Tag: M.W=150-200

Dalkas, Georgios A. published the artcileStudy of a lipophilic captopril analogue binding to angiotensin I converting enzyme, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is Journal of Peptide Science (2010), 16(2), 91-97, database is CAplus and MEDLINE.

Human ACE is a central component of the renin-angiotensin system and a major therapeutic target for cardiovascular diseases. The somatic form of the enzyme (sACE) comprises two homologous metallopeptidase domains (N and C), each bearing a zinc active site with similar but distinct substrate and inhibitor specificities. In this study, we present the biol. activity of silacaptopril, a silylated analog of captopril, and its binding affinity towards ACE. Based on the recently determined crystal structures of both the ACE domains, a series of docking calculations were carried out in order to study the structural characteristics and the binding properties of silacaptopril and its analogs with ACE. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.

Journal of Peptide Science published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Recommanded Product: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bauer, Adriano published the artcileChemoselective formal β-functionalization of substituted aliphatic amides enabled by a facile stereoselective oxidation event, Safety of 7-Bromohept-1-yne, the publication is Chemical Science (2019), 10(42), 9836-9840, database is CAplus and MEDLINE.

A facile and stereoselective dehydrogenation event enabling the functionalization of aliphatic amides, e.g., 1-(indolin-1-yl)-2-methylpropan-1-one at different positions in a one-pot fashion has been described. Derivatives of relevant pharmaceuticals were formally functionalized in the β-position in late-stage manner. A single-step synthesis of incrustoporine from a simple precursor further showcases the potential utility of this approach.

Chemical Science published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Safety of 7-Bromohept-1-yne.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Labanauskas, Linas published the artcileSynthesis of 1-substituted 4-[4-(1H-indol-3-yl)butyl]piperazines, Safety of 2-Bromoethyl Methyl Sulfone, the publication is ARKIVOC (Gainesville, FL, United States) (2013), 363-376, 14 pp., database is CAplus.

A convenient synthetic route for preparation of various 4-[4-(1H-indol-3-yl)butyl]piperazines bearing heterocyclic and aliphatic substituents in position 1 has been developed. During this work, some synthetic possibilities of the common precursor, 4-[4-(1H-indol-3-yl)butyl]piperazine, were studied and evaluated.

ARKIVOC (Gainesville, FL, United States) published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, Safety of 2-Bromoethyl Methyl Sulfone.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Xu, Feng published the artcileDeveloping versatile and highly selective chemosensor for amines detection based on bis-thiophene methane containing cyclopalladated compounds, Recommanded Product: 1-Bromooctane, the publication is Sensors and Actuators, B: Chemical (2022), 131561, database is CAplus.

Cyclopalladated compounds (CPCs) have special properties due to its internal multiple conjugate planes in their structure. Herein, a series of bis-thiophene methane-pyridine-Schiff base derivatives (L_n) and their CPCs (L_n-Pd) as monomers were prepared All cyclopalladated monomers showed extreme sensitivity to organic amines in both solution and vapor states. The results of structural anal. manifested that the complexes before and after alkali-treated have a relationship between monomer and dimer. Furthermore, the base-induced mechanism was expounded. To take full advantage of this feature, we utilized the monomer containing tetraphenylethylene (L₄-Pd) to detect organic amines in solution, which showed excellent sensitivity toward triethylamine and diethylamine with the limit of detection of 41 nM and 104 nM, resp. Then, the L₄-Pd coated labels were exposed to amine vapors at ppm level, which showed visible color variation in n-butylamine, ethylenediamine, diethylamine, and cyclohexylamine atm. It is suggesting that the materials have potential applications to detect organic amines in solution at trace anal. and a solid colorimetric chemosensor for organic amine vapors.

Sensors and Actuators, B: Chemical published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H10S, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhao, Yin-Na published the artcileA new approach to access difluoroalkylated diarylmethanes via visible-light photocatalytic cross-coupling reactions, Recommanded Product: Ethylbromofluoroacetate, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(32), 3993-3996, database is CAplus and MEDLINE.

Difluoroalkylated diarylmethanes with biol. and pharmacol. potentials were synthesized from para-quinone methides (p-QMs) and difluoroalkylating reagents via a visible light photocatalysis strategy. Mechanism studies showed that the excited photocatalyst, *fac-Ir(ppy)₃, was primarily quenched by p-QMs and the generated diarylmethane radical intermediates then underwent a radical-radical cross-coupling reaction with difluoroalkyl radicals. This reaction features mild conditions, high efficiency and wide functional group compatibility.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C7H6Cl2O, Recommanded Product: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chan-Seng, Delphine published the artcilePrimary Structure Control of Oligomers Based on Natural and Synthetic Building Blocks, Related Products of bromides-buliding-blocks, the publication is ACS Macro Letters (2014), 3(3), 291-294, database is CAplus and MEDLINE.

Solid-phase synthesis was exploited for the preparation of oligomers constructed from natural and synthetic building blocks by combining the formation of amide bonds and copper-assisted alkyne-azide cycloaddition reactions extending the variety of oligomers with well-defined primary structures accessible through this technique and providing control over the spacing between amino acids.

ACS Macro Letters published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lin, Hang published the artcileOrganic dyads and triads based on the triphenylene-rylenediimide couple: Molecular design, self-organization, and photo-physical properties, Synthetic Route of 111-83-1, the publication is Dyes and Pigments (2022), 109911, database is CAplus.

Liquid-crystalline D-A dyads and A-D-A triads, based on the chem. association of electron-donor (D) triphenylene discogens and electron-acceptor (A) perylene/benzoperylene diimides, have been synthesized by the Pd-catalyzed Sonogashira coupling/DBU-promoted cyclization reactions tandem. These mol. heterojunctions spontaneously self-organize into columnar hexagonal (Col_hex) or/and rectangular (Col_rec) mesophases, over broad temperature ranges including room temperature, with the antagonist moieties segregated into alternated homo-mol. (homolithic) stacks within mixed columns. Their intramol. electron and energy transfers have been studied by UV/Vis absorption and fluorescence emission spectroscopies. Due to photo-induced electron transfer between donor and acceptor units, fluorescence quenching is systematically observed for all the dyads and triads. This study further reveals that perylenediimide is a stronger electron acceptor than the larger benzoperylenediimide building block. D. function theory calculations of their mol. structures and HOMO-LUMO energy levels and gaps support the exptl. results and demonstrate that these donor-acceptor systems have potential applications in various optoelectronic devices.

Dyes and Pigments published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Synthetic Route of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Song, Jinming published the artcileReversible Multilevel Stimuli-Responsiveness and Multicolor Room-Temperature Phosphorescence Emission Based on a Single-Component System, Recommanded Product: 1-Bromooctane, the publication is Angewandte Chemie, International Edition (2022), 61(29), e202206157, database is CAplus and MEDLINE.

There are limited reports about the transformation of pure organic room-temperature phosphorescence (RTP) materials with multilevel stimuli-responsiveness at different RTP emission wavelengths under external stimuli. It is difficult to ensure efficient intersystem crossing (ISC) in different states of a single-component system. This research reports the conversion of the organic single-component small mol. 1,2-bis(4-alkoxyphenyl)ethane-1,2-dione (N-BOX) with multilevel stimuli-responsiveness between high-efficiency blue and yellow RTP by grinding or thermal annealing N-BOX crystals. The RTP emission of N-BOX in the crystalline state was easy to adjust by external stimuli (grinding or thermal annealing) due to its non-compact packing, which led to a phase transition and generated unique multilevel stimuli-responsiveness. In particular, the RTP quantum yield of 7-BOX with multilevel stimuli-responsiveness reached 68.4%, which provides an opportunity for regulation of smart optical materials based on pure organic RTP.

Angewandte Chemie, International Edition published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C12H14O2, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mazzarella, Daniele published the artcilePhotochemical Organocatalytic Borylation of Alkyl Chlorides, Bromides, and Sulfonates, HPLC of Formula: 401-55-8, the publication is ACS Catalysis (2019), 9(7), 5876-5880, database is CAplus.

Reported herein is a photochem. strategy for the borylation of alkyl halides using bis(catecholato)diboron as the boron source. This method exploits the ability of a nucleophilic dithiocarbonyl anion organocatalyst to generate radicals via an S_N2-based photochem. catalytic mechanism, which is not reliant on the redox properties of the substrates. Therefore, it grants access to alkyl boronic esters from readily available but difficult-to-reduce electrophiles, including benzylic and allylic chlorides, bromides, and mesylates, which were inert to or unsuitable for previously reported metal-free borylation protocols.

ACS Catalysis published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Truscott, Roger J. W. published the artcileTwo new sulfur-containing amino acids in man, Category: bromides-buliding-blocks, the publication is Biomedical Mass Spectrometry (1981), 8(3), 99-104, database is CAplus and MEDLINE.

Two unusual S-containing amino acids were isolated from the urine of a baby (of 1st cousin parents) who died with major phys. malformations and failure of growth and development. These acids were identified as (S)-(2-carboxypropyl)-cysteamine and -cysteine by mass spectral anal. and by synthesis. A recessively inherited error in valine metabolism at the level of methacrylyl-CoA hydratase, with conjugation of the methacrylic acid so formed with cysteine, is proposed as the origin of the compounds Possibly methacrylic acid or one of its derivatives caused the malformations in the baby.

Biomedical Mass Spectrometry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C25H23NO4, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary