Tag: M.W=150-200

Katariya, Kanubhai D. published the artcileCoumarin Schiff base-esters liquid crystals with symmetrical and unsymmetrical alkoxy chains: synthesis, mesomorphic properties and DFT approach, Related Products of bromides-buliding-blocks, the publication is Journal of Molecular Liquids (2022), 119073, database is CAplus.

Herein, two series of coumarin Schiff base-esters liquid crystals I (R¹ = R² = Et, n-Pr, n-octadecyl, etc.) and I (R¹ = Et, n-Pr, n-octadecyl, etc.; R² = n-dodecyl) were prepared Both series were studied for their mesomorphic behavior using differential scanning calorimetry (DSC) for the phase transitions and polarized optical microscopy (POM) to identify the type of mesophase. On varying the alkyl chain length at the both end of mols. systematically in the series I (R¹ = R²), compounds of chain lengths 2-7 exhibited an enantiotropic nematic (N) phase whereas I (R¹ = R² = n-octyl) exhibited enantiotropic smectic C (SmC) phase in addition to enantiotropic nematic phase. Compounds of the sym. series I (R¹ = R² = n-decyl, n-dodecyl, n-tetradecyl, n-hexadecyl, n-octadecyl) showed enantiotropic SmC phase. In the unsym. series, enantiotropic nematic mesophase was observed for compounds I (R¹ = from Et to n-tetradecyl; R² = n-dodecyl), while enantiotropic SmC mesophase was observed for compounds I (R¹ = from n-hexyl to n-octadecyl; R² = n-dodecyl). The DFT theor. calculations was conducted for both series to understand the mesomorphic behavior of the investigated compounds Moreover, they were compared with similar reported compounds to explain the relationship between the structural parameters and the mesomorphic behavior.

Journal of Molecular Liquids published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Deyab, M. A. published the artcileTheoretical and experimental investigation of four ionic liquids for their ability to prevent carbon steel corrosion in 1 M HCl, Recommanded Product: 1-Bromooctane, the publication is Journal of Molecular Liquids (2022), 118414, database is CAplus.

The inhibitory mechanism of four ionic liquids (ILs) generated from imidazolium is reported in this study. The goal of the research was to see how the cation structure of ILs affected the corrosion inhibition of carbon steel in 1 M HCl. The chem. structure of ILs was verified by elements anal., Fourier-transform-IR (FTIR), thermo gravimetric (TGA), NMR (¹HNMR, D₂O, ¹³C NMR) and hetero-nuclear single-quantum correlation (HSQC). The inhibitory efficiency was measured using mass loss and electrochem. tests and varied from 62.5% to 97.2%. The Langmuir model accurately defined their adsorption on a steel substrate. Adsorption of novel ILs on steel substrates is a mixed physisorption and chemisorption method. To ensure the mechanism of adsorption of current ionic liquids, FTIR and UV spectra were employed.

Journal of Molecular Liquids published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Okuda, Yasuhiro published the artcileIntramolecular cyclization mediated by silylmetalation of acetylenes with dimethylphenylsilylmethylmagnesium (PhMe₂SiMgMe)/cuprous iodide and radical nature of the reagent, Computed Properties of 81216-14-0, the publication is Tetrahedron Letters (1984), 25(23), 2483-6, database is CAplus.

HCC(CH₂)₃XR (X = bond, CH₂, CHMe, CHBu,CH₂CH₂; R = O₃SC₆H₄Me-4, O₃SMe, Br) underwent CuI-catalyzed reaction with Me₂SiPhMgMe to give 25-91% methylenylcycloalkanes I. However, the same treatment of HCCCH₂CHR¹O₃SMe (R¹ = H, Me) gave 30-45% methylenecyclopropanes II and 10-41% silylcyclobutenes III.

Tetrahedron Letters published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Computed Properties of 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Choi, Isaac published the artcileRecyclable Ruthenium Catalyst for Distal meta-C-H Activation, HPLC of Formula: 401-55-8, the publication is Chemistry – A European Journal (2020), 26(66), 15290-15297, database is CAplus and MEDLINE.

The unprecedented hybrid-ruthenium catalysis for distal meta-C-H activation was disclosed. The hybrid-ruthenium catalyst was recyclable, as was proven by various heterogeneity tests, and fully characterized with various microscopic and spectroscopic techniques, highlighting the phys. and chem. stability. Thereby, the hybrid-ruthenium catalysis proved broadly applicable for meta-C-H alkylations of among others purine-based nucleosides and natural product conjugates. Addnl., its versatility was further reflected by meta-C-H activations through visible-light irradiation, as well as para-selective C-H activations.

Chemistry – A European Journal published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bhuyan, Bhaskar J. published the artcileSynthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors, Formula: C4H7BrO2, the publication is Organic & Biomolecular Chemistry (2011), 9(5), 1356-1365, database is CAplus and MEDLINE.

Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I (Ang I) to angiotensin II (Ang II). ACE also cleaves the terminal dipeptide of vasodilating hormone bradykinin (a nonapeptide) to inactivate this hormone. Therefore, inhibition of ACE is generally used as one of the methods for the treatment of hypertension. Oxidative stress’ is another disease state caused by an imbalance in the production of oxidants and antioxidants. A number of studies suggest that hypertension and oxidative stress are interdependent. Therefore, ACE inhibitors having antioxidant property are considered beneficial for the treatment of hypertension. As selenium compounds are known to exhibit better antioxidant behavior than their sulfur analogs, we have synthesized a number of selenium analogs of captopril, an ACE inhibitor used as an antihypertensive drug. The selenium analogs of captopril not only inhibit ACE activity but also effectively scavenge peroxynitrite, a strong oxidant found in vivo.

Organic & Biomolecular Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Formula: C4H7BrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sabbaghan, Maryam published the artcileThe effect of aromatic and non-aromatic ionic liquids on the optical nonlinearity responses of porphyrins, Synthetic Route of 111-83-1, the publication is Journal of Molecular Liquids (2022), 118398, database is CAplus.

The effects of adding aromatic and nonaromatic ionic liquids (ILs) on third-order nonlinear optical (NLO) responses of 5,10,15,20-Tetrakis(4-methoxycarbonylphenyl) porphyrin (S1) and [5,10,15,20-Tetrakis(4-methoxycarbonylphenyl)-porphyrin]-Co (II) (S2) at 532 nm were investigated using the Z-scan technique. ILs show negligible nonlinear response in compare with porphyrins. A significant increase in NLO response with adding DABCO-based IL to S1 was observed which approx. equal to Cobalt(II) ion substitution at the core of porphyrin structure. The obtained value of nonlinear absorption coefficient β (cm/W) and the nonlinear refractive index n₂ (cm²/W), are of the order of 10^-4 and 10^-8, resp. The pos. synergetic effects were interpreted for enhanced nonlinear optical response by adding imidazolium-based IL and Cobalt(II) ion substitution at the core of porphyrin structure. Using ILs as additive led to excellent nonlinear properties which implies their promising applications in the optical devices.

Journal of Molecular Liquids published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Synthetic Route of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yokohama, Shuichi published the artcileSynthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives. II. 6-Alkyl- and 6-cycloalkylalkyl derivatives, HPLC of Formula: 18928-94-4, the publication is Chemical & Pharmaceutical Bulletin (1992), 40(9), 2391-8, database is CAplus and MEDLINE.

A series of 6-alkyl- or 6-(cycloalkylalkyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-ones, including I (R = cyclopentylethyl, cyclopentylpropyl, cyclohexylmethyl, cyclohexylpropyl, cycloheptylethyl, cyclooctylethyl, cyclododecylethyl), was synthesized from the corresponding 1,3,4-thiadiazol-5-amines II and the antiallergic activities of the products were evaluated. Among these compounds 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one (I, R = cyclohexylethyl), whose x-ray crystallog. stereostructure was determined, is a promising new antiallergic agent, which has low toxicity and dual activity as a leukotriene D₄ receptor antagonist and as an orally active mast cell stabilizer.

Chemical & Pharmaceutical Bulletin published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C9H6N2O2, HPLC of Formula: 18928-94-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Abiru, Toichi published the artcileNucleosides and nucleotides. 107. 2-(Cycloalkylalkynyl)adenosines: adenosine A₂ receptor agonists with potent antihypertensive effects, Safety of (2-Bromoethyl)cyclopentane, the publication is Journal of Medicinal Chemistry (1992), 35(12), 2253-60, database is CAplus and MEDLINE.

Adenosine receptor-binding profiles in rat brain tissues and antihypertensive effects in spontaneously hypertensive rats (SHR) of a series of 2-(cycloalkylalkynyl)adenosines, e.g. I [R = Ph, CH₂CH₂Ph, C(OH)Me₂, cyclopentyl, cyclohexyl], and their congeners are described. MSBAR of this series of compounds I is discussed, focusing on the length of the alkynyl side chain, and bulkiness of the terminal cycloalkyl substituents in terms of binding activity and cardiovascular effects. I had a preferential affinity of for A₂ receptors. Of these derivatives, 2-(3-cyclopenyl-1-propyn-1-yl)adenosine (II) exhibited the most selective affinity for A₂ receptors. In the C-2 binding region of adenosine, compounds often have potent and/or selective A₂ activity from introduction of an acetylenic group at the C-2 position followed by one methylene residue further followed by a hydrophobic substituent such as a cycloalkyl ring at the terminal position of the alkynyl side chain. I.v. injection of II up to 100 μg/kg had a potent hypotensive effect without a marked decrease in heart rate in anesthetized SHR. These compounds caused a marked bradycardia upon i.v. administration in anesthetized SHR. Oral administration of II (0.1-1 mg/kg) had a potent and long-lasting antihypertensive effect in conscious SHR.

Journal of Medicinal Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Safety of (2-Bromoethyl)cyclopentane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Abdelhafiz, Fatma M. published the artcileDesigning of quaternized hyperbranched polyamidoamines dendrimers: Surface activity, pharmaceutical efficacy, and safety approach, Recommanded Product: 1-Bromooctane, the publication is Journal of Drug Delivery Science and Technology (2022), 102929, database is CAplus.

The low solubility of the drug considers a major challenge for pharmaceutical formulation of both oral and parenteral products. In this work various generations of cationic hyperbranched polyamidoamine (PAMAM) quaternary ammonium salt dendrimers terminated with amine end groups were synthesized. The pharmaceutical application of these quaternized cationic surfactants ended with amine end groups and those ended with ester end groups which prepared in an earlier study were investigated. These dendrimers were compared as solubilizing agents for coenzyme Q10 (poorly soluble drug) and the dendrimers that showed high solubilizing potential (G_2.5 C₈, G_2.5 C₁₂) were selected to be evaluated as a dendrimer in dissolution study for coenzyme Q10 or Ledipasvir drug. In our investigation a comparison between four dissolution media with different surfactants namely, G_2.5 C₈, G_2.5 C₁₂, CTAB and Labrasol used for the dissolution test of Q10 was carried out. The results revealed that % Q10 released after 4 h was 86.7, 70.5, 43 and 10.5% for these dissolution media, resp. These results indicated the priority of the synthesized cationic surfactants than the known com. cationic surfactant (CTAB) or than Labrasol as recommended surfactant in previous lectures. Therefore, the profiles of the ledipasvir dissolution in the three-dissolution media G_2.5 C₈, G_2.5 C₁₂ and FDA surfactant (1.5% tween 80 and 0.0075 mg/mL Butylated Hydroxytoluene (BHT)) are similar. The obtained results emphasized that the new surfactants can be used as alternative to FDA surfactant in the dissolution media of Ledipasvir. Eventually, the toxicity study was performed for two selected compounds from the prepared dendrimers, and these compounds were proved to be safe.

Journal of Drug Delivery Science and Technology published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wenny, Malia B. published the artcileUnderstanding Relationships between Free Volume and Oxygen Absorption in Ionic Liquids, HPLC of Formula: 111-83-1, the publication is Journal of Physical Chemistry B (2022), 126(6), 1268-1274, database is CAplus and MEDLINE.

Understanding the factors that govern gas absorption in ionic liquids is critical to the development of high-capacity solvents for catalysis, electrochem., and gas separations Here, we report exptl. probes of liquid structure that provide insights into how free volume impacts the O₂ absorption properties of ionic liquids Specifically, we establish that isothermal compressibility-measured rapidly and accurately through small-angle X-ray scattering-reports on the size distribution of transient voids within a representative series of ionic liquids and is correlated with O₂ absorption capacity. Addnl., O₂ absorption capacities are correlated with thermal expansion coefficients, reflecting the beneficial effect of weak intermol. interactions in ionic liquids on free volume and gas absorption capacity. Mol. dynamics simulations show that the void size distribution-in particular, the probability of forming larger voids within an ionic liquid-has a greater impact on O₂ absorption than the total free volume These results establish relationships between the ionic liquid structure and gas absorption properties that offer design strategies for ionic liquids with high gas solubilities.

Journal of Physical Chemistry B published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C25H47NO8, HPLC of Formula: 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary