Tag: M.W=150-200

Cai, Rongbin; Zhou, Qi; Hou, Tianjiao; Li, Bing; Liu, Yunzhi; Li, Huan; Gao, Yuan; Zhu, Longyi; Luo, Jun published the artcile< Facile construction of the all-bridge-position-functionalized 2,4,6,8-tetraazaadamantane skeleton and conversion of its N-functionalities>, Safety of 4-Bromobenzylamine, the main research area is tetraazaadamantanyl tricyclic preparation.

In this article, an unusual protocol of a “”one-pot”” three-step strategy to build the special all-bridge-position-functionalized tetraazaadamantane skeletons I [R = i-Bu, Bn, CH2-2-furyl, etc.] from 2,2-dipropenyl-1,3-dioxolane via ozonation, hydrogenation with 5% Pd/BaSO4, and condensation of the in-situ generated dial intermediate with primary amines was reported for the first time. Different primary amines were compatible with this process and the corresponding 2,4,6,8-tetraalkyl-2,4,6,8-tetraazaadamantane-9,10-dione bis(ethylene ketals) were achieved in 19-46% yields. The conversion of the N-benzyl group to some other functionalities such as acetyl, benzoyl, nitroso and nitro was also investigated.

Organic Chemistry Frontiers published new progress about Condensation reaction. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shah, Akshara P.; Sharma, Anuj S.; Sharma, Vinay S.; Shimpi, Navinchandra G. published the artcile< Polyacrylonitrile Nanofibers Incorporating Silver-Decorated Graphitic Carbon Nitride for the Visible-Light-Activated Selective Oxidation of Styrene, Benzylic Methylene Groups, and Benzene>, Recommanded Product: 1-Bromo-3-ethylbenzene, the main research area is photooxidation catalyst nanofiber nanocomposite visible light.

A polyacrylonitrile nanofiber (PAN NF) supported silver nanoparticles-graphitic carbon nitride (Ag NPs/g-C3N4) nanoparticles catalyst was fabricated by electrospinning technique. Structural and morphol. studies indicate that the spherical Ag NPs present in the g-C3N4 material were well-dispersed on the surfaces of the PAN NFs or embedded in the PAN NFs without agglomerating. The catalytic potential of PAN/Ag NPs/g-C3N4 NFs was developed for oxidation of organic substrate such as styrene, -CH2 bonded mols., and benzene under visible light. The visible-light-mediated activity of the catalyst could be aided by the photoactive nature of the g-C3N4 surface. PAN/Ag NPs/g-C3N4 NFs show good selectivity toward epoxide with higher conversion (98%) in the case of styrene oxidation Further, ethylbenzene was oxidized to acetophenone with 99% conversion using H2O2. Addnl., the present material also shows excellent C-H oxidation of benzene (99%) into the desired phenol with higher selectivity. PAN/Ag NPs/g-C3N4 NFs possess mesoporous properties with excellent absorptive performance. This hybrid NFs exhibited enhanced activity, excellent stabilization, and recyclability.

ACS Applied Nano Materials published new progress about Electrospinning. 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Recommanded Product: 1-Bromo-3-ethylbenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Banerji, Biswadip; Adhikary, Saswati; Majumder, Leena; Ghosh, Saswati published the artcile< A Green Synthetic Approach towards Polyarylated Oxazoles via Iodine-Catalyzed One-Pot sp3 C-H Functionalization in Water: From Natural Product Synthesis To Photophysical Studies>, Safety of 4-Bromobenzylamine, the main research area is polyaryl oxazole preparation green chem regioselective; primary amine diketone acyloin aerobic oxidative cyclization iodine catalyst.

A ‘green’ methodol. for the convenient synthesis of specific regioisomers of polysubstituted oxazoles through iodine catalyzed, water-mediated, aerobic oxidative C(sp3)-H functionalization of primary amines has been developed. This mild and regioselective domino procedure does not require toxic peroxides, transition metals and organic solvents. The versatility of this methodol. was demonstrated by preparing a natural product, texaline. It is also scalable and has a wide substrate scope. This methodol. opens up a simple avenue for the synthesis of polyarylated oxazoles from various readily available amines as well as 1,2-diketones and acyloins (α-hydroxyl ketones) in moderate to excellent yields. Furthermore, these highly substituted oxazole mols. showed excellent fluorescence properties and thus have enormous potential to be a new type of fluorescent probe for use in medicinal applications and materials science.

Asian Journal of Organic Chemistry published new progress about Diketones, 1,2-diketones Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jinno, Shunki; Senoo, Takahiro; Mori, Keiji published the artcile< Access to ortho-Hydroxyphenyl Ketimines via Imine Anion-Mediated Smiles Rearrangement>, Computed Properties of 576-83-0, the main research area is phenoxy benzonitrile aryl bromide nucleophilic addition Smiles rearrangement; phenyliminomethyl aryl phenol preparation.

Access to N-(2-halophenyl)-2-hydroxyphenylimine derivatives via imine anion-mediated Smiles rearrangement. When 2-(2-halophenoxy)benzonitriles were treated with 1.2-1.4 equiv of organolithium reagents, nucleophilic addition to the nitrile group followed by Smiles rearrangement occurred to give various N-(2-halophenyl)-2-hydroxyphenylimine derivatives, which are sometimes difficult to synthesize by the conventional acid-promoted condensation reaction between carbonyl compounds and aniline derivatives, in good to excellent chem. yields (up to 91%).

Organic Letters published new progress about Aromatic ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Computed Properties of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Wenxing; Zhang, Shuo; Shi, Guang; Chen, Zhiwei published the artcile< Electrochemical synthesis of 1,2,4,5-tetrasubstituted imidazoles from enamines and benzylamines>, Related Products of 3959-07-7, the main research area is imidazole preparation green chem; enamine benzylamine electrochem amination.

An electrochem. method for synthesizing 1,2,4,5-tetrasubstituted imidazoles I (R = Me, Et, Ph, i-Pr; R1 = n-Bu, Bn, cyclohexyl, 4-chlorophenyl, naphthalen-1-yl, etc.; R2 = Me, OMe, OEt, Ot-Bu; R3 = Ph, 2,3-dichlorophenyl, thiophen-2-yl, etc.) was developed under undivided electrolytic conditions. This synthesis was specifically realized based on electrochem. C(sp3)-H amination via enamines (Z)-RC(NHR1)=C(O)R2 and amines R3NH2. Readily available starting materials were used, avoiding the use of both transition metals and oxidants. The practicability of the method lies in its broad substrate adaptability and in its ability to provide a simple green pathway for synthesizing GABAA receptor analogs I (R = Me; R1 = 2,4-dichlorophenyl; R2 = OEt; R3 = 4-bromophenyl).

Organic & Biomolecular Chemistry published new progress about Amination. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Setati, Boitumelo; Moshapo, Paseka Thendo; Holzapfel, Cedric Wahl; Maumela, Munaka Christopher published the artcile< Palladium-catalyzed Heck reactions promoted by limonene-derived bicyclic phosphines>, Related Products of 576-83-0, the main research area is halobenzene aryl alkene palladium catalyst Heck reaction; aryl ester preparation; aromatic ketone preparation.

Tertiary bicyclic phosphines derived from (R)-(+)-limonene provided efficient palladium catalysts for Heck cross-coupling reactions. Overall, high yields of the desired aryl alkenes products were obtained for cross-coupling of sterically and electronically diverse substrates. The efficiency of the catalysts was further demonstrated in the synthesis of com. ketones, such as raspberry ketone and its derivatives

Synthetic Communications published new progress about Aromatic esters Role: SPN (Synthetic Preparation), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Related Products of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Garcia, Kevin J.; Gilbert, Michael M.; Weix, Daniel J. published the artcile< Nickel-Catalyzed Addition of Aryl Bromides to Aldehydes To Form Hindered Secondary Alcohols>, Formula: C9H11Br, the main research area is aryl halide aldehyde nickel catalyst zinc reducing agent addition; hindered secondary alc preparation.

Transition-metal-catalyzed addition of aryl halides across carbonyls remains poorly developed, especially for aliphatic aldehydes and hindered substrate combinations. We report here that simple nickel complexes of bipyridine and PyBox can catalyze the addition of aryl halides to both aromatic and aliphatic aldehydes using zinc metal as the reducing agent. This convenient approach tolerates acidic functional groups that are not compatible with Grignard reactions, yet sterically hindered substrates still couple in high yield (33 examples, 70% average yield). Mechanistic studies show that an arylnickel, and not an arylzinc, adds efficiently to cyclohexanecarboxaldehyde, but only in the presence of a Lewis acid co-catalyst (ZnBr2).

Journal of the American Chemical Society published new progress about Addition reaction. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Formula: C9H11Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Xia; Xu, Hui; Shi, Ji-Long; Hao, Huimin; Yuan, Hong; Lang, Xianjun published the artcile< Salicylic acid complexed with TiO2 for visible light-driven selective oxidation of amines into imines with air>, Recommanded Product: 4-Bromobenzylamine, the main research area is salicylic acid complexed anatase visible light selective oxidation amines; selective oxidation amine imines air.

The interplay of salicylic acid (SA) and reactive oxygen species (ROS) can modulate biotic and abiotic stress of plants, essential biol. aerobic oxidation processes. Meanwhile, ROS plays a critical role in TiO2 photocatalytic system for the degradation of organic species. Herein, we developed a system consisted of SA and TiO2 aiming at the selective oxidation of organic mols. by ROS. Interestingly, SA complexed with TiO2 leads to ligand-to-metal charge transfer (LMCT) under visible light irradiation The charge transfer from ligand (chem. adsorbed SA) to metal (conduction band of TiO2) activates O2 to ROS, superoxide (O·-2). The pos. charge located at ligand SA is connected with (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) catalysis for direct two-electron oxidation of amines and later regenerated by O·2-. SA and its derivatives were screened as ligands of TiO2 for the selective aerobic oxidation of amines into imines under blue light-emitting diode (LED) irradiation in which 5-CH3O-SA (5-methoxysalicylic acid, 0.8 mol%) complexed with anatase TiO2 and coupled with TEMPO (5 mol%) confers significantly better results than the others. By this visible light LMCT route, both primary amines and secondary amines can be selectively oxidized into corresponding imines with atm. O2 as the terminal oxidant. Importantly, the desired product of N-benzylidenebenzylamine can be isolated in 92% yield.

Applied Catalysis, B: Environmental published new progress about Amines Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Baker, Sarah I.; Yaghoubi, Mahshid; Bidwell, Samantha L.; Pierce, Savannah L.; Hratchian, Hrant P.; Baxter, Ryan D. published the artcile< Enhanced Reactivity for Aromatic Bromination via Halogen Bonding with Lactic Acid Derivatives>, COA of Formula: C9H11Br, the main research area is arene bromination regioselective lactic acid bromosuccinimide.

Herein, a new method for regioselective aromatic bromination using lactic acid derivatives as halogen bond acceptors with N-bromosuccinimide (NBS) is reported. Several structural analogs of lactic acid affected the efficiency of aromatic brominations, presumably via Lewis acid/base halogen-bonding interactions. Rate comparisons of aromatic brominations demonstrated the reactivity enhancement available via catalytic additives capable of halogen bonding. Computational results demonstrated that Lewis basic additives interact with NBS to increase the electropos. character of bromine prior to electrophilic transfer. An optimized procedure using catalytic mandelic acid under aqueous conditions at room temperature has been developed to promote aromatic bromination on a variety of arene substrates with complete regioselectivity.

Journal of Organic Chemistry published new progress about Aryl bromides Role: SPN (Synthetic Preparation), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, COA of Formula: C9H11Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lin, Xia; Fang, Chengtao; Huang, Xiaolei; Xiao, Xiaohui published the artcile< 1,1,2-Tribromoethyl arenes: novel and highly efficient precursors for the synthesis of 1-bromoalkynes and α-bromoketones>, Computed Properties of 2725-82-8, the main research area is bromoalkyne bromoketone preparation; tribromoethyl arene preparation elimination reaction; ethylbenzene bromination.

Herein, a novel method to synthesize 1,1,2-tribromoethyl arenes, which can be easily transformed to 1-bromoalkynes via base-mediated elimination reaction is reported. The bromination reagent was in situ generated from the reaction of NaBr/NaBrO3/H2SO4, resulting in high reactivity, excellent chem. selectivity and outstanding functional group tolerance. Moreover, 1,1,2-tribromoethyl arenes encounter a selectivity switch to afford α-bromoketones under strong acidic conditions.

Organic Chemistry Frontiers published new progress about Alkynes, bromo Role: SPN (Synthetic Preparation), PREP (Preparation). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Computed Properties of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary