronic structure. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Synthetic Route of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Oi, Miku; Takita, Ryo; Kanazawa, Junichiro; Muranaka, Atsuya; Wang, Chao; Uchiyama, Masanobu published the artcile< Organocopper cross-coupling reaction for C-C bond formation on highly sterically hindered structures>, Related Products of 576-83-0, the main research area is organocopper compound aryl iodide cross coupling reaction mechanism.

A powerful, broadly applicable cross-coupling protocol that enabled carbon-carbon bond formation at highly sterically hindered carbon centers (both sp2 and sp3) by employing organocopper reagents under palladium catalysis was described. Exptl. studies and theor. calculations indicated that the key to the unique reactivity of copper was the relatively low activation energy of the compact transmetalation transition state, due to Cu(I)-Pd(II) interaction, which was associated with small values of deformation energy of the reactants. This reaction was applicable to a variety of bulky substrates, including compounds inert to previous cross-coupling chem. and has high functional group tolerance.

Chemical Science published new progress about Aryl bromides Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Related Products of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Faltracco, Matteo; Cotogno, Silvia; Vande Velde, Christophe M. L.; Ruijter, Eelco published the artcile< Catalytic Asymmetric Synthesis of Diketopiperazines by Intramolecular Tsuji-Trost Allylation>, Formula: C7H8BrN, the main research area is diketopiperazine preparation palladium catalyst asym Tsuji Trost allylation.

The authors report the intramol. Tsuji-Trost reaction of Ugi adducts to give spiro-diketopiperazines in high yield and with high enantioselectivity. This approach allows the catalytic asym. construction of a broad range of these medicinally important heterocycles under mild conditions, in two steps from cheap, com. available starting materials.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lahtigui, Ouidad; Forster, Dan; Duchemin, Coralie; Cramer, Nicolai published the artcile< Enantioselective Access to 3-Azabicyclo[3.1.0]hexanes by CpxRhIII Catalyzed C-H Activation and Cp*IrIII Transfer Hydrogenation>, Reference of 3959-07-7, the main research area is azabicyclohexane enantioselective diastereoselective preparation; cyclopropane enantioselective diastereoselective preparation amine CH activation transfer hydrogenation; enoxysuccinimide alkenyl aldehyde enantioselective diastereoselective cyclopropanation.

A flexible two-step protocol for efficient and selective access such as 3-azabicyclo[3.1.0]hexanes I [R1 = cyclopropyl, Ph, 3-thienyl, etc.; R2 = Bn, PNB] was disclosed. A tailored CpxRhIII catalyst promoted alkenyl C-H functionalization of N-enoxysuccinimides engaging in rare cis-cyclopropanation of acrolein to access disubstituted cis-cyclopropanes in high enantio- and diastereoselectivity. Subsequently, in the presence of a broad range of primary amines, the dicarbonyl cis-cyclopropanes were efficiently and completely diastereoselectively cyclized by a Cp*IrIII catalyst via an iterative aminative transfer hydrogen to an exquisite set of substituted 3-azabicyclo[3.1.0]hexanes.

ACS Catalysis published new progress about C-H bond activation. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reese, Cassandra M.; Thompson, Brittany J.; Logan, Phillip K.; Stafford, Christopher M.; Blanton, Michael; Patton, Derek L. published the artcile< Sequential and one-pot post-polymerization modification reactions of thiolactone-containing polymer brushes>, Product Details of C7H8BrN, the main research area is homocysteine thiolactone acrylamide polymer brush amine post polymerization; surface property wettability.

Thiolactone chem. has garnered significant attention as a powerful post-polymerization modification (PPM) route to mutlifunctional polymeric materials. Here, we apply this versatile chem. to the fabrication of ultrathin, multifunctional polymer surfaces via aminolysis and thiol-mediated double modifications of thiolactone-containing polymer brushes. Polymer brush surfaces were synthesized via microwave-assisted surface-initiated polymerization of DL-homocysteine thiolactone acrylamide. Aminolysis and thiol-Michael double modifications of the thiolactone-functional brush were explored using both sequential and one-pot reactions with bromobenzyl amine and 1H,1H-perfluoro-N-decyl acrylate. XPS and argon gas cluster ion sputter depth profiling enabled quant. comparison of the sequential and one-pot PPM routes with regard to conversion and spatial distribution of functional groups immobilized throughout thickness of the brush. While one-pot conditions proved to be more effective in immobilizing the amine and acrylate within the brush, the sequential reaction enabled the fabrication of multifunctional, micropatterned brush surfaces using reactive microcontact printing.

Polymer Chemistry published new progress about Aminolysis. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Adachi, Yohei; Arai, Fuka; Sakabe, Mitsuru; Ohshita, Joji published the artcile< Effect of the conjugation pathway on the electronic structures of p-π* conjugated polymers with fused borepin units>, SDS of cas: 576-83-0, the main research area is fused borepin pi conjugated polymer electronic structure conjugation effect.

Among conjugated materials, p-π* conjugated polymers have attracted much attention due to their unique electronic structures derived from the orbital interaction between the empty p-orbital on boron and the π*-orbitals of the adjacent π-systems. On the other hand, borepin, an isoelectronic ring system of tropylium ions, has been investigated as an aromatic system containing heteroatoms. In this work, the first examples of p-π* conjugated polymers consisting of tetracyclic borepin structures with different conjugation pathways were prepared Optical investigations revealed that the borepin polymers have more extended conjugations than conventional p-π* conjugated polymers. Furthermore, the two borepin polymers exhibited drastically different optical responses when cyanide was added to the solution Photophys. measurements and DFT calculations disclosed the characteristic electronic effects of the borepin structures and the influence of different conjugation pathways.

Polymer Chemistry published new progress about Absorption spectra. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, SDS of cas: 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shi, Jing Bo; Chen, Liu Zeng; Wang, Bao Shi; Huang, Xin; Jiao, Ming Ming; Liu, Ming Ming; Tang, Wen Jian; Liu, Xin Hua published the artcile< Novel Pyrazolo[4,3-d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model>, COA of Formula: C7H8BrN, the main research area is pyrazolopyrimidine preparation inducible nitric oxide synthase dimerization inhibitor; antiflammatory activity SAR pyrazolopyrimidine rheumatoid arthritis mouse model.

In order to discover novel anti-inflammatory agents for treatment of arthritis and based on preliminary structure-activity relationships, four series (A-D) of total 90 new pyrazolo[4,3-d]pyrimidine compounds were designed and synthesized. All the compounds have been tested for their anti-inflammatory activities by inhibiting of LPS-induced NO production A clear structure-activity relationship has been concluded step by step, and finally 3,4,5-trimethoxystyryl-1H-pyrazolo[4,3-d]pyrimidine was found to be the most active scaffold. Among them, compound I was discovered as the most potent anti-inflammatory agent (IC50 = 3.17 μM) with low toxicity and strong inhibitory of NO release (IR = 90.4% at 10 μM). This compound also showed potent inhibition of iNOS with IC50 value of 1.12 μM. Preliminary mechanism studies indicated that it could interfere with the stability and formation of active dimeric iNOS. The anti-inflammatory effect of this compound was determined by adjuvant-induced arthritis in rat model. We believe these findings would further support the study of rational design of more efficient iNOS inhibitors in the future.

Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, COA of Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Russ, Nadine; Schroeder, Martin; Berger, Benedict-Tilman; Mandel, Sebastian; Aydogan, Yagmur; Mauer, Sandy; Pohl, Christian; Drewry, David H.; Chaikuad, Apirat; Mueller, Susanne; Knapp, Stefan published the artcile< Design and Development of a Chemical Probe for Pseudokinase Ca2+/calmodulin-Dependent Ser/Thr Kinase>, Reference of 3959-07-7, the main research area is calcium calmodulin dependent Ser Thr kinase chem probe; design synthesis diaminopyrimidine carboxamide CASK inhibitor structure property relationship.

CASK (Ca2+/calmodulin-dependent Ser/Thr kinase) is a member of the MAGUK (membrane-associated guanylate kinase) family that functions as neurexin kinases with roles implicated in neuronal synapses and trafficking. The lack of a canonical DFG motif, which is altered to GFG in CASK, led to the classification as a pseudokinase. However, functional studies revealed that CASK can still phosphorylate substrates in the absence of divalent metals. CASK dysfunction has been linked to many diseases, including colorectal cancer, Parkinson’s disease, and X-linked mental retardation, suggesting CASK as a potential drug target. Here, we exploited structure-based design for the development of highly potent and selective CASK inhibitors based on 2,4-diaminopyrimidine-5-carboxamides targeting an unusual pocket created by the GFG motif. The presented inhibitor design offers a more general strategy for the development of pseudokinase ligands that harbor unusual sequence motifs. It also provides a first chem. probe for studying the biol. roles of CASK.

Journal of Medicinal Chemistry published new progress about Amides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Yanan; Ji, Kaihui; Wang, Jing; Li, Huafeng; Zhu, Xueyu; Ma, Pengtao; Niu, Jingyang; Wang, Jingping published the artcile< Enhanced Carrier Separation in Visible-Light-Responsive Polyoxometalate-Based Metal-Organic Frameworks for Highly Efficient Oxidative Coupling of Amines>, Computed Properties of 3959-07-7, the main research area is visible light responsive polyoxometalate metal organic framework photocatalyst; amine oxidative coupling; POM-based metal−organic frameworks; oxidative coupling of amines; photocatalytic; photosensitizers; polyoxometalates.

Photocatalytic technol. is widely studied, while it comes with drawbacks such as low sunlight utilization efficiency and high carrier recombination rates. Herein, for the first time, we present two crystalline polyoxometalate (POM)-based metal-organic frameworks (POMOFs), {[Cd(DMF)2Ru(bpy)2(dcbpy)]2(POMs)(DMF)2} xDMF (PMo-1, POMs = [PMoVI11MoVO40]4-, x = 5; SiW-2, POMs = [SiW12O40]4-, x = 4) through assembling the photosensitizer [Ru(bpy)2(H2dcbpy)]Cl2 and POMs into a single framework. The assembly not only enhances light absorption in the visible light regime but also improves carrier separation efficiency; atop of that, both POMOFs demonstrate activities in the photocatalytic oxidative coupling of amines. Particularly, PMo-1 enables the quant. completion of oxidative coupling of benzylamine reaction within 30 min (yield = 99.6%) with a high turnover frequency (TOF = 6631.6 h-1). To our knowledge, the PMo-1 catalyst outperforms any other photocatalysts previously reported in similar use cases where TOF values were usually obtained <2000 h-1. ACS Applied Materials & Interfaces published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary